LeishMANIAdb
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Methyltransf_11 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Methyltransf_11 domain-containing protein
Gene product:
methyltransferase domain containing protein, putative
Species:
Leishmania mexicana
UniProt:
E9AQQ5_LEIMU
TriTrypDb:
LmxM.16.0960
Length:
488

Annotations

LeishMANIAdb annotations

Homologous to yeast mitochondrial OMS1 methyltransferase, but many Kinetoplastid homologs lack the transit signal.. One sub-group of these proteins have an N-terminal membrane anchor, while others might possess an internal Tm segment potentially targeted to mitochondria.. Localization: Mitochondrial (by homology) / Others (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 9
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQQ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQQ5

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 2
GO:0032259 methylation 2 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008168 methyltransferase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016741 transferase activity, transferring one-carbon groups 3 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 319 323 PF00656 0.318
CLV_NRD_NRD_1 213 215 PF00675 0.641
CLV_NRD_NRD_1 283 285 PF00675 0.593
CLV_NRD_NRD_1 295 297 PF00675 0.603
CLV_NRD_NRD_1 437 439 PF00675 0.459
CLV_NRD_NRD_1 478 480 PF00675 0.649
CLV_NRD_NRD_1 483 485 PF00675 0.667
CLV_NRD_NRD_1 71 73 PF00675 0.496
CLV_PCSK_FUR_1 69 73 PF00082 0.494
CLV_PCSK_KEX2_1 201 203 PF00082 0.701
CLV_PCSK_KEX2_1 215 217 PF00082 0.635
CLV_PCSK_KEX2_1 283 285 PF00082 0.582
CLV_PCSK_KEX2_1 295 297 PF00082 0.655
CLV_PCSK_KEX2_1 312 314 PF00082 0.461
CLV_PCSK_KEX2_1 437 439 PF00082 0.449
CLV_PCSK_KEX2_1 71 73 PF00082 0.494
CLV_PCSK_PC1ET2_1 201 203 PF00082 0.572
CLV_PCSK_PC1ET2_1 215 217 PF00082 0.635
CLV_PCSK_PC1ET2_1 312 314 PF00082 0.471
CLV_PCSK_PC7_1 291 297 PF00082 0.685
CLV_PCSK_SKI1_1 112 116 PF00082 0.682
CLV_PCSK_SKI1_1 210 214 PF00082 0.723
CLV_PCSK_SKI1_1 399 403 PF00082 0.531
CLV_PCSK_SKI1_1 423 427 PF00082 0.470
CLV_PCSK_SKI1_1 72 76 PF00082 0.494
DEG_APCC_DBOX_1 346 354 PF00400 0.282
DEG_APCC_KENBOX_2 142 146 PF00400 0.459
DEG_Nend_UBRbox_1 1 4 PF02207 0.660
DOC_CKS1_1 229 234 PF01111 0.422
DOC_MAPK_gen_1 392 402 PF00069 0.236
DOC_MAPK_gen_1 41 50 PF00069 0.380
DOC_MAPK_gen_1 434 442 PF00069 0.239
DOC_PP2B_LxvP_1 28 31 PF13499 0.396
DOC_PP4_FxxP_1 380 383 PF00568 0.249
DOC_USP7_MATH_1 244 248 PF00917 0.536
