Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQP8_LEIMU

TriTrypDb:

LmxM.16.0895

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.603
CLV_NRD_NRD_1	193	195	PF00675	0.590
CLV_NRD_NRD_1	30	32	PF00675	0.553
CLV_NRD_NRD_1	88	90	PF00675	0.613
CLV_NRD_NRD_1	99	101	PF00675	0.490
CLV_PCSK_KEX2_1	19	21	PF00082	0.594
CLV_PCSK_KEX2_1	192	194	PF00082	0.598
CLV_PCSK_KEX2_1	30	32	PF00082	0.557
CLV_PCSK_KEX2_1	88	90	PF00082	0.729
CLV_PCSK_KEX2_1	99	101	PF00082	0.471
CLV_PCSK_PC7_1	189	195	PF00082	0.587
CLV_PCSK_SKI1_1	193	197	PF00082	0.608
CLV_PCSK_SKI1_1	77	81	PF00082	0.674
CLV_Separin_Metazoa	233	237	PF03568	0.408
DEG_APCC_KENBOX_2	261	265	PF00400	0.609
DOC_MAPK_gen_1	30	38	PF00069	0.537
DOC_PP1_RVXF_1	97	104	PF00149	0.502
DOC_USP7_MATH_1	135	139	PF00917	0.546
DOC_USP7_MATH_1	150	154	PF00917	0.519
DOC_USP7_MATH_1	276	280	PF00917	0.567
DOC_USP7_MATH_1	37	41	PF00917	0.532
DOC_WW_Pin1_4	289	294	PF00397	0.668
DOC_WW_Pin1_4	50	55	PF00397	0.643
LIG_14-3-3_CanoR_1	169	175	PF00244	0.485
LIG_14-3-3_CanoR_1	77	87	PF00244	0.630
LIG_14-3-3_CanoR_1	99	104	PF00244	0.509
LIG_APCC_ABBA_1	142	147	PF00400	0.427
LIG_BIR_II_1	1	5	PF00653	0.566
LIG_FHA_1	212	218	PF00498	0.549
LIG_FHA_2	179	185	PF00498	0.579
LIG_Integrin_RGD_1	20	22	PF01839	0.477
LIG_LIR_Gen_1	138	148	PF02991	0.593
LIG_LIR_Nem_3	138	143	PF02991	0.584
LIG_LIR_Nem_3	285	291	PF02991	0.612
LIG_LYPXL_yS_3	32	35	PF13949	0.432
LIG_NRBOX	106	112	PF00104	0.380
LIG_PCNA_yPIPBox_3	169	178	PF02747	0.450
LIG_PDZ_Class_3	293	298	PF00595	0.588
LIG_Rb_LxCxE_1	117	138	PF01857	0.551
LIG_SH2_STAT5	228	231	PF00017	0.532
LIG_SH3_3	138	144	PF00018	0.412
LIG_SH3_3	284	290	PF00018	0.605
LIG_SH3_CIN85_PxpxPR_1	25	30	PF14604	0.458
LIG_SUMO_SIM_par_1	34	41	PF11976	0.508
MOD_CDK_SPK_2	289	294	PF00069	0.531
MOD_CK1_1	102	108	PF00069	0.471
MOD_CK1_1	203	209	PF00069	0.608
MOD_CK1_1	254	260	PF00069	0.540
MOD_CK1_1	269	275	PF00069	0.657
MOD_CK1_1	67	73	PF00069	0.622
MOD_CK1_1	81	87	PF00069	0.640
MOD_CK2_1	170	176	PF00069	0.540
MOD_CK2_1	178	184	PF00069	0.687
MOD_GlcNHglycan	152	155	PF01048	0.629
MOD_GlcNHglycan	202	205	PF01048	0.654
MOD_GlcNHglycan	221	224	PF01048	0.450
MOD_GlcNHglycan	256	