LeishMANIAdb
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Stealth_CR2 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR2 domain-containing protein
Gene product:
Protein of unknown function (DUF3184), putative
Species:
Leishmania mexicana
UniProt:
E9AQR4_LEIMU
TriTrypDb:
LmxM.16.1060
Length:
979

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 120
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 32
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 36
NetGPI no yes: 0, no: 36
Cellular components
Term Name Level Count
GO:0016020 membrane 2 20
GO:0110165 cellular anatomical entity 1 27
GO:0005794 Golgi apparatus 5 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9

Expansion

Sequence features

E9AQR4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQR4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 35
GO:0016740 transferase activity 2 35
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 16 20 PF00656 0.643
CLV_C14_Caspase3-7 172 176 PF00656 0.454
CLV_C14_Caspase3-7 308 312 PF00656 0.467
CLV_C14_Caspase3-7 507 511 PF00656 0.429
CLV_NRD_NRD_1 179 181 PF00675 0.775
CLV_NRD_NRD_1 211 213 PF00675 0.624
CLV_NRD_NRD_1 264 266 PF00675 0.662
CLV_NRD_NRD_1 31 33 PF00675 0.650
CLV_NRD_NRD_1 65 67 PF00675 0.441
CLV_NRD_NRD_1 78 80 PF00675 0.472
CLV_NRD_NRD_1 846 848 PF00675 0.724
CLV_PCSK_KEX2_1 179 181 PF00082 0.764
CLV_PCSK_KEX2_1 211 213 PF00082 0.556
CLV_PCSK_KEX2_1 264 266 PF00082 0.680
CLV_PCSK_KEX2_1 31 33 PF00082 0.650
CLV_PCSK_KEX2_1 652 654 PF00082 0.604
CLV_PCSK_KEX2_1 67 69 PF00082 0.444
CLV_PCSK_KEX2_1 77 79 PF00082 0.465
CLV_PCSK_KEX2_1 846 848 PF00082 0.724
CLV_PCSK_PC1ET2_1 652 654 PF00082 0.604
CLV_PCSK_PC1ET2_1 67 69 PF00082 0.397
CLV_PCSK_PC1ET2_1 77 79 PF00082 0.426
CLV_PCSK_SKI1_1 123 127 PF00082 0.619
CLV_PCSK_SKI1_1 212 216 PF00082 0.570
CLV_PCSK_SKI1_1 314 318 PF00082 0.678
CLV_PCSK_SKI1_1 368 372 PF00082 0.586
CLV_PCSK_SKI1_1 724 728 PF00082 0.676
CLV_PCSK_SKI1_1 79 83 PF00082 0.303
CLV_PCSK_SKI1_1 846 850 PF00082 0.701
DEG_APCC_DBOX_1 280 288 PF00400 0.447
DEG_APCC_DBOX_1 723 731 PF00400 0.332
DEG_APCC_DBOX_1 78 86 PF00400 0.534
DEG_COP1_1 19 28 PF00400 0.652
DEG_Nend_UBRbox_1 1 4 PF02207 0.658
DEG_SPOP_SBC_1 244 248 PF00917 0.351
DOC_CKS1_1 731 736 PF01111 0.490
DOC_CYCLIN_yCln2_LP_2 568 574 PF00134 0.361
DOC_MAPK_DCC_7 652 661 PF00069 0.447
DOC_MAPK_gen_1 330 338 PF00069 0.279
DOC_MAPK_gen_1 366 375 PF00069 0.386
DOC_MAPK_gen_1 561 570 PF00069 0.472
DOC_MAPK_gen_1 698 708 PF00069 0.474
DOC_MAPK_gen_1 834 844 PF00069 0.466
DOC_MAPK_MEF2A_6 223 231 PF00069 0.345
DOC_MAPK_MEF2A_6 368 377 PF00069 0.386
DOC_MAPK_MEF2A_6 483 490 PF00069 0.386
DOC_MAPK_MEF2A_6 563 572 PF00069 0.472
DOC_MAPK_MEF2A_6 642 649 PF00069 0.601
DOC_MAPK_MEF2A_6 785 792 PF00069 0.509
DOC_MIT_MIM_1 181 190 PF04212 0.413
DOC_PP1_RVXF_1 77 84 PF00149 0.476
DOC_PP1_RVXF_1 933 940 PF00149 0.406
DOC_PP1_RVXF_1 965 972 PF00149 0.426
DOC_PP2B_LxvP_1 568 571 PF13499 0.472
DOC_PP2B_LxvP_1 899 902 PF13499 0.449
DOC_PP4_FxxP_1 731 734 PF00568 0.442
DOC_USP7_MATH_1 158 162 PF00917 0.472
DOC_USP7_MATH_1 17 21 PF00917 0.670
DOC_USP7_MATH_1 328 332 PF00917 0.415
DOC_USP7_MATH_1 515 519 PF00917 0.582
DOC_USP7_MATH_1 645 649 PF00917 0.510
DOC_USP7_MATH_1 676 680 PF00917 0.452
DOC_USP7_MATH_1 943 947 PF00917 0.538
DOC_WW_Pin1_4 150 155 PF00397 0.532
DOC_WW_Pin1_4 299 304 PF00397 0.361
DOC_WW_Pin1_4 493 498 PF00397 0.454
DOC_WW_Pin1_4 583 588 PF00397 0.488
DOC_WW_Pin1_4 607 612 PF00397 0.505
DOC_WW_Pin1_4 730 735 PF00397 0.488
DOC_WW_Pin1_4 832 837 PF00397 0.347
LIG_14-3-3_CanoR_1 129 135 PF00244 0.514
LIG_14-3-3_CanoR_1 265 271 PF00244 0.462
LIG_14-3-3_CanoR_1 281 285 PF00244 0.424
LIG_14-3-3_CanoR_1 31 37 PF00244 0.661
LIG_14-3-3_CanoR_1 337 342 PF00244 0.379
LIG_14-3-3_CanoR_1 352 356 PF00244 0.320
LIG_14-3-3_CanoR_1 368 377 PF00244 0.361
LIG_14-3-3_CanoR_1 38 44 PF00244 0.653
LIG_14-3-3_CanoR_1 561 570 PF00244 0.378
LIG_14-3-3_CanoR_1 596 604 PF00244 0.477
LIG_14-3-3_CanoR_1 605 610 PF00244 0.485
LIG_14-3-3_CanoR_1 71 77 PF00244 0.634
LIG_14-3-3_CanoR_1 78 82 PF00244 0.485
LIG_14-3-3_CanoR_1 789 793 PF00244 0.500
LIG_14-3-3_CanoR_1 812 820 PF00244 0.464
LIG_14-3-3_CanoR_1 893 902 PF00244 0.346
LIG_14-3-3_CterR_2 974 979 PF00244 0.458
LIG_Actin_WH2_2 322 339 PF00022 0.474
LIG_Actin_WH2_2 592 607 PF00022 0.346
LIG_Actin_WH2_2 797 814 PF00022 0.395
LIG_BRCT_BRCA1_1 517 521 PF00533 0.428
LIG_BRCT_BRCA1_1 585 589 PF00533 0.400
LIG_BRCT_BRCA1_1 747 751 PF00533 0.534
LIG_deltaCOP1_diTrp_1 965 971 PF00928 0.370
LIG_DLG_GKlike_1 837 844 PF00625 0.366
LIG_eIF4E_1 210 216 PF01652 0.332
LIG_FHA_1 239 245 PF00498 0.418
LIG_FHA_1 275 281 PF00498 0.481
LIG_FHA_1 355 361 PF00498 0.284
LIG_FHA_1 431 437 PF00498 0.412
LIG_FHA_1 537 543 PF00498 0.284
LIG_FHA_1 604 610 PF00498 0.400
LIG_FHA_1 621 627 PF00498 0.517
LIG_FHA_1 669 675 PF00498 0.414
LIG_FHA_1 903 909 PF00498 0.434
LIG_FHA_1 94 100 PF00498 0.373
LIG_FHA_1 949 955 PF00498 0.433
LIG_FHA_2 14 20 PF00498 0.641
LIG_FHA_2 252 258 PF00498 0.419
LIG_FHA_2 269 275 PF00498 0.500
LIG_FHA_2 306 312 PF00498 0.467
LIG_FHA_2 418 424 PF00498 0.427
LIG_FHA_2 458 464 PF00498 0.391
LIG_FHA_2 713 719 PF00498 0.340
LIG_FHA_2 801 807 PF00498 0.471
LIG_GBD_Chelix_1 85 93 PF00786 0.334
LIG_LIR_Apic_2 108 112 PF02991 0.358
LIG_LIR_Apic_2 729 734 PF02991 0.349
LIG_LIR_Apic_2 951 955 PF02991 0.413
LIG_LIR_Gen_1 128 138 PF02991 0.476
LIG_LIR_Gen_1 80 91 PF02991 0.310
LIG_LIR_Gen_1 957 966 PF02991 0.507
LIG_LIR_LC3C_4 922 927 PF02991 0.487
LIG_LIR_Nem_3 128 133 PF02991 0.467
LIG_LIR_Nem_3 390 396 PF02991 0.377
LIG_LIR_Nem_3 518 524 PF02991 0.415
LIG_LIR_Nem_3 566 572 PF02991 0.349
LIG_LIR_Nem_3 586 592 PF02991 0.479
LIG_LIR_Nem_3 680 686 PF02991 0.410
LIG_LIR_Nem_3 748 754 PF02991 0.431
LIG_LIR_Nem_3 80 86 PF02991 0.310
LIG_LIR_Nem_3 909 914 PF02991 0.463
LIG_NRBOX 89 95 PF00104 0.301
LIG_PCNA_yPIPBox_3 223 235 PF02747 0.390
LIG_PCNA_yPIPBox_3 251 262 PF02747 0.395
LIG_Pex14_2 196 200 PF04695 0.353
LIG_PTB_Apo_2 375 382 PF02174 0.361
LIG_PTB_Phospho_1 375 381 PF10480 0.361
LIG_RPA_C_Fungi 924 936 PF08784 0.494
LIG_SH2_CRK 198 202 PF00017 0.527
LIG_SH2_CRK 210 214 PF00017 0.490
LIG_SH2_CRK 62 66 PF00017 0.416
LIG_SH2_GRB2like 376 379 PF00017 0.564
LIG_SH2_PTP2 592 595 PF00017 0.366
LIG_SH2_SRC 765 768 PF00017 0.645
LIG_SH2_STAP1 529 533 PF00017 0.498
LIG_SH2_STAP1 826 830 PF00017 0.442
LIG_SH2_STAT5 198 201 PF00017 0.512
LIG_SH2_STAT5 221 224 PF00017 0.569
LIG_SH2_STAT5 381 384 PF00017 0.409
LIG_SH2_STAT5 535 538 PF00017 0.400
LIG_SH2_STAT5 544 547 PF00017 0.393
LIG_SH2_STAT5 569 572 PF00017 0.340
LIG_SH2_STAT5 58 61 PF00017 0.495
LIG_SH2_STAT5 592 595 PF00017 0.484
LIG_SH3_2 140 145 PF14604 0.564
LIG_SH3_3 137 143 PF00018 0.607
LIG_SH3_3 148 154 PF00018 0.590
LIG_SH3_3 474 480 PF00018 0.439
LIG_SH3_3 584 590 PF00018 0.616
LIG_SH3_3 633 639 PF00018 0.622
LIG_SH3_3 857 863 PF00018 0.543
LIG_SH3_3 947 953 PF00018 0.524
LIG_SUMO_SIM_anti_2 922 928 PF11976 0.546
LIG_SUMO_SIM_anti_2 98 103 PF11976 0.446
LIG_SUMO_SIM_par_1 103 108 PF11976 0.547
LIG_SUMO_SIM_par_1 297 302 PF11976 0.444
LIG_SUMO_SIM_par_1 904 910 PF11976 0.543
LIG_SUMO_SIM_par_1 91 96 PF11976 0.358
LIG_SUMO_SIM_par_1 922 928 PF11976 0.359
LIG_TRAF2_1 764 767 PF00917 0.623
LIG_TYR_ITIM 542 547 PF00017 0.462
LIG_WRC_WIRS_1 197 202 PF05994 0.526
LIG_WW_3 496 500 PF00397 0.540
MOD_CDC14_SPxK_1 496 499 PF00782 0.534
MOD_CDK_SPK_2 583 588 PF00069 0.502
MOD_CDK_SPK_2 832 837 PF00069 0.389
MOD_CDK_SPxK_1 493 499 PF00069 0.525
MOD_CK1_1 128 134 PF00069 0.591
MOD_CK1_1 283 289 PF00069 0.466
MOD_CK1_1 331 337 PF00069 0.513
MOD_CK1_1 49 55 PF00069 0.543
MOD_CK1_1 517 523 PF00069 0.509
MOD_CK1_1 612 618 PF00069 0.535
MOD_CK2_1 251 257 PF00069 0.504
MOD_CK2_1 417 423 PF00069 0.515
MOD_CK2_1 712 718 PF00069 0.613
MOD_CK2_1 761 767 PF00069 0.474
MOD_CK2_1 800 806 PF00069 0.628
MOD_CK2_1 855 861 PF00069 0.484
MOD_CMANNOS 968 971 PF00535 0.429
MOD_Cter_Amidation 650 653 PF01082 0.491
MOD_GlcNHglycan 130 133 PF01048 0.610
MOD_GlcNHglycan 404 407 PF01048 0.639
MOD_GlcNHglycan 563 566 PF01048 0.400
MOD_GlcNHglycan 614 617 PF01048 0.614
MOD_GlcNHglycan 816 819 PF01048 0.548
MOD_GlcNHglycan 857 860 PF01048 0.447
MOD_GlcNHglycan 918 921 PF01048 0.424
MOD_GSK3_1 13 20 PF00069 0.525
MOD_GSK3_1 158 165 PF00069 0.547
MOD_GSK3_1 239 246 PF00069 0.538
MOD_GSK3_1 264 271 PF00069 0.511
MOD_GSK3_1 396 403 PF00069 0.476
MOD_GSK3_1 45 52 PF00069 0.540
MOD_GSK3_1 493 500 PF00069 0.643
MOD_GSK3_1 553 560 PF00069 0.401
MOD_GSK3_1 603 610 PF00069 0.617
MOD_GSK3_1 828 835 PF00069 0.437
MOD_LATS_1 335 341 PF00433 0.409
MOD_N-GLC_1 201 206 PF02516 0.526
MOD_N-GLC_1 368 373 PF02516 0.409
MOD_N-GLC_2 662 664 PF02516 0.410
MOD_NEK2_1 125 130 PF00069 0.525
MOD_NEK2_1 196 201 PF00069 0.419
MOD_NEK2_1 280 285 PF00069 0.389
MOD_NEK2_1 336 341 PF00069 0.478
MOD_NEK2_1 50 55 PF00069 0.530
MOD_NEK2_1 553 558 PF00069 0.445
MOD_NEK2_1 6 11 PF00069 0.560
MOD_NEK2_1 772 777 PF00069 0.440
MOD_NEK2_1 811 816 PF00069 0.431
MOD_NEK2_1 93 98 PF00069 0.417
MOD_NEK2_1 948 953 PF00069 0.510
MOD_NEK2_2 147 152 PF00069 0.578
MOD_NEK2_2 245 250 PF00069 0.415
MOD_NEK2_2 46 51 PF00069 0.538
MOD_NEK2_2 591 596 PF00069 0.381
MOD_NEK2_2 72 77 PF00069 0.409
MOD_PIKK_1 111 117 PF00454 0.412
MOD_PIKK_1 634 640 PF00454 0.625
MOD_PIKK_1 811 817 PF00454 0.482
MOD_PK_1 32 38 PF00069 0.528
MOD_PKA_1 264 270 PF00069 0.567
MOD_PKA_1 77 83 PF00069 0.274
MOD_PKA_2 128 134 PF00069 0.657
MOD_PKA_2 169 175 PF00069 0.718
MOD_PKA_2 264 270 PF00069 0.622
MOD_PKA_2 274 280 PF00069 0.430
MOD_PKA_2 331 337 PF00069 0.426
MOD_PKA_2 351 357 PF00069 0.393
MOD_PKA_2 6 12 PF00069 0.546
MOD_PKA_2 77 83 PF00069 0.282
MOD_PKA_2 788 794 PF00069 0.566
MOD_PKA_2 811 817 PF00069 0.422
MOD_PKB_1 366 374 PF00069 0.462
MOD_PKB_1 561 569 PF00069 0.345
MOD_Plk_1 368 374 PF00069 0.462
MOD_Plk_1 800 806 PF00069 0.438
MOD_Plk_2-3 274 280 PF00069 0.564
MOD_Plk_2-3 457 463 PF00069 0.420
MOD_Plk_4 158 164 PF00069 0.564
MOD_Plk_4 196 202 PF00069 0.529
MOD_Plk_4 305 311 PF00069 0.497
MOD_Plk_4 396 402 PF00069 0.477
MOD_Plk_4 444 450 PF00069 0.474
MOD_Plk_4 457 463 PF00069 0.466
MOD_Plk_4 553 559 PF00069 0.302
MOD_Plk_4 609 615 PF00069 0.554
MOD_Plk_4 668 674 PF00069 0.465
MOD_Plk_4 837 843 PF00069 0.403
MOD_ProDKin_1 150 156 PF00069 0.646
MOD_ProDKin_1 299 305 PF00069 0.409
MOD_ProDKin_1 493 499 PF00069 0.543
MOD_ProDKin_1 583 589 PF00069 0.586
MOD_ProDKin_1 607 613 PF00069 0.620
MOD_ProDKin_1 730 736 PF00069 0.587