DOC_USP7_MATH_1 364 368 PF00917 0.292
DOC_USP7_MATH_1 465 469 PF00917 0.353
DOC_USP7_UBL2_3 395 399 PF12436 0.331
DOC_USP7_UBL2_3 43 47 PF12436 0.347
DOC_USP7_UBL2_3 449 453 PF12436 0.348
DOC_WW_Pin1_4 171 176 PF00397 0.369
DOC_WW_Pin1_4 228 233 PF00397 0.422
DOC_WW_Pin1_4 321 326 PF00397 0.165
LIG_14-3-3_CanoR_1 102 110 PF00244 0.366
LIG_14-3-3_CanoR_1 307 311 PF00244 0.445
LIG_14-3-3_CanoR_1 41 46 PF00244 0.421
LIG_14-3-3_CanoR_1 423 429 PF00244 0.212
LIG_BRCT_BRCA1_1 451 455 PF00533 0.346
LIG_Clathr_ClatBox_1 400 404 PF01394 0.249
LIG_CtBP_PxDLS_1 335 339 PF00389 0.282
LIG_deltaCOP1_diTrp_1 448 455 PF00928 0.393
LIG_deltaCOP1_diTrp_1 470 475 PF00928 0.403
LIG_DLG_GKlike_1 41 48 PF00625 0.420
LIG_FHA_1 340 346 PF00498 0.338
LIG_FHA_1 9 15 PF00498 0.302
LIG_FHA_2 222 228 PF00498 0.442
LIG_FHA_2 234 240 PF00498 0.499
LIG_FHA_2 368 374 PF00498 0.275
LIG_IRF3_LxIS_1 63 68 PF10401 0.238
LIG_LIR_Apic_2 174 179 PF02991 0.368
LIG_LIR_Apic_2 379 383 PF02991 0.236
LIG_LIR_Gen_1 365 375 PF02991 0.252
LIG_LIR_Gen_1 44 53 PF02991 0.335
LIG_LIR_Gen_1 470 477 PF02991 0.400
LIG_LIR_Nem_3 365 371 PF02991 0.252
LIG_LIR_Nem_3 44 48 PF02991 0.332
LIG_LIR_Nem_3 470 475 PF02991 0.387
LIG_LIR_Nem_3 62 67 PF02991 0.436
LIG_PCNA_yPIPBox_3 426 440 PF02747 0.236
LIG_PTB_Apo_2 92 99 PF02174 0.333
LIG_PTB_Phospho_1 92 98 PF10480 0.334
LIG_SH2_CRK 45 49 PF00017 0.329
LIG_SH2_STAT3 136 139 PF00017 0.519
LIG_SH2_STAT5 103 106 PF00017 0.481
LIG_SH2_STAT5 173 176 PF00017 0.340
LIG_SH2_STAT5 22 25 PF00017 0.271
LIG_SH2_STAT5 34 37 PF00017 0.373
LIG_SH2_STAT5 460 463 PF00017 0.260
LIG_SH2_STAT5 64 67 PF00017 0.317
LIG_SH3_3 329 335 PF00018 0.235
LIG_SH3_3 390 396 PF00018 0.236
LIG_SH3_3 459 465 PF00018 0.229
LIG_SH3_4 395 402 PF00018 0.331
LIG_SUMO_SIM_par_1 399 404 PF11976 0.236
LIG_TRAF2_1 224 227 PF00917 0.496
LIG_TRAF2_1 236 239 PF00917 0.438
LIG_TRAF2_1 468 471 PF00917 0.448
LIG_UBA3_1 137 143 PF00899 0.505
LIG_UBA3_1 400 407 PF00899 0.236
LIG_WRC_WIRS_1 377 382 PF05994 0.249
LIG_WW_1 31 34 PF00397 0.399
MOD_CDK_SPxK_1 171 177 PF00069 0.367
MOD_CDK_SPxxK_3 321 328 PF00069 0.165
MOD_CK1_1 246 252 PF00069 0.528
MOD_CK1_1 367 373 PF00069 0.256
MOD_CK1_1 443 449 PF00069 0.352
MOD_CK2_1 221 227 PF00069 0.433
MOD_CK2_1 231 237 PF00069 0.495
MOD_CK2_1 321 327 PF00069 0.348
MOD_CK2_1 465 471 PF00069 0.337
MOD_CMANNOS 428 431 PF00535 0.436
MOD_Cter_Amidation 281 284 PF01082 0.491
MOD_GlcNHglycan 128 131 PF01048 0.734
MOD_GlcNHglycan 154 158 PF01048 0.557
MOD_GlcNHglycan 182 186 PF01048 0.686
MOD_GlcNHglycan 19 22 PF01048 0.411
MOD_GlcNHglycan 206 209 PF01048 0.729
MOD_GlcNHglycan 233 236 PF01048 0.659
MOD_GlcNHglycan 317 321 PF01048 0.481
MOD_GlcNHglycan 442 445 PF01048 0.531
MOD_GSK3_1 126 133 PF00069 0.557
MOD_GSK3_1 242 249 PF00069 0.512
MOD_GSK3_1 8 15 PF00069 0.272
MOD_LATS_1 405 411 PF00433 0.331
MOD_N-GLC_1 131 136 PF02516 0.724
MOD_N-GLC_1 32 37 PF02516 0.665
MOD_NEK2_1 159 164 PF00069 0.294
MOD_NEK2_1 17 22 PF00069 0.299
MOD_NEK2_1 242 247 PF00069 0.542
MOD_NEK2_1 455 460 PF00069 0.291
MOD_NEK2_1 65 70 PF00069 0.291
MOD_PIKK_1 121 127 PF00454 0.454
MOD_PIKK_1 244 250 PF00454 0.525
MOD_PKA_2 186 192 PF00069 0.475
MOD_PKA_2 306 312 PF00069 0.509
MOD_PKA_2 440 446 PF00069 0.331
MOD_PKB_1 202 210 PF00069 0.366
MOD_Plk_1 121 127 PF00069 0.561
MOD_Plk_1 131 137 PF00069 0.548
MOD_Plk_1 32 38 PF00069 0.461
MOD_Plk_1 364 370 PF00069 0.262
MOD_Plk_1 388 394 PF00069 0.244
MOD_Plk_2-3 221 227 PF00069 0.511
MOD_Plk_2-3 46 52 PF00069 0.303
MOD_Plk_4 12 18 PF00069 0.272
MOD_Plk_4 132 138 PF00069 0.528
MOD_Plk_4 306 312 PF00069 0.500
MOD_Plk_4 367 373 PF00069 0.244
MOD_ProDKin_1 171 177 PF00069 0.367
MOD_ProDKin_1 228 234 PF00069 0.422
MOD_ProDKin_1 321 327 PF00069 0.165
MOD_SUMO_rev_2 446 455 PF00179 0.344
MOD_SUMO_rev_2 49 58 PF00179 0.328
TRG_DiLeu_BaEn_2 236 242 PF01217 0.487
TRG_DiLeu_BaEn_3 305 311 PF01217 0.442
TRG_DiLeu_BaEn_4 237 243 PF01217 0.489
TRG_DiLeu_BaLyEn_6 268 273 PF01217 0.430
TRG_ENDOCYTIC_2 45 48 PF00928 0.320
TRG_ENDOCYTIC_2 466 469 PF00928 0.381
TRG_ENDOCYTIC_2 64 67 PF00928 0.304
TRG_ER_diArg_1 213 216 PF00400 0.516
TRG_ER_diArg_1 294 296 PF00400 0.463
TRG_ER_diArg_1 436 438 PF00400 0.249
TRG_ER_diArg_1 70 72 PF00400 0.281
TRG_ER_diArg_1 81 84 PF00400 0.292
TRG_NLS_Bipartite_1 201 219 PF00514 0.397
TRG_NLS_Bipartite_1 295 316 PF00514 0.409
TRG_NLS_MonoCore_2 213 218 PF00514 0.514
TRG_NLS_MonoExtC_3 200 206 PF00514 0.370
TRG_NLS_MonoExtC_3 311 317 PF00514 0.251
TRG_NLS_MonoExtN_4 214 219 PF00514 0.515
TRG_Pf-PMV_PEXEL_1 343 348 PF00026 0.527
TRG_Pf-PMV_PEXEL_1 385 389 PF00026 0.436

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8I0 Leptomonas seymouri 73% 100%
A0A1X0NZ02 Trypanosomatidae 47% 100%
A0A3Q8I9F7 Leishmania donovani 93% 100%
A0A3R7NGZ3 Trypanosoma rangeli 47% 100%
A4H8M0 Leishmania braziliensis 85% 100%
A4HWZ1 Leishmania infantum 93% 100%
C9ZW11 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
Q4QES4 Leishmania major 93% 100%
V5ANK2 Trypanosoma cruzi 48% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS