Paraflagellar rod protein 2C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9AQV6_LEIMU

TriTrypDb:

Length:

668

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 41
NetGPI	no	yes: 0, no: 41

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	42
GO:0031514	motile cilium	5	42
GO:0042995	cell projection	2	42
GO:0043226	organelle	2	42
GO:0043227	membrane-bounded organelle	3	42
GO:0110165	cellular anatomical entity	1	42
GO:0120025	plasma membrane bounded cell projection	3	42
GO:0005737	cytoplasm	2	3
GO:0031974	membrane-enclosed lumen	2	3
GO:0031981	nuclear lumen	5	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0043233	organelle lumen	3	3
GO:0070013	intracellular organelle lumen	4	3
GO:0097014	ciliary plasm	5	3
GO:0099568	cytoplasmic region	3	3
GO:0005930	axoneme	2	1

Expansion

Sequence features

E9AQV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQV6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	42
GO:0005515	protein binding	2	42
GO:0005516	calmodulin binding	3	42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.480
CLV_NRD_NRD_1	356	358	PF00675	0.383
CLV_NRD_NRD_1	409	411	PF00675	0.376
CLV_NRD_NRD_1	432	434	PF00675	0.392
CLV_NRD_NRD_1	443	445	PF00675	0.364
CLV_NRD_NRD_1	516	518	PF00675	0.369
CLV_NRD_NRD_1	621	623	PF00675	0.377
CLV_NRD_NRD_1	99	101	PF00675	0.612
CLV_PCSK_KEX2_1	342	344	PF00082	0.537
CLV_PCSK_KEX2_1	355	357	PF00082	0.352
CLV_PCSK_KEX2_1	385	387	PF00082	0.381
CLV_PCSK_KEX2_1	431	433	PF00082	0.384
CLV_PCSK_KEX2_1	442	444	PF00082	0.391
CLV_PCSK_KEX2_1	516	518	PF00082	0.373
CLV_PCSK_KEX2_1	531	533	PF00082	0.380
CLV_PCSK_KEX2_1	621	623	PF00082	0.377
CLV_PCSK_KEX2_1	648	650	PF00082	0.548
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.548
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.358
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.383
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.380
CLV_PCSK_PC1ET2_1	531	533	PF00082	0.379
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.548
CLV_PCSK_PC7_1	439	445	PF00082	0.421
CLV_PCSK_PC7_1	644	650	PF00082	0.548
CLV_PCSK_SKI1_1	155	159	PF00082	0.740
CLV_PCSK_SKI1_1	342	346	PF00082	0.524
CLV_PCSK_SKI1_1	356	360	PF00082	0.368
CLV_PCSK_SKI1_1	386	390	PF00082	0.484
CLV_PCSK_SKI1_1	458	462	PF00082	0.381
DEG_SCF_FBW7_1	62	67	PF00400	0.508
DOC_CYCLIN_RxL_1	455	464	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.494
DOC_MAPK_gen_1	100	109	PF00069	0.606
DOC_MAPK_gen_1	458	465	PF00069	0.372
DOC_MAPK_gen_1	538	547	PF00069	0.376
DOC_MAPK_MEF2A_6	458	465	PF00069	0.372
DOC_MAPK_MEF2A_6	541	549	PF00069	0.379
DOC_MAPK_NFAT4_5	458	466	PF00069	0.376
DOC_PP2B_LxvP_1	26	29	PF13499	0.461
DOC_PP4_FxxP_1	22	25	PF00568	0.490
DOC_PP4_FxxP_1	607	610	PF00568	0.387
DOC_USP7_MATH_1	11	15	PF00917	0.545
DOC_USP7_MATH_1	149	153	PF00917	0.713
DOC_USP7_MATH_1	43	47	PF00917	0.566
DOC_USP7_MATH_1	89	93	PF00917	0.666
DOC_USP7_UBL2_3	182	186	PF12436	0.540
DOC_USP7_UBL2_3	355	359	PF12436	0.346
DOC_USP7_UBL2_3	566	570	PF12436	0.359
DOC_WW_Pin1_4	2	7	PF00397	0.586
DOC_WW_Pin1_4	39	44	PF00397	0.740
DOC_WW_Pin1_4	45	50	PF00397	0.512
DOC_WW_Pin1_4	55	60	PF00397	0.562
LIG_14-3-3_CanoR_1	10	20	PF00244	0.547
LIG_14-3-3_CanoR_1	210	215	PF00244	0.498
