t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AQV8_LEIMU

TriTrypDb:

LmxM.16.1450

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQV8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.559
CLV_NRD_NRD_1	194	196	PF00675	0.576
CLV_NRD_NRD_1	54	56	PF00675	0.574
CLV_NRD_NRD_1	58	60	PF00675	0.573
CLV_NRD_NRD_1	94	96	PF00675	0.734
CLV_PCSK_KEX2_1	194	196	PF00082	0.572
CLV_PCSK_KEX2_1	241	243	PF00082	0.565
CLV_PCSK_KEX2_1	54	56	PF00082	0.574
CLV_PCSK_KEX2_1	58	60	PF00082	0.573
CLV_PCSK_KEX2_1	94	96	PF00082	0.700
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.489
CLV_PCSK_PC7_1	54	60	PF00082	0.526
CLV_PCSK_SKI1_1	156	160	PF00082	0.643
DEG_Nend_UBRbox_1	1	4	PF02207	0.406
DEG_SPOP_SBC_1	170	174	PF00917	0.676
DOC_MAPK_gen_1	247	255	PF00069	0.527
DOC_USP7_MATH_1	18	22	PF00917	0.513
DOC_USP7_MATH_1	4	8	PF00917	0.464
DOC_USP7_UBL2_3	241	245	PF12436	0.502
DOC_WW_Pin1_4	178	183	PF00397	0.532
DOC_WW_Pin1_4	83	88	PF00397	0.774
LIG_14-3-3_CanoR_1	116	125	PF00244	0.794
LIG_14-3-3_CanoR_1	20	26	PF00244	0.374
LIG_14-3-3_CanoR_1	221	225	PF00244	0.561
LIG_Actin_WH2_2	5	22	PF00022	0.344
LIG_BIR_III_4	139	143	PF00653	0.599
LIG_FHA_1	172	178	PF00498	0.714
LIG_FHA_1	228	234	PF00498	0.545
LIG_FHA_2	115	121	PF00498	0.690
LIG_FHA_2	126	132	PF00498	0.572
LIG_FHA_2	205	211	PF00498	0.589
LIG_FHA_2	29	35	PF00498	0.445
LIG_FHA_2	9	15	PF00498	0.440
LIG_LIR_Gen_1	223	233	PF02991	0.661
LIG_SH3_3	164	170	PF00018	0.572
LIG_TRAF2_1	11	14	PF00917	0.513
MOD_CDC14_SPxK_1	181	184	PF00782	0.524
MOD_CDK_SPxK_1	178	184	PF00069	0.533
MOD_CDK_SPxxK_3	87	94	PF00069	0.625
MOD_CK1_1	119	125	PF00069	0.626
MOD_CK1_1	172	178	PF00069	0.645
MOD_CK1_1	21	27	PF00069	0.529
MOD_CK2_1	114	120	PF00069	0.689
MOD_CK2_1	204	210	PF00069	0.601
MOD_CK2_1	28	34	PF00069	0.445
MOD_CK2_1	8	14	PF00069	0.523
MOD_Cter_Amidation	52	55	PF01082	0.529
MOD_GlcNHglycan	120	124	PF01048	0.681
MOD_GlcNHglycan	143	147	PF01048	0.582
MOD_GlcNHglycan	75	78	PF01048	0.514
MOD_GlcNHglycan	96	99	PF01048	0.664
MOD_GSK3_1	100	107	PF00069	0.611
MOD_GSK3_1	112	119	PF00069	0.781
MOD_GSK3_1	169	176	PF00069	0.692
MOD_GSK3_1	21	28	PF00069	0.620
MOD_GSK3_1	220	227	PF00069	0.389
MOD_GSK3_1	4	11	PF00069	0.472
MOD_GSK3_1	73	80	PF00069	0.501
MOD_GSK3_1	83	90	PF00069	0.581
MOD_N-GLC_1	83	88	PF02516	0.685
MOD_NEK2_1	19	24	PF00069	0.536
MOD_NEK2_1	224	229	PF00069	0.404
MOD_NEK2_1	57	62	PF00069	0.548
MOD_NEK2_1	8	13	PF00069	0.455
MOD_PIKK_1	125	131	PF00454	0.691
MOD_PIKK_1	19	25	PF00454	0.483
MOD_PIKK_1	28	34	PF00454	0.420
MOD_PIKK_1	77	83	PF00454	0.730
MOD_PKA_1	94	100	PF00069	0.694
MOD_PKA_2	112	118	PF00069	0.607
MOD_PKA_2	19	25	PF00069	0.370
MOD_PKA_2	220	226	PF00069	0.562
MOD_PKA_2	57	63	PF00069	0.531
MOD_PKA_2	94	100	PF00069	0.694
MOD_Plk_1	4	10	PF00069	0.462
MOD_Plk_2-3	34	40	PF00069	0.528
MOD_Plk_4	220	226	PF00069	0.562
MOD_Plk_4	34	40	PF00069	0.528
MOD_ProDKin_1	178	184	PF00069	0.533
MOD_ProDKin_1	83	89	PF00069	0.777
MOD_SUMO_rev_2	161	170	PF00179	0.527
TRG_DiLeu_BaEn_2	33	39	PF01217	0.430
TRG_ER_diArg_1	194	196	PF00400	0.567
TRG_ER_diArg_1	57	59	PF00400	0.572
TRG_ER_diArg_1	93	95	PF00400	0.768
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT54	Leptomonas seymouri	32%	79%
A0A3S5H6Z1	Leishmania donovani	82%	84%
A4HX42	Leishmania infantum	83%	84%
Q4QEM0	Leishmania major	79%	100%