Putative flagellar calcium-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar calcium-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQQ1_LEIMU

TriTrypDb:

LmxM.16.0920

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	18
GO:0031514	motile cilium	5	18
GO:0042995	cell projection	2	18
GO:0043226	organelle	2	18
GO:0043227	membrane-bounded organelle	3	18
GO:0110165	cellular anatomical entity	1	18
GO:0120025	plasma membrane bounded cell projection	3	18
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AQQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQQ1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	19
GO:0005509	calcium ion binding	5	19
GO:0043167	ion binding	2	19
GO:0043169	cation binding	3	19
GO:0046872	metal ion binding	4	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.557
CLV_NRD_NRD_1	190	192	PF00675	0.515
CLV_NRD_NRD_1	20	22	PF00675	0.421
CLV_NRD_NRD_1	43	45	PF00675	0.340
CLV_PCSK_KEX2_1	43	45	PF00082	0.377
CLV_PCSK_KEX2_1	86	88	PF00082	0.453
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.453
CLV_PCSK_SKI1_1	115	119	PF00082	0.404
CLV_PCSK_SKI1_1	145	149	PF00082	0.415
CLV_PCSK_SKI1_1	86	90	PF00082	0.462
DEG_APCC_DBOX_1	114	122	PF00400	0.404
DOC_CKS1_1	35	40	PF01111	0.524
DOC_CYCLIN_RxL_1	67	78	PF00134	0.283
DOC_PP1_RVXF_1	19	26	PF00149	0.429
DOC_USP7_MATH_1	199	203	PF00917	0.763
DOC_USP7_MATH_1	9	13	PF00917	0.732
DOC_USP7_UBL2_3	7	11	PF12436	0.761
DOC_WW_Pin1_4	34	39	PF00397	0.549
LIG_14-3-3_CanoR_1	43	51	PF00244	0.624
LIG_BRCT_BRCA1_1	44	48	PF00533	0.356
LIG_BRCT_BRCA1_2	44	50	PF00533	0.339
LIG_FHA_1	54	60	PF00498	0.474
LIG_FHA_1	76	82	PF00498	0.446
LIG_FHA_2	15	21	PF00498	0.565
LIG_FHA_2	35	41	PF00498	0.333
LIG_FHA_2	58	64	PF00498	0.455
LIG_FHA_2	96	102	PF00498	0.579
LIG_LIR_Gen_1	105	116	PF02991	0.463
LIG_LIR_Gen_1	128	135	PF02991	0.362
LIG_LIR_Gen_1	180	188	PF02991	0.373
LIG_LIR_Nem_3	105	111	PF02991	0.475
LIG_LIR_Nem_3	123	127	PF02991	0.353
LIG_LIR_Nem_3	128	134	PF02991	0.414
LIG_LIR_Nem_3	156	160	PF02991	0.413
LIG_LIR_Nem_3	165	171	PF02991	0.344
LIG_LIR_Nem_3	180	184	PF02991	0.347
LIG_LIR_Nem_3	45	51	PF02991	0.400
LIG_Rb_pABgroove_1	125	133	PF01858	0.365
LIG_SH2_STAT5	120	123	PF00017	0.389
LIG_SH2_STAT5	124	127	PF00017	0.379
LIG_TRAF2_1	195	198	PF00917	0.468
LIG_TRAF2_1	60	63	PF00917	0.556
LIG_UBA3_1	117	126	PF00899	0.368
MOD_CDK_SPxxK_3	34	41	PF00069	0.543
MOD_CK1_1	186	192	PF00069	0.446
MOD_CK2_1	14	20	PF00069	0.563
MOD_CK2_1	177	183	PF00069	0.358
MOD_CK2_1	57	63	PF00069	0.419
MOD_GlcNHglycan	11	14	PF01048	0.655
MOD_GlcNHglycan	135	139	PF01048	0.398
MOD_GlcNHglycan	175	178	PF01048	0.358
MOD_GSK3_1	173	180	PF00069	0.374
MOD_GSK3_1	49	56	PF00069	0.524
MOD_GSK3_1	91	98	PF00069	0.528
MOD_N-GLC_1	173	178	PF02516	0.398
MOD_N-GLC_1	3	8	PF02516	0.766
MOD_N-GLC_1	53	58	PF02516	0.386
MOD_NEK2_1	125	130	PF00069	0.386
MOD_NEK2_1	95	100	PF00069	0.585
MOD_NMyristoyl	1	7	PF02799	0.629
MOD_PIKK_1	49	55	PF00454	0.400
MOD_PKA_1	49	55	PF00069	0.400
MOD_PKA_2	42	48	PF00069	0.602
MOD_Plk_2-3	57	63	PF00069	0.404
MOD_Plk_4	125	131	PF00069	0.386
MOD_Plk_4	163	169	PF00069	0.445
MOD_ProDKin_1	34	40	PF00069	0.541
MOD_SUMO_rev_2	12	18	PF00179	0.544
MOD_SUMO_rev_2	137	147	PF00179	0.377
TRG_AP2beta_CARGO_1	105	115	PF09066	0.463
TRG_DiLeu_BaEn_2	106	112	PF01217	0.553
TRG_ENDOCYTIC_2	122	125	PF00928	0.378
TRG_ER_diArg_1	33	36	PF00400	0.482
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S0	Leptomonas seymouri	64%	99%
A0A0S4J8L5	Bodo saltans	38%	100%
A0A0S4KMR0	Bodo saltans	42%	100%
A0A1X0NZ95	Trypanosomatidae	62%	99%
A0A1X0P0A5	Trypanosomatidae	60%	100%
A0A1X0P0I3	Trypanosomatidae	66%	93%
A0A3R7KL32	Trypanosoma rangeli	66%	100%
A0A3S7WTZ3	Leishmania donovani	81%	100%
A0A422NDP3	Trypanosoma rangeli	60%	99%
A4H8L5	Leishmania braziliensis	76%	100%
A4H8L6	Leishmania braziliensis	73%	100%
A4HWY6	Leishmania infantum	84%	100%
A4HWY7	Leishmania infantum	83%	100%
C9ZW14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	93%
C9ZW16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	87%
E9AQQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
P07749	Trypanosoma cruzi	57%	96%
P17882	Trypanosoma brucei brucei	52%	87%
Q26677	Trypanosoma brucei brucei	55%	89%
Q26680	Trypanosoma brucei brucei	54%	93%
Q27052	Trypanosoma rangeli	62%	100%
V5D941	Trypanosoma cruzi	56%	82%