LeishMANIAdb
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MIF4G domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MIF4G domain-containing protein
Gene product:
eukaryotic translation initiation factor 4 gamma 3
Species:
Leishmania mexicana
UniProt:
E9AQX3_LEIMU
TriTrypDb:
LmxM.16.1600
Length:
635

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: opmn@cpqam.biocruz.br
Publication title: Translation initiation in Leishmania major: characterisation of multiple eIF4F subunit homologues
Publication 1st author(s): Dhalia
Publication Identifier(s): 15694484
Host organism: -1
Interaction detection method(s): pull down
Interaction type: physical association
Identification method participant A: autoradiography
Identification method participant B: autoradiography
ID(s) interactor A: P60842
ID(s) interactor B: Q4QEK5
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania major
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0010494 cytoplasmic stress granule 5 1
GO:0016281 eukaryotic translation initiation factor 4F complex 2 1
GO:0032991 protein-containing complex 1 1
GO:0035770 ribonucleoprotein granule 3 1
GO:0036464 cytoplasmic ribonucleoprotein granule 4 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0099080 supramolecular complex 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

E9AQX3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQX3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 13
GO:0003723 RNA binding 4 13
GO:0003743 translation initiation factor activity 4 13
GO:0005488 binding 1 13
GO:0008135 translation factor activity, RNA binding 3 13
GO:0045182 translation regulator activity 1 13
GO:0090079 translation regulator activity, nucleic acid binding 2 13
GO:0097159 organic cyclic compound binding 2 13
GO:1901363 heterocyclic compound binding 2 13
GO:0003729 mRNA binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 329 333 PF00656 0.783
CLV_C14_Caspase3-7 456 460 PF00656 0.515
CLV_NRD_NRD_1 182 184 PF00675 0.277
CLV_NRD_NRD_1 281 283 PF00675 0.283
CLV_NRD_NRD_1 32 34 PF00675 0.501
CLV_NRD_NRD_1 456 458 PF00675 0.548
CLV_PCSK_FUR_1 182 186 PF00082 0.320
CLV_PCSK_FUR_1 30 34 PF00082 0.554
CLV_PCSK_KEX2_1 182 184 PF00082 0.276
CLV_PCSK_KEX2_1 283 285 PF00082 0.500
CLV_PCSK_KEX2_1 30 32 PF00082 0.475
CLV_PCSK_PC1ET2_1 184 186 PF00082 0.294
CLV_PCSK_PC1ET2_1 283 285 PF00082 0.617
CLV_PCSK_SKI1_1 103 107 PF00082 0.294
CLV_PCSK_SKI1_1 251 255 PF00082 0.347
