Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 41

Species:

Leishmania mexicana

UniProt:

E9AQU1_LEIMU

TriTrypDb:

LmxM.16.1300

Length:

995

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQU1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	739	743	PF00656	0.506
CLV_C14_Caspase3-7	887	891	PF00656	0.549
CLV_NRD_NRD_1	286	288	PF00675	0.864
CLV_NRD_NRD_1	399	401	PF00675	0.556
CLV_NRD_NRD_1	453	455	PF00675	0.662
CLV_NRD_NRD_1	680	682	PF00675	0.546
CLV_NRD_NRD_1	69	71	PF00675	0.699
CLV_NRD_NRD_1	710	712	PF00675	0.530
CLV_NRD_NRD_1	794	796	PF00675	0.613
CLV_NRD_NRD_1	906	908	PF00675	0.810
CLV_PCSK_FUR_1	792	796	PF00082	0.665
CLV_PCSK_KEX2_1	286	288	PF00082	0.864
CLV_PCSK_KEX2_1	399	401	PF00082	0.653
CLV_PCSK_KEX2_1	453	455	PF00082	0.662
CLV_PCSK_KEX2_1	69	71	PF00082	0.653
CLV_PCSK_KEX2_1	710	712	PF00082	0.530
CLV_PCSK_KEX2_1	794	796	PF00082	0.613
CLV_PCSK_KEX2_1	905	907	PF00082	0.822
CLV_PCSK_SKI1_1	327	331	PF00082	0.552
CLV_PCSK_SKI1_1	33	37	PF00082	0.770
CLV_PCSK_SKI1_1	43	47	PF00082	0.645
CLV_PCSK_SKI1_1	635	639	PF00082	0.718
CLV_PCSK_SKI1_1	659	663	PF00082	0.639
CLV_PCSK_SKI1_1	668	672	PF00082	0.482
CLV_PCSK_SKI1_1	759	763	PF00082	0.464
CLV_PCSK_SKI1_1	907	911	PF00082	0.695
CLV_PCSK_SKI1_1	934	938	PF00082	0.693
DEG_APCC_DBOX_1	729	737	PF00400	0.521
DEG_APCC_DBOX_1	835	843	PF00400	0.645
DEG_SCF_FBW7_1	407	414	PF00400	0.556
DEG_SCF_FBW7_1	81	87	PF00400	0.758
DEG_SCF_FBW7_1	911	918	PF00400	0.818
DEG_SPOP_SBC_1	188	192	PF00917	0.783
DEG_SPOP_SBC_1	221	225	PF00917	0.762
DEG_SPOP_SBC_1	715	719	PF00917	0.585
DOC_CKS1_1	117	122	PF01111	0.707
DOC_CKS1_1	317	322	PF01111	0.761
DOC_CKS1_1	81	86	PF01111	0.757
DOC_CKS1_1	917	922	PF01111	0.817
DOC_CYCLIN_yClb3_PxF_3	751	759	PF00134	0.654
DOC_CYCLIN_yCln2_LP_2	780	786	PF00134	0.562
DOC_MAPK_gen_1	399	407	PF00069	0.537
DOC_MAPK_gen_1	666	674	PF00069	0.532
DOC_MAPK_gen_1	679	688	PF00069	0.542
DOC_MAPK_gen_1	728	736	PF00069	0.513
DOC_MAPK_gen_1	982	990	PF00069	0.585
DOC_MAPK_MEF2A_6	400	409	PF00069	0.541
DOC_MAPK_MEF2A_6	668	676	PF00069	0.615
DOC_MAPK_MEF2A_6	984	992	PF00069	0.675
DOC_PP1_RVXF_1	19	26	PF00149	0.579
DOC_PP2B_LxvP_1	227	230	PF13499	0.755
DOC_PP2B_LxvP_1	522	525	PF13499	0.759
DOC_USP7_MATH_1	130	134	PF00917	0.619
DOC_USP7_MATH_1	221	225	PF00917	0.779
DOC_USP7_MATH_1	306	310	PF00917	0.626
DOC_USP7_MATH_1	332	336	PF00917	0.787
DOC_USP7_MATH_1	357	361	PF00917	0.804
DOC_USP7_MATH_1	411	415	PF00917	0.624
DOC_USP7_MATH_1	465	469	PF00917	0.523
DOC_USP7_MATH_1	495	499	PF00917	0.844
DOC_USP7_MATH_1	559	563	PF00917	0.767
DOC_USP7_MATH_1	577	581	PF00917	0.749
DOC_USP7_MATH_1	657	661	PF00917	0.719
DOC_USP7_MATH_1	715	719	PF00917	0.585
DOC_USP7_MATH_1	818	822	PF00917	0.714
DOC_USP7_MATH_1	832	836	PF00917	0.617
DOC_USP7_MATH_1	852	856	PF00917	0.442
DOC_USP7_MATH_1	860	864	PF00917	0.672
DOC_USP7_MATH_1	873	877	PF00917	0.602
DOC_USP7_MATH_1	897	901	PF00917	0.646
DOC_WW_Pin1_4	112	117	PF00397	0.709
DOC_WW_Pin1_4	13	18	PF00397	0.669
DOC_WW_Pin1_4	161	166	PF00397	0.783
DOC_WW_Pin1_4	207	212	PF00397	0.788
DOC_WW_Pin1_4	222	227	PF00397	0.803
DOC_WW_Pin1_4	310	315	PF00397	0.774
DOC_WW_Pin1_4	316	321	PF00397	0.724
DOC_WW_Pin1_4	360	365	PF00397	0.833
DOC_WW_Pin1_4	407	412	PF00397	0.561
DOC_WW_Pin1_4	461	466	PF00397	0.576
DOC_WW_Pin1_4	549	554	PF00397	0.730
DOC_WW_Pin1_4	561	566	PF00397	0.835
DOC_WW_Pin1_4	567	572	PF00397	0.703
DOC_WW_Pin1_4	573	578	PF00397	0.671
DOC_WW_Pin1_4	585	590	PF00397	0.596
DOC_WW_Pin1_4	609	614	PF00397	0.564
DOC_WW_Pin1_4	659	664	PF00397	0.547
DOC_WW_Pin1_4	80	85	PF00397	0.754
DOC_WW_Pin1_4	891	896	PF00397	0.792
DOC_WW_Pin1_4	911	916	PF00397	0.616
DOC_WW_Pin1_4	920	925	PF00397	0.756
LIG_14-3-3_CanoR_1	220	226	PF00244	0.762
LIG_14-3-3_CanoR_1	286	290	PF00244	0.781
LIG_14-3-3_CanoR_1	307	314	PF00244	0.595
LIG_14-3-3_CanoR_1	427	437	PF00244	0.632
LIG_14-3-3_CanoR_1	759	769	PF00244	0.532
LIG_Actin_WH2_2	8	23	PF00022	0.570
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_BIR_III_2	147	151	PF00653	0.740
LIG_BRCT_BRCA1_1	716	720	PF00533	0.501
LIG_CaM_NSCaTE_8	298	305	PF13499	0.627
LIG_deltaCOP1_diTrp_1	628	632	PF00928	0.698
LIG_deltaCOP1_diTrp_1	642	646	PF00928	0.536
LIG_deltaCOP1_diTrp_1	985	989	PF00928	0.561
LIG_eIF4E_1	387	393	PF01652	0.431
LIG_FHA_1	189	195	PF00498	0.658
LIG_FHA_1	197	203	PF00498	0.720
LIG_FHA_1	400	406	PF00498	0.612
LIG_FHA_1	517	523	PF00498	0.774
LIG_FHA_1	766	772	PF00498	0.479
LIG_FHA_1	851	857	PF00498	0.468
LIG_FHA_1	867	873	PF00498	0.660
LIG_FHA_1	912	918	PF00498	0.774
LIG_FHA_1	923	929	PF00498	0.668
LIG_FHA_2	102	108	PF00498	0.517
LIG_FHA_2	162	168	PF00498	0.841
LIG_FHA_2	44	50	PF00498	0.614
LIG_FHA_2	594	600	PF00498	0.713
LIG_FHA_2	638	644	PF00498	0.624
LIG_FHA_2	737	743	PF00498	0.516
LIG_IRF3_LxIS_1	960	967	PF10401	0.579
LIG_LIR_Apic_2	115	120	PF02991	0.707
LIG_LIR_Apic_2	662	667	PF02991	0.658
LIG_LIR_Gen_1	44	51	PF02991	0.680
LIG_LIR_Gen_1	446	451	PF02991	0.480
LIG_LIR_Gen_1	719	729	PF02991	0.479
LIG_LIR_Gen_1	858	868	PF02991	0.697
LIG_LIR_Gen_1	985	992	PF02991	0.549
LIG_LIR_Nem_3	106	111	PF02991	0.800
LIG_LIR_Nem_3	24	28	PF02991	0.601
LIG_LIR_Nem_3	257	261	PF02991	0.551
LIG_LIR_Nem_3	44	48	PF02991	0.479
LIG_LIR_Nem_3	717	723	PF02991	0.517
LIG_LIR_Nem_3	779	784	PF02991	0.501
LIG_LIR_Nem_3	801	807	PF02991	0.494
LIG_LIR_Nem_3	846	850	PF02991	0.628
LIG_LIR_Nem_3	858	864	PF02991	0.640
LIG_LIR_Nem_3	985	989	PF02991	0.570
LIG_MYND_1	366	370	PF01753	0.662
LIG_PCNA_yPIPBox_3	369	380	PF02747	0.743
LIG_Pex14_1	629	633	PF04695	0.619
LIG_SH2_CRK	270	274	PF00017	0.790
LIG_SH2_CRK	387	391	PF00017	0.652
LIG_SH2_CRK	680	684	PF00017	0.595
LIG_SH2_CRK	781	785	PF00017	0.531
LIG_SH2_CRK	804	808	PF00017	0.503
LIG_SH2_NCK_1	607	611	PF00017	0.536
LIG_SH2_SRC	443	446	PF00017	0.501
LIG_SH2_STAP1	3	7	PF00017	0.720
LIG_SH2_STAP1	607	611	PF00017	0.536
LIG_SH2_STAP1	946	950	PF00017	0.730
LIG_SH2_STAT3	62	65	PF00017	0.771
LIG_SH2_STAT3	631	634	PF00017	0.623
LIG_SH2_STAT3	848	851	PF00017	0.436
LIG_SH2_STAT5	118	121	PF00017	0.682
LIG_SH2_STAT5	424	427	PF00017	0.635
LIG_SH2_STAT5	443	446	PF00017	0.325
LIG_SH2_STAT5	849	852	PF00017	0.620
LIG_SH3_1	748	754	PF00018	0.683
LIG_SH3_2	569	574	PF14604	0.778
LIG_SH3_3	162	168	PF00018	0.777
LIG_SH3_3	191	197	PF00018	0.730
LIG_SH3_3	314	320	PF00018	0.829
LIG_SH3_3	359	365	PF00018	0.836
LIG_SH3_3	522	528	PF00018	0.735
LIG_SH3_3	566	572	PF00018	0.827
LIG_SH3_3	748	754	PF00018	0.581
LIG_SH3_3	90	96	PF00018	0.824
LIG_SH3_3	921	927	PF00018	0.760
LIG_SUMO_SIM_par_1	961	967	PF11976	0.580
LIG_TRAF2_1	457	460	PF00917	0.809
LIG_TRAF2_1	63	66	PF00917	0.683
LIG_TRFH_1	13	17	PF08558	0.670
LIG_TYR_ITSM	777	784	PF00017	0.567
LIG_UBA3_1	988	995	PF00899	0.564
LIG_WRC_WIRS_1	444	449	PF05994	0.454
LIG_WW_3	283	287	PF00397	0.740
MOD_CDK_SPK_2	316	321	PF00069	0.763
MOD_CDK_SPxxK_3	567	574	PF00069	0.778
MOD_CDK_SPxxK_3	659	666	PF00069	0.598
MOD_CK1_1	103	109	PF00069	0.688
MOD_CK1_1	112	118	PF00069	0.748
MOD_CK1_1	187	193	PF00069	0.807
MOD_CK1_1	2	8	PF00069	0.615
MOD_CK1_1	360	366	PF00069	0.763
MOD_CK1_1	463	469	PF00069	0.817
MOD_CK1_1	53	59	PF00069	0.730
MOD_CK1_1	560	566	PF00069	0.822
MOD_CK1_1	570	576	PF00069	0.720
MOD_CK1_1	588	594	PF00069	0.790
MOD_CK1_1	74	80	PF00069	0.803
MOD_CK1_1	855	861	PF00069	0.624
MOD_CK1_1	874	880	PF00069	0.758
MOD_CK1_1	884	890	PF00069	0.683
MOD_CK1_1	977	983	PF00069	0.698
MOD_CK2_1	101	107	PF00069	0.518
MOD_CK2_1	161	167	PF00069	0.848
MOD_CK2_1	183	189	PF00069	0.732
MOD_CK2_1	330	336	PF00069	0.717
MOD_CK2_1	475	481	PF00069	0.763
MOD_CK2_1	637	643	PF00069	0.621
MOD_CMANNOS	629	632	PF00535	0.722
MOD_Cter_Amidation	451	454	PF01082	0.627
MOD_DYRK1A_RPxSP_1	659	663	PF00069	0.708
MOD_GlcNHglycan	111	114	PF01048	0.775
MOD_GlcNHglycan	123	126	PF01048	0.661
MOD_GlcNHglycan	132	135	PF01048	0.657
MOD_GlcNHglycan	186	189	PF01048	0.745
MOD_GlcNHglycan	191	194	PF01048	0.700
MOD_GlcNHglycan	205	208	PF01048	0.794
MOD_GlcNHglycan	216	219	PF01048	0.843
MOD_GlcNHglycan	280	284	PF01048	0.662
MOD_GlcNHglycan	314	317	PF01048	0.806
MOD_GlcNHglycan	339	342	PF01048	0.681
MOD_GlcNHglycan	358	362	PF01048	0.730
MOD_GlcNHglycan	37	40	PF01048	0.493
MOD_GlcNHglycan	413	416	PF01048	0.606
MOD_GlcNHglycan	467	470	PF01048	0.743
MOD_GlcNHglycan	580	583	PF01048	0.859
MOD_GlcNHglycan	602	605	PF01048	0.801
MOD_GlcNHglycan	659	662	PF01048	0.583
MOD_GlcNHglycan	692	695	PF01048	0.490
MOD_GlcNHglycan	702	705	PF01048	0.478
MOD_GlcNHglycan	76	80	PF01048	0.707
MOD_GlcNHglycan	762	765	PF01048	0.555
MOD_GlcNHglycan	788	791	PF01048	0.458
MOD_GlcNHglycan	809	812	PF01048	0.710
MOD_GlcNHglycan	858	861	PF01048	0.650
MOD_GlcNHglycan	876	879	PF01048	0.609
MOD_GlcNHglycan	884	887	PF01048	0.739
MOD_GlcNHglycan	911	914	PF01048	0.816
MOD_GlcNHglycan	97	100	PF01048	0.772
MOD_GSK3_1	112	119	PF00069	0.697
MOD_GSK3_1	157	164	PF00069	0.779
MOD_GSK3_1	180	187	PF00069	0.667
MOD_GSK3_1	203	210	PF00069	0.777
MOD_GSK3_1	294	301	PF00069	0.717
MOD_GSK3_1	306	313	PF00069	0.738
MOD_GSK3_1	31	38	PF00069	0.591
MOD_GSK3_1	319	326	PF00069	0.661
MOD_GSK3_1	360	367	PF00069	0.824
MOD_GSK3_1	407	414	PF00069	0.556
MOD_GSK3_1	460	467	PF00069	0.717
MOD_GSK3_1	49	56	PF00069	0.726
MOD_GSK3_1	497	504	PF00069	0.679
MOD_GSK3_1	516	523	PF00069	0.707
MOD_GSK3_1	536	543	PF00069	0.685
MOD_GSK3_1	545	552	PF00069	0.763
MOD_GSK3_1	557	564	PF00069	0.627
MOD_GSK3_1	573	580	PF00069	0.627
MOD_GSK3_1	591	598	PF00069	0.836
MOD_GSK3_1	71	78	PF00069	0.779
MOD_GSK3_1	710	717	PF00069	0.497
MOD_GSK3_1	732	739	PF00069	0.536
MOD_GSK3_1	760	767	PF00069	0.507
MOD_GSK3_1	80	87	PF00069	0.748
MOD_GSK3_1	852	859	PF00069	0.626
MOD_GSK3_1	873	880	PF00069	0.781
MOD_GSK3_1	909	916	PF00069	0.808
MOD_GSK3_1	969	976	PF00069	0.546
MOD_N-GLC_1	203	208	PF02516	0.741
MOD_N-GLC_1	53	58	PF02516	0.683
MOD_N-GLC_1	565	570	PF02516	0.772
MOD_N-GLC_1	619	624	PF02516	0.560
MOD_N-GLC_1	764	769	PF02516	0.540
MOD_N-GLC_1	969	974	PF02516	0.544
MOD_NEK2_1	180	185	PF00069	0.811
MOD_NEK2_1	700	705	PF00069	0.469
MOD_NEK2_1	723	728	PF00069	0.537
MOD_NEK2_1	736	741	PF00069	0.529
MOD_NEK2_1	760	765	PF00069	0.648
MOD_NEK2_1	850	855	PF00069	0.627
MOD_NEK2_1	964	969	PF00069	0.561
MOD_NEK2_2	248	253	PF00069	0.567
MOD_NEK2_2	860	865	PF00069	0.746
MOD_NEK2_2	940	945	PF00069	0.646
MOD_PIKK_1	235	241	PF00454	0.717
MOD_PIKK_1	306	312	PF00454	0.610
MOD_PKA_1	399	405	PF00069	0.535
MOD_PKA_1	710	716	PF00069	0.502
MOD_PKA_2	221	227	PF00069	0.760
MOD_PKA_2	285	291	PF00069	0.857
MOD_PKA_2	306	312	PF00069	0.551
MOD_PKA_2	399	405	PF00069	0.636
MOD_PKA_2	452	458	PF00069	0.656
MOD_PKA_2	540	546	PF00069	0.659
MOD_PKA_2	71	77	PF00069	0.683
MOD_PKA_2	710	716	PF00069	0.569
MOD_PKA_2	786	792	PF00069	0.644
MOD_PKB_1	982	990	PF00069	0.605
MOD_Plk_1	101	107	PF00069	0.568
MOD_Plk_1	43	49	PF00069	0.731
MOD_Plk_1	431	437	PF00069	0.523
MOD_Plk_1	495	501	PF00069	0.548
MOD_Plk_1	53	59	PF00069	0.557
MOD_Plk_1	723	729	PF00069	0.486
MOD_Plk_1	818	824	PF00069	0.810
MOD_Plk_1	969	975	PF00069	0.548
MOD_Plk_1	984	990	PF00069	0.567
MOD_Plk_4	180	186	PF00069	0.605
MOD_Plk_4	248	254	PF00069	0.480
MOD_Plk_4	294	300	PF00069	0.542
MOD_Plk_4	431	437	PF00069	0.523
MOD_Plk_4	443	449	PF00069	0.526
MOD_Plk_4	776	782	PF00069	0.563
MOD_Plk_4	852	858	PF00069	0.429
MOD_ProDKin_1	112	118	PF00069	0.711
MOD_ProDKin_1	13	19	PF00069	0.669
MOD_ProDKin_1	161	167	PF00069	0.783
MOD_ProDKin_1	207	213	PF00069	0.789
MOD_ProDKin_1	222	228	PF00069	0.804
MOD_ProDKin_1	310	316	PF00069	0.775
MOD_ProDKin_1	360	366	PF00069	0.832
MOD_ProDKin_1	407	413	PF00069	0.574
MOD_ProDKin_1	461	467	PF00069	0.577
MOD_ProDKin_1	549	555	PF00069	0.732
MOD_ProDKin_1	561	567	PF00069	0.838
MOD_ProDKin_1	573	579	PF00069	0.672
MOD_ProDKin_1	585	591	PF00069	0.642
MOD_ProDKin_1	609	615	PF00069	0.565
MOD_ProDKin_1	659	665	PF00069	0.545
MOD_ProDKin_1	80	86	PF00069	0.754
MOD_ProDKin_1	891	897	PF00069	0.792
MOD_ProDKin_1	911	917	PF00069	0.618
MOD_ProDKin_1	920	926	PF00069	0.756
MOD_SUMO_for_1	291	294	PF00179	0.845
TRG_DiLeu_BaEn_2	984	990	PF01217	0.592
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.650
TRG_ENDOCYTIC_2	270	273	PF00928	0.786
TRG_ENDOCYTIC_2	387	390	PF00928	0.662
TRG_ENDOCYTIC_2	781	784	PF00928	0.535
TRG_ENDOCYTIC_2	804	807	PF00928	0.503
TRG_ER_diArg_1	285	287	PF00400	0.865
TRG_ER_diArg_1	399	401	PF00400	0.653
TRG_ER_diArg_1	453	456	PF00400	0.775
TRG_ER_diArg_1	69	72	PF00400	0.703
TRG_ER_diArg_1	709	711	PF00400	0.551
TRG_ER_diArg_1	727	730	PF00400	0.488
TRG_ER_diArg_1	791	794	PF00400	0.582
TRG_ER_diArg_1	904	907	PF00400	0.817
TRG_NLS_MonoCore_2	680	685	PF00514	0.586
TRG_NLS_MonoExtN_4	679	685	PF00514	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G9	Leptomonas seymouri	42%	99%
A0A3Q8IAI0	Leishmania donovani	89%	100%
A4H8Q8	Leishmania braziliensis	71%	99%
A4HX27	Leishmania infantum	88%	100%
Q4QEN7	Leishmania major	88%	100%