Dynein regulatory complex protein 10

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQV3_LEIMU

TriTrypDb:

LmxM.16.1410

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005856	cytoskeleton	5	10
GO:0005929	cilium	4	10
GO:0031514	motile cilium	5	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

E9AQV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQV3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.552
CLV_NRD_NRD_1	366	368	PF00675	0.573
CLV_NRD_NRD_1	377	379	PF00675	0.538
CLV_NRD_NRD_1	386	388	PF00675	0.338
CLV_NRD_NRD_1	513	515	PF00675	0.646
CLV_NRD_NRD_1	57	59	PF00675	0.625
CLV_PCSK_FUR_1	406	410	PF00082	0.582
CLV_PCSK_KEX2_1	366	368	PF00082	0.574
CLV_PCSK_KEX2_1	386	388	PF00082	0.298
CLV_PCSK_KEX2_1	408	410	PF00082	0.582
CLV_PCSK_KEX2_1	513	515	PF00082	0.628
CLV_PCSK_KEX2_1	57	59	PF00082	0.676
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.582
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.628
CLV_PCSK_SKI1_1	140	144	PF00082	0.555
CLV_PCSK_SKI1_1	177	181	PF00082	0.481
CLV_PCSK_SKI1_1	248	252	PF00082	0.364
CLV_PCSK_SKI1_1	509	513	PF00082	0.504
DEG_Nend_UBRbox_2	1	3	PF02207	0.586
DEG_SPOP_SBC_1	122	126	PF00917	0.727
DOC_MAPK_gen_1	57	65	PF00069	0.395
DOC_USP7_MATH_1	108	112	PF00917	0.526
DOC_USP7_MATH_1	122	126	PF00917	0.746
DOC_USP7_MATH_1	238	242	PF00917	0.754
DOC_USP7_MATH_1	244	248	PF00917	0.660
DOC_USP7_MATH_1	411	415	PF00917	0.470
DOC_USP7_MATH_1	90	94	PF00917	0.707
DOC_USP7_MATH_2	32	38	PF00917	0.598
DOC_USP7_UBL2_3	218	222	PF12436	0.589
DOC_USP7_UBL2_3	509	513	PF12436	0.630
DOC_USP7_UBL2_3	515	519	PF12436	0.628
DOC_WW_Pin1_4	77	82	PF00397	0.729
LIG_14-3-3_CanoR_1	280	286	PF00244	0.514
LIG_14-3-3_CanoR_1	366	371	PF00244	0.540
LIG_14-3-3_CanoR_1	500	507	PF00244	0.658
LIG_CaM_IQ_9	487	502	PF13499	0.477
LIG_FHA_1	184	190	PF00498	0.607
LIG_FHA_1	199	205	PF00498	0.523
LIG_FHA_1	304	310	PF00498	0.562
LIG_FHA_1	345	351	PF00498	0.447
LIG_FHA_1	440	446	PF00498	0.503
LIG_FHA_2	115	121	PF00498	0.637
LIG_FHA_2	156	162	PF00498	0.530
LIG_FHA_2	205	211	PF00498	0.449
LIG_FHA_2	282	288	PF00498	0.505
LIG_FHA_2	359	365	PF00498	0.597
LIG_FHA_2	405	411	PF00498	0.491
LIG_FHA_2	416	422	PF00498	0.396
LIG_FHA_2	46	52	PF00498	0.691
LIG_FHA_2	5	11	PF00498	0.628
LIG_FHA_2	501	507	PF00498	0.651
LIG_FHA_2	64	70	PF00498	0.376
LIG_LIR_Gen_1	170	180	PF02991	0.466
LIG_LIR_Gen_1	353	362	PF02991	0.529
LIG_LIR_Gen_1	461	469	PF02991	0.530
LIG_LIR_LC3C_4	268	271	PF02991	0.470
LIG_LIR_Nem_3	152	157	PF02991	0.598
LIG_LIR_Nem_3	170	175	PF02991	0.403
LIG_LIR_Nem_3	210	216	PF02991	0.545
LIG_PTB_Apo_2	310	317	PF02174	0.566
LIG_PTB_Phospho_1	310	316	PF10480	0.569
LIG_SH2_CRK	292	296	PF00017	0.476
LIG_SH2_SRC	59	62	PF00017	0.668
LIG_SH2_STAP1	225	229	PF00017	0.668
LIG_SH2_STAP1	59	63	PF00017	0.659
LIG_SH2_STAT3	420	423	PF00017	0.451
LIG_SH2_STAT5	225	228	PF00017	0.569
LIG_SH2_STAT5	316	319	PF00017	0.553
LIG_SH2_STAT5	343	346	PF00017	0.444
LIG_SH2_STAT5	55	58	PF00017	0.635
LIG_SUMO_SIM_par_1	439	450	PF11976	0.514
LIG_TRAF2_1	336	339	PF00917	0.582
LIG_TRAF2_1	361	364	PF00917	0.533
LIG_TRAF2_1	447	450	PF00917	0.585
LIG_TRAF2_1	7	10	PF00917	0.638
MOD_CK1_1	124	130	PF00069	0.732
MOD_CK1_1	227	233	PF00069	0.677
MOD_CK1_1	404	410	PF00069	0.577
MOD_CK1_1	89	95	PF00069	0.714
MOD_CK1_1	97	103	PF00069	0.705
MOD_CK2_1	281	287	PF00069	0.525
MOD_CK2_1	358	364	PF00069	0.600
MOD_CK2_1	4	10	PF00069	0.636
MOD_CK2_1	404	410	PF00069	0.577
MOD_CK2_1	500	506	PF00069	0.645
MOD_CK2_1	63	69	PF00069	0.517
MOD_GlcNHglycan	413	416	PF01048	0.456
MOD_GlcNHglycan	423	426	PF01048	0.446
MOD_GlcNHglycan	88	91	PF01048	0.674
MOD_GlcNHglycan	96	99	PF01048	0.593
MOD_GSK3_1	122	129	PF00069	0.637
MOD_GSK3_1	178	185	PF00069	0.381
MOD_GSK3_1	223	230	PF00069	0.565
MOD_GSK3_1	238	245	PF00069	0.768
MOD_GSK3_1	411	418	PF00069	0.495
MOD_GSK3_1	45	52	PF00069	0.624
MOD_GSK3_1	496	503	PF00069	0.475
MOD_GSK3_1	86	93	PF00069	0.711
MOD_N-GLC_1	108	113	PF02516	0.471
MOD_N-GLC_1	280	285	PF02516	0.512
MOD_N-GLC_1	404	409	PF02516	0.609
MOD_NEK2_1	123	128	PF00069	0.586
MOD_NEK2_1	204	209	PF00069	0.508
MOD_NEK2_1	224	229	PF00069	0.347
MOD_NEK2_1	269	274	PF00069	0.552
MOD_NEK2_1	358	363	PF00069	0.554
MOD_NEK2_1	49	54	PF00069	0.669
MOD_NEK2_1	86	91	PF00069	0.714
MOD_PIKK_1	232	238	PF00454	0.729
MOD_PIKK_1	248	254	PF00454	0.579
MOD_PIKK_1	500	506	PF00454	0.624
MOD_PK_1	40	46	PF00069	0.660
MOD_PKA_1	366	372	PF00069	0.589
MOD_PKA_2	366	372	PF00069	0.543
MOD_PKA_2	49	55	PF00069	0.678
MOD_PKB_1	278	286	PF00069	0.632
MOD_Plk_1	280	286	PF00069	0.514
MOD_Plk_1	33	39	PF00069	0.609
MOD_Plk_1	40	46	PF00069	0.651
MOD_Plk_1	50	56	PF00069	0.647
MOD_Plk_4	34	40	PF00069	0.568
MOD_Plk_4	50	56	PF00069	0.647
MOD_ProDKin_1	77	83	PF00069	0.729
MOD_SUMO_rev_2	241	250	PF00179	0.423
TRG_DiLeu_BaEn_4	23	29	PF01217	0.545
TRG_DiLeu_BaEn_4	60	66	PF01217	0.381
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.588
TRG_ENDOCYTIC_2	154	157	PF00928	0.596
TRG_ENDOCYTIC_2	172	175	PF00928	0.311
TRG_ENDOCYTIC_2	213	216	PF00928	0.483
TRG_ENDOCYTIC_2	292	295	PF00928	0.478
TRG_ENDOCYTIC_2	316	319	PF00928	0.484
TRG_ENDOCYTIC_2	494	497	PF00928	0.578
TRG_ER_diArg_1	277	280	PF00400	0.623
TRG_ER_diArg_1	386	388	PF00400	0.604
TRG_ER_diArg_1	56	58	PF00400	0.585
TRG_ER_diLys_1	517	522	PF00400	0.609
TRG_NLS_MonoCore_2	511	516	PF00514	0.620
TRG_NLS_MonoExtC_3	511	516	PF00514	0.615
TRG_NLS_MonoExtN_4	509	516	PF00514	0.594
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I290	Leptomonas seymouri	55%	94%
A0A1X0NYT0	Trypanosomatidae	31%	100%
A0A3Q8IJ71	Leishmania donovani	91%	100%
A0A3R7M3F0	Trypanosoma rangeli	37%	100%
A4HX37	Leishmania infantum	91%	100%
C9ZVV2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4QEM5	Leishmania major	89%	100%
V5DJ53	Trypanosoma cruzi	36%	100%