WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WW domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQS4_LEIMU

TriTrypDb:

LmxM.16.1140

Length:

649

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005685	U1 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071004	U2-type prespliceosome	5	1
GO:0071010	prespliceosome	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AQS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQS4

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	78	80	PF00675	0.561
CLV_PCSK_KEX2_1	78	80	PF00082	0.561
CLV_PCSK_SKI1_1	28	32	PF00082	0.629
CLV_PCSK_SKI1_1	53	57	PF00082	0.532
DEG_SPOP_SBC_1	350	354	PF00917	0.763
DEG_SPOP_SBC_1	372	376	PF00917	0.816
DOC_CKS1_1	138	143	PF01111	0.681
DOC_CKS1_1	94	99	PF01111	0.623
DOC_CYCLIN_RxL_1	102	110	PF00134	0.665
DOC_CYCLIN_RxL_1	432	444	PF00134	0.658
DOC_CYCLIN_RxL_1	75	84	PF00134	0.567
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.698
DOC_CYCLIN_yCln2_LP_2	617	623	PF00134	0.485
DOC_PP1_RVXF_1	51	58	PF00149	0.515
DOC_PP1_RVXF_1	76	83	PF00149	0.543
DOC_PP2B_LxvP_1	272	275	PF13499	0.809
DOC_PP2B_LxvP_1	303	306	PF13499	0.754
DOC_PP2B_LxvP_1	617	620	PF13499	0.485
DOC_PP4_FxxP_1	273	276	PF00568	0.799
DOC_PP4_MxPP_1	369	372	PF00568	0.720
DOC_USP7_MATH_1	121	125	PF00917	0.567
DOC_USP7_MATH_1	252	256	PF00917	0.767
DOC_USP7_MATH_1	283	287	PF00917	0.749
DOC_USP7_MATH_1	292	296	PF00917	0.673
DOC_USP7_MATH_1	337	341	PF00917	0.702
DOC_USP7_MATH_1	387	391	PF00917	0.618
DOC_USP7_MATH_1	394	398	PF00917	0.465
DOC_USP7_MATH_1	49	53	PF00917	0.601
DOC_USP7_MATH_1	492	496	PF00917	0.692
DOC_WW_Pin1_4	137	142	PF00397	0.679
DOC_WW_Pin1_4	333	338	PF00397	0.581
DOC_WW_Pin1_4	352	357	PF00397	0.686
DOC_WW_Pin1_4	361	366	PF00397	0.668
DOC_WW_Pin1_4	599	604	PF00397	0.683
DOC_WW_Pin1_4	605	610	PF00397	0.779
DOC_WW_Pin1_4	93	98	PF00397	0.558
LIG_14-3-3_CanoR_1	15	22	PF00244	0.693
LIG_14-3-3_CanoR_1	28	37	PF00244	0.442
LIG_14-3-3_CanoR_1	307	313	PF00244	0.706
LIG_14-3-3_CanoR_1	317	321	PF00244	0.747
LIG_14-3-3_CanoR_1	425	431	PF00244	0.628
LIG_14-3-3_CanoR_1	528	534	PF00244	0.408
LIG_14-3-3_CanoR_1	585	594	PF00244	0.501
LIG_14-3-3_CanoR_1	81	90	PF00244	0.625
LIG_FHA_1	102	108	PF00498	0.333
LIG_FHA_1	183	189	PF00498	0.754
LIG_FHA_1	342	348	PF00498	0.783
LIG_FHA_1	373	379	PF00498	0.817
LIG_FHA_1	397	403	PF00498	0.638
LIG_FHA_1	46	52	PF00498	0.630
LIG_FHA_1	475	481	PF00498	0.420
