RSN1_7TM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF221, putative

Species:

Leishmania mexicana

UniProt:

E9AQT0_LEIMU

TriTrypDb:

LmxM.16.1190

Length:

1434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

E9AQT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0005216	monoatomic ion channel activity	4	11
GO:0005227	calcium activated cation channel activity	6	11
GO:0005261	monoatomic cation channel activity	5	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0015267	channel activity	4	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	11
GO:0022803	passive transmembrane transporter activity	3	11
GO:0022836	gated channel activity	5	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1247	1251	PF00656	0.669
CLV_C14_Caspase3-7	436	440	PF00656	0.468
CLV_NRD_NRD_1	1028	1030	PF00675	0.255
CLV_NRD_NRD_1	114	116	PF00675	0.388
CLV_NRD_NRD_1	1172	1174	PF00675	0.463
CLV_NRD_NRD_1	1365	1367	PF00675	0.445
CLV_NRD_NRD_1	147	149	PF00675	0.449
CLV_NRD_NRD_1	186	188	PF00675	0.541
CLV_NRD_NRD_1	318	320	PF00675	0.604
CLV_NRD_NRD_1	457	459	PF00675	0.429

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV91	Leptomonas seymouri	57%	100%
A0A1X0NZ70	Trypanosomatidae	35%	100%
A0A3S5H6Y5	Leishmania donovani	89%	100%
A0A422N6V5	Trypanosoma rangeli	38%	100%
A4H8P6	Leishmania braziliensis	77%	100%
A4HX16	Leishmania infantum	89%	100%
C9ZVY6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4QEP8	Leishmania major	87%	100%
V5B2J6	Trypanosoma cruzi	34%	100%

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