CLV_PCSK_SKI1_1 291 295 PF00082 0.736
CLV_PCSK_SKI1_1 306 310 PF00082 0.728
CLV_PCSK_SKI1_1 32 36 PF00082 0.590
CLV_PCSK_SKI1_1 331 335 PF00082 0.491
CLV_PCSK_SKI1_1 462 466 PF00082 0.487
CLV_PCSK_SKI1_1 81 85 PF00082 0.362
DEG_APCC_DBOX_1 567 575 PF00400 0.561
DEG_Nend_UBRbox_3 1 3 PF02207 0.652
DEG_SPOP_SBC_1 368 372 PF00917 0.760
DEG_SPOP_SBC_1 452 456 PF00917 0.563
DOC_CYCLIN_RxL_1 81 92 PF00134 0.535
DOC_MAPK_gen_1 182 190 PF00069 0.471
DOC_MAPK_gen_1 270 278 PF00069 0.491
DOC_PP1_RVXF_1 268 274 PF00149 0.471
DOC_PP2B_LxvP_1 16 19 PF13499 0.603
DOC_SPAK_OSR1_1 272 276 PF12202 0.520
DOC_USP7_MATH_1 109 113 PF00917 0.504
DOC_USP7_MATH_1 299 303 PF00917 0.558
DOC_USP7_MATH_1 324 328 PF00917 0.749
DOC_USP7_MATH_1 344 348 PF00917 0.771
DOC_USP7_MATH_1 368 372 PF00917 0.649
DOC_USP7_MATH_1 486 490 PF00917 0.374
DOC_USP7_MATH_1 541 545 PF00917 0.508
DOC_USP7_MATH_1 557 561 PF00917 0.431
DOC_USP7_UBL2_3 160 164 PF12436 0.563
DOC_USP7_UBL2_3 243 247 PF12436 0.587
DOC_USP7_UBL2_3 81 85 PF12436 0.551
DOC_WW_Pin1_4 319 324 PF00397 0.621
DOC_WW_Pin1_4 340 345 PF00397 0.679
DOC_WW_Pin1_4 389 394 PF00397 0.702
DOC_WW_Pin1_4 537 542 PF00397 0.579
LIG_14-3-3_CanoR_1 138 147 PF00244 0.536
LIG_14-3-3_CanoR_1 214 222 PF00244 0.577
LIG_14-3-3_CanoR_1 251 257 PF00244 0.452
LIG_14-3-3_CanoR_1 31 40 PF00244 0.531
LIG_14-3-3_CanoR_1 355 362 PF00244 0.732
LIG_14-3-3_CanoR_1 403 408 PF00244 0.408
LIG_14-3-3_CanoR_1 505 510 PF00244 0.430
LIG_14-3-3_CanoR_1 532 536 PF00244 0.409
LIG_14-3-3_CanoR_1 593 599 PF00244 0.419
LIG_Actin_WH2_2 115 133 PF00022 0.585
LIG_APCC_ABBAyCdc20_2 520 526 PF00400 0.512
LIG_BH_BH3_1 226 242 PF00452 0.577
LIG_BRCT_BRCA1_1 202 206 PF00533 0.554
LIG_Clathr_ClatBox_1 397 401 PF01394 0.557
LIG_DLG_GKlike_1 505 512 PF00625 0.527
LIG_Dynein_DLC8_1 31 37 PF01221 0.569
LIG_EH1_1 272 280 PF00400 0.491
LIG_FHA_1 35 41 PF00498 0.553
LIG_FHA_1 364 370 PF00498 0.780
LIG_FHA_1 378 384 PF00498 0.632
LIG_FHA_1 414 420 PF00498 0.623
LIG_FHA_1 82 88 PF00498 0.486
LIG_FHA_2 205 211 PF00498 0.546
LIG_FHA_2 234 240 PF00498 0.525
LIG_FHA_2 252 258 PF00498 0.341
LIG_FHA_2 454 460 PF00498 0.453
LIG_FHA_2 511 517 PF00498 0.524
LIG_FHA_2 52 58 PF00498 0.471
LIG_FHA_2 559 565 PF00498 0.623
LIG_GBD_Chelix_1 487 495 PF00786 0.532
LIG_Integrin_isoDGR_2 353 355 PF01839 0.800
LIG_LIR_Gen_1 203 213 PF02991 0.562
LIG_LIR_Gen_1 250 259 PF02991 0.520
LIG_LIR_Gen_1 463 473 PF02991 0.420
LIG_LIR_Gen_1 504 512 PF02991 0.419
LIG_LIR_Gen_1 534 541 PF02991 0.472
