Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQV4_LEIMU

TriTrypDb:

LmxM.16.1420

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.684
CLV_NRD_NRD_1	12	14	PF00675	0.723
CLV_NRD_NRD_1	312	314	PF00675	0.556
CLV_NRD_NRD_1	51	53	PF00675	0.512
CLV_NRD_NRD_1	95	97	PF00675	0.654
CLV_PCSK_KEX2_1	102	104	PF00082	0.570
CLV_PCSK_KEX2_1	12	14	PF00082	0.723
CLV_PCSK_KEX2_1	120	122	PF00082	0.567
CLV_PCSK_KEX2_1	130	132	PF00082	0.625
CLV_PCSK_KEX2_1	50	52	PF00082	0.507
CLV_PCSK_KEX2_1	95	97	PF00082	0.546
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.551
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.567
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.625
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.524
CLV_PCSK_SKI1_1	191	195	PF00082	0.553
CLV_PCSK_SKI1_1	21	25	PF00082	0.655
CLV_PCSK_SKI1_1	26	30	PF00082	0.740
CLV_PCSK_SKI1_1	299	303	PF00082	0.541
CLV_PCSK_SKI1_1	313	317	PF00082	0.475
CLV_PCSK_SKI1_1	43	47	PF00082	0.452
DEG_APCC_DBOX_1	145	153	PF00400	0.621
DOC_MAPK_DCC_7	287	295	PF00069	0.372
DOC_MAPK_gen_1	146	155	PF00069	0.666
DOC_MAPK_gen_1	50	58	PF00069	0.641
DOC_MAPK_MEF2A_6	236	244	PF00069	0.593
DOC_MAPK_MEF2A_6	287	295	PF00069	0.372
DOC_MAPK_RevD_3	237	253	PF00069	0.376
DOC_PP1_RVXF_1	297	304	PF00149	0.565
DOC_USP7_MATH_1	192	196	PF00917	0.553
DOC_USP7_MATH_1	36	40	PF00917	0.699
DOC_USP7_UBL2_3	120	124	PF12436	0.703
DOC_USP7_UBL2_3	187	191	PF12436	0.571
DOC_WW_Pin1_4	317	322	PF00397	0.662
LIG_14-3-3_CanoR_1	26	34	PF00244	0.680
LIG_14-3-3_CanoR_1	3	7	PF00244	0.763
LIG_BRCT_BRCA1_1	19	23	PF00533	0.723
LIG_EH1_1	223	231	PF00400	0.467
LIG_FHA_1	244	250	PF00498	0.401
LIG_FHA_1	320	326	PF00498	0.531
LIG_FHA_1	61	67	PF00498	0.573
LIG_FHA_2	139	145	PF00498	0.724
LIG_FHA_2	246	252	PF00498	0.608
LIG_LIR_Gen_1	334	343	PF02991	0.491
LIG_LIR_Gen_1	76	86	PF02991	0.431
LIG_LIR_Nem_3	33	37	PF02991	0.651
LIG_LIR_Nem_3	76	81	PF02991	0.502
LIG_LIR_Nem_3	85	90	PF02991	0.573
LIG_SH2_CRK	298	302	PF00017	0.569
LIG_SH2_NCK_1	132	136	PF00017	0.422
LIG_SH2_STAP1	132	136	PF00017	0.422
LIG_SH2_STAP1	78	82	PF00017	0.590
LIG_SH2_STAT5	283	286	PF00017	0.662
LIG_SH2_STAT5	34	37	PF00017	0.633
LIG_SH2_STAT5	44	47	PF00017	0.511
LIG_SH3_2	291	296	PF14604	0.380
LIG_SH3_3	285	291	PF00018	0.589
LIG_SH3_3	298	304	PF00018	0.486
LIG_SUMO_SIM_anti_2	328	334	PF11976	0.536
LIG_SUMO_SIM_anti_2	347	353	PF11976	0.542
LIG_SUMO_SIM_par_1	238	243	PF11976	0.642
LIG_SUMO_SIM_par_1	253	259	PF11976	0.498
LIG_SUMO_SIM_par_1	328	334	PF11976	0.530
LIG_TRFH_1	58	62	PF08558	0.627
LIG_UBA3_1	152	158	PF00899	0.534
MOD_CK1_1	17	23	PF00069	0.737
MOD_CK1_1	243	249	PF00069	0.628
MOD_CK1_1	341	347	PF00069	0.586
MOD_CK1_1	39	45	PF00069	0.561
MOD_CK2_1	138	144	PF00069	0.706
MOD_CK2_1	331	337	PF00069	0.487
MOD_CK2_1	73	79	PF00069	0.383
MOD_GlcNHglycan	226	229	PF01048	0.600
MOD_GlcNHglycan	271	274	PF01048	0.664
MOD_GlcNHglycan	7	10	PF01048	0.721
MOD_GlcNHglycan	75	78	PF01048	0.436
MOD_GSK3_1	197	204	PF00069	0.553
MOD_GSK3_1	220	227	PF00069	0.555
MOD_GSK3_1	32	39	PF00069	0.684
MOD_GSK3_1	337	344	PF00069	0.547
MOD_GSK3_1	7	14	PF00069	0.728
MOD_N-GLC_1	224	229	PF02516	0.591
MOD_NEK2_1	224	229	PF00069	0.559
MOD_NEK2_1	7	12	PF00069	0.712
MOD_PKA_2	11	17	PF00069	0.681
MOD_PKA_2	197	203	PF00069	0.534
MOD_PKA_2	2	8	PF00069	0.733
MOD_PKA_2	235	241	PF00069	0.483
MOD_Plk_1	224	230	PF00069	0.609
MOD_Plk_1	240	246	PF00069	0.453
MOD_Plk_1	32	38	PF00069	0.638
MOD_Plk_4	148	154	PF00069	0.733
MOD_Plk_4	2	8	PF00069	0.752
MOD_Plk_4	235	241	PF00069	0.559
MOD_ProDKin_1	317	323	PF00069	0.658
MOD_SUMO_for_1	286	289	PF00179	0.674
TRG_DiLeu_BaEn_2	84	90	PF01217	0.625
TRG_ENDOCYTIC_2	298	301	PF00928	0.575
TRG_ENDOCYTIC_2	335	338	PF00928	0.604
TRG_ENDOCYTIC_2	78	81	PF00928	0.595
TRG_ER_diArg_1	11	13	PF00400	0.711
TRG_ER_diArg_1	49	52	PF00400	0.514
TRG_NES_CRM1_1	144	156	PF08389	0.696

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL8	Leptomonas seymouri	60%	69%
A0A1X0NYW3	Trypanosomatidae	43%	100%
A0A3R7JY16	Trypanosoma rangeli	36%	94%
A0A3S7WU51	Leishmania donovani	92%	100%
A4H8S0	Leishmania braziliensis	77%	100%
A4HX38	Leishmania infantum	91%	100%
Q4QEM4	Leishmania major	90%	100%
V5BMN4	Trypanosoma cruzi	40%	96%