Putative flagellar calcium-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar calcium-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQQ0_LEIMU

TriTrypDb:

LmxM.16.0910

Length:

160

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	17
GO:0031514	motile cilium	5	17
GO:0042995	cell projection	2	17
GO:0043226	organelle	2	17
GO:0043227	membrane-bounded organelle	3	17
GO:0110165	cellular anatomical entity	1	17
GO:0120025	plasma membrane bounded cell projection	3	17

Expansion

Sequence features

E9AQQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQQ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	18
GO:0005509	calcium ion binding	5	18
GO:0043167	ion binding	2	18
GO:0043169	cation binding	3	18
GO:0046872	metal ion binding	4	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	8	12	PF00656	0.498
CLV_NRD_NRD_1	146	148	PF00675	0.460
CLV_PCSK_KEX2_1	42	44	PF00082	0.433
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.433
CLV_PCSK_SKI1_1	101	105	PF00082	0.399
CLV_PCSK_SKI1_1	42	46	PF00082	0.427
CLV_PCSK_SKI1_1	71	75	PF00082	0.410
DEG_APCC_DBOX_1	70	78	PF00400	0.403
LIG_BRCT_BRCA1_1	3	7	PF00533	0.344
LIG_FHA_1	32	38	PF00498	0.477
LIG_FHA_2	52	58	PF00498	0.511
LIG_LIR_Gen_1	136	144	PF02991	0.353
LIG_LIR_Gen_1	61	72	PF02991	0.464
LIG_LIR_Gen_1	84	91	PF02991	0.335
LIG_LIR_Nem_3	112	116	PF02991	0.394
LIG_LIR_Nem_3	121	127	PF02991	0.350
LIG_LIR_Nem_3	136	140	PF02991	0.372
LIG_LIR_Nem_3	61	67	PF02991	0.470
LIG_LIR_Nem_3	79	83	PF02991	0.444
LIG_LIR_Nem_3	84	90	PF02991	0.413
LIG_Rb_pABgroove_1	81	89	PF01858	0.377
LIG_SH2_STAT5	154	157	PF00017	0.412
LIG_SH2_STAT5	76	79	PF00017	0.435
LIG_SH2_STAT5	80	83	PF00017	0.403
LIG_UBA3_1	73	82	PF00899	0.356
MOD_CK1_1	142	148	PF00069	0.383
MOD_CK2_1	133	139	PF00069	0.315
MOD_Cter_Amidation	157	160	PF01082	0.452
MOD_GlcNHglycan	131	134	PF01048	0.315
MOD_GlcNHglycan	91	95	PF01048	0.367
MOD_GSK3_1	1	8	PF00069	0.473
MOD_GSK3_1	129	136	PF00069	0.333
MOD_GSK3_1	47	54	PF00069	0.458
MOD_N-GLC_1	129	134	PF02516	0.354
MOD_NEK2_1	1	6	PF00069	0.353
MOD_NEK2_1	51	56	PF00069	0.519
MOD_NEK2_1	81	86	PF00069	0.354
MOD_PIKK_1	5	11	PF00454	0.374
MOD_PKA_1	5	11	PF00069	0.374
MOD_Plk_4	119	125	PF00069	0.421
MOD_Plk_4	81	87	PF00069	0.354
MOD_SUMO_rev_2	93	103	PF00179	0.276
TRG_AP2beta_CARGO_1	61	71	PF09066	0.458
TRG_DiLeu_BaEn_2	62	68	PF01217	0.566
TRG_ENDOCYTIC_2	78	81	PF00928	0.424
TRG_Pf-PMV_PEXEL_1	147	152	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S0	Leptomonas seymouri	69%	78%
A0A0S4J8L5	Bodo saltans	37%	87%
A0A0S4KMR0	Bodo saltans	39%	87%
A0A1X0NZ95	Trypanosomatidae	61%	78%
A0A1X0P0A5	Trypanosomatidae	60%	98%
A0A1X0P0I3	Trypanosomatidae	63%	73%
A0A3R7KL32	Trypanosoma rangeli	61%	95%
A0A3S7WTZ3	Leishmania donovani	73%	82%
A0A422NDP3	Trypanosoma rangeli	61%	78%
A4H8L5	Leishmania braziliensis	69%	100%
A4H8L6	Leishmania braziliensis	67%	100%
A4HWY6	Leishmania infantum	78%	100%
A4HWY7	Leishmania infantum	75%	79%
C9ZW14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	73%
C9ZW16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	69%
E9AQQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	79%
P07749	Trypanosoma cruzi	57%	76%
P17882	Trypanosoma brucei brucei	51%	69%
Q26677	Trypanosoma brucei brucei	52%	70%
Q26680	Trypanosoma brucei brucei	52%	73%
Q27052	Trypanosoma rangeli	62%	78%