Amidase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amidase, putative

Species:

Leishmania mexicana

UniProt:

E9AQU7_LEIMU

TriTrypDb:

LmxM.16.1360

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AQU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQU7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.496
CLV_NRD_NRD_1	321	323	PF00675	0.285
CLV_NRD_NRD_1	536	538	PF00675	0.315
CLV_PCSK_KEX2_1	134	136	PF00082	0.269
CLV_PCSK_KEX2_1	536	538	PF00082	0.315
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.269
CLV_PCSK_SKI1_1	322	326	PF00082	0.269
CLV_PCSK_SKI1_1	433	437	PF00082	0.261
CLV_PCSK_SKI1_1	460	464	PF00082	0.254
CLV_PCSK_SKI1_1	5	9	PF00082	0.267
CLV_PCSK_SKI1_1	580	584	PF00082	0.361
DEG_SCF_FBW7_1	375	381	PF00400	0.469
DOC_CKS1_1	375	380	PF01111	0.477
DOC_CYCLIN_RxL_1	320	328	PF00134	0.395
DOC_CYCLIN_RxL_1	457	468	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	309	315	PF00134	0.365
DOC_CYCLIN_yCln2_LP_2	503	509	PF00134	0.439
DOC_CYCLIN_yCln2_LP_2	518	524	PF00134	0.439
DOC_MAPK_DCC_7	438	448	PF00069	0.425
DOC_MAPK_gen_1	178	188	PF00069	0.439
DOC_MAPK_gen_1	536	542	PF00069	0.491
DOC_MAPK_MEF2A_6	181	190	PF00069	0.425
DOC_MAPK_MEF2A_6	395	403	PF00069	0.434
DOC_MAPK_MEF2A_6	5	12	PF00069	0.493
DOC_MAPK_NFAT4_5	5	13	PF00069	0.517
DOC_PP2B_LxvP_1	141	144	PF13499	0.425
DOC_PP2B_LxvP_1	456	459	PF13499	0.469
DOC_PP2B_LxvP_1	518	521	PF13499	0.425
DOC_PP2B_LxvP_1	548	551	PF13499	0.339
DOC_PP2B_PxIxI_1	342	348	PF00149	0.504
DOC_PP4_FxxP_1	554	557	PF00568	0.517
DOC_USP7_MATH_1	157	161	PF00917	0.420
DOC_USP7_MATH_1	276	280	PF00917	0.457
DOC_USP7_MATH_1	378	382	PF00917	0.489
DOC_USP7_MATH_1	51	55	PF00917	0.567
DOC_USP7_MATH_2	387	393	PF00917	0.434
DOC_WW_Pin1_4	171	176	PF00397	0.425
DOC_WW_Pin1_4	260	265	PF00397	0.437
DOC_WW_Pin1_4	374	379	PF00397	0.555
DOC_WW_Pin1_4	498	503	PF00397	0.347
LIG_14-3-3_CanoR_1	438	444	PF00244	0.415
LIG_Actin_WH2_2	447	465	PF00022	0.339
LIG_APCC_ABBA_1	540	545	PF00400	0.504
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_Clathr_ClatBox_1	480	484	PF01394	0.469
LIG_deltaCOP1_diTrp_1	121	127	PF00928	0.425
LIG_EH_1	504	508	PF12763	0.504
LIG_eIF4E_1	20	26	PF01652	0.392
LIG_eIF4E_1	214	220	PF01652	0.425
LIG_eIF4E_1	588	594	PF01652	0.362
LIG_FHA_1	191	197	PF00498	0.439
LIG_FHA_1	21	27	PF00498	0.299
LIG_FHA_1	214	220	PF00498	0.425
LIG_FHA_1	235	241	PF00498	0.425
LIG_FHA_1	28	34	PF00498	0.300
LIG_FHA_1	284	290	PF00498	0.434
LIG_FHA_1	451	457	PF00498	0.483
LIG_FHA_2	144	150	PF00498	0.449
LIG_FHA_2	564	570	PF00498	0.517
LIG_GBD_Chelix_1	575	583	PF00786	0.265
LIG_IBAR_NPY_1	212	214	PF08397	0.415
LIG_IBAR_NPY_1	99	101	PF08397	0.425
LIG_LIR_Apic_2	338	343	PF02991	0.474
LIG_LIR_Apic_2	553	557	PF02991	0.427
LIG_LIR_Gen_1	371	378	PF02991	0.506
LIG_LIR_Gen_1	389	398	PF02991	0.483
LIG_LIR_Gen_1	410	417	PF02991	0.405
LIG_LIR_Gen_1	512	522	PF02991	0.425
LIG_LIR_Gen_1	590	599	PF02991	0.589
LIG_LIR_Nem_3	371	375	PF02991	0.478
LIG_LIR_Nem_3	389	393	PF02991	0.458
LIG_LIR_Nem_3	410	416	PF02991	0.405
LIG_LIR_Nem_3	501	507	PF02991	0.412
LIG_LIR_Nem_3	512	518	PF02991	0.416
LIG_LIR_Nem_3	590	594	PF02991	0.533
LIG_MAD2	323	331	PF02301	0.517
LIG_NRBOX	476	482	PF00104	0.425
LIG_Pex14_1	42	46	PF04695	0.560
LIG_Pex14_1	528	532	PF04695	0.374
LIG_PTB_Apo_2	252	259	PF02174	0.415
LIG_PTB_Phospho_1	252	258	PF10480	0.457
LIG_Rb_LxCxE_1	79	90	PF01857	0.514
LIG_SH2_CRK	340	344	PF00017	0.475
LIG_SH2_CRK	586	590	PF00017	0.445
LIG_SH2_GRB2like	101	104	PF00017	0.425
LIG_SH2_GRB2like	372	375	PF00017	0.425
LIG_SH2_NCK_1	511	515	PF00017	0.415
LIG_SH2_PTP2	372	375	PF00017	0.439
LIG_SH2_SRC	101	104	PF00017	0.440
LIG_SH2_SRC	372	375	PF00017	0.517
LIG_SH2_STAP1	511	515	PF00017	0.416
LIG_SH2_STAT3	64	67	PF00017	0.436
LIG_SH2_STAT5	101	104	PF00017	0.452
LIG_SH2_STAT5	21	24	PF00017	0.454
LIG_SH2_STAT5	266	269	PF00017	0.425
LIG_SH2_STAT5	372	375	PF00017	0.428
LIG_SH2_STAT5	511	514	PF00017	0.415
LIG_SH2_STAT5	64	67	PF00017	0.469
LIG_SH3_2	317	322	PF14604	0.485
LIG_SH3_3	169	175	PF00018	0.469
LIG_SH3_3	310	316	PF00018	0.424
LIG_SH3_3	372	378	PF00018	0.509
LIG_SH3_3	487	493	PF00018	0.415
LIG_SH3_3	523	529	PF00018	0.486
LIG_SH3_CIN85_PxpxPR_1	493	498	PF14604	0.457
LIG_SUMO_SIM_anti_2	452	458	PF11976	0.411
LIG_SUMO_SIM_anti_2	83	90	PF11976	0.517
LIG_SUMO_SIM_par_1	323	328	PF11976	0.398
LIG_SUMO_SIM_par_1	478	484	PF11976	0.434
LIG_TRFH_1	308	312	PF08558	0.517
LIG_TYR_ITIM	370	375	PF00017	0.439
LIG_WRC_WIRS_1	235	240	PF05994	0.425
LIG_WRC_WIRS_1	390	395	PF05994	0.434
LIG_WRC_WIRS_1	88	93	PF05994	0.469
MOD_CDK_SPxK_1	374	380	PF00069	0.469
MOD_CDK_SPxxK_3	171	178	PF00069	0.439
MOD_CK1_1	236	242	PF00069	0.425
MOD_CK1_1	275	281	PF00069	0.391
MOD_CK1_1	379	385	PF00069	0.462
MOD_CK1_1	402	408	PF00069	0.449
MOD_CK1_1	439	445	PF00069	0.415
MOD_CK2_1	143	149	PF00069	0.425
MOD_CK2_1	221	227	PF00069	0.425
MOD_CK2_1	347	353	PF00069	0.466
MOD_CK2_1	462	468	PF00069	0.497
MOD_CK2_1	538	544	PF00069	0.457
MOD_CK2_1	66	72	PF00069	0.518
MOD_CK2_1	80	86	PF00069	0.453
MOD_CMANNOS	124	127	PF00535	0.225
MOD_GlcNHglycan	1	4	PF01048	0.446
MOD_GlcNHglycan	159	162	PF01048	0.241
MOD_GlcNHglycan	223	226	PF01048	0.215
MOD_GlcNHglycan	274	277	PF01048	0.295
MOD_GlcNHglycan	278	281	PF01048	0.295
MOD_GlcNHglycan	43	46	PF01048	0.363
MOD_GlcNHglycan	493	496	PF01048	0.291
MOD_GlcNHglycan	563	566	PF01048	0.317
MOD_GlcNHglycan	68	71	PF01048	0.275
MOD_GSK3_1	167	174	PF00069	0.505
MOD_GSK3_1	272	279	PF00069	0.528
MOD_GSK3_1	374	381	PF00069	0.517
