Putative U1 small nuclear ribonucleoprotein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

u1 small nuclear ribonucleoprotein 70 kDa

Species:

Leishmania mexicana

UniProt:

E9AQX2_LEIMU

TriTrypDb:

LmxM.16.1590

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005634	nucleus	5	1
GO:0005681	spliceosomal complex	3	1
GO:0005685	U1 snRNP	5	1
GO:0005689	U12-type spliceosomal complex	4	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AQX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQX2

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045292	mRNA cis splicing, via spliceosome	9	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003729	mRNA binding	5	1
GO:0017069	snRNA binding	5	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0044877	protein-containing complex binding	2	1
GO:0070990	snRNP binding	4	1
GO:1990446	U1 snRNP binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	76	80	PF00656	0.508
CLV_NRD_NRD_1	120	122	PF00675	0.537
CLV_NRD_NRD_1	189	191	PF00675	0.275
CLV_NRD_NRD_1	196	198	PF00675	0.252
CLV_NRD_NRD_1	46	48	PF00675	0.672
CLV_PCSK_FUR_1	197	201	PF00082	0.334
CLV_PCSK_KEX2_1	120	122	PF00082	0.550
CLV_PCSK_KEX2_1	13	15	PF00082	0.524
CLV_PCSK_KEX2_1	199	201	PF00082	0.309
CLV_PCSK_KEX2_1	222	224	PF00082	0.488
CLV_PCSK_KEX2_1	28	30	PF00082	0.553
CLV_PCSK_KEX2_1	46	48	PF00082	0.512
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.545
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.314
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.488
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.563
CLV_PCSK_PC7_1	9	15	PF00082	0.564
CLV_PCSK_SKI1_1	177	181	PF00082	0.350
CLV_PCSK_SKI1_1	199	203	PF00082	0.383
CLV_PCSK_SKI1_1	222	226	PF00082	0.534
CLV_PCSK_SKI1_1	239	243	PF00082	0.723
CLV_PCSK_SKI1_1	29	33	PF00082	0.586
DEG_Nend_UBRbox_2	1	3	PF02207	0.625
DOC_CKS1_1	230	235	PF01111	0.603
DOC_CYCLIN_RxL_1	219	229	PF00134	0.523
DOC_MAPK_gen_1	174	183	PF00069	0.513
DOC_MAPK_gen_1	197	208	PF00069	0.529
DOC_PP1_RVXF_1	189	196	PF00149	0.562
DOC_PP4_FxxP_1	230	233	PF00568	0.585
DOC_USP7_MATH_1	226	230	PF00917	0.514
DOC_USP7_MATH_1	85	89	PF00917	0.692
DOC_USP7_UBL2_3	198	202	PF12436	0.584
DOC_WW_Pin1_4	229	234	PF00397	0.584
DOC_WW_Pin1_4	86	91	PF00397	0.617
LIG_14-3-3_CanoR_1	121	129	PF00244	0.528
LIG_14-3-3_CanoR_1	160	165	PF00244	0.473
LIG_AP2alpha_1	154	158	PF02296	0.562
LIG_CSL_BTD_1	230	233	PF09270	0.585
LIG_EH_1	121	125	PF12763	0.683
LIG_FHA_1	257	263	PF00498	0.666
LIG_FHA_2	144	150	PF00498	0.496
LIG_FHA_2	240	246	PF00498	0.791
LIG_LIR_Apic_2	228	234	PF02991	0.666
LIG_LIR_Gen_1	175	186	PF02991	0.562
LIG_LIR_Nem_3	156	161	PF02991	0.482
LIG_LIR_Nem_3	175	181	PF02991	0.476
LIG_LIR_Nem_3	182	186	PF02991	0.482
LIG_Pex14_1	27	31	PF04695	0.545
LIG_Pex14_2	154	158	PF04695	0.482
LIG_REV1ctd_RIR_1	29	35	PF16727	0.572
LIG_SH2_CRK	204	208	PF00017	0.542
LIG_SH2_STAP1	204	208	PF00017	0.573
LIG_SH3_1	263	269	PF00018	0.707
LIG_SH3_3	263	269	PF00018	0.705
LIG_SH3_3	33	39	PF00018	0.570
LIG_SH3_3	84	90	PF00018	0.682
LIG_TRAF2_1	105	108	PF00917	0.614
LIG_TRAF2_1	146	149	PF00917	0.482
LIG_TRAF2_1	68	71	PF00917	0.658
MOD_CK1_1	229	235	PF00069	0.612
MOD_CK1_1	240	246	PF00069	0.790
MOD_CK1_1	88	94	PF00069	0.672
MOD_CK1_1	95	101	PF00069	0.639
MOD_CK2_1	102	108	PF00069	0.662
MOD_CK2_1	143	149	PF00069	0.354
MOD_CK2_1	239	245	PF00069	0.790
MOD_CK2_1	264	270	PF00069	0.647
MOD_GlcNHglycan	239	242	PF01048	0.697
MOD_GlcNHglycan	253	256	PF01048	0.691
MOD_GSK3_1	225	232	PF00069	0.565
MOD_GSK3_1	237	244	PF00069	0.625
MOD_GSK3_1	27	34	PF00069	0.484
MOD_GSK3_1	49	56	PF00069	0.685
MOD_GSK3_1	73	80	PF00069	0.550
MOD_GSK3_1	86	93	PF00069	0.720
MOD_LATS_1	18	24	PF00433	0.359
MOD_NEK2_1	225	230	PF00069	0.552
MOD_NEK2_1	31	36	PF00069	0.444
MOD_NEK2_1	92	97	PF00069	0.771
MOD_NEK2_2	27	32	PF00069	0.643
MOD_PK_1	160	166	PF00069	0.352
MOD_PK_1	202	208	PF00069	0.579
MOD_PKA_2	77	83	PF00069	0.516
MOD_Plk_1	5	11	PF00069	0.646
MOD_Plk_4	202	208	PF00069	0.579
MOD_Plk_4	226	232	PF00069	0.605
MOD_ProDKin_1	229	235	PF00069	0.590
MOD_ProDKin_1	86	92	PF00069	0.618
MOD_SUMO_for_1	68	71	PF00179	0.467
MOD_SUMO_rev_2	243	252	PF00179	0.561
TRG_DiLeu_BaEn_4	5	11	PF01217	0.647
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.520
TRG_ENDOCYTIC_2	178	181	PF00928	0.335
TRG_ENDOCYTIC_2	204	207	PF00928	0.582
TRG_NLS_MonoCore_2	196	201	PF00514	0.407
TRG_NLS_MonoExtC_3	197	202	PF00514	0.447
TRG_NLS_MonoExtN_4	197	203	PF00514	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T1	Leptomonas seymouri	60%	96%
A0A0S4J1P9	Bodo saltans	29%	100%
A0A1X0NYS6	Trypanosomatidae	39%	100%
A0A3Q8IAQ7	Leishmania donovani	90%	100%
A4H8T7	Leishmania braziliensis	79%	100%
A4HX57	Leishmania infantum	90%	75%
C9ZVT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4QEK6	Leishmania major	88%	100%
V5B2N5	Trypanosoma cruzi	41%	100%