SAC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQR6_LEIMU

TriTrypDb:

LmxM.16.1070

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.599
CLV_C14_Caspase3-7	442	446	PF00656	0.539
CLV_NRD_NRD_1	105	107	PF00675	0.453
CLV_NRD_NRD_1	201	203	PF00675	0.684
CLV_NRD_NRD_1	260	262	PF00675	0.553
CLV_NRD_NRD_1	352	354	PF00675	0.487
CLV_NRD_NRD_1	403	405	PF00675	0.566
CLV_NRD_NRD_1	468	470	PF00675	0.603
CLV_PCSK_KEX2_1	105	107	PF00082	0.457
CLV_PCSK_KEX2_1	201	203	PF00082	0.684
CLV_PCSK_KEX2_1	352	354	PF00082	0.497
CLV_PCSK_KEX2_1	362	364	PF00082	0.459
CLV_PCSK_KEX2_1	403	405	PF00082	0.442
CLV_PCSK_KEX2_1	468	470	PF00082	0.675
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.491
CLV_PCSK_SKI1_1	215	219	PF00082	0.507
CLV_PCSK_SKI1_1	431	435	PF00082	0.457
CLV_PCSK_SKI1_1	486	490	PF00082	0.489
CLV_PCSK_SKI1_1	493	497	PF00082	0.486
DEG_APCC_DBOX_1	221	229	PF00400	0.447
DEG_SPOP_SBC_1	196	200	PF00917	0.706
DOC_MAPK_gen_1	144	152	PF00069	0.466
DOC_MAPK_gen_1	407	417	PF00069	0.586
DOC_MAPK_MEF2A_6	119	126	PF00069	0.476
DOC_MAPK_MEF2A_6	410	419	PF00069	0.472
DOC_PP4_FxxP_1	87	90	PF00568	0.433
DOC_USP7_MATH_1	196	200	PF00917	0.721
DOC_USP7_MATH_1	2	6	PF00917	0.664
DOC_USP7_MATH_1	318	322	PF00917	0.577
DOC_USP7_MATH_1	60	64	PF00917	0.522
DOC_USP7_MATH_1	90	94	PF00917	0.416
DOC_USP7_UBL2_3	362	366	PF12436	0.418
DOC_WW_Pin1_4	192	197	PF00397	0.722
DOC_WW_Pin1_4	382	387	PF00397	0.520
DOC_WW_Pin1_4	390	395	PF00397	0.445
DOC_WW_Pin1_4	54	59	PF00397	0.632
LIG_14-3-3_CanoR_1	14	22	PF00244	0.566
LIG_14-3-3_CanoR_1	209	219	PF00244	0.681
LIG_14-3-3_CanoR_1	222	226	PF00244	0.607
LIG_14-3-3_CanoR_1	353	359	PF00244	0.543
LIG_14-3-3_CanoR_1	407	413	PF00244	0.600
LIG_14-3-3_CanoR_1	45	52	PF00244	0.570
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_BRCT_BRCA1_1	185	189	PF00533	0.476
LIG_BRCT_BRCA1_1	83	87	PF00533	0.537
LIG_CSL_BTD_1	87	90	PF09270	0.451
LIG_FHA_1	301	307	PF00498	0.646
LIG_FHA_1	414	420	PF00498	0.506
LIG_FHA_1	84	90	PF00498	0.445
LIG_FHA_2	15	21	PF00498	0.563
LIG_FHA_2	156	162	PF00498	0.605
LIG_FHA_2	355	361	PF00498	0.560
LIG_FHA_2	77	83	PF00498	0.605
LIG_Integrin_RGD_1	459	461	PF01839	0.595
LIG_Integrin_RGD_1	472	474	PF01839	0.468
LIG_LIR_Apic_2	381	387	PF02991	0.482
LIG_LIR_Apic_2	84	90	PF02991	0.446
LIG_LIR_Gen_1	329	340	PF02991	0.446
LIG_LIR_Gen_1	494	504	PF02991	0.471
LIG_LIR_Nem_3	230	236	PF02991	0.397
LIG_LIR_Nem_3	247	252	PF02991	0.393
LIG_LIR_Nem_3	321	326	PF02991	0.571
LIG_LIR_Nem_3	329	335	PF02991	0.416
LIG_LIR_Nem_3	338	343	PF02991	0.312
LIG_Pex14_2	73	77	PF04695	0.547
LIG_REV1ctd_RIR_1	425	435	PF16727	0.300
LIG_RPA_C_Fungi	363	375	PF08784	0.388
LIG_SH2_CRK	249	253	PF00017	0.473
LIG_SH2_CRK	332	336	PF00017	0.414
LIG_SH2_CRK	384	388	PF00017	0.566
LIG_SH2_CRK	409	413	PF00017	0.418
LIG_SH2_CRK	430	434	PF00017	0.538
LIG_SH2_NCK_1	384	388	PF00017	0.507
LIG_SH2_SRC	166	169	PF00017	0.631
LIG_SH2_SRC	436	439	PF00017	0.486
LIG_SH2_SRC	81	84	PF00017	0.592
LIG_SH2_STAP1	241	245	PF00017	0.360
LIG_SH2_STAT3	263	266	PF00017	0.358
LIG_SH2_STAT5	102	105	PF00017	0.561
LIG_SH2_STAT5	234	237	PF00017	0.351
LIG_SH2_STAT5	263	266	PF00017	0.358
LIG_SH2_STAT5	384	387	PF00017	0.454
LIG_SH2_STAT5	436	439	PF00017	0.511
LIG_SH2_STAT5	476	479	PF00017	0.447
LIG_SH3_3	18	24	PF00018	0.641
LIG_SH3_3	303	309	PF00018	0.643
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.436
LIG_SUMO_SIM_par_1	278	284	PF11976	0.578
LIG_TRAF2_1	227	230	PF00917	0.481
LIG_TRAF2_1	357	360	PF00917	0.663
LIG_TRFH_1	498	502	PF08558	0.520
LIG_TYR_ITIM	330	335	PF00017	0.427
LIG_UBA3_1	142	147	PF00899	0.460
LIG_UBA3_1	484	493	PF00899	0.614
MOD_CK1_1	129	135	PF00069	0.481
MOD_CK1_1	183	189	PF00069	0.589
MOD_CK1_1	191	197	PF00069	0.687
MOD_CK1_1	211	217	PF00069	0.693
MOD_CK1_1	224	230	PF00069	0.627
MOD_CK1_1	5	11	PF00069	0.619
MOD_CK2_1	14	20	PF00069	0.561
MOD_CK2_1	224	230	PF00069	0.471
MOD_CK2_1	354	360	PF00069	0.508
MOD_CK2_1	90	96	PF00069	0.517
MOD_CMANNOS	389	392	PF00535	0.610
MOD_Cter_Amidation	259	262	PF01082	0.477
MOD_GlcNHglycan	204	207	PF01048	0.693
MOD_GlcNHglycan	240	244	PF01048	0.404
MOD_GlcNHglycan	332	335	PF01048	0.455
MOD_GlcNHglycan	469	472	PF01048	0.616
MOD_GlcNHglycan	61	65	PF01048	0.778
MOD_GlcNHglycan	67	71	PF01048	0.714
MOD_GlcNHglycan	74	77	PF01048	0.699
MOD_GSK3_1	1	8	PF00069	0.565
MOD_GSK3_1	171	178	PF00069	0.708
MOD_GSK3_1	183	190	PF00069	0.613
MOD_GSK3_1	191	198	PF00069	0.460
MOD_GSK3_1	244	251	PF00069	0.509
MOD_GSK3_1	72	79	PF00069	0.616
MOD_N-GLC_1	109	114	PF02516	0.480
MOD_N-GLC_1	126	131	PF02516	0.391
MOD_N-GLC_1	171	176	PF02516	0.606
MOD_N-GLC_1	187	192	PF02516	0.682
MOD_N-GLC_1	28	33	PF02516	0.644
MOD_N-GLC_1	318	323	PF02516	0.643
MOD_N-GLC_1	330	335	PF02516	0.379
MOD_NEK2_1	1	6	PF00069	0.669
MOD_NEK2_1	115	120	PF00069	0.483
MOD_NEK2_1	126	131	PF00069	0.445
MOD_NEK2_1	143	148	PF00069	0.336
MOD_NEK2_1	155	160	PF00069	0.484
MOD_NEK2_1	189	194	PF00069	0.498
MOD_NEK2_1	221	226	PF00069	0.624
MOD_NEK2_1	484	489	PF00069	0.504
MOD_PIKK_1	2	8	PF00454	0.617
MOD_PIKK_1	81	87	PF00454	0.680
MOD_PKA_2	13	19	PF00069	0.654
MOD_PKA_2	143	149	PF00069	0.431
MOD_PKA_2	208	214	PF00069	0.693
MOD_PKA_2	221	227	PF00069	0.531
MOD_PKA_2	467	473	PF00069	0.726
MOD_PKA_2	65	71	PF00069	0.628
MOD_Plk_1	109	115	PF00069	0.468
MOD_Plk_1	155	161	PF00069	0.605
MOD_Plk_1	171	177	PF00069	0.738
MOD_Plk_1	239	245	PF00069	0.356
MOD_Plk_1	318	324	PF00069	0.631
MOD_Plk_1	330	336	PF00069	0.378
MOD_Plk_4	254	260	PF00069	0.549
MOD_Plk_4	83	89	PF00069	0.522
MOD_ProDKin_1	192	198	PF00069	0.724
MOD_ProDKin_1	382	388	PF00069	0.514
MOD_ProDKin_1	390	396	PF00069	0.432
MOD_ProDKin_1	54	60	PF00069	0.634
MOD_SUMO_rev_2	359	364	PF00179	0.565
TRG_DiLeu_BaEn_1	231	236	PF01217	0.377
TRG_DiLeu_BaEn_1	275	280	PF01217	0.404
TRG_ENDOCYTIC_2	233	236	PF00928	0.351
TRG_ENDOCYTIC_2	249	252	PF00928	0.400
TRG_ENDOCYTIC_2	332	335	PF00928	0.401
TRG_ENDOCYTIC_2	409	412	PF00928	0.422
TRG_ENDOCYTIC_2	430	433	PF00928	0.484
TRG_ER_diArg_1	104	106	PF00400	0.549
TRG_ER_diArg_1	201	203	PF00400	0.667
TRG_ER_diArg_1	351	353	PF00400	0.425
TRG_ER_diArg_1	397	400	PF00400	0.504
TRG_ER_diArg_1	403	405	PF00400	0.514
TRG_ER_diArg_1	44	47	PF00400	0.534
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	296	301	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM4	Leptomonas seymouri	69%	100%
A0A0S4KPP2	Bodo saltans	32%	100%
A0A1X0NYW7	Trypanosomatidae	42%	100%
A0A3S7WU15	Leishmania donovani	92%	98%
A0A422NAT9	Trypanosoma rangeli	43%	100%
A4H8N3	Leishmania braziliensis	80%	99%
A4HX03	Leishmania infantum	92%	98%
C9ZW04	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4QER0	Leishmania major	89%	100%