Polyketide_cyc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Polyketide cyclase / dehydrase and lipid transport, putative

Species:

Leishmania mexicana

UniProt:

E9AQS0_LEIMU

TriTrypDb:

LmxM.16.1110

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQS0

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	10
GO:0006743	ubiquinone metabolic process	5	10
GO:0006744	ubiquinone biosynthetic process	6	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0015980	energy derivation by oxidation of organic compounds	4	10
GO:0042180	cellular ketone metabolic process	3	10
GO:0042181	ketone biosynthetic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0044283	small molecule biosynthetic process	3	10
GO:0045333	cellular respiration	5	10
GO:0071704	organic substance metabolic process	2	10
GO:1901576	organic substance biosynthetic process	3	10
GO:1901661	quinone metabolic process	4	10
GO:1901663	quinone biosynthetic process	5	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0048038	quinone binding	2	10
GO:0048039	ubiquinone binding	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.530
CLV_C14_Caspase3-7	191	195	PF00656	0.371
CLV_C14_Caspase3-7	265	269	PF00656	0.181
CLV_NRD_NRD_1	158	160	PF00675	0.290
CLV_NRD_NRD_1	167	169	PF00675	0.287
CLV_NRD_NRD_1	223	225	PF00675	0.268
CLV_NRD_NRD_1	275	277	PF00675	0.384
CLV_NRD_NRD_1	32	34	PF00675	0.736
CLV_NRD_NRD_1	343	345	PF00675	0.475
CLV_PCSK_KEX2_1	158	160	PF00082	0.272
CLV_PCSK_KEX2_1	167	169	PF00082	0.264
CLV_PCSK_KEX2_1	223	225	PF00082	0.238
CLV_PCSK_KEX2_1	287	289	PF00082	0.302
CLV_PCSK_KEX2_1	32	34	PF00082	0.651
CLV_PCSK_KEX2_1	343	345	PF00082	0.458
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.376
CLV_PCSK_PC7_1	339	345	PF00082	0.450
CLV_PCSK_SKI1_1	288	292	PF00082	0.326
DEG_APCC_DBOX_1	287	295	PF00400	0.371
DEG_Nend_UBRbox_2	1	3	PF02207	0.548
DEG_SPOP_SBC_1	105	109	PF00917	0.567
DOC_AGCK_PIF_2	315	320	PF00069	0.273
DOC_CKS1_1	259	264	PF01111	0.170
DOC_MAPK_MEF2A_6	306	314	PF00069	0.312
DOC_PP1_SILK_1	288	293	PF00149	0.371
DOC_PP4_FxxP_1	320	323	PF00568	0.238
DOC_USP7_MATH_1	105	109	PF00917	0.563
DOC_USP7_MATH_1	187	191	PF00917	0.405
DOC_USP7_MATH_1	21	25	PF00917	0.610
DOC_USP7_MATH_1	286	290	PF00917	0.401
DOC_USP7_MATH_1	43	47	PF00917	0.629
DOC_USP7_MATH_1	58	62	PF00917	0.411
DOC_USP7_MATH_1	65	69	PF00917	0.466
DOC_USP7_MATH_2	129	135	PF00917	0.273
DOC_WW_Pin1_4	125	130	PF00397	0.333
DOC_WW_Pin1_4	176	181	PF00397	0.293
DOC_WW_Pin1_4	258	263	PF00397	0.170
DOC_WW_Pin1_4	87	92	PF00397	0.800
LIG_14-3-3_CanoR_1	216	220	PF00244	0.408
LIG_14-3-3_CanoR_1	246	254	PF00244	0.302
LIG_14-3-3_CanoR_1	276	284	PF00244	0.462
LIG_14-3-3_CanoR_1	64	72	PF00244	0.683
LIG_14-3-3_CanoR_1	9	17	PF00244	0.627
LIG_APCC_ABBA_1	116	121	PF00400	0.501
LIG_BRCT_BRCA1_1	316	320	PF00533	0.256
LIG_deltaCOP1_diTrp_1	297	300	PF00928	0.371
LIG_FHA_1	155	161	PF00498	0.462
LIG_FHA_1	197	203	PF00498	0.243
LIG_FHA_1	212	218	PF00498	0.224
LIG_FHA_1	279	285	PF00498	0.403
LIG_FHA_1	307	313	PF00498	0.273
LIG_FHA_2	181	187	PF00498	0.414
LIG_FHA_2	29	35	PF00498	0.754
LIG_LIR_Apic_2	257	262	PF02991	0.170
LIG_LIR_Apic_2	317	323	PF02991	0.255
LIG_LIR_Apic_2	346	352	PF02991	0.362
LIG_LIR_Gen_1	130	139	PF02991	0.293
LIG_LIR_Gen_1	140	150	PF02991	0.246
LIG_LIR_Gen_1	203	213	PF02991	0.243
LIG_LIR_Nem_3	130	136	PF02991	0.294
LIG_LIR_Nem_3	140	145	PF02991	0.256
LIG_LIR_Nem_3	203	209	PF02991	0.243
LIG_LIR_Nem_3	297	303	PF02991	0.255
LIG_LIR_Nem_3	324	328	PF02991	0.222
LIG_NRBOX	2	8	PF00104	0.558
LIG_Pex14_2	314	318	PF04695	0.238
LIG_PTB_Apo_2	319	326	PF02174	0.312
LIG_PTB_Phospho_1	319	325	PF10480	0.312
LIG_Rb_pABgroove_1	224	232	PF01858	0.371
LIG_SH2_CRK	133	137	PF00017	0.255
LIG_SH2_CRK	259	263	PF00017	0.170
LIG_SH2_CRK	349	353	PF00017	0.371
LIG_SH2_NCK_1	133	137	PF00017	0.312
LIG_SH2_NCK_1	259	263	PF00017	0.170
LIG_SH2_STAP1	133	137	PF00017	0.272
LIG_SH2_STAP1	142	146	PF00017	0.208
LIG_SH2_STAP1	213	217	PF00017	0.238
LIG_SH2_STAT5	213	216	PF00017	0.247
LIG_SH3_1	167	173	PF00018	0.248
LIG_SH3_3	14	20	PF00018	0.733
LIG_SH3_3	157	163	PF00018	0.356
LIG_SH3_3	167	173	PF00018	0.371
LIG_SH3_3	354	360	PF00018	0.489
LIG_SUMO_SIM_anti_2	309	314	PF11976	0.273
LIG_WRC_WIRS_1	271	276	PF05994	0.273
LIG_WRC_WIRS_1	315	320	PF05994	0.277
MOD_CDC14_SPxK_1	90	93	PF00782	0.488
MOD_CDK_SPxK_1	87	93	PF00069	0.497
MOD_CK1_1	104	110	PF00069	0.603
MOD_CK1_1	15	21	PF00069	0.612
MOD_CK1_1	215	221	PF00069	0.371
MOD_CK1_1	245	251	PF00069	0.287
MOD_CK1_1	255	261	PF00069	0.232
MOD_CK1_1	74	80	PF00069	0.594
MOD_CK2_1	125	131	PF00069	0.376
MOD_CK2_1	180	186	PF00069	0.414
MOD_CK2_1	21	27	PF00069	0.676
MOD_CK2_1	28	34	PF00069	0.608
MOD_GlcNHglycan	103	106	PF01048	0.556
MOD_GlcNHglycan	142	145	PF01048	0.273
MOD_GlcNHglycan	17	20	PF01048	0.686
MOD_GlcNHglycan	248	251	PF01048	0.475
MOD_GlcNHglycan	265	268	PF01048	0.308
MOD_GlcNHglycan	352	355	PF01048	0.491
MOD_GlcNHglycan	67	70	PF01048	0.665
MOD_GSK3_1	101	108	PF00069	0.575
MOD_GSK3_1	11	18	PF00069	0.599
MOD_GSK3_1	121	128	PF00069	0.336
MOD_GSK3_1	176	183	PF00069	0.203
MOD_GSK3_1	19	26	PF00069	0.533
MOD_GSK3_1	196	203	PF00069	0.258
MOD_GSK3_1	211	218	PF00069	0.214
MOD_GSK3_1	241	248	PF00069	0.389
MOD_GSK3_1	257	264	PF00069	0.232
MOD_GSK3_1	67	74	PF00069	0.567
MOD_GSK3_1	92	99	PF00069	0.633
MOD_N-GLC_1	242	247	PF02516	0.273
MOD_N-GLC_1	44	49	PF02516	0.489
MOD_N-GLC_1	65	70	PF02516	0.557
MOD_N-GLC_1	74	79	PF02516	0.538
MOD_NEK2_1	1	6	PF00069	0.639
MOD_NEK2_1	198	203	PF00069	0.303
MOD_NEK2_1	270	275	PF00069	0.414
MOD_NEK2_1	28	33	PF00069	0.626
MOD_PKA_2	215	221	PF00069	0.401
MOD_PKA_2	245	251	PF00069	0.273
MOD_PKA_2	255	261	PF00069	0.217
MOD_PKA_2	28	34	PF00069	0.691
MOD_PKA_2	92	98	PF00069	0.520
MOD_Plk_1	1	7	PF00069	0.540
MOD_Plk_1	44	50	PF00069	0.494
MOD_Plk_4	12	18	PF00069	0.639
MOD_Plk_4	131	137	PF00069	0.341
MOD_Plk_4	215	221	PF00069	0.371
MOD_Plk_4	270	276	PF00069	0.395
MOD_Plk_4	344	350	PF00069	0.406
MOD_ProDKin_1	125	131	PF00069	0.278
MOD_ProDKin_1	176	182	PF00069	0.293
MOD_ProDKin_1	258	264	PF00069	0.170
MOD_ProDKin_1	87	93	PF00069	0.801
MOD_SUMO_rev_2	299	307	PF00179	0.273
MOD_SUMO_rev_2	317	323	PF00179	0.157
TRG_DiLeu_BaEn_1	188	193	PF01217	0.170
TRG_DiLeu_BaEn_1	2	7	PF01217	0.539
TRG_DiLeu_LyEn_5	2	7	PF01217	0.539
TRG_ENDOCYTIC_2	133	136	PF00928	0.255
TRG_ENDOCYTIC_2	142	145	PF00928	0.262
TRG_ENDOCYTIC_2	325	328	PF00928	0.467
TRG_ER_diArg_1	158	161	PF00400	0.280
TRG_ER_diArg_1	167	169	PF00400	0.308
TRG_ER_diArg_1	223	225	PF00400	0.220
TRG_Pf-PMV_PEXEL_1	292	297	PF00026	0.273

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIQ5	Leptomonas seymouri	56%	67%
A0A1X0NYV9	Trypanosomatidae	35%	86%
A0A3R7N6U8	Trypanosoma rangeli	37%	100%
A0A3S7WU24	Leishmania donovani	85%	98%
A4HX08	Leishmania infantum	86%	98%
C9ZVZ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4QEQ6	Leishmania major	85%	99%
V5B2J0	Trypanosoma cruzi	37%	100%