LIG_LIR_Gen_1 551 559 PF02991 0.343
LIG_LIR_Gen_1 610 617 PF02991 0.504
LIG_LIR_LC3C_4 466 470 PF02991 0.513
LIG_LIR_Nem_3 112 118 PF02991 0.471
LIG_LIR_Nem_3 154 158 PF02991 0.575
LIG_LIR_Nem_3 17 23 PF02991 0.484
LIG_LIR_Nem_3 250 256 PF02991 0.491
LIG_LIR_Nem_3 463 468 PF02991 0.388
LIG_LIR_Nem_3 477 483 PF02991 0.324
LIG_LIR_Nem_3 534 538 PF02991 0.436
LIG_LIR_Nem_3 551 556 PF02991 0.338
LIG_LIR_Nem_3 610 615 PF02991 0.495
LIG_NRBOX 229 235 PF00104 0.539
LIG_NRBOX 586 592 PF00104 0.504
LIG_PCNA_TLS_4 246 253 PF02747 0.523
LIG_PCNA_yPIPBox_3 415 424 PF02747 0.603
LIG_PCNA_yPIPBox_3 584 593 PF02747 0.490
LIG_Pex14_1 423 427 PF04695 0.429
LIG_Pex14_2 502 506 PF04695 0.376
LIG_PTB_Apo_2 96 103 PF02174 0.554
LIG_SH2_CRK 115 119 PF00017 0.462
LIG_SH2_NCK_1 307 311 PF00017 0.687
LIG_SH2_SRC 15 18 PF00017 0.608
LIG_SH2_STAP1 125 129 PF00017 0.539
LIG_SH2_STAT5 15 18 PF00017 0.667
LIG_SH2_STAT5 195 198 PF00017 0.539
LIG_SH2_STAT5 252 255 PF00017 0.491
LIG_SH2_STAT5 524 527 PF00017 0.453
LIG_SH3_1 15 21 PF00018 0.564
LIG_SH3_3 15 21 PF00018 0.543
LIG_SH3_3 263 269 PF00018 0.521
LIG_SH3_3 390 396 PF00018 0.662
LIG_SH3_3 553 559 PF00018 0.586
LIG_SUMO_SIM_anti_2 223 231 PF11976 0.512
LIG_SUMO_SIM_anti_2 570 576 PF11976 0.553
LIG_TRAF2_1 169 172 PF00917 0.524
LIG_TRAF2_1 515 518 PF00917 0.660
LIG_TRAF2_1 54 57 PF00917 0.522
LIG_TRAF2_1 561 564 PF00917 0.662
LIG_TYR_ITIM 533 538 PF00017 0.460
LIG_UBA3_1 275 283 PF00899 0.504
LIG_UBA3_1 78 85 PF00899 0.525
LIG_WRC_WIRS_1 549 554 PF05994 0.520
LIG_WW_3 267 271 PF00397 0.520
MOD_CK1_1 216 222 PF00069 0.577
MOD_CK1_1 451 457 PF00069 0.577
MOD_CK2_1 160 166 PF00069 0.498
MOD_CK2_1 21 27 PF00069 0.499
MOD_CK2_1 251 257 PF00069 0.580
MOD_CK2_1 433 439 PF00069 0.557
MOD_CK2_1 486 492 PF00069 0.394
MOD_CK2_1 51 57 PF00069 0.467
MOD_CK2_1 510 516 PF00069 0.505
MOD_CK2_1 557 563 PF00069 0.602
MOD_GlcNHglycan 358 361 PF01048 0.720
MOD_GlcNHglycan 371 374 PF01048 0.682
MOD_GlcNHglycan 450 453 PF01048 0.519
MOD_GlcNHglycan 484 487 PF01048 0.368
MOD_GlcNHglycan 488 491 PF01048 0.355
MOD_GlcNHglycan 542 546 PF01048 0.572
MOD_GSK3_1 156 163 PF00069 0.547
MOD_GSK3_1 200 207 PF00069 0.560
MOD_GSK3_1 209 216 PF00069 0.536
MOD_GSK3_1 241 248 PF00069 0.464
MOD_GSK3_1 331 338 PF00069 0.690
MOD_GSK3_1 340 347 PF00069 0.713
MOD_GSK3_1 363 370 PF00069 0.763
MOD_GSK3_1 373 380 PF00069 0.751
MOD_GSK3_1 448 455 PF00069 0.486
MOD_GSK3_1 48 55 PF00069 0.508
MOD_GSK3_1 482 489 PF00069 0.477
MOD_GSK3_1 512 519 PF00069 0.537
MOD_GSK3_1 537 544 PF00069 0.559
MOD_N-GLC_2 428 430 PF02516 0.545
MOD_NEK2_1 200 205 PF00069 0.512
MOD_NEK2_1 209 214 PF00069 0.520
MOD_NEK2_1 233 238 PF00069 0.491
MOD_NEK2_1 241 246 PF00069 0.491
MOD_NEK2_1 34 39 PF00069 0.566
MOD_NEK2_1 369 374 PF00069 0.759
MOD_NEK2_1 510 515 PF00069 0.472
MOD_NEK2_1 531 536 PF00069 0.461
MOD_NEK2_1 63 68 PF00069 0.558
MOD_PIKK_1 138 144 PF00454 0.586
MOD_PIKK_1 32 38 PF00454 0.551
MOD_PKA_1 183 189 PF00069 0.554
MOD_PKA_1 32 38 PF00069 0.533
MOD_PKA_2 213 219 PF00069 0.577
MOD_PKA_2 32 38 PF00069 0.555
MOD_PKA_2 354 360 PF00069 0.763
MOD_PKA_2 510 516 PF00069 0.504
MOD_PKA_2 531 537 PF00069 0.500
MOD_PKB_1 30 38 PF00069 0.602
MOD_Plk_1 209 215 PF00069 0.562
MOD_Plk_1 541 547 PF00069 0.466
MOD_Plk_2-3 166 172 PF00069 0.504
MOD_Plk_4 201 207 PF00069 0.474
MOD_Plk_4 403 409 PF00069 0.490
MOD_Plk_4 505 511 PF00069 0.489
MOD_Plk_4 545 551 PF00069 0.418
MOD_Plk_4 594 600 PF00069 0.475
MOD_ProDKin_1 319 325 PF00069 0.620
MOD_ProDKin_1 340 346 PF00069 0.678
MOD_ProDKin_1 389 395 PF00069 0.693
MOD_ProDKin_1 537 543 PF00069 0.581
MOD_SUMO_for_1 398 401 PF00179 0.581
MOD_SUMO_rev_2 161 169 PF00179 0.577
MOD_SUMO_rev_2 300 308 PF00179 0.794
MOD_SUMO_rev_2 72 77 PF00179 0.575
TRG_DiLeu_BaEn_1 225 230 PF01217 0.577
TRG_DiLeu_BaEn_2 462 468 PF01217 0.385
TRG_DiLeu_BaEn_3 72 78 PF01217 0.535
TRG_DiLeu_BaLyEn_6 58 63 PF01217 0.505
TRG_ENDOCYTIC_2 115 118 PF00928 0.464
TRG_ENDOCYTIC_2 20 23 PF00928 0.488
TRG_ENDOCYTIC_2 535 538 PF00928 0.394
TRG_ER_diArg_1 181 183 PF00400 0.487
TRG_ER_diArg_1 269 272 PF00400 0.500
TRG_ER_diArg_1 281 284 PF00400 0.473
TRG_ER_diArg_1 29 32 PF00400 0.520
TRG_NES_CRM1_1 547 562 PF08389 0.596
TRG_NES_CRM1_1 607 618 PF08389 0.539
TRG_NLS_MonoExtN_4 182 187 PF00514 0.493
TRG_Pf-PMV_PEXEL_1 104 108 PF00026 0.264
TRG_Pf-PMV_PEXEL_1 156 161 PF00026 0.377
TRG_Pf-PMV_PEXEL_1 189 193 PF00026 0.362
TRG_Pf-PMV_PEXEL_1 32 36 PF00026 0.606

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDA5 Leptomonas seymouri 65% 100%
A0A0S4IUF0 Bodo saltans 31% 98%
A0A0S4KJH6 Bodo saltans 25% 100%
A0A1X0NZC7 Trypanosomatidae 41% 100%
A0A3Q8IAL0 Leishmania donovani 95% 100%
A0A422NEE1 Trypanosoma rangeli 43% 100%
A4H8T8 Leishmania braziliensis 90% 100%
A4HX58 Leishmania infantum 96% 100%
C9ZVT3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
Q4QEK5 Leishmania major 97% 100%
V5DJ79 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS