Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AQQ8_LEIMU

TriTrypDb:

LmxM.16.0990

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AQQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQQ8

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	404	408	PF00656	0.213
CLV_PCSK_FUR_1	97	101	PF00082	0.388
CLV_PCSK_KEX2_1	36	38	PF00082	0.388
CLV_PCSK_KEX2_1	361	363	PF00082	0.388
CLV_PCSK_KEX2_1	91	93	PF00082	0.388
CLV_PCSK_KEX2_1	99	101	PF00082	0.303
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.388
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.388
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.388
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.303
CLV_PCSK_SKI1_1	109	113	PF00082	0.281
CLV_PCSK_SKI1_1	130	134	PF00082	0.388
CLV_PCSK_SKI1_1	272	276	PF00082	0.490
CLV_PCSK_SKI1_1	394	398	PF00082	0.438
CLV_PCSK_SKI1_1	99	103	PF00082	0.388
DEG_APCC_DBOX_1	108	116	PF00400	0.388
DOC_CYCLIN_RxL_1	269	276	PF00134	0.338
DOC_CYCLIN_RxL_1	96	105	PF00134	0.400
DOC_MAPK_gen_1	130	139	PF00069	0.388
DOC_MAPK_gen_1	59	69	PF00069	0.388
DOC_MAPK_gen_1	6	13	PF00069	0.388
DOC_MAPK_MEF2A_6	133	141	PF00069	0.388
DOC_PP1_RVXF_1	270	276	PF00149	0.388
DOC_PP1_RVXF_1	29	36	PF00149	0.388
DOC_PP4_FxxP_1	392	395	PF00568	0.388
DOC_PP4_FxxP_1	74	77	PF00568	0.388
DOC_USP7_MATH_1	202	206	PF00917	0.521
DOC_USP7_MATH_1	377	381	PF00917	0.388
DOC_USP7_UBL2_3	8	12	PF12436	0.388
DOC_WW_Pin1_4	149	154	PF00397	0.664
DOC_WW_Pin1_4	193	198	PF00397	0.612
DOC_WW_Pin1_4	239	244	PF00397	0.388
DOC_WW_Pin1_4	290	295	PF00397	0.472
LIG_14-3-3_CanoR_1	362	368	PF00244	0.388
LIG_14-3-3_CanoR_1	37	47	PF00244	0.388
LIG_14-3-3_CanoR_1	378	386	PF00244	0.225
LIG_14-3-3_CanoR_1	429	436	PF00244	0.500
LIG_APCC_ABBAyCdc20_2	125	131	PF00400	0.388
LIG_BIR_II_1	1	5	PF00653	0.537
LIG_deltaCOP1_diTrp_1	257	266	PF00928	0.388
LIG_deltaCOP1_diTrp_1	389	397	PF00928	0.388
LIG_FAT_LD_1	452	460	PF03623	0.569
LIG_FHA_1	268	274	PF00498	0.388
LIG_FHA_1	27	33	PF00498	0.388
LIG_FHA_1	381	387	PF00498	0.406
LIG_FHA_1	410	416	PF00498	0.211
LIG_FHA_1	455	461	PF00498	0.563
LIG_FHA_2	39	45	PF00498	0.388
LIG_FHA_2	402	408	PF00498	0.371
LIG_LIR_Apic_2	237	243	PF02991	0.388
LIG_LIR_Apic_2	249	255	PF02991	0.388
LIG_LIR_Apic_2	383	387	PF02991	0.380
LIG_LIR_Apic_2	389	395	PF02991	0.316
LIG_LIR_Apic_2	71	77	PF02991	0.388
LIG_LIR_Gen_1	145	153	PF02991	0.629
LIG_LIR_Gen_1	68	77	PF02991	0.388
LIG_LIR_Nem_3	145	149	PF02991	0.616
LIG_LIR_Nem_3	15	21	PF02991	0.388
LIG_LIR_Nem_3	68	73	PF02991	0.388
LIG_Pex14_2	70	74	PF04695	0.388
LIG_SH2_CRK	18	22	PF00017	0.388
LIG_SH2_CRK	252	256	PF00017	0.388
LIG_SH2_CRK	364	368	PF00017	0.388
LIG_SH2_CRK	384	388	PF00017	0.175
LIG_SH2_SRC	121	124	PF00017	0.388
LIG_SH2_SRC	440	443	PF00017	0.417
LIG_SH2_STAP1	231	235	PF00017	0.455
LIG_SH2_STAT5	121	124	PF00017	0.388
LIG_SH2_STAT5	440	443	PF00017	0.459
LIG_SH3_3	138	144	PF00018	0.388
LIG_SH3_3	180	186	PF00018	0.485
LIG_SH3_3	297	303	PF00018	0.200
LIG_SH3_3	441	447	PF00018	0.479
LIG_SUMO_SIM_anti_2	411	419	PF11976	0.301
LIG_SUMO_SIM_par_1	253	260	PF11976	0.388
LIG_SUMO_SIM_par_1	64	71	PF11976	0.388
LIG_UBA3_1	264	272	PF00899	0.421
LIG_UBA3_1	354	361	PF00899	0.388
LIG_UBA3_1	69	78	PF00899	0.388
MOD_CAAXbox	466	469	PF01239	0.558
MOD_CDC14_SPxK_1	293	296	PF00782	0.388
MOD_CDK_SPxK_1	290	296	PF00069	0.388
MOD_CK1_1	301	307	PF00069	0.399
MOD_CK1_1	329	335	PF00069	0.257
MOD_CK1_1	342	348	PF00069	0.383
MOD_CK1_1	376	382	PF00069	0.434
MOD_CK1_1	408	414	PF00069	0.429
MOD_CK2_1	193	199	PF00069	0.556
MOD_CK2_1	39	45	PF00069	0.388
MOD_GlcNHglycan	165	168	PF01048	0.811
MOD_GlcNHglycan	248	251	PF01048	0.467
MOD_GlcNHglycan	275	278	PF01048	0.360
MOD_GlcNHglycan	374	378	PF01048	0.388
MOD_GlcNHglycan	379	382	PF01048	0.335
MOD_GlcNHglycan	401	404	PF01048	0.467
MOD_GSK3_1	147	154	PF00069	0.650
MOD_GSK3_1	163	170	PF00069	0.523
MOD_GSK3_1	175	182	PF00069	0.558
MOD_GSK3_1	22	29	PF00069	0.388
MOD_GSK3_1	246	253	PF00069	0.388
MOD_GSK3_1	301	308	PF00069	0.341
MOD_GSK3_1	340	347	PF00069	0.370
MOD_GSK3_1	373	380	PF00069	0.388
MOD_GSK3_1	401	408	PF00069	0.338
MOD_GSK3_1	455	462	PF00069	0.604
MOD_NEK2_1	246	251	PF00069	0.467
MOD_NEK2_1	268	273	PF00069	0.388
MOD_NEK2_1	363	368	PF00069	0.395
MOD_NEK2_1	401	406	PF00069	0.388
MOD_NEK2_1	455	460	PF00069	0.634
MOD_NEK2_1	93	98	PF00069	0.444
MOD_PIKK_1	340	346	PF00454	0.388
MOD_PIKK_1	353	359	PF00454	0.250
MOD_PKA_1	229	235	PF00069	0.388
MOD_PKA_2	295	301	PF00069	0.435
MOD_PKA_2	313	319	PF00069	0.388
MOD_PKA_2	377	383	PF00069	0.388
MOD_PKA_2	428	434	PF00069	0.418
MOD_Plk_1	329	335	PF00069	0.200
MOD_Plk_4	17	23	PF00069	0.388
MOD_Plk_4	234	240	PF00069	0.410
MOD_Plk_4	455	461	PF00069	0.630
MOD_ProDKin_1	149	155	PF00069	0.665
MOD_ProDKin_1	193	199	PF00069	0.611
MOD_ProDKin_1	239	245	PF00069	0.388
MOD_ProDKin_1	290	296	PF00069	0.472
MOD_SUMO_rev_2	126	134	PF00179	0.338
MOD_SUMO_rev_2	84	93	PF00179	0.388
TRG_DiLeu_BaEn_1	280	285	PF01217	0.325
TRG_DiLeu_BaEn_1	413	418	PF01217	0.388
TRG_DiLeu_BaEn_1	464	469	PF01217	0.552
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.388
TRG_ENDOCYTIC_2	18	21	PF00928	0.271
TRG_ENDOCYTIC_2	364	367	PF00928	0.388
TRG_ENDOCYTIC_2	7	10	PF00928	0.388
TRG_NES_CRM1_1	210	224	PF08389	0.388
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P759	Leptomonas seymouri	74%	99%
A0A0N1I304	Leptomonas seymouri	29%	81%
A0A0S4JZV2	Bodo saltans	30%	100%
A0A0S4KIN4	Bodo saltans	25%	69%
A0A1X0NQM7	Trypanosomatidae	23%	100%
A0A1X0NZD5	Trypanosomatidae	40%	94%
A0A1X0P018	Trypanosomatidae	29%	85%
A0A3R7KDC2	Trypanosoma rangeli	26%	100%
A0A3R7NBN7	Trypanosoma rangeli	37%	100%
A0A3S5H6Y0	Leishmania donovani	95%	99%
A0A3S5IQV1	Trypanosoma rangeli	43%	99%
A0A422NT89	Trypanosoma rangeli	26%	71%
A4H7F4	Leishmania braziliensis	28%	79%
A4H8M3	Leishmania braziliensis	90%	99%
A4HHL5	Leishmania braziliensis	29%	100%
A4HWZ4	Leishmania infantum	94%	100%
C9ZLG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZVG3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZW07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AE77	Leishmania major	28%	100%
P23293	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	71%
Q00534	Homo sapiens	28%	100%
Q01917	Crithidia fasciculata	76%	99%
Q4I5U9	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	26%	87%
Q4QES1	Leishmania major	94%	99%
Q64261	Mus musculus	28%	100%
Q6BV06	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	77%
Q6C842	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	66%
Q6CRA9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	73%
Q6FQ83	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	25%	70%
V5D488	Trypanosoma cruzi	41%	100%
V5DCN7	Trypanosoma cruzi	29%	79%
V5DDT1	Trypanosoma cruzi	25%	100%