LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AQW4_LEIMU
TriTrypDb:
LmxM.16.1510
Length:
113

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AQW4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQW4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 101 105 PF00656 0.666
CLV_NRD_NRD_1 24 26 PF00675 0.450
CLV_NRD_NRD_1 61 63 PF00675 0.569
CLV_PCSK_KEX2_1 24 26 PF00082 0.450
CLV_PCSK_KEX2_1 61 63 PF00082 0.594
CLV_PCSK_KEX2_1 74 76 PF00082 0.304
CLV_PCSK_PC1ET2_1 74 76 PF00082 0.445
CLV_PCSK_SKI1_1 27 31 PF00082 0.402
CLV_PCSK_SKI1_1 47 51 PF00082 0.402
DOC_MAPK_gen_1 53 60 PF00069 0.502
DOC_MAPK_gen_1 74 80 PF00069 0.406
DOC_MAPK_MEF2A_6 103 112 PF00069 0.666
DOC_PP4_MxPP_1 66 69 PF00568 0.490
DOC_WW_Pin1_4 104 109 PF00397 0.612
LIG_BIR_II_1 1 5 PF00653 0.633
LIG_CaM_IQ_9 89 105 PF13499 0.654
LIG_FHA_1 3 9 PF00498 0.636
LIG_FHA_2 8 14 PF00498 0.591
LIG_Integrin_RGD_1 62 64 PF01839 0.508
LIG_LIR_Apic_2 64 68 PF02991 0.578
LIG_Pex14_2 81 85 PF04695 0.415
LIG_SH2_CRK 65 69 PF00017 0.560
LIG_SH2_GRB2like 36 39 PF00017 0.517
LIG_SH2_STAT5 36 39 PF00017 0.447
LIG_TRAF2_1 10 13 PF00917 0.552
LIG_UBA3_1 49 55 PF00899 0.439
MOD_CK1_1 2 8 PF00069 0.629
MOD_CK1_1 91 97 PF00069 0.584
MOD_CK2_1 45 51 PF00069 0.399
MOD_CK2_1 7 13 PF00069 0.536
MOD_GSK3_1 104 111 PF00069 0.614
MOD_NEK2_1 85 90 PF00069 0.489
MOD_NEK2_1 98 103 PF00069 0.546
MOD_NEK2_2 108 113 PF00069 0.607
MOD_PIKK_1 2 8 PF00454 0.677
MOD_PIKK_1 29 35 PF00454 0.526
MOD_PIKK_1 67 73 PF00454 0.454
MOD_PIKK_1 91 97 PF00454 0.588
MOD_Plk_4 45 51 PF00069 0.425
MOD_ProDKin_1 104 110 PF00069 0.614
TRG_ER_diArg_1 16 19 PF00400 0.584
TRG_ER_diArg_1 60 62 PF00400 0.572
TRG_NLS_MonoExtN_4 24 29 PF00514 0.421

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3Y0 Leptomonas seymouri 89% 98%
A0A0S4IH66 Bodo saltans 61% 84%
A0A0S4IPB4 Bodo saltans 70% 84%
A0A1X0NYT5 Trypanosomatidae 77% 99%
A0A3S7WU56 Leishmania donovani 98% 100%
A0A422N416 Trypanosoma rangeli 76% 99%
A4H8T0 Leishmania braziliensis 93% 100%
A4HX49 Leishmania infantum 98% 100%
C9ZVU3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 72% 99%
Q4QEL4 Leishmania major 97% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS