Diacylglycerol kinase (ATP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

diacylglycerol kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AQU0_LEIMU

TriTrypDb:

LmxM.16.1290

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQU0

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0007165	signal transduction	2	10
GO:0007186	G protein-coupled receptor signaling pathway	3	10
GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0044237	cellular metabolic process	2	10
GO:0050789	regulation of biological process	2	10
GO:0050794	regulation of cellular process	3	10
GO:0065007	biological regulation	1	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004143	diacylglycerol kinase activity	5	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	47	51	PF00656	0.683
CLV_NRD_NRD_1	254	256	PF00675	0.485
CLV_NRD_NRD_1	476	478	PF00675	0.345
CLV_NRD_NRD_1	81	83	PF00675	0.701
CLV_PCSK_KEX2_1	193	195	PF00082	0.444
CLV_PCSK_KEX2_1	214	216	PF00082	0.429
CLV_PCSK_KEX2_1	254	256	PF00082	0.484
CLV_PCSK_KEX2_1	476	478	PF00082	0.355
CLV_PCSK_KEX2_1	570	572	PF00082	0.408
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.444
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.408
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.408
CLV_PCSK_PC7_1	210	216	PF00082	0.474
CLV_PCSK_SKI1_1	194	198	PF00082	0.344
CLV_PCSK_SKI1_1	280	284	PF00082	0.269
CLV_PCSK_SKI1_1	577	581	PF00082	0.485
CLV_PCSK_SKI1_1	82	86	PF00082	0.774
DEG_APCC_DBOX_1	517	525	PF00400	0.388
DEG_COP1_1	100	108	PF00400	0.756
DEG_Nend_UBRbox_3	1	3	PF02207	0.714
DEG_SCF_FBW7_1	586	591	PF00400	0.408
DEG_SCF_TRCP1_1	155	161	PF00400	0.508
DEG_SPOP_SBC_1	322	326	PF00917	0.414
DEG_SPOP_SBC_1	34	38	PF00917	0.768
DEG_SPOP_SBC_1	410	414	PF00917	0.463
DOC_CKS1_1	109	114	PF01111	0.647
DOC_CKS1_1	220	225	PF01111	0.291
DOC_CKS1_1	652	657	PF01111	0.485
DOC_CYCLIN_RxL_1	547	555	PF00134	0.485
DOC_MAPK_DCC_7	364	374	PF00069	0.495
DOC_MAPK_DCC_7	506	516	PF00069	0.408
DOC_MAPK_gen_1	505	516	PF00069	0.408
DOC_MAPK_MEF2A_6	509	516	PF00069	0.382
DOC_MAPK_MEF2A_6	538	545	PF00069	0.427
DOC_MAPK_MEF2A_6	688	695	PF00069	0.495
DOC_PP2B_LxvP_1	543	546	PF13499	0.444
DOC_PP4_FxxP_1	203	206	PF00568	0.344
DOC_PP4_FxxP_1	297	300	PF00568	0.401
DOC_USP7_MATH_1	104	108	PF00917	0.587
DOC_USP7_MATH_1	133	137	PF00917	0.711
DOC_USP7_MATH_1	139	143	PF00917	0.563
DOC_USP7_MATH_1	284	288	PF00917	0.348
DOC_USP7_MATH_1	29	33	PF00917	0.699
DOC_USP7_MATH_1	322	326	PF00917	0.561
DOC_USP7_MATH_1	34	38	PF00917	0.639
DOC_USP7_MATH_1	378	382	PF00917	0.515
DOC_USP7_MATH_1	410	414	PF00917	0.677
DOC_USP7_MATH_1	530	534	PF00917	0.393
DOC_USP7_MATH_1	715	719	PF00917	0.540
DOC_USP7_MATH_1	88	92	PF00917	0.764
DOC_USP7_UBL2_3	505	509	PF12436	0.429
DOC_WW_Pin1_4	10	15	PF00397	0.736
DOC_WW_Pin1_4	108	113	PF00397	0.642
DOC_WW_Pin1_4	219	224	PF00397	0.478
DOC_WW_Pin1_4	392	397	PF00397	0.630
DOC_WW_Pin1_4	418	423	PF00397	0.711
DOC_WW_Pin1_4	584	589	PF00397	0.435
DOC_WW_Pin1_4	601	606	PF00397	0.280
DOC_WW_Pin1_4	651	656	PF00397	0.454
LIG_14-3-3_CanoR_1	194	199	PF00244	0.380
LIG_14-3-3_CanoR_1	499	503	PF00244	0.358
LIG_14-3-3_CanoR_1	577	582	PF00244	0.408
LIG_14-3-3_CanoR_1	688	692	PF00244	0.527
LIG_14-3-3_CanoR_1	722	729	PF00244	0.494
LIG_14-3-3_CanoR_1	95	99	PF00244	0.696
LIG_AP2alpha_1	319	323	PF02296	0.194
LIG_APCC_ABBA_1	67	72	PF00400	0.518
LIG_BIR_III_2	103	107	PF00653	0.472
LIG_BIR_III_4	28	32	PF00653	0.518
LIG_BRCT_BRCA1_1	36	40	PF00533	0.756
LIG_BRCT_BRCA1_1	50	54	PF00533	0.725
LIG_FHA_1	108	114	PF00498	0.496
LIG_FHA_1	190	196	PF00498	0.386
LIG_FHA_1	283	289	PF00498	0.454
LIG_FHA_1	393	399	PF00498	0.669
LIG_FHA_1	451	457	PF00498	0.514
LIG_FHA_1	585	591	PF00498	0.455
LIG_FHA_1	637	643	PF00498	0.392
LIG_FHA_1	715	721	PF00498	0.577
LIG_FHA_2	307	313	PF00498	0.344
LIG_FHA_2	652	658	PF00498	0.486
LIG_FHA_2	95	101	PF00498	0.612
LIG_LIR_Apic_2	201	206	PF02991	0.401
LIG_LIR_Gen_1	159	169	PF02991	0.432
LIG_LIR_Gen_1	441	447	PF02991	0.422
LIG_LIR_Gen_1	537	546	PF02991	0.449
LIG_LIR_Gen_1	645	655	PF02991	0.406
LIG_LIR_Gen_1	666	675	PF02991	0.635
LIG_LIR_Nem_3	159	165	PF02991	0.425
LIG_LIR_Nem_3	258	264	PF02991	0.414
LIG_LIR_Nem_3	328	333	PF02991	0.618
LIG_LIR_Nem_3	441	445	PF02991	0.418
LIG_LIR_Nem_3	453	457	PF02991	0.403
LIG_LIR_Nem_3	537	543	PF02991	0.449
LIG_LIR_Nem_3	645	651	PF02991	0.373
LIG_LIR_Nem_3	666	671	PF02991	0.618
LIG_MYND_1	300	304	PF01753	0.444
LIG_PCNA_yPIPBox_3	484	496	PF02747	0.448
LIG_Pex14_2	319	323	PF04695	0.444
LIG_SH2_CRK	162	166	PF00017	0.478
LIG_SH2_CRK	454	458	PF00017	0.371
LIG_SH2_CRK	508	512	PF00017	0.310
LIG_SH2_CRK	576	580	PF00017	0.444
LIG_SH2_CRK	628	632	PF00017	0.444
LIG_SH2_CRK	668	672	PF00017	0.587
LIG_SH2_GRB2like	313	316	PF00017	0.369
LIG_SH2_STAP1	150	154	PF00017	0.500
LIG_SH2_STAP1	313	317	PF00017	0.369
LIG_SH2_STAP1	677	681	PF00017	0.589
LIG_SH2_STAT5	150	153	PF00017	0.446
LIG_SH2_STAT5	164	167	PF00017	0.308
LIG_SH2_STAT5	296	299	PF00017	0.444
LIG_SH2_STAT5	459	462	PF00017	0.344
LIG_SH2_STAT5	467	470	PF00017	0.344
LIG_SH2_STAT5	628	631	PF00017	0.485
LIG_SH2_STAT5	659	662	PF00017	0.539
LIG_SH2_STAT5	668	671	PF00017	0.533
LIG_SH3_1	220	226	PF00018	0.291
LIG_SH3_2	109	114	PF14604	0.472
LIG_SH3_2	396	401	PF14604	0.589
LIG_SH3_2	566	571	PF14604	0.408
LIG_SH3_3	103	109	PF00018	0.691
LIG_SH3_3	11	17	PF00018	0.699
LIG_SH3_3	220	226	PF00018	0.465
LIG_SH3_3	352	358	PF00018	0.411
LIG_SH3_3	393	399	PF00018	0.654
LIG_SH3_3	511	517	PF00018	0.387
LIG_SH3_3	563	569	PF00018	0.444
LIG_SH3_3	63	69	PF00018	0.735
LIG_SH3_3	696	702	PF00018	0.422
LIG_SH3_CIN85_PxpxPR_1	603	608	PF14604	0.422
LIG_SUMO_SIM_par_1	608	614	PF11976	0.444
LIG_SUMO_SIM_par_1	97	103	PF11976	0.774
LIG_SxIP_EBH_1	585	599	PF03271	0.194
LIG_TYR_ITIM	457	462	PF00017	0.344
LIG_TYR_ITIM	574	579	PF00017	0.444
LIG_TYR_ITIM	626	631	PF00017	0.444
LIG_WW_3	79	83	PF00397	0.609
MOD_CDK_SPK_2	603	608	PF00069	0.369
MOD_CDK_SPxK_1	108	114	PF00069	0.579
MOD_CDK_SPxK_1	219	225	PF00069	0.369
MOD_CDK_SPxxK_3	601	608	PF00069	0.291
MOD_CK1_1	107	113	PF00069	0.443
MOD_CK1_1	173	179	PF00069	0.314
MOD_CK1_1	32	38	PF00069	0.692
MOD_CK1_1	325	331	PF00069	0.612
MOD_CK1_1	381	387	PF00069	0.644
MOD_CK1_1	533	539	PF00069	0.366
MOD_CK1_1	561	567	PF00069	0.420
MOD_CK1_1	636	642	PF00069	0.463
MOD_CK1_1	666	672	PF00069	0.530
MOD_CK1_1	683	689	PF00069	0.601
MOD_CK1_1	90	96	PF00069	0.687
MOD_CK2_1	153	159	PF00069	0.539
MOD_CK2_1	88	94	PF00069	0.709
MOD_GlcNHglycan	124	127	PF01048	0.757
MOD_GlcNHglycan	155	158	PF01048	0.379
MOD_GlcNHglycan	172	175	PF01048	0.263
MOD_GlcNHglycan	279	283	PF01048	0.423
MOD_GlcNHglycan	327	330	PF01048	0.583
MOD_GlcNHglycan	406	409	PF01048	0.685
MOD_GlcNHglycan	447	450	PF01048	0.498
MOD_GlcNHglycan	521	524	PF01048	0.429
MOD_GlcNHglycan	54	57	PF01048	0.730
MOD_GlcNHglycan	560	563	PF01048	0.466
MOD_GlcNHglycan	594	597	PF01048	0.485
MOD_GlcNHglycan	661	664	PF01048	0.611
MOD_GlcNHglycan	665	668	PF01048	0.560
MOD_GlcNHglycan	724	727	PF01048	0.517
MOD_GlcNHglycan	77	80	PF01048	0.596
MOD_GSK3_1	104	111	PF00069	0.616
MOD_GSK3_1	278	285	PF00069	0.452
MOD_GSK3_1	29	36	PF00069	0.818
MOD_GSK3_1	321	328	PF00069	0.508
MOD_GSK3_1	381	388	PF00069	0.429
MOD_GSK3_1	478	485	PF00069	0.407
MOD_GSK3_1	48	55	PF00069	0.697
MOD_GSK3_1	530	537	PF00069	0.368
MOD_GSK3_1	58	65	PF00069	0.779
MOD_GSK3_1	584	591	PF00069	0.389
MOD_GSK3_1	659	666	PF00069	0.538
MOD_GSK3_1	683	690	PF00069	0.564
MOD_GSK3_1	90	97	PF00069	0.778
MOD_LATS_1	575	581	PF00433	0.408
MOD_N-GLC_1	29	34	PF02516	0.821
MOD_N-GLC_1	48	53	PF02516	0.697
MOD_NEK2_1	265	270	PF00069	0.331
MOD_NEK2_1	283	288	PF00069	0.485
MOD_NEK2_1	323	328	PF00069	0.635
MOD_NEK2_1	472	477	PF00069	0.380
MOD_NEK2_1	552	557	PF00069	0.344
MOD_NEK2_1	626	631	PF00069	0.425
MOD_NEK2_1	635	640	PF00069	0.422
MOD_NEK2_2	284	289	PF00069	0.252
MOD_PIKK_1	265	271	PF00454	0.194
MOD_PIKK_1	381	387	PF00454	0.700
MOD_PIKK_1	666	672	PF00454	0.567
MOD_PK_1	724	730	PF00069	0.552
MOD_PKA_2	230	236	PF00069	0.344
MOD_PKA_2	498	504	PF00069	0.397
MOD_PKA_2	687	693	PF00069	0.522
MOD_PKA_2	94	100	PF00069	0.669
MOD_PKB_1	276	284	PF00069	0.194
MOD_PKB_1	722	730	PF00069	0.539
MOD_Plk_1	158	164	PF00069	0.491
MOD_Plk_1	278	284	PF00069	0.485
MOD_Plk_1	365	371	PF00069	0.482
MOD_Plk_1	683	689	PF00069	0.552
MOD_Plk_1	704	710	PF00069	0.588
MOD_Plk_2-3	94	100	PF00069	0.556
MOD_Plk_4	230	236	PF00069	0.344
MOD_Plk_4	241	247	PF00069	0.344
MOD_Plk_4	365	371	PF00069	0.482
MOD_Plk_4	62	68	PF00069	0.739
MOD_Plk_4	704	710	PF00069	0.498
MOD_Plk_4	715	721	PF00069	0.476
MOD_Plk_4	724	730	PF00069	0.266
MOD_Plk_4	94	100	PF00069	0.798
MOD_ProDKin_1	10	16	PF00069	0.735
MOD_ProDKin_1	108	114	PF00069	0.649
MOD_ProDKin_1	219	225	PF00069	0.478
MOD_ProDKin_1	392	398	PF00069	0.630
MOD_ProDKin_1	418	424	PF00069	0.706
MOD_ProDKin_1	584	590	PF00069	0.435
MOD_ProDKin_1	601	607	PF00069	0.280
MOD_ProDKin_1	651	657	PF00069	0.454
MOD_SUMO_for_1	675	678	PF00179	0.490
MOD_SUMO_rev_2	3	8	PF00179	0.532
TRG_DiLeu_BaEn_2	645	651	PF01217	0.369
TRG_DiLeu_BaEn_3	259	265	PF01217	0.194
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.412
TRG_ENDOCYTIC_2	162	165	PF00928	0.443
TRG_ENDOCYTIC_2	296	299	PF00928	0.401
TRG_ENDOCYTIC_2	454	457	PF00928	0.393
TRG_ENDOCYTIC_2	459	462	PF00928	0.353
TRG_ENDOCYTIC_2	493	496	PF00928	0.429
TRG_ENDOCYTIC_2	508	511	PF00928	0.401
TRG_ENDOCYTIC_2	576	579	PF00928	0.444
TRG_ENDOCYTIC_2	628	631	PF00928	0.444
TRG_ENDOCYTIC_2	668	671	PF00928	0.581
TRG_ER_diArg_1	253	255	PF00400	0.485
TRG_ER_diArg_1	721	724	PF00400	0.435
TRG_NLS_MonoExtN_4	569	574	PF00514	0.408
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRI7	Leptomonas seymouri	50%	97%
A0A3Q8IAN3	Leishmania donovani	86%	100%
A0A3R7MJ80	Trypanosoma rangeli	33%	100%
A4H8Q7	Leishmania braziliensis	69%	96%
A4HX26	Leishmania infantum	86%	100%
C9ZVX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QEN8	Leishmania major	85%	99%
V5DJ39	Trypanosoma cruzi	33%	100%