LIG_14-3-3_CanoR_1	517	523	PF00244	0.366
LIG_14-3-3_CanoR_1	538	547	PF00244	0.346
LIG_14-3-3_CanoR_1	659	664	PF00244	0.618
LIG_Actin_WH2_2	218	235	PF00022	0.486
LIG_Actin_WH2_2	458	475	PF00022	0.501
LIG_APCC_ABBA_1	505	510	PF00400	0.383
LIG_APCC_ABBAyCdc20_2	504	510	PF00400	0.383
LIG_CtBP_PxDLS_1	172	178	PF00389	0.532
LIG_EH1_1	161	169	PF00400	0.504
LIG_eIF4E_1	162	168	PF01652	0.510
LIG_eIF4E_1	304	310	PF01652	0.442
LIG_EVH1_1	26	30	PF00568	0.464
LIG_FHA_1	109	115	PF00498	0.607
LIG_FHA_1	207	213	PF00498	0.515
LIG_FHA_1	346	352	PF00498	0.422
LIG_FHA_1	540	546	PF00498	0.330
LIG_FHA_1	648	654	PF00498	0.677
LIG_FHA_2	196	202	PF00498	0.501
LIG_FHA_2	325	331	PF00498	0.481
LIG_FHA_2	387	393	PF00498	0.408
LIG_FHA_2	494	500	PF00498	0.360
LIG_GBD_Chelix_1	68	76	PF00786	0.498
LIG_LIR_Apic_2	606	610	PF02991	0.374
LIG_LIR_Gen_1	333	338	PF02991	0.626
LIG_LIR_Gen_1	424	434	PF02991	0.382
LIG_LIR_Gen_1	446	453	PF02991	0.333
LIG_LIR_Nem_3	319	324	PF02991	0.442
LIG_LIR_Nem_3	333	337	PF02991	0.515
LIG_LIR_Nem_3	406	412	PF02991	0.378
LIG_LIR_Nem_3	424	430	PF02991	0.384
LIG_LIR_Nem_3	446	450	PF02991	0.333
LIG_LIR_Nem_3	513	518	PF02991	0.380
LIG_PTB_Apo_2	113	120	PF02174	0.589
LIG_SH2_CRK	519	523	PF00017	0.390
LIG_SH2_SRC	511	514	PF00017	0.410
LIG_SH2_STAT3	162	165	PF00017	0.578
LIG_SH2_STAT3	387	390	PF00017	0.471
LIG_SH2_STAT5	304	307	PF00017	0.436
LIG_SH2_STAT5	511	514	PF00017	0.375
LIG_SH3_3	21	27	PF00018	0.483
LIG_SH3_3	242	248	PF00018	0.586
LIG_SH3_3	46	52	PF00018	0.519
LIG_SH3_3	56	62	PF00018	0.659
LIG_SH3_4	182	189	PF00018	0.524
LIG_SUMO_SIM_par_1	209	215	PF11976	0.630
LIG_SUMO_SIM_par_1	459	464	PF11976	0.383
LIG_TRAF2_1	115	118	PF00917	0.601
LIG_TRAF2_1	228	231	PF00917	0.588
LIG_TRAF2_1	344	347	PF00917	0.506
LIG_TRAF2_1	610	613	PF00917	0.374
LIG_TRAF2_1	633	636	PF00917	0.530
LIG_WRC_WIRS_1	551	556	PF05994	0.370
LIG_WW_3	48	52	PF00397	0.514
MOD_CDK_SPxK_1	45	51	PF00069	0.519
MOD_CK1_1	126	132	PF00069	0.626
MOD_CK1_1	14	20	PF00069	0.537
MOD_CK1_1	32	38	PF00069	0.519
MOD_CK1_1	92	98	PF00069	0.719
MOD_CK2_1	112	118	PF00069	0.600
MOD_CK2_1	173	179	PF00069	0.525
MOD_CK2_1	195	201	PF00069	0.479
MOD_CK2_1	324	330	PF00069	0.443
MOD_CK2_1	386	392	PF00069	0.403
MOD_CK2_1	493	499	PF00069	0.349
MOD_Cter_Amidation	353	356	PF01082	0.487
MOD_GlcNHglycan	151	154	PF01048	0.656
MOD_GlcNHglycan	474	477	PF01048	0.440
MOD_GlcNHglycan	486	489	PF01048	0.352
MOD_GSK3_1	10	17	PF00069	0.528
MOD_GSK3_1	108	115	PF00069	0.576
MOD_GSK3_1	2	9	PF00069	0.552
MOD_GSK3_1	206	213	PF00069	0.517
MOD_GSK3_1	257	264	PF00069	0.425
MOD_GSK3_1	32	39	PF00069	0.551
MOD_GSK3_1	41	48	PF00069	0.536
MOD_GSK3_1	60	67	PF00069	0.539
MOD_LATS_1	8	14	PF00433	0.522
MOD_N-GLC_1	206	211	PF02516	0.517
MOD_N-GLC_1	257	262	PF02516	0.468
MOD_N-GLC_1	330	335	PF02516	0.581
MOD_NEK2_1	173	178	PF00069	0.514
MOD_NEK2_1	195	200	PF00069	0.487
MOD_NEK2_1	232	237	PF00069	0.490
MOD_NEK2_1	257	262	PF00069	0.465
MOD_NEK2_1	345	350	PF00069	0.390
MOD_NEK2_1	461	466	PF00069	0.374
MOD_NEK2_1	472	477	PF00069	0.376
MOD_NEK2_1	518	523	PF00069	0.370
MOD_NEK2_1	647	652	PF00069	0.564
MOD_NEK2_1	68	73	PF00069	0.787
MOD_PIKK_1	11	17	PF00454	0.610
MOD_PIKK_1	128	134	PF00454	0.643
MOD_PIKK_1	232	238	PF00454	0.510
MOD_PIKK_1	337	343	PF00454	0.562
MOD_PIKK_1	386	392	PF00454	0.393
MOD_PKA_1	559	565	PF00069	0.390
MOD_PKA_2	232	238	PF00069	0.500
MOD_PKA_2	472	478	PF00069	0.402
MOD_PKA_2	540	546	PF00069	0.349
MOD_PKA_2	620	626	PF00069	0.371
MOD_PKA_2	9	15	PF00069	0.550
MOD_Plk_1	173	179	PF00069	0.566
MOD_Plk_1	257	263	PF00069	0.500
MOD_Plk_1	330	336	PF00069	0.632
MOD_Plk_1	461	467	PF00069	0.396
MOD_Plk_1	92	98	PF00069	0.626
MOD_Plk_2-3	330	336	PF00069	0.413
MOD_Plk_2-3	365	371	PF00069	0.460
MOD_Plk_4	257	263	PF00069	0.507
MOD_Plk_4	461	467	PF00069	0.383
MOD_ProDKin_1	2	8	PF00069	0.586
MOD_ProDKin_1	39	45	PF00069	0.736
MOD_ProDKin_1	55	61	PF00069	0.758
MOD_SUMO_for_1	223	226	PF00179	0.509
MOD_SUMO_for_1	564	567	PF00179	0.388
MOD_SUMO_for_1	633	636	PF00179	0.542
MOD_SUMO_rev_2	179	187	PF00179	0.526
MOD_SUMO_rev_2	328	334	PF00179	0.471
MOD_SUMO_rev_2	636	641	PF00179	0.500
MOD_SUMO_rev_2	643	650	PF00179	0.474
TRG_DiLeu_BaEn_2	445	451	PF01217	0.383
TRG_DiLeu_BaEn_3	576	582	PF01217	0.384
TRG_DiLeu_BaEn_4	577	583	PF01217	0.383
TRG_ENDOCYTIC_2	447	450	PF00928	0.319
TRG_ENDOCYTIC_2	519	522	PF00928	0.378
TRG_ER_diArg_1	356	358	PF00400	0.372
TRG_ER_diArg_1	432	434	PF00400	0.386
TRG_ER_diArg_1	442	444	PF00400	0.390
TRG_ER_diArg_1	515	517	PF00400	0.386
TRG_NES_CRM1_1	165	179	PF08389	0.590
TRG_NES_CRM1_1	311	326	PF08389	0.455
TRG_NLS_Bipartite_1	342	359	PF00514	0.390
TRG_NLS_MonoExtC_3	354	359	PF00514	0.383
TRG_NLS_MonoExtN_4	352	359	PF00514	0.383
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I5	Leptomonas seymouri	66%	100%
A0A0N0P5J5	Leptomonas seymouri	26%	84%
A0A0N1IFZ5	Leptomonas seymouri	93%	100%
A0A0S4IZY8	Bodo saltans	83%	100%
A0A0S4J193	Bodo saltans	29%	100%
A0A0S4J561	Bodo saltans	30%	94%
A0A0S4JS20	Bodo saltans	68%	100%
A0A1X0NR57	Trypanosomatidae	26%	85%
A0A1X0NYU4	Trypanosomatidae	83%	100%
A0A1X0P0B7	Trypanosomatidae	68%	100%
A0A381MH18	Leishmania infantum	97%	100%
A0A381MN58	Leishmania infantum	65%	100%
A0A3Q8IAP5	Leishmania donovani	97%	100%
A0A3Q8IEH2	Leishmania donovani	65%	100%
A0A3R7KDB9	Trypanosoma rangeli	83%	100%
A0A3S5IRI8	Trypanosoma rangeli	68%	100%
A0A3S7WQV4	Leishmania donovani	23%	100%
A0A3S7X0V5	Leishmania donovani	26%	86%
A0A3S7X2K1	Leishmania donovani	65%	100%
A0A422NJR9	Trypanosoma rangeli	25%	90%
A4H5W0	Leishmania braziliensis	23%	100%
A4H8S1	Leishmania braziliensis	92%	100%
A4HFV9	Leishmania braziliensis	26%	86%
A4HIY0	Leishmania braziliensis	65%	100%
A4HU55	Leishmania infantum	23%	100%
A4HX40	Leishmania infantum	98%	100%
A4I2Z1	Leishmania infantum	26%	86%
C9ZLC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
C9ZLC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
C9ZU76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	97%
C9ZVV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	100%
E9ADG3	Leishmania major	24%	85%
E9AE36	Leishmania major	66%	100%
E9AE37	Leishmania major	66%	100%
E9AHJ2	Leishmania infantum	65%	100%
E9ALP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
E9ALP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
P22225	Trypanosoma brucei brucei	82%	100%
Q26789	Trypanosoma brucei brucei	66%	100%
Q4QEM2	Leishmania major	97%	100%
V5BDW8	Trypanosoma cruzi	67%	100%
V5BIN9	Trypanosoma cruzi	27%	90%