Putative cyclophilin (Putative ppiase) (Putative rotamase) (Putative peptidyl-prolyl cis-trans isomerase)

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rotamase, putative

Species:

Leishmania mexicana

UniProt:

E9AQT1_LEIMU

TriTrypDb:

LmxM.16.1200

Length:

361

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005930	axoneme	2	1

Expansion

Sequence features

E9AQT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQT1

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0018193	peptidyl-amino acid modification	5	16
GO:0018208	peptidyl-proline modification	6	16
GO:0019538	protein metabolic process	3	16
GO:0036211	protein modification process	4	16
GO:0043170	macromolecule metabolic process	3	16
GO:0043412	macromolecule modification	4	16
GO:0044238	primary metabolic process	2	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16
GO:0006457	protein folding	2	6
GO:0009987	cellular process	1	6

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	16
GO:0003824	catalytic activity	1	16
GO:0016853	isomerase activity	2	16
GO:0016859	cis-trans isomerase activity	3	16
GO:0140096	catalytic activity, acting on a protein	2	16
GO:0005488	binding	1	2
GO:0016018	cyclosporin A binding	4	2
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.269
CLV_NRD_NRD_1	7	9	PF00675	0.760
CLV_NRD_NRD_1	97	99	PF00675	0.310
CLV_PCSK_KEX2_1	167	169	PF00082	0.270
CLV_PCSK_KEX2_1	7	9	PF00082	0.760
CLV_PCSK_KEX2_1	97	99	PF00082	0.348
CLV_PCSK_SKI1_1	281	285	PF00082	0.595
CLV_PCSK_SKI1_1	355	359	PF00082	0.677
DEG_Nend_UBRbox_3	1	3	PF02207	0.596
DOC_CDC14_PxL_1	46	54	PF14671	0.452
DOC_MAPK_gen_1	165	174	PF00069	0.269
DOC_MAPK_gen_1	30	40	PF00069	0.451
DOC_MAPK_MEF2A_6	33	42	PF00069	0.333
DOC_PP1_RVXF_1	31	38	PF00149	0.224
DOC_PP2B_LxvP_1	221	224	PF13499	0.401
DOC_USP7_MATH_1	257	261	PF00917	0.593
DOC_USP7_MATH_1	334	338	PF00917	0.768
DOC_USP7_UBL2_3	336	340	PF12436	0.700
DOC_USP7_UBL2_3	351	355	PF12436	0.686
DOC_WW_Pin1_4	11	16	PF00397	0.573
DOC_WW_Pin1_4	115	120	PF00397	0.302
DOC_WW_Pin1_4	252	257	PF00397	0.612
DOC_WW_Pin1_4	272	277	PF00397	0.740
DOC_WW_Pin1_4	313	318	PF00397	0.602
DOC_WW_Pin1_4	323	328	PF00397	0.606
DOC_WW_Pin1_4	69	74	PF00397	0.553
LIG_14-3-3_CanoR_1	281	286	PF00244	0.775
LIG_14-3-3_CanoR_1	30	36	PF00244	0.403
LIG_APCC_ABBA_1	82	87	PF00400	0.324
LIG_BRCT_BRCA1_1	186	190	PF00533	0.324
LIG_FHA_1	139	145	PF00498	0.269
LIG_FHA_1	156	162	PF00498	0.200
LIG_FHA_1	20	26	PF00498	0.424
LIG_FHA_1	307	313	PF00498	0.473
LIG_FHA_1	4	10	PF00498	0.546
LIG_FHA_2	282	288	PF00498	0.557
LIG_FHA_2	70	76	PF00498	0.534
LIG_Integrin_isoDGR_2	202	204	PF01839	0.288
LIG_LIR_Gen_1	124	133	PF02991	0.311
LIG_LIR_Gen_1	216	225	PF02991	0.367
LIG_LIR_Gen_1	233	239	PF02991	0.172
LIG_LIR_Gen_1	34	43	PF02991	0.290
LIG_LIR_Gen_1	76	85	PF02991	0.308
LIG_LIR_Nem_3	124	129	PF02991	0.311
LIG_LIR_Nem_3	216	221	PF02991	0.346
LIG_LIR_Nem_3	233	238	PF02991	0.172
LIG_LIR_Nem_3	34	40	PF02991	0.290
LIG_LIR_Nem_3	44	49	PF02991	0.369
LIG_LIR_Nem_3	76	82	PF02991	0.387
LIG_MLH1_MIPbox_1	186	190	PF16413	0.324
LIG_PDZ_Class_2	356	361	PF00595	0.579
LIG_SH2_CRK	114	118	PF00017	0.260
LIG_SH2_CRK	235	239	PF00017	0.313
LIG_SH2_NCK_1	152	156	PF00017	0.401
LIG_SH2_STAP1	235	239	PF00017	0.313
LIG_SH2_STAT3	112	115	PF00017	0.269
LIG_SH2_STAT3	133	136	PF00017	0.401
LIG_SH2_STAT5	112	115	PF00017	0.278
LIG_SH2_STAT5	121	124	PF00017	0.274
LIG_SH2_STAT5	125	128	PF00017	0.239
LIG_SH2_STAT5	133	136	PF00017	0.169
LIG_SH2_STAT5	24	27	PF00017	0.592
LIG_SH3_2	331	336	PF14604	0.550
LIG_SH3_3	250	256	PF00018	0.435
LIG_SH3_3	328	334	PF00018	0.667
LIG_SH3_3	44	50	PF00018	0.378
LIG_TRAF2_1	284	287	PF00917	0.715
LIG_TRAF2_1	72	75	PF00917	0.578
MOD_CK1_1	151	157	PF00069	0.401
MOD_CK1_1	17	23	PF00069	0.504
MOD_CK1_1	184	190	PF00069	0.269
MOD_CK1_1	26	32	PF00069	0.536
MOD_CK1_1	260	266	PF00069	0.654
MOD_CK2_1	264	270	PF00069	0.599
MOD_CK2_1	281	287	PF00069	0.676
MOD_CK2_1	69	75	PF00069	0.542
MOD_GlcNHglycan	153	156	PF01048	0.392
MOD_GlcNHglycan	16	19	PF01048	0.506
MOD_GlcNHglycan	193	196	PF01048	0.316
MOD_GlcNHglycan	250	253	PF01048	0.614
MOD_GlcNHglycan	281	284	PF01048	0.708
MOD_GSK3_1	117	124	PF00069	0.348
MOD_GSK3_1	146	153	PF00069	0.394
MOD_GSK3_1	19	26	PF00069	0.490
MOD_GSK3_1	248	255	PF00069	0.549
MOD_GSK3_1	260	267	PF00069	0.534
MOD_GSK3_1	268	275	PF00069	0.666
MOD_GSK3_1	277	284	PF00069	0.752
MOD_GSK3_1	323	330	PF00069	0.478
MOD_GSK3_1	48	55	PF00069	0.449
MOD_GSK3_1	69	76	PF00069	0.458
MOD_LATS_1	353	359	PF00433	0.537
MOD_N-GLC_1	184	189	PF02516	0.324
MOD_NEK2_1	189	194	PF00069	0.322
MOD_NEK2_1	19	24	PF00069	0.648
MOD_NEK2_1	335	340	PF00069	0.690
MOD_NEK2_1	52	57	PF00069	0.480
MOD_NEK2_1	63	68	PF00069	0.478
MOD_NEK2_1	9	14	PF00069	0.553
MOD_NEK2_2	138	143	PF00069	0.303
MOD_PIKK_1	184	190	PF00454	0.324
MOD_PIKK_1	257	263	PF00454	0.539
MOD_PIKK_1	41	47	PF00454	0.525
MOD_PIKK_1	52	58	PF00454	0.540
MOD_Plk_1	138	144	PF00069	0.269
MOD_Plk_1	73	79	PF00069	0.548
MOD_Plk_4	121	127	PF00069	0.320
MOD_Plk_4	245	251	PF00069	0.555
MOD_Plk_4	74	80	PF00069	0.485
MOD_ProDKin_1	11	17	PF00069	0.571
MOD_ProDKin_1	115	121	PF00069	0.302
MOD_ProDKin_1	252	258	PF00069	0.612
MOD_ProDKin_1	272	278	PF00069	0.741
MOD_ProDKin_1	313	319	PF00069	0.602
MOD_ProDKin_1	323	329	PF00069	0.609
MOD_ProDKin_1	69	75	PF00069	0.559
MOD_SUMO_rev_2	162	166	PF00179	0.159
TRG_DiLeu_BaEn_3	74	80	PF01217	0.502
TRG_ENDOCYTIC_2	114	117	PF00928	0.260
TRG_ENDOCYTIC_2	235	238	PF00928	0.372
TRG_ER_diArg_1	166	168	PF00400	0.162
TRG_ER_diArg_1	7	9	PF00400	0.551
TRG_ER_diArg_1	96	98	PF00400	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJB8	Leptomonas seymouri	80%	99%
A0A1X0P0F8	Trypanosomatidae	60%	100%
A0A3Q8IDR1	Leishmania donovani	94%	100%
A0A3R7MER6	Trypanosoma rangeli	62%	100%
A0A3S7WXF4	Leishmania donovani	34%	100%
A4H8P7	Leishmania braziliensis	78%	95%
A4HCL8	Leishmania braziliensis	35%	100%
A4HX17	Leishmania infantum	92%	99%
A4I042	Leishmania infantum	33%	100%
C9ZVY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AW05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
G5EEW6	Caenorhabditis elegans	28%	85%
Q13356	Homo sapiens	32%	69%
Q4QBH1	Leishmania major	37%	100%
Q4QEP7	Leishmania major	90%	100%
V5DJ29	Trypanosoma cruzi	60%	100%