Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQS2_LEIMU

TriTrypDb:

LmxM.16.1120

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQS2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.563
CLV_NRD_NRD_1	156	158	PF00675	0.407
CLV_NRD_NRD_1	160	162	PF00675	0.412
CLV_NRD_NRD_1	93	95	PF00675	0.518
CLV_PCSK_FUR_1	157	161	PF00082	0.427
CLV_PCSK_KEX2_1	156	158	PF00082	0.407
CLV_PCSK_KEX2_1	159	161	PF00082	0.430
CLV_PCSK_KEX2_1	210	212	PF00082	0.437
CLV_PCSK_KEX2_1	93	95	PF00082	0.595
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.450
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.437
CLV_PCSK_PC7_1	156	162	PF00082	0.427
CLV_PCSK_SKI1_1	156	160	PF00082	0.553
CLV_PCSK_SKI1_1	197	201	PF00082	0.403
CLV_PCSK_SKI1_1	34	38	PF00082	0.508
DOC_ANK_TNKS_1	71	78	PF00023	0.527
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.513
DOC_MAPK_DCC_7	78	86	PF00069	0.519
DOC_MAPK_gen_1	18	26	PF00069	0.504
DOC_MAPK_MEF2A_6	20	28	PF00069	0.514
DOC_MAPK_MEF2A_6	78	86	PF00069	0.519
DOC_PP2B_LxvP_1	199	202	PF13499	0.392
DOC_PP2B_LxvP_1	223	226	PF13499	0.523
DOC_PP2B_LxvP_1	37	40	PF13499	0.572
DOC_PP2B_LxvP_1	43	46	PF13499	0.555
DOC_PP2B_LxvP_1	82	85	PF13499	0.525
DOC_USP7_MATH_1	164	168	PF00917	0.499
DOC_USP7_MATH_1	178	182	PF00917	0.492
DOC_USP7_MATH_2	226	232	PF00917	0.490
DOC_WW_Pin1_4	2	7	PF00397	0.492
DOC_WW_Pin1_4	35	40	PF00397	0.504
DOC_WW_Pin1_4	63	68	PF00397	0.499
LIG_14-3-3_CanoR_1	18	28	PF00244	0.584
LIG_14-3-3_CanoR_1	62	67	PF00244	0.488
LIG_BIR_III_4	185	189	PF00653	0.489
LIG_BRCT_BRCA1_1	125	129	PF00533	0.394
LIG_CtBP_PxDLS_1	25	29	PF00389	0.495
LIG_eIF4E_1	149	155	PF01652	0.384
LIG_EVH1_1	43	47	PF00568	0.486
LIG_FHA_1	190	196	PF00498	0.455
LIG_FHA_1	212	218	PF00498	0.646
LIG_FHA_1	27	33	PF00498	0.515
LIG_FHA_1	77	83	PF00498	0.518
LIG_FHA_2	169	175	PF00498	0.561
LIG_LIR_Gen_1	126	137	PF02991	0.383
LIG_LIR_LC3C_4	65	70	PF02991	0.511
LIG_LIR_Nem_3	126	132	PF02991	0.382
LIG_LIR_Nem_3	174	179	PF02991	0.638
LIG_LIR_Nem_3	218	223	PF02991	0.514
LIG_Pex14_1	220	224	PF04695	0.521
LIG_Pex14_2	129	133	PF04695	0.369
LIG_SH2_NCK_1	3	7	PF00017	0.486
LIG_SH2_NCK_1	54	58	PF00017	0.539
LIG_SH2_SRC	224	227	PF00017	0.519
LIG_SH2_SRC	54	57	PF00017	0.553
LIG_SH2_STAT5	134	137	PF00017	0.391
LIG_SH2_STAT5	224	227	PF00017	0.519
LIG_SH3_1	3	9	PF00018	0.477
LIG_SH3_3	139	145	PF00018	0.468
LIG_SH3_3	3	9	PF00018	0.477
LIG_SH3_3	36	42	PF00018	0.509
LIG_SUMO_SIM_par_1	24	29	PF11976	0.497
LIG_SUMO_SIM_par_1	46	52	PF11976	0.502
LIG_TYR_ITIM	132	137	PF00017	0.380
LIG_WW_2	41	44	PF00397	0.478
MOD_CK1_1	96	102	PF00069	0.680
MOD_CK2_1	100	106	PF00069	0.646
MOD_GlcNHglycan	102	105	PF01048	0.585
MOD_GlcNHglycan	111	114	PF01048	0.589
MOD_GlcNHglycan	164	167	PF01048	0.551
MOD_GlcNHglycan	176	179	PF01048	0.451
MOD_GlcNHglycan	230	233	PF01048	0.518
MOD_GlcNHglycan	87	90	PF01048	0.664
MOD_GlcNHglycan	95	98	PF01048	0.592
MOD_GSK3_1	162	169	PF00069	0.530
MOD_GSK3_1	174	181	PF00069	0.458
MOD_GSK3_1	211	218	PF00069	0.463
MOD_GSK3_1	24	31	PF00069	0.581
MOD_GSK3_1	93	100	PF00069	0.623
MOD_LATS_1	60	66	PF00433	0.481
MOD_LATS_1	91	97	PF00433	0.599
MOD_NEK2_1	19	24	PF00069	0.589
MOD_NEK2_1	26	31	PF00069	0.501
MOD_NEK2_1	87	92	PF00069	0.598
MOD_NEK2_1	95	100	PF00069	0.554
MOD_OFUCOSY	135	140	PF10250	0.411
MOD_OFUCOSY	16	23	PF10250	0.512
MOD_PKA_1	93	99	PF00069	0.601
MOD_PKA_2	19	25	PF00069	0.571
MOD_PKA_2	93	99	PF00069	0.601
MOD_Plk_1	123	129	PF00069	0.389
MOD_Plk_1	212	218	PF00069	0.656
MOD_Plk_4	128	134	PF00069	0.427
MOD_Plk_4	150	156	PF00069	0.471
MOD_Plk_4	49	55	PF00069	0.647
MOD_ProDKin_1	2	8	PF00069	0.488
MOD_ProDKin_1	35	41	PF00069	0.500
MOD_ProDKin_1	63	69	PF00069	0.501
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.514
TRG_ENDOCYTIC_2	134	137	PF00928	0.391
TRG_ENDOCYTIC_2	149	152	PF00928	0.293
TRG_ER_diArg_1	155	157	PF00400	0.405
TRG_ER_diArg_1	160	162	PF00400	0.405
TRG_ER_diArg_1	92	94	PF00400	0.597
TRG_NLS_MonoExtN_4	156	163	PF00514	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q4QEQ5	Leishmania major	81%	91%