LIG_FHA_1	530	536	PF00498	0.498
LIG_FHA_1	577	583	PF00498	0.434
LIG_FHA_1	630	636	PF00498	0.498
LIG_FHA_1	82	88	PF00498	0.553
LIG_FHA_2	145	151	PF00498	0.633
LIG_FHA_2	15	21	PF00498	0.609
LIG_FHA_2	161	167	PF00498	0.651
LIG_FHA_2	241	247	PF00498	0.551
LIG_FHA_2	266	272	PF00498	0.697
LIG_FHA_2	29	35	PF00498	0.560
LIG_FHA_2	485	491	PF00498	0.485
LIG_FHA_2	540	546	PF00498	0.485
LIG_FHA_2	640	646	PF00498	0.424
LIG_FHA_2	94	100	PF00498	0.653
LIG_LIR_Apic_2	271	276	PF02991	0.801
LIG_LIR_Apic_2	428	433	PF02991	0.549
LIG_LIR_Apic_2	486	492	PF02991	0.372
LIG_LIR_Apic_2	541	547	PF02991	0.401
LIG_LIR_Apic_2	589	594	PF02991	0.444
LIG_LIR_Apic_2	641	647	PF02991	0.370
LIG_LIR_Gen_1	403	411	PF02991	0.564
LIG_LIR_Nem_3	159	165	PF02991	0.660
LIG_LIR_Nem_3	403	407	PF02991	0.577
LIG_Pex14_1	404	408	PF04695	0.458
LIG_SH2_GRB2like	534	537	PF00017	0.401
LIG_SH2_GRB2like	581	584	PF00017	0.444
LIG_SH2_GRB2like	634	637	PF00017	0.369
LIG_SH2_SRC	479	482	PF00017	0.444
LIG_SH2_SRC	534	537	PF00017	0.401
LIG_SH2_SRC	634	637	PF00017	0.369
LIG_SH2_STAT5	144	147	PF00017	0.548
LIG_SH2_STAT5	419	422	PF00017	0.514
LIG_SH2_STAT5	479	482	PF00017	0.369
LIG_SH2_STAT5	534	537	PF00017	0.401
LIG_SH2_STAT5	581	584	PF00017	0.429
LIG_SH2_STAT5	634	637	PF00017	0.401
LIG_SH2_STAT5	9	12	PF00017	0.562
LIG_SH3_2	433	438	PF14604	0.675
LIG_SH3_3	246	252	PF00018	0.733
LIG_SH3_3	258	264	PF00018	0.704
LIG_SH3_3	273	279	PF00018	0.766
LIG_SH3_3	303	309	PF00018	0.749
LIG_SH3_3	317	323	PF00018	0.529
LIG_SH3_3	430	436	PF00018	0.673
LIG_SH3_3	493	499	PF00018	0.757
LIG_SH3_3	595	601	PF00018	0.817
LIG_SH3_3	612	618	PF00018	0.579
LIG_SH3_3	91	97	PF00018	0.646
LIG_SH3_4	595	602	PF00018	0.640
LIG_TRAF2_1	17	20	PF00917	0.583
MOD_CK1_1	224	230	PF00069	0.498
MOD_CK1_1	245	251	PF00069	0.552
MOD_CK1_1	286	292	PF00069	0.703
MOD_CK1_1	328	334	PF00069	0.515
MOD_CK1_1	364	370	PF00069	0.783
MOD_CK1_1	374	380	PF00069	0.816
MOD_CK1_1	484	490	PF00069	0.491
MOD_CK1_1	507	513	PF00069	0.755
MOD_CK2_1	14	20	PF00069	0.559
MOD_CK2_1	144	150	PF00069	0.585
MOD_CK2_1	160	166	PF00069	0.590
MOD_CK2_1	240	246	PF00069	0.656
MOD_CK2_1	265	271	PF00069	0.705
MOD_CK2_1	28	34	PF00069	0.525
MOD_CK2_1	337	343	PF00069	0.753
MOD_CK2_1	387	393	PF00069	0.691
MOD_CK2_1	484	490	PF00069	0.485
MOD_CK2_1	539	545	PF00069	0.485
MOD_CK2_1	639	645	PF00069	0.424
MOD_DYRK1A_RPxSP_1	93	97	PF00069	0.596
MOD_GlcNHglycan	11	14	PF01048	0.583
MOD_GlcNHglycan	119	122	PF01048	0.738
MOD_GlcNHglycan	178	181	PF01048	0.628
MOD_GlcNHglycan	223	226	PF01048	0.680
MOD_GlcNHglycan	294	297	PF01048	0.721
MOD_GlcNHglycan	327	330	PF01048	0.553
MOD_GlcNHglycan	366	369	PF01048	0.811
MOD_GlcNHglycan	459	462	PF01048	0.683
MOD_GlcNHglycan	500	503	PF01048	0.695
MOD_GlcNHglycan	509	512	PF01048	0.806
MOD_GlcNHglycan	556	559	PF01048	0.828
MOD_GlcNHglycan	58	61	PF01048	0.673
MOD_GSK3_1	107	114	PF00069	0.679
MOD_GSK3_1	117	124	PF00069	0.684
MOD_GSK3_1	195	202	PF00069	0.645
MOD_GSK3_1	238	245	PF00069	0.593
MOD_GSK3_1	279	286	PF00069	0.685
MOD_GSK3_1	287	294	PF00069	0.642
MOD_GSK3_1	333	340	PF00069	0.680
MOD_GSK3_1	346	353	PF00069	0.591
MOD_GSK3_1	372	379	PF00069	0.763
MOD_GSK3_1	419	426	PF00069	0.532
MOD_GSK3_1	45	52	PF00069	0.605
MOD_GSK3_1	467	474	PF00069	0.466
MOD_GSK3_1	481	488	PF00069	0.280
MOD_GSK3_1	536	543	PF00069	0.390
MOD_GSK3_1	583	590	PF00069	0.444
MOD_GSK3_1	636	643	PF00069	0.374
MOD_N-GLC_1	122	127	PF02516	0.625
MOD_N-GLC_1	219	224	PF02516	0.704
MOD_N-GLC_1	290	295	PF02516	0.720
MOD_NEK2_1	107	112	PF00069	0.639
MOD_NEK2_1	221	226	PF00069	0.651
MOD_NEK2_1	325	330	PF00069	0.737
MOD_NEK2_1	341	346	PF00069	0.728
MOD_NEK2_1	373	378	PF00069	0.592
MOD_NEK2_1	395	400	PF00069	0.565
MOD_NEK2_1	56	61	PF00069	0.569
MOD_NEK2_1	72	77	PF00069	0.531
MOD_PKA_2	14	20	PF00069	0.663
MOD_PKA_2	316	322	PF00069	0.501
MOD_PKA_2	553	559	PF00069	0.809
MOD_PKA_2	586	592	PF00069	0.485
MOD_PKB_1	585	593	PF00069	0.194
MOD_PKB_1	79	87	PF00069	0.555
MOD_Plk_1	122	128	PF00069	0.628
MOD_Plk_1	219	225	PF00069	0.699
MOD_Plk_1	245	251	PF00069	0.505
MOD_Plk_4	107	113	PF00069	0.603
MOD_Plk_4	195	201	PF00069	0.744
MOD_Plk_4	245	251	PF00069	0.785
MOD_Plk_4	337	343	PF00069	0.743
MOD_ProDKin_1	137	143	PF00069	0.678
MOD_ProDKin_1	333	339	PF00069	0.580
MOD_ProDKin_1	352	358	PF00069	0.688
MOD_ProDKin_1	361	367	PF00069	0.669
MOD_ProDKin_1	599	605	PF00069	0.686
MOD_ProDKin_1	93	99	PF00069	0.550
MOD_SUMO_rev_2	222	232	PF00179	0.604
MOD_SUMO_rev_2	467	474	PF00179	0.280
TRG_ER_diArg_1	77	79	PF00400	0.548
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ37	Leptomonas seymouri	49%	100%
A0A3Q8IJ47	Leishmania donovani	87%	100%
A0A3R7LE31	Trypanosoma rangeli	36%	99%
A4H8P0	Leishmania braziliensis	72%	92%
A4HX11	Leishmania infantum	88%	100%
C9ZVZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4QEQ3	Leishmania major	86%	97%
V5BML0	Trypanosoma cruzi	36%	100%