LeishMANIAdb
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Sm domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Sm domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AQT6_LEIMU
TriTrypDb:
LmxM.16.1250
Length:
149

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

E9AQT6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQT6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 127 131 PF00656 0.524
CLV_C14_Caspase3-7 46 50 PF00656 0.256
CLV_NRD_NRD_1 59 61 PF00675 0.556
CLV_NRD_NRD_1 92 94 PF00675 0.613
CLV_PCSK_FUR_1 57 61 PF00082 0.504
CLV_PCSK_KEX2_1 57 59 PF00082 0.498
DEG_SPOP_SBC_1 76 80 PF00917 0.737
DOC_CYCLIN_RxL_1 115 128 PF00134 0.486
DOC_MAPK_gen_1 93 101 PF00069 0.568
DOC_PP1_RVXF_1 118 125 PF00149 0.417
DOC_USP7_MATH_1 76 80 PF00917 0.707
DOC_USP7_MATH_1 84 88 PF00917 0.695
DOC_WW_Pin1_4 79 84 PF00397 0.691
DOC_WW_Pin1_4 99 104 PF00397 0.402
LIG_Clathr_ClatBox_1 21 25 PF01394 0.362
LIG_Clathr_ClatBox_1 36 40 PF01394 0.392
LIG_FHA_1 28 34 PF00498 0.370
LIG_FHA_1 68 74 PF00498 0.610
LIG_FHA_1 96 102 PF00498 0.503
LIG_FHA_2 44 50 PF00498 0.361
LIG_LIR_Nem_3 133 138 PF02991 0.542
LIG_SH2_STAT5 121 124 PF00017 0.473
LIG_SUMO_SIM_par_1 96 102 PF11976 0.359
LIG_TYR_ITSM 131 138 PF00017 0.553
MOD_CK1_1 4 10 PF00069 0.560
MOD_CK1_1 78 84 PF00069 0.665
MOD_CK2_1 131 137 PF00069 0.562
MOD_GSK3_1 72 79 PF00069 0.706
MOD_GSK3_1 95 102 PF00069 0.432
MOD_N-GLC_1 27 32 PF02516 0.466
MOD_NEK2_1 1 6 PF00069 0.642
MOD_Plk_1 95 101 PF00069 0.527
MOD_Plk_4 108 114 PF00069 0.384
MOD_Plk_4 27 33 PF00069 0.407
MOD_ProDKin_1 79 85 PF00069 0.693
MOD_ProDKin_1 99 105 PF00069 0.406
TRG_DiLeu_BaLyEn_6 32 37 PF01217 0.461
TRG_ENDOCYTIC_2 121 124 PF00928 0.416
TRG_ENDOCYTIC_2 135 138 PF00928 0.415
TRG_ER_diArg_1 56 59 PF00400 0.499
TRG_ER_diArg_1 60 63 PF00400 0.599
TRG_Pf-PMV_PEXEL_1 35 40 PF00026 0.428

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4W6 Leptomonas seymouri 65% 100%
A0A1X0NYY2 Trypanosomatidae 44% 96%
A0A3R7LUA9 Trypanosoma rangeli 45% 100%
A0A3S7WU38 Leishmania donovani 89% 100%
A4H8Q3 Leishmania braziliensis 79% 99%
A4HX22 Leishmania infantum 89% 100%
C9ZVX7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
Q4QEP2 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS