Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQR7_LEIMU

TriTrypDb:

LmxM.16.1080

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQR7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.702
CLV_C14_Caspase3-7	393	397	PF00656	0.778
CLV_C14_Caspase3-7	434	438	PF00656	0.769
CLV_C14_Caspase3-7	446	450	PF00656	0.614
CLV_C14_Caspase3-7	57	61	PF00656	0.625
CLV_NRD_NRD_1	198	200	PF00675	0.798
CLV_NRD_NRD_1	272	274	PF00675	0.733
CLV_NRD_NRD_1	285	287	PF00675	0.603
CLV_NRD_NRD_1	508	510	PF00675	0.699
CLV_NRD_NRD_1	612	614	PF00675	0.738
CLV_NRD_NRD_1	629	631	PF00675	0.606
CLV_NRD_NRD_1	7	9	PF00675	0.504
CLV_NRD_NRD_1	83	85	PF00675	0.810
CLV_PCSK_FUR_1	283	287	PF00082	0.810
CLV_PCSK_FUR_1	80	84	PF00082	0.809
CLV_PCSK_KEX2_1	198	200	PF00082	0.798
CLV_PCSK_KEX2_1	272	274	PF00082	0.778
CLV_PCSK_KEX2_1	285	287	PF00082	0.733
CLV_PCSK_KEX2_1	527	529	PF00082	0.725
CLV_PCSK_KEX2_1	612	614	PF00082	0.722
CLV_PCSK_KEX2_1	7	9	PF00082	0.504
CLV_PCSK_KEX2_1	82	84	PF00082	0.814
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.718
CLV_PCSK_SKI1_1	540	544	PF00082	0.745
CLV_Separin_Metazoa	147	151	PF03568	0.539
DEG_Nend_UBRbox_1	1	4	PF02207	0.511
DEG_SCF_TRCP1_1	621	627	PF00400	0.727
DEG_SPOP_SBC_1	551	555	PF00917	0.513
DOC_ANK_TNKS_1	198	205	PF00023	0.573
DOC_ANK_TNKS_1	579	586	PF00023	0.726
DOC_MAPK_DCC_7	8	18	PF00069	0.483
DOC_MAPK_gen_1	346	354	PF00069	0.756
DOC_MAPK_gen_1	612	618	PF00069	0.712
DOC_MAPK_JIP1_4	348	354	PF00069	0.554
DOC_MAPK_MEF2A_6	348	356	PF00069	0.554
DOC_MAPK_MEF2A_6	45	52	PF00069	0.559
DOC_PP2B_LxvP_1	18	21	PF13499	0.499
DOC_PP2B_LxvP_1	455	458	PF13499	0.776
DOC_PP2B_LxvP_1	593	596	PF13499	0.723
DOC_USP7_MATH_1	139	143	PF00917	0.831
DOC_USP7_MATH_1	157	161	PF00917	0.561
DOC_USP7_MATH_1	228	232	PF00917	0.561
DOC_USP7_MATH_2	256	262	PF00917	0.751
DOC_USP7_UBL2_3	101	105	PF12436	0.682
DOC_USP7_UBL2_3	527	531	PF12436	0.713
DOC_WW_Pin1_4	155	160	PF00397	0.711
DOC_WW_Pin1_4	186	191	PF00397	0.624
DOC_WW_Pin1_4	202	207	PF00397	0.644
DOC_WW_Pin1_4	34	39	PF00397	0.574
DOC_WW_Pin1_4	476	481	PF00397	0.558
DOC_WW_Pin1_4	594	599	PF00397	0.790
DOC_WW_Pin1_4	9	14	PF00397	0.512
LIG_14-3-3_CanoR_1	132	140	PF00244	0.765
LIG_14-3-3_CanoR_1	272	278	PF00244	0.623
LIG_14-3-3_CanoR_1	28	36	PF00244	0.636
LIG_14-3-3_CanoR_1	298	308	PF00244	0.703
LIG_14-3-3_CanoR_1	351	357	PF00244	0.552
LIG_14-3-3_CanoR_1	472	476	PF00244	0.776
LIG_14-3-3_CanoR_1	545	551	PF00244	0.820
LIG_14-3-3_CterR_2	643	646	PF00244	0.701
LIG_Actin_WH2_2	137	152	PF00022	0.650
LIG_BRCT_BRCA1_1	621	625	PF00533	0.510
LIG_deltaCOP1_diTrp_1	400	408	PF00928	0.756
LIG_FHA_1	353	359	PF00498	0.546
LIG_FHA_1	490	496	PF00498	0.858
LIG_FHA_1	554	560	PF00498	0.796
LIG_FHA_1	563	569	PF00498	0.644
LIG_FHA_2	277	283	PF00498	0.863
LIG_FHA_2	376	382	PF00498	0.555
LIG_FHA_2	55	61	PF00498	0.672
LIG_GSK3_LRP6_1	594	600	PF00069	0.729
LIG_Integrin_isoDGR_2	628	630	PF01839	0.726
LIG_LIR_Apic_2	160	166	PF02991	0.788
LIG_LIR_Apic_2	360	366	PF02991	0.540
LIG_LIR_Apic_2	451	457	PF02991	0.670
LIG_LIR_Nem_3	96	102	PF02991	0.759
LIG_MYND_1	190	194	PF01753	0.551
LIG_SH2_CRK	163	167	PF00017	0.678
LIG_SH2_GRB2like	425	428	PF00017	0.749
LIG_SH2_GRB2like	440	443	PF00017	0.582
LIG_SH2_STAP1	232	236	PF00017	0.610
LIG_SH2_STAT3	277	280	PF00017	0.797
LIG_SH2_STAT5	454	457	PF00017	0.673
LIG_SH2_STAT5	99	102	PF00017	0.538
LIG_SH3_1	121	127	PF00018	0.778
LIG_SH3_1	188	194	PF00018	0.774
LIG_SH3_1	246	252	PF00018	0.860
LIG_SH3_1	454	460	PF00018	0.665
LIG_SH3_1	7	13	PF00018	0.486
LIG_SH3_2	638	643	PF14604	0.803
LIG_SH3_3	121	127	PF00018	0.778
LIG_SH3_3	153	159	PF00018	0.624
LIG_SH3_3	188	194	PF00018	0.847
LIG_SH3_3	241	247	PF00018	0.804
LIG_SH3_3	33	39	PF00018	0.837
LIG_SH3_3	351	357	PF00018	0.602
LIG_SH3_3	454	460	PF00018	0.775
LIG_SH3_3	477	483	PF00018	0.846
LIG_SH3_3	53	59	PF00018	0.586
LIG_SH3_3	556	562	PF00018	0.807
LIG_SH3_3	566	572	PF00018	0.637
LIG_SH3_3	576	582	PF00018	0.472
LIG_SH3_3	589	595	PF00018	0.626
LIG_SH3_3	635	641	PF00018	0.804
LIG_SH3_3	7	13	PF00018	0.522
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.694
LIG_TRAF2_1	263	266	PF00917	0.663
LIG_WRC_WIRS_1	209	214	PF05994	0.569
MOD_CK1_1	142	148	PF00069	0.746
MOD_CK1_1	205	211	PF00069	0.569
MOD_CK1_1	260	266	PF00069	0.782
MOD_CK1_1	27	33	PF00069	0.661
MOD_CK1_1	300	306	PF00069	0.803
MOD_CK1_1	37	43	PF00069	0.796
MOD_CK1_1	390	396	PF00069	0.595
MOD_CK1_1	512	518	PF00069	0.720
MOD_CK1_1	54	60	PF00069	0.680
MOD_CK1_1	552	558	PF00069	0.806
MOD_CK1_1	597	603	PF00069	0.806
MOD_CK2_1	260	266	PF00069	0.681
MOD_CK2_1	276	282	PF00069	0.722
MOD_CK2_1	611	617	PF00069	0.828
MOD_Cter_Amidation	196	199	PF01082	0.797
MOD_Cter_Amidation	628	631	PF01082	0.724
MOD_GlcNHglycan	113	116	PF01048	0.768
MOD_GlcNHglycan	159	162	PF01048	0.723
MOD_GlcNHglycan	219	222	PF01048	0.738
MOD_GlcNHglycan	226	229	PF01048	0.612
MOD_GlcNHglycan	317	320	PF01048	0.759
MOD_GlcNHglycan	324	328	PF01048	0.760
MOD_GlcNHglycan	375	378	PF01048	0.642
MOD_GlcNHglycan	53	56	PF01048	0.727
MOD_GlcNHglycan	60	63	PF01048	0.666
MOD_GlcNHglycan	620	624	PF01048	0.751
MOD_GSK3_1	204	211	PF00069	0.720
MOD_GSK3_1	213	220	PF00069	0.732
MOD_GSK3_1	224	231	PF00069	0.593
MOD_GSK3_1	24	31	PF00069	0.784
MOD_GSK3_1	260	267	PF00069	0.753
MOD_GSK3_1	268	275	PF00069	0.792
MOD_GSK3_1	467	474	PF00069	0.809
MOD_GSK3_1	505	512	PF00069	0.734
MOD_GSK3_1	54	61	PF00069	0.708
MOD_GSK3_1	546	553	PF00069	0.814
MOD_N-GLC_1	268	273	PF02516	0.863
MOD_N-GLC_1	543	548	PF02516	0.820
MOD_N-GLC_1	67	72	PF02516	0.583
MOD_NEK2_1	297	302	PF00069	0.567
MOD_NEK2_1	352	357	PF00069	0.550
MOD_NEK2_1	471	476	PF00069	0.775
MOD_NEK2_1	543	548	PF00069	0.747
MOD_NEK2_1	619	624	PF00069	0.738
MOD_NEK2_2	467	472	PF00069	0.562
MOD_OGLYCOS	17	22	PF02709	0.499
MOD_PIKK_1	142	148	PF00454	0.532
MOD_PIKK_1	276	282	PF00454	0.578
MOD_PIKK_1	357	363	PF00454	0.535
MOD_PIKK_1	37	43	PF00454	0.658
MOD_PIKK_1	481	487	PF00454	0.790
MOD_PIKK_1	509	515	PF00454	0.783
MOD_PIKK_1	600	606	PF00454	0.793
MOD_PKA_1	272	278	PF00069	0.642
MOD_PKA_1	509	515	PF00069	0.694
MOD_PKA_2	131	137	PF00069	0.770
MOD_PKA_2	217	223	PF00069	0.664
MOD_PKA_2	27	33	PF00069	0.715
MOD_PKA_2	272	278	PF00069	0.698
MOD_PKA_2	297	303	PF00069	0.827
MOD_PKA_2	3	9	PF00069	0.534
MOD_PKA_2	471	477	PF00069	0.782
MOD_PKA_2	489	495	PF00069	0.629
MOD_PKA_2	505	511	PF00069	0.594
MOD_PKA_2	532	538	PF00069	0.618
MOD_PKA_2	611	617	PF00069	0.828
MOD_Plk_1	232	238	PF00069	0.624
MOD_Plk_1	67	73	PF00069	0.583
MOD_Plk_2-3	90	96	PF00069	0.565
MOD_Plk_4	546	552	PF00069	0.816
MOD_Plk_4	555	561	PF00069	0.658
MOD_ProDKin_1	155	161	PF00069	0.712
MOD_ProDKin_1	186	192	PF00069	0.625
MOD_ProDKin_1	202	208	PF00069	0.645
MOD_ProDKin_1	34	40	PF00069	0.575
MOD_ProDKin_1	476	482	PF00069	0.558
MOD_ProDKin_1	594	600	PF00069	0.792
MOD_ProDKin_1	9	15	PF00069	0.509
MOD_SUMO_rev_2	525	532	PF00179	0.649
TRG_DiLeu_BaEn_1	67	72	PF01217	0.657
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.550
TRG_ER_diArg_1	1	4	PF00400	0.511
TRG_ER_diArg_1	185	188	PF00400	0.564
TRG_ER_diArg_1	272	274	PF00400	0.726
TRG_ER_diArg_1	285	288	PF00400	0.598
TRG_ER_diArg_1	346	349	PF00400	0.589
TRG_ER_diArg_1	612	615	PF00400	0.537
TRG_ER_diArg_1	81	84	PF00400	0.807

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDQ3	Leishmania donovani	78%	100%
A4H8N4	Leishmania braziliensis	50%	96%
A4HX04	Leishmania infantum	78%	100%
Q4QEQ9	Leishmania major	76%	100%