Polyketide_cyc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Polyketide cyclase / dehydrase and lipid transport, putative

Species:

Leishmania mexicana

UniProt:

E9AQS1_LEIMU

TriTrypDb:

LmxM.16.1111

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQS1

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	3
GO:0006743	ubiquinone metabolic process	5	3
GO:0006744	ubiquinone biosynthetic process	6	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009987	cellular process	1	3
GO:0015980	energy derivation by oxidation of organic compounds	4	3
GO:0042180	cellular ketone metabolic process	3	3
GO:0042181	ketone biosynthetic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044281	small molecule metabolic process	2	3
GO:0044283	small molecule biosynthetic process	3	3
GO:0045333	cellular respiration	5	3
GO:0071704	organic substance metabolic process	2	3
GO:1901576	organic substance biosynthetic process	3	3
GO:1901661	quinone metabolic process	4	3
GO:1901663	quinone biosynthetic process	5	3

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0048038	quinone binding	2	3
GO:0048039	ubiquinone binding	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.500
CLV_C14_Caspase3-7	57	61	PF00656	0.500
CLV_NRD_NRD_1	141	143	PF00675	0.399
CLV_NRD_NRD_1	209	211	PF00675	0.615
CLV_NRD_NRD_1	24	26	PF00675	0.324
CLV_NRD_NRD_1	33	35	PF00675	0.324
CLV_NRD_NRD_1	89	91	PF00675	0.500
CLV_PCSK_KEX2_1	153	155	PF00082	0.324
CLV_PCSK_KEX2_1	209	211	PF00082	0.615
CLV_PCSK_KEX2_1	24	26	PF00082	0.324
CLV_PCSK_KEX2_1	33	35	PF00082	0.324
CLV_PCSK_KEX2_1	89	91	PF00082	0.500
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.500
CLV_PCSK_PC7_1	205	211	PF00082	0.602
CLV_PCSK_SKI1_1	154	158	PF00082	0.324
DEG_APCC_DBOX_1	153	161	PF00400	0.324
DOC_AGCK_PIF_2	181	186	PF00069	0.500
DOC_CKS1_1	125	130	PF01111	0.500
DOC_MAPK_MEF2A_6	172	180	PF00069	0.500
DOC_PP1_SILK_1	154	159	PF00149	0.500
DOC_PP4_FxxP_1	186	189	PF00568	0.324
DOC_USP7_MATH_1	152	156	PF00917	0.500
DOC_USP7_MATH_1	53	57	PF00917	0.500
DOC_WW_Pin1_4	124	129	PF00397	0.500
DOC_WW_Pin1_4	42	47	PF00397	0.500
LIG_14-3-3_CanoR_1	112	120	PF00244	0.500
LIG_14-3-3_CanoR_1	142	150	PF00244	0.399
LIG_14-3-3_CanoR_1	82	86	PF00244	0.500
LIG_BRCT_BRCA1_1	182	186	PF00533	0.500
LIG_deltaCOP1_diTrp_1	163	166	PF00928	0.500
LIG_FHA_1	145	151	PF00498	0.500
LIG_FHA_1	173	179	PF00498	0.500
LIG_FHA_1	21	27	PF00498	0.500
LIG_FHA_1	63	69	PF00498	0.324
LIG_FHA_1	78	84	PF00498	0.324
LIG_FHA_2	47	53	PF00498	0.500
LIG_LIR_Apic_2	123	128	PF02991	0.500
LIG_LIR_Apic_2	183	189	PF02991	0.500
LIG_LIR_Apic_2	212	218	PF02991	0.635
LIG_LIR_Gen_1	6	16	PF02991	0.324
LIG_LIR_Gen_1	69	79	PF02991	0.324
LIG_LIR_Nem_3	163	169	PF02991	0.334
LIG_LIR_Nem_3	190	194	PF02991	0.500
LIG_LIR_Nem_3	6	11	PF02991	0.324
LIG_LIR_Nem_3	69	75	PF02991	0.324
LIG_Pex14_2	180	184	PF04695	0.324
LIG_PTB_Apo_2	185	192	PF02174	0.324
LIG_PTB_Phospho_1	185	191	PF10480	0.324
LIG_Rb_pABgroove_1	90	98	PF01858	0.500
LIG_SH2_CRK	125	129	PF00017	0.500
LIG_SH2_CRK	215	219	PF00017	0.644
LIG_SH2_NCK_1	125	129	PF00017	0.500
LIG_SH2_STAP1	79	83	PF00017	0.324
LIG_SH2_STAP1	8	12	PF00017	0.375
LIG_SH2_STAT5	79	82	PF00017	0.324
LIG_SH3_1	33	39	PF00018	0.500
LIG_SH3_3	220	226	PF00018	0.676
LIG_SH3_3	23	29	PF00018	0.500
LIG_SH3_3	33	39	PF00018	0.324
LIG_SUMO_SIM_anti_2	175	180	PF11976	0.500
LIG_WRC_WIRS_1	137	142	PF05994	0.500
LIG_WRC_WIRS_1	181	186	PF05994	0.500
MOD_CK1_1	111	117	PF00069	0.500
MOD_CK1_1	121	127	PF00069	0.324
MOD_CK1_1	81	87	PF00069	0.500
MOD_CK2_1	46	52	PF00069	0.500
MOD_GlcNHglycan	114	117	PF01048	0.500
MOD_GlcNHglycan	131	134	PF01048	0.202
MOD_GlcNHglycan	218	221	PF01048	0.660
MOD_GlcNHglycan	8	11	PF01048	0.500
MOD_GSK3_1	107	114	PF00069	0.500
MOD_GSK3_1	123	130	PF00069	0.219
MOD_GSK3_1	42	49	PF00069	0.419
MOD_GSK3_1	62	69	PF00069	0.150
MOD_GSK3_1	77	84	PF00069	0.324
MOD_N-GLC_1	108	113	PF02516	0.500
MOD_NEK2_1	136	141	PF00069	0.500
MOD_NEK2_1	64	69	PF00069	0.334
MOD_PKA_2	111	117	PF00069	0.500
MOD_PKA_2	121	127	PF00069	0.324
MOD_PKA_2	81	87	PF00069	0.500
MOD_Plk_4	136	142	PF00069	0.500
MOD_Plk_4	210	216	PF00069	0.522
MOD_Plk_4	81	87	PF00069	0.500
MOD_ProDKin_1	124	130	PF00069	0.500
MOD_ProDKin_1	42	48	PF00069	0.500
MOD_SUMO_rev_2	165	173	PF00179	0.500
MOD_SUMO_rev_2	183	189	PF00179	0.184
TRG_DiLeu_BaEn_1	54	59	PF01217	0.500
TRG_ENDOCYTIC_2	191	194	PF00928	0.482
TRG_ENDOCYTIC_2	8	11	PF00928	0.375
TRG_ER_diArg_1	24	27	PF00400	0.329
TRG_ER_diArg_1	33	35	PF00400	0.333
TRG_ER_diArg_1	89	91	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	158	163	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
V5B2J0	Trypanosoma cruzi	35%	68%