Putative endoplasmic reticulum oxidoreductin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endoplasmic reticulum oxidoreductin, putative

Species:

Leishmania mexicana

UniProt:

E9AQW6_LEIMU

TriTrypDb:

LmxM.16.1530

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 4
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	13
GO:0016020	membrane	2	13
GO:0031090	organelle membrane	3	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E9AQW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQW6

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	13
GO:0009987	cellular process	1	13
GO:0034975	protein folding in endoplasmic reticulum	3	13

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	13
GO:0015035	protein-disulfide reductase activity	3	13
GO:0015036	disulfide oxidoreductase activity	4	13
GO:0016491	oxidoreductase activity	2	13
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	13
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	4	13
GO:0016972	thiol oxidase activity	5	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0050660	flavin adenine dinucleotide binding	4	13
GO:0071949	FAD binding	5	13
GO:0097159	organic cyclic compound binding	2	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0003756	protein disulfide isomerase activity	3	1
GO:0016853	isomerase activity	2	1
GO:0016860	intramolecular oxidoreductase activity	3	1
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	262	264	PF00082	0.321
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.413
CLV_PCSK_SKI1_1	144	148	PF00082	0.335
CLV_PCSK_SKI1_1	212	216	PF00082	0.386
CLV_PCSK_SKI1_1	289	293	PF00082	0.317
CLV_PCSK_SKI1_1	45	49	PF00082	0.513
CLV_PCSK_SKI1_1	70	74	PF00082	0.419
CLV_PCSK_SKI1_1	86	90	PF00082	0.227
DEG_APCC_DBOX_1	211	219	PF00400	0.413
DEG_Nend_UBRbox_4	1	3	PF02207	0.527
DEG_ODPH_VHL_1	264	276	PF01847	0.324
DEG_SCF_FBW7_1	135	141	PF00400	0.388
DOC_CKS1_1	135	140	PF01111	0.414
DOC_CYCLIN_RxL_1	209	216	PF00134	0.420
DOC_CYCLIN_RxL_1	407	415	PF00134	0.343
DOC_CYCLIN_yClb5_NLxxxL_5	403	412	PF00134	0.319
DOC_MAPK_DCC_7	144	152	PF00069	0.324
DOC_MAPK_MEF2A_6	11	20	PF00069	0.580
DOC_PP1_RVXF_1	408	415	PF00149	0.413
DOC_PP1_SILK_1	208	213	PF00149	0.388
DOC_PP2B_PxIxI_1	28	34	PF00149	0.405
DOC_USP7_MATH_1	138	142	PF00917	0.392
DOC_USP7_MATH_1	239	243	PF00917	0.308
DOC_USP7_UBL2_3	374	378	PF12436	0.413
DOC_WW_Pin1_4	134	139	PF00397	0.386
DOC_WW_Pin1_4	235	240	PF00397	0.284
DOC_WW_Pin1_4	326	331	PF00397	0.313
DOC_WW_Pin1_4	37	42	PF00397	0.674
DOC_WW_Pin1_4	58	63	PF00397	0.539
DOC_WW_Pin1_4	79	84	PF00397	0.357
LIG_14-3-3_CanoR_1	11	17	PF00244	0.443
LIG_14-3-3_CanoR_1	394	398	PF00244	0.443
LIG_14-3-3_CanoR_1	78	82	PF00244	0.402
LIG_APCC_ABBA_1	264	269	PF00400	0.401
LIG_BRCT_BRCA1_1	287	291	PF00533	0.358
LIG_BRCT_BRCA1_1	328	332	PF00533	0.275
LIG_BRCT_BRCA1_1	81	85	PF00533	0.321
LIG_deltaCOP1_diTrp_1	153	158	PF00928	0.319
LIG_eIF4E_1	98	104	PF01652	0.299
LIG_FHA_1	109	115	PF00498	0.413
LIG_FHA_1	291	297	PF00498	0.426
LIG_FHA_1	375	381	PF00498	0.291
LIG_FHA_1	48	54	PF00498	0.488
LIG_FHA_1	67	73	PF00498	0.253
LIG_FHA_2	104	110	PF00498	0.345
LIG_FHA_2	202	208	PF00498	0.463
LIG_FHA_2	306	312	PF00498	0.299
LIG_FHA_2	329	335	PF00498	0.284
LIG_FHA_2	49	55	PF00498	0.500
LIG_FHA_2	61	67	PF00498	0.360
LIG_LIR_Apic_2	178	183	PF02991	0.298
LIG_LIR_Apic_2	228	234	PF02991	0.415
LIG_LIR_Gen_1	166	174	PF02991	0.289
LIG_LIR_LC3C_4	15	20	PF02991	0.379
LIG_LIR_Nem_3	166	170	PF02991	0.289
LIG_LIR_Nem_3	82	88	PF02991	0.302
LIG_MLH1_MIPbox_1	81	85	PF16413	0.373
LIG_NRBOX	210	216	PF00104	0.373
LIG_Pex14_1	189	193	PF04695	0.270
LIG_SH2_CRK	180	184	PF00017	0.299
LIG_SH2_CRK	246	250	PF00017	0.418
LIG_SH2_NCK_1	246	250	PF00017	0.388
LIG_SH2_PTP2	167	170	PF00017	0.284
LIG_SH2_STAT5	167	170	PF00017	0.278
LIG_SH2_STAT5	275	278	PF00017	0.328
LIG_SH2_STAT5	57	60	PF00017	0.492
LIG_SH2_STAT5	84	87	PF00017	0.347
LIG_SH3_3	143	149	PF00018	0.443
LIG_SH3_3	38	44	PF00018	0.608
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.586
LIG_SUMO_SIM_anti_2	207	213	PF11976	0.413
LIG_SUMO_SIM_anti_2	400	407	PF11976	0.274
LIG_SUMO_SIM_anti_2	71	77	PF11976	0.375
LIG_SxIP_EBH_1	342	353	PF03271	0.388
LIG_TRAF2_1	204	207	PF00917	0.424
MOD_CDC14_SPxK_1	40	43	PF00782	0.378
MOD_CDK_SPxK_1	37	43	PF00069	0.390
MOD_CDK_SPxxK_3	79	86	PF00069	0.356
MOD_CK1_1	35	41	PF00069	0.632
MOD_CK1_1	424	430	PF00069	0.430
MOD_CK1_1	60	66	PF00069	0.278
MOD_CK2_1	103	109	PF00069	0.345
MOD_CK2_1	118	124	PF00069	0.155
MOD_CK2_1	169	175	PF00069	0.448
MOD_CK2_1	201	207	PF00069	0.379
MOD_CK2_1	328	334	PF00069	0.286
MOD_CK2_1	58	64	PF00069	0.451
MOD_CMANNOS	155	158	PF00535	0.319
MOD_GlcNHglycan	106	109	PF01048	0.223
MOD_GlcNHglycan	180	183	PF01048	0.301
MOD_GlcNHglycan	215	218	PF01048	0.270
MOD_GlcNHglycan	241	244	PF01048	0.373
MOD_GlcNHglycan	34	37	PF01048	0.500
MOD_GlcNHglycan	91	94	PF01048	0.422
MOD_GSK3_1	130	137	PF00069	0.310
MOD_GSK3_1	138	145	PF00069	0.435
MOD_GSK3_1	206	213	PF00069	0.331
MOD_GSK3_1	235	242	PF00069	0.319
MOD_GSK3_1	290	297	PF00069	0.365
MOD_GSK3_1	393	400	PF00069	0.459
MOD_GSK3_1	99	106	PF00069	0.355
MOD_N-GLC_1	249	254	PF02516	0.299
MOD_N-GLC_1	355	360	PF02516	0.270
MOD_N-GLC_2	110	112	PF02516	0.319
MOD_NEK2_1	103	108	PF00069	0.374
MOD_NEK2_1	218	223	PF00069	0.270
MOD_NEK2_1	285	290	PF00069	0.314
MOD_NEK2_1	321	326	PF00069	0.296
MOD_NEK2_1	355	360	PF00069	0.413
MOD_NEK2_1	412	417	PF00069	0.319
MOD_NEK2_1	48	53	PF00069	0.469
MOD_NEK2_2	249	254	PF00069	0.413
MOD_NEK2_2	278	283	PF00069	0.451
MOD_OFUCOSY	105	112	PF10250	0.303
MOD_PKA_2	393	399	PF00069	0.388
MOD_PKA_2	77	83	PF00069	0.402
MOD_Plk_1	118	124	PF00069	0.436
MOD_Plk_1	206	212	PF00069	0.388
MOD_Plk_1	249	255	PF00069	0.302
MOD_Plk_1	294	300	PF00069	0.341
MOD_Plk_1	305	311	PF00069	0.291
MOD_Plk_1	355	361	PF00069	0.273
MOD_Plk_1	6	12	PF00069	0.637
MOD_Plk_2-3	118	124	PF00069	0.463
MOD_Plk_2-3	393	399	PF00069	0.388
MOD_Plk_4	12	18	PF00069	0.617
MOD_Plk_4	142	148	PF00069	0.340
MOD_Plk_4	206	212	PF00069	0.386
MOD_Plk_4	226	232	PF00069	0.118
MOD_Plk_4	294	300	PF00069	0.370
MOD_Plk_4	401	407	PF00069	0.324
MOD_Plk_4	68	74	PF00069	0.427
MOD_Plk_4	99	105	PF00069	0.400
MOD_ProDKin_1	134	140	PF00069	0.386
MOD_ProDKin_1	235	241	PF00069	0.284
MOD_ProDKin_1	326	332	PF00069	0.313
MOD_ProDKin_1	37	43	PF00069	0.672
MOD_ProDKin_1	58	64	PF00069	0.537
MOD_ProDKin_1	79	85	PF00069	0.356
TRG_DiLeu_BaEn_1	401	406	PF01217	0.270
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.373
TRG_ENDOCYTIC_2	167	170	PF00928	0.284
TRG_ENDOCYTIC_2	87	90	PF00928	0.312
TRG_ENDOCYTIC_2	98	101	PF00928	0.243
TRG_Pf-PMV_PEXEL_1	344	349	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYQ4	Leptomonas seymouri	75%	100%
A0A0S4JAH9	Bodo saltans	34%	90%
A0A0S4JHX0	Bodo saltans	38%	87%
A0A1X0P0B6	Trypanosomatidae	49%	96%
A0A3S7WU69	Leishmania donovani	93%	97%
A0A422NE38	Trypanosoma rangeli	53%	94%
A4H8T2	Leishmania braziliensis	86%	100%
A4HX51	Leishmania infantum	93%	97%
A5PJN2	Bos taurus	30%	92%
B1H1F9	Xenopus tropicalis	28%	91%
B6CVD7	Sus scrofa	31%	92%
C9ZVU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
O74401	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	92%
Q03103	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	76%
Q4QEL2	Leishmania major	92%	100%
Q6DD71	Xenopus laevis	29%	92%
Q75BB5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	29%	79%
Q7T3D1	Danio rerio	28%	88%
Q7X9I4	Arabidopsis thaliana	30%	91%
Q7YTU4	Caenorhabditis elegans	28%	90%
Q86YB8	Homo sapiens	30%	92%
Q8NIP5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	28%	77%
Q8R180	Mus musculus	31%	93%
Q8R2E9	Mus musculus	29%	92%
Q8R4A1	Rattus norvegicus	30%	93%
Q96HE7	Homo sapiens	30%	92%
Q9C7S7	Arabidopsis thaliana	33%	92%
Q9V3A6	Drosophila melanogaster	27%	89%
Q9Y7P1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	76%
V5BI75	Trypanosoma cruzi	52%	97%