MOD_GSK3_1	402	409	PF00069	0.500
MOD_GSK3_1	411	418	PF00069	0.527
MOD_N-GLC_1	157	162	PF02516	0.210
MOD_N-GLC_1	191	196	PF02516	0.239
MOD_N-GLC_2	164	166	PF02516	0.139
MOD_N-GLC_2	426	428	PF02516	0.191
MOD_NEK2_1	188	193	PF00069	0.431
MOD_NEK2_1	26	31	PF00069	0.157
MOD_NEK2_1	399	404	PF00069	0.466
MOD_NEK2_1	436	441	PF00069	0.466
MOD_NEK2_1	509	514	PF00069	0.434
MOD_NEK2_1	571	576	PF00069	0.477
MOD_NEK2_1	71	76	PF00069	0.499
MOD_PIKK_1	297	303	PF00454	0.426
MOD_PIKK_1	347	353	PF00454	0.427
MOD_PIKK_1	415	421	PF00454	0.469
MOD_PK_1	536	542	PF00069	0.538
MOD_PKA_1	536	542	PF00069	0.517
MOD_PKA_2	379	385	PF00069	0.448
MOD_PKA_2	51	57	PF00069	0.589
MOD_PKA_2	536	542	PF00069	0.482
MOD_Plk_1	544	550	PF00069	0.434
MOD_Plk_1	80	86	PF00069	0.376
MOD_Plk_4	135	141	PF00069	0.425
MOD_Plk_4	368	374	PF00069	0.435
MOD_Plk_4	399	405	PF00069	0.508
MOD_Plk_4	476	482	PF00069	0.517
MOD_Plk_4	528	534	PF00069	0.545
MOD_Plk_4	87	93	PF00069	0.469
MOD_ProDKin_1	171	177	PF00069	0.425
MOD_ProDKin_1	260	266	PF00069	0.437
MOD_ProDKin_1	374	380	PF00069	0.555
MOD_ProDKin_1	498	504	PF00069	0.347
MOD_SUMO_rev_2	407	414	PF00179	0.460
MOD_SUMO_rev_2	465	471	PF00179	0.388
TRG_DiLeu_BaEn_1	452	457	PF01217	0.434
TRG_DiLeu_BaEn_1	466	471	PF01217	0.356
TRG_ENDOCYTIC_2	372	375	PF00928	0.425
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3K3	Leptomonas seymouri	79%	100%
A0A0S4JR69	Bodo saltans	44%	100%
A0A1X0NYV8	Trypanosomatidae	62%	99%
A0A3R7KJH6	Trypanosoma rangeli	61%	99%
A0A3S7WU46	Leishmania donovani	94%	100%
A0L5G0	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	23%	100%
A4H8R4	Leishmania braziliensis	84%	100%
A4HX32	Leishmania infantum	94%	100%
A5WCI2	Psychrobacter sp. (strain PRwf-1)	25%	100%
B8GL95	Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)	26%	100%
C9ZVW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
Q05AM4	Danio rerio	38%	100%
Q0ACB5	Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)	25%	100%
Q0AFP4	Nitrosomonas eutropha (strain DSM 101675 / C91 / Nm57)	26%	100%
Q1J0C2	Deinococcus geothermalis (strain DSM 11300 / AG-3a)	25%	100%
Q1QVB5	Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)	25%	100%
Q4QEN1	Leishmania major	92%	100%
Q4ZNS7	Pseudomonas syringae pv. syringae (strain B728a)	23%	100%
Q60CK8	Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)	26%	100%
Q6DH69	Danio rerio	38%	100%
Q6GMR7	Homo sapiens	35%	100%
Q87WR9	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	23%	100%
Q8R679	Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)	25%	100%
Q8RC40	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	26%	100%
Q9LCX3	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	25%	100%
V5BS79	Trypanosoma cruzi	62%	100%