MOD_ProDKin_1 832 838 PF00069 0.397
MOD_SUMO_rev_2 463 473 PF00179 0.546
MOD_SUMO_rev_2 612 620 PF00179 0.580
MOD_SUMO_rev_2 648 654 PF00179 0.516
MOD_SUMO_rev_2 928 937 PF00179 0.684
TRG_DiLeu_BaEn_1 945 950 PF01217 0.531
TRG_DiLeu_BaLyEn_6 183 188 PF01217 0.491
TRG_ENDOCYTIC_2 198 201 PF00928 0.561
TRG_ENDOCYTIC_2 210 213 PF00928 0.629
TRG_ENDOCYTIC_2 544 547 PF00928 0.469
TRG_ENDOCYTIC_2 569 572 PF00928 0.418
TRG_ENDOCYTIC_2 574 577 PF00928 0.414
TRG_ENDOCYTIC_2 592 595 PF00928 0.484
TRG_ENDOCYTIC_2 62 65 PF00928 0.453
TRG_ENDOCYTIC_2 959 962 PF00928 0.453
TRG_ER_diArg_1 210 212 PF00400 0.392
TRG_ER_diArg_1 295 298 PF00400 0.444
TRG_ER_diArg_1 31 34 PF00400 0.835
TRG_ER_diArg_1 329 332 PF00400 0.287
TRG_ER_diArg_1 365 368 PF00400 0.444
TRG_ER_diArg_1 4 7 PF00400 0.511
TRG_ER_diArg_1 524 527 PF00400 0.523
TRG_ER_diArg_1 65 68 PF00400 0.492
TRG_ER_diArg_1 846 848 PF00400 0.419
TRG_ER_diArg_1 873 876 PF00400 0.572
TRG_ER_diArg_1 971 974 PF00400 0.488
TRG_NES_CRM1_1 891 904 PF08389 0.446
TRG_NLS_Bipartite_1 66 81 PF00514 0.396
TRG_Pf-PMV_PEXEL_1 41 45 PF00026 0.534

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NYY7 Trypanosomatidae 40% 100%
A0A3Q8IAD3 Leishmania donovani 90% 100%
A0A3Q8IAF8 Leishmania donovani 49% 100%
A0A3Q8IAK8 Leishmania donovani 53% 100%
A0A3Q8IJ32 Leishmania donovani 53% 100%
A0A3S5H6Y1 Leishmania donovani 52% 100%
A0A3S7WTZ8 Leishmania donovani 51% 95%
A0A3S7WU13 Leishmania donovani 53% 100%
A0A422NAR5 Trypanosoma rangeli 39% 100%
A4H8M5 Leishmania braziliensis 47% 100%
A4H8M7 Leishmania braziliensis 52% 100%
A4H8N0 Leishmania braziliensis 45% 100%
A4H8N1 Leishmania braziliensis 77% 100%
A4HWZ5 Leishmania infantum 53% 100%
A4HWZ6 Leishmania infantum 48% 100%
A4HWZ8 Leishmania infantum 53% 100%
A4HX00 Leishmania infantum 51% 95%
A4HX01 Leishmania infantum 93% 100%
A4HX05 Leishmania infantum 56% 100%
E8NHI9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 100%
E9AQQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 100%
E9AQR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 100%
E9AQR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 100%
E9AQR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9AQR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 100%
Q4QER2 Leishmania major 87% 100%
Q4QER3 Leishmania major 53% 100%
Q4QER4 Leishmania major 57% 94%
Q4QER5 Leishmania major 53% 100%
Q4QER6 Leishmania major 53% 100%
Q4QER7 Leishmania major 53% 100%
Q4QER8 Leishmania major 52% 100%
Q4QER9 Leishmania major 54% 100%
Q4QES0 Leishmania major 53% 95%
V5ANJ8 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS