Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQR9_LEIMU

TriTrypDb:

LmxM.16.1100

Length:

558

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.583
CLV_C14_Caspase3-7	49	53	PF00656	0.518
CLV_NRD_NRD_1	109	111	PF00675	0.533
CLV_NRD_NRD_1	203	205	PF00675	0.676
CLV_NRD_NRD_1	22	24	PF00675	0.681
CLV_NRD_NRD_1	294	296	PF00675	0.672
CLV_NRD_NRD_1	421	423	PF00675	0.543
CLV_NRD_NRD_1	449	451	PF00675	0.569
CLV_NRD_NRD_1	479	481	PF00675	0.660
CLV_NRD_NRD_1	77	79	PF00675	0.422
CLV_PCSK_FUR_1	201	205	PF00082	0.526
CLV_PCSK_KEX2_1	13	15	PF00082	0.633
CLV_PCSK_KEX2_1	203	205	PF00082	0.676
CLV_PCSK_KEX2_1	22	24	PF00082	0.627
CLV_PCSK_KEX2_1	421	423	PF00082	0.543
CLV_PCSK_KEX2_1	449	451	PF00082	0.572
CLV_PCSK_KEX2_1	469	471	PF00082	0.604
CLV_PCSK_KEX2_1	473	475	PF00082	0.643
CLV_PCSK_KEX2_1	479	481	PF00082	0.552
CLV_PCSK_KEX2_1	76	78	PF00082	0.423
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.551
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.530
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.493
CLV_PCSK_PC7_1	73	79	PF00082	0.421
CLV_PCSK_SKI1_1	368	372	PF00082	0.673
CLV_PCSK_SKI1_1	437	441	PF00082	0.393
DEG_APCC_DBOX_1	75	83	PF00400	0.549
DEG_SCF_FBW7_1	151	156	PF00400	0.526
DOC_CKS1_1	150	155	PF01111	0.530
DOC_CKS1_1	369	374	PF01111	0.681
DOC_CKS1_1	376	381	PF01111	0.807
DOC_MAPK_gen_1	110	119	PF00069	0.422
DOC_PP4_FxxP_1	34	37	PF00568	0.479
DOC_PP4_FxxP_1	405	408	PF00568	0.608
DOC_USP7_MATH_1	129	133	PF00917	0.589
DOC_USP7_MATH_1	153	157	PF00917	0.787
DOC_USP7_MATH_1	312	316	PF00917	0.567
DOC_USP7_MATH_1	53	57	PF00917	0.503
DOC_USP7_UBL2_3	167	171	PF12436	0.591
DOC_USP7_UBL2_3	469	473	PF12436	0.537
DOC_WW_Pin1_4	149	154	PF00397	0.527
DOC_WW_Pin1_4	325	330	PF00397	0.705
DOC_WW_Pin1_4	368	373	PF00397	0.681
DOC_WW_Pin1_4	375	380	PF00397	0.735
DOC_WW_Pin1_4	404	409	PF00397	0.610
LIG_14-3-3_CanoR_1	36	42	PF00244	0.557
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_BIR_III_2	52	56	PF00653	0.507
LIG_BRCT_BRCA1_1	390	394	PF00533	0.613
LIG_eIF4E_1	100	106	PF01652	0.534
LIG_FHA_1	107	113	PF00498	0.424
LIG_FHA_1	369	375	PF00498	0.678
LIG_FHA_1	376	382	PF00498	0.671
LIG_FHA_1	518	524	PF00498	0.512
LIG_FHA_2	140	146	PF00498	0.550
LIG_FHA_2	44	50	PF00498	0.650
LIG_FHA_2	482	488	PF00498	0.543
LIG_FHA_2	7	13	PF00498	0.570
LIG_LIR_Apic_2	149	153	PF02991	0.566
LIG_LIR_Apic_2	402	408	PF02991	0.722
LIG_LIR_Gen_1	135	141	PF02991	0.496
LIG_LIR_Nem_3	132	137	PF02991	0.604
LIG_LIR_Nem_3	29	34	PF02991	0.591
LIG_LIR_Nem_3	392	398	PF02991	0.689
LIG_LIR_Nem_3	56	61	PF02991	0.499
LIG_MYND_1	379	383	PF01753	0.665
LIG_Pex14_1	401	405	PF04695	0.598
LIG_Pex14_2	459	463	PF04695	0.442
LIG_SH2_CRK	61	65	PF00017	0.611
LIG_SH2_NCK_1	319	323	PF00017	0.547
LIG_SH2_SRC	61	64	PF00017	0.614
LIG_SH2_STAP1	100	104	PF00017	0.538
LIG_SH2_STAP1	137	141	PF00017	0.506
LIG_SH2_STAP1	265	269	PF00017	0.566
LIG_SH2_STAT5	123	126	PF00017	0.593
LIG_SH2_STAT5	162	165	PF00017	0.629
LIG_SH2_STAT5	180	183	PF00017	0.405
LIG_SH2_STAT5	220	223	PF00017	0.523
LIG_SH3_3	114	120	PF00018	0.711
LIG_SH3_3	323	329	PF00018	0.684
LIG_SH3_3	338	344	PF00018	0.690
LIG_SH3_3	347	353	PF00018	0.652
LIG_SH3_3	366	372	PF00018	0.825
LIG_SH3_3	373	379	PF00018	0.719
LIG_SH3_3	383	389	PF00018	0.660
LIG_TRAF2_1	241	244	PF00917	0.579
LIG_TRAF2_1	304	307	PF00917	0.671
LIG_TRAF2_1	536	539	PF00917	0.503
LIG_TRAF2_1	67	70	PF00917	0.563
LIG_WW_2	350	353	PF00397	0.545
MOD_CDK_SPxxK_3	368	375	PF00069	0.678
MOD_CK1_1	132	138	PF00069	0.609
MOD_CK1_1	149	155	PF00069	0.521
MOD_CK1_1	335	341	PF00069	0.668
MOD_CK1_1	550	556	PF00069	0.719
MOD_CK2_1	220	226	PF00069	0.541
MOD_CK2_1	312	318	PF00069	0.567
MOD_CK2_1	43	49	PF00069	0.651
MOD_CK2_1	481	487	PF00069	0.411
MOD_CK2_1	533	539	PF00069	0.507
MOD_CK2_1	6	12	PF00069	0.574
MOD_CK2_1	64	70	PF00069	0.573
MOD_DYRK1A_RPxSP_1	325	329	PF00069	0.668
MOD_DYRK1A_RPxSP_1	368	372	PF00069	0.673
MOD_DYRK1A_RPxSP_1	375	379	PF00069	0.680
MOD_GlcNHglycan	159	162	PF01048	0.653
MOD_GlcNHglycan	298	301	PF01048	0.754
MOD_GlcNHglycan	314	317	PF01048	0.611
MOD_GlcNHglycan	336	340	PF01048	0.693
MOD_GlcNHglycan	550	553	PF01048	0.717
MOD_GSK3_1	149	156	PF00069	0.747
MOD_GSK3_1	325	332	PF00069	0.695
MOD_GSK3_1	84	91	PF00069	0.630
MOD_N-GLC_1	413	418	PF02516	0.585
MOD_N-GLC_1	517	522	PF02516	0.512
MOD_NEK2_1	106	111	PF00069	0.609
MOD_NEK2_1	26	31	PF00069	0.573
MOD_NEK2_1	459	464	PF00069	0.542
MOD_NEK2_1	547	552	PF00069	0.698
MOD_PIKK_1	354	360	PF00454	0.675
MOD_PIKK_1	381	387	PF00454	0.663
MOD_PIKK_1	437	443	PF00454	0.515
MOD_PIKK_1	481	487	PF00454	0.589
MOD_PIKK_1	517	523	PF00454	0.512
MOD_PKA_2	234	240	PF00069	0.589
MOD_PKA_2	32	38	PF00069	0.583
MOD_PKA_2	88	94	PF00069	0.539
MOD_Plk_1	517	523	PF00069	0.512
MOD_Plk_4	119	125	PF00069	0.586
MOD_Plk_4	220	226	PF00069	0.541
MOD_Plk_4	27	33	PF00069	0.582
MOD_Plk_4	53	59	PF00069	0.503
MOD_ProDKin_1	149	155	PF00069	0.530
MOD_ProDKin_1	325	331	PF00069	0.707
MOD_ProDKin_1	368	374	PF00069	0.682
MOD_ProDKin_1	375	381	PF00069	0.735
MOD_ProDKin_1	404	410	PF00069	0.607
TRG_DiLeu_BaEn_1	101	106	PF01217	0.532
TRG_DiLeu_BaEn_4	49	55	PF01217	0.648
TRG_DiLeu_BaEn_4	540	546	PF01217	0.519
TRG_ENDOCYTIC_2	137	140	PF00928	0.503
TRG_ENDOCYTIC_2	31	34	PF00928	0.682
TRG_ENDOCYTIC_2	61	64	PF00928	0.614
TRG_ER_diArg_1	201	204	PF00400	0.529
TRG_ER_diArg_1	21	23	PF00400	0.703
TRG_ER_diArg_1	228	231	PF00400	0.652
TRG_ER_diArg_1	283	286	PF00400	0.573
TRG_ER_diArg_1	420	422	PF00400	0.522
TRG_ER_diArg_1	449	451	PF00400	0.628
TRG_ER_diArg_1	71	74	PF00400	0.557
TRG_ER_diArg_1	76	78	PF00400	0.515
TRG_NLS_MonoExtC_3	109	115	PF00514	0.411
TRG_NLS_MonoExtN_4	108	114	PF00514	0.414
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICK9	Leishmania donovani	88%	100%
A4HX07	Leishmania infantum	87%	100%
Q4QEQ7	Leishmania major	88%	100%