Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AQS7_LEIMU

TriTrypDb:

LmxM.16.1160

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQS7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.518
CLV_NRD_NRD_1	298	300	PF00675	0.703
CLV_NRD_NRD_1	372	374	PF00675	0.716
CLV_NRD_NRD_1	483	485	PF00675	0.683
CLV_PCSK_KEX2_1	298	300	PF00082	0.703
CLV_PCSK_KEX2_1	321	323	PF00082	0.648
CLV_PCSK_KEX2_1	372	374	PF00082	0.716
CLV_PCSK_KEX2_1	418	420	PF00082	0.497
CLV_PCSK_KEX2_1	436	438	PF00082	0.665
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.644
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.497
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.746
CLV_PCSK_SKI1_1	236	240	PF00082	0.711
CLV_PCSK_SKI1_1	401	405	PF00082	0.503
CLV_PCSK_SKI1_1	433	437	PF00082	0.721
CLV_Separin_Metazoa	21	25	PF03568	0.605
DEG_APCC_DBOX_1	235	243	PF00400	0.646
DEG_APCC_DBOX_1	400	408	PF00400	0.496
DOC_CKS1_1	201	206	PF01111	0.718
DOC_CKS1_1	213	218	PF01111	0.580
DOC_CYCLIN_RxL_1	233	243	PF00134	0.715
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.583
DOC_MAPK_DCC_7	205	213	PF00069	0.532
DOC_MAPK_gen_1	24	32	PF00069	0.545
DOC_MAPK_gen_1	418	426	PF00069	0.437
DOC_MAPK_MEF2A_6	205	213	PF00069	0.573
DOC_MAPK_MEF2A_6	397	404	PF00069	0.613
DOC_MAPK_NFAT4_5	397	405	PF00069	0.617
DOC_MAPK_RevD_3	405	419	PF00069	0.452
DOC_MAPK_RevD_3	470	485	PF00069	0.516
DOC_PP2B_LxvP_1	211	214	PF13499	0.745
DOC_PP4_FxxP_1	93	96	PF00568	0.733
DOC_USP7_MATH_1	320	324	PF00917	0.522
DOC_USP7_MATH_1	379	383	PF00917	0.611
DOC_USP7_MATH_1	390	394	PF00917	0.520
DOC_USP7_MATH_1	453	457	PF00917	0.640
DOC_USP7_MATH_1	5	9	PF00917	0.533
DOC_USP7_MATH_1	94	98	PF00917	0.606
DOC_WW_Pin1_4	200	205	PF00397	0.726
DOC_WW_Pin1_4	212	217	PF00397	0.576
DOC_WW_Pin1_4	3	8	PF00397	0.699
DOC_WW_Pin1_4	303	308	PF00397	0.686
DOC_WW_Pin1_4	362	367	PF00397	0.572
DOC_WW_Pin1_4	74	79	PF00397	0.773
LIG_14-3-3_CanoR_1	298	304	PF00244	0.592
LIG_14-3-3_CanoR_1	322	331	PF00244	0.562
LIG_14-3-3_CanoR_1	332	339	PF00244	0.570
LIG_14-3-3_CanoR_1	352	357	PF00244	0.402
LIG_14-3-3_CanoR_1	372	378	PF00244	0.493
LIG_APCC_ABBA_1	23	28	PF00400	0.626
LIG_BIR_II_1	1	5	PF00653	0.673
LIG_eIF4E_1	111	117	PF01652	0.535
LIG_FHA_1	232	238	PF00498	0.703
LIG_FHA_1	304	310	PF00498	0.719
LIG_FHA_2	411	417	PF00498	0.626
LIG_FHA_2	82	88	PF00498	0.521
LIG_IRF3_LxIS_1	188	195	PF10401	0.481
LIG_LIR_Apic_2	90	96	PF02991	0.743
LIG_LIR_Gen_1	245	255	PF02991	0.494
LIG_LIR_Gen_1	340	351	PF02991	0.595
LIG_LIR_Nem_3	153	159	PF02991	0.539
LIG_LIR_Nem_3	245	250	PF02991	0.519
LIG_LIR_Nem_3	340	346	PF02991	0.532
LIG_NRBOX	112	118	PF00104	0.535
LIG_PCNA_yPIPBox_3	19	27	PF02747	0.609
LIG_PTAP_UEV_1	6	11	PF05743	0.569
LIG_SH2_STAT5	202	205	PF00017	0.535
LIG_SH2_STAT5	356	359	PF00017	0.640
LIG_SH3_3	1	7	PF00018	0.724
LIG_SH3_3	185	191	PF00018	0.725
LIG_SH3_3	198	204	PF00018	0.595
LIG_SH3_3	375	381	PF00018	0.716
LIG_SUMO_SIM_anti_2	248	253	PF11976	0.499
LIG_SUMO_SIM_par_1	190	196	PF11976	0.482
LIG_SUMO_SIM_par_1	422	432	PF11976	0.451
LIG_TYR_ITIM	220	225	PF00017	0.703
LIG_UBA3_1	250	259	PF00899	0.630
LIG_WW_2	378	381	PF00397	0.480
MOD_CDK_SPK_2	200	205	PF00069	0.524
MOD_CDK_SPK_2	362	367	PF00069	0.644
MOD_CK1_1	3	9	PF00069	0.556
MOD_CK1_1	334	340	PF00069	0.661
MOD_CK1_1	382	388	PF00069	0.540
MOD_CK1_1	389	395	PF00069	0.620
MOD_CK1_1	77	83	PF00069	0.760
MOD_CK1_1	97	103	PF00069	0.611
MOD_CK2_1	109	115	PF00069	0.520
MOD_CK2_1	139	145	PF00069	0.784
MOD_CK2_1	152	158	PF00069	0.587
MOD_CK2_1	410	416	PF00069	0.662
MOD_GlcNHglycan	105	108	PF01048	0.510
MOD_GlcNHglycan	141	144	PF01048	0.687
MOD_GlcNHglycan	280	283	PF01048	0.734
MOD_GlcNHglycan	290	293	PF01048	0.766
MOD_GlcNHglycan	388	391	PF01048	0.651
MOD_GlcNHglycan	7	10	PF01048	0.574
MOD_GlcNHglycan	96	99	PF01048	0.555
MOD_GSK3_1	120	127	PF00069	0.676
MOD_GSK3_1	130	137	PF00069	0.646
MOD_GSK3_1	139	146	PF00069	0.553
MOD_GSK3_1	178	185	PF00069	0.739
MOD_GSK3_1	299	306	PF00069	0.627
MOD_GSK3_1	327	334	PF00069	0.659
MOD_GSK3_1	382	389	PF00069	0.569
MOD_GSK3_1	77	84	PF00069	0.698
MOD_N-GLC_2	170	172	PF02516	0.609
MOD_NEK2_1	346	351	PF00069	0.474
MOD_NEK2_1	464	469	PF00069	0.681
MOD_NEK2_1	72	77	PF00069	0.515
MOD_PIKK_1	145	151	PF00454	0.605
MOD_PIKK_1	322	328	PF00454	0.627
MOD_PK_1	299	305	PF00069	0.517
MOD_PK_1	439	445	PF00069	0.490
MOD_PKA_1	372	378	PF00069	0.699
MOD_PKA_2	255	261	PF00069	0.605
MOD_PKA_2	287	293	PF00069	0.768
MOD_PKA_2	331	337	PF00069	0.718
MOD_PKA_2	372	378	PF00069	0.699
MOD_PKA_2	410	416	PF00069	0.621
MOD_PKB_1	437	445	PF00069	0.670
MOD_Plk_1	152	158	PF00069	0.508
MOD_Plk_2-3	134	140	PF00069	0.783
MOD_Plk_4	334	340	PF00069	0.701
MOD_Plk_4	346	352	PF00069	0.447
MOD_Plk_4	379	385	PF00069	0.640
MOD_Plk_4	410	416	PF00069	0.662
MOD_Plk_4	97	103	PF00069	0.691
MOD_ProDKin_1	200	206	PF00069	0.728
MOD_ProDKin_1	212	218	PF00069	0.572
MOD_ProDKin_1	3	9	PF00069	0.696
MOD_ProDKin_1	303	309	PF00069	0.687
MOD_ProDKin_1	362	368	PF00069	0.579
MOD_ProDKin_1	74	80	PF00069	0.772
TRG_DiLeu_BaEn_1	38	43	PF01217	0.527
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.544
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.643
TRG_ENDOCYTIC_2	222	225	PF00928	0.703
TRG_ER_diArg_1	298	300	PF00400	0.695
TRG_NLS_Bipartite_1	418	440	PF00514	0.528
TRG_NLS_MonoCore_2	435	440	PF00514	0.744
TRG_NLS_MonoExtC_3	435	441	PF00514	0.743
TRG_NLS_MonoExtN_4	433	440	PF00514	0.739

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Q0	Leptomonas seymouri	32%	100%
A0A3Q8IAM2	Leishmania donovani	88%	100%
A4H8P3	Leishmania braziliensis	74%	100%
A4HX13	Leishmania infantum	88%	100%
Q4QEQ1	Leishmania major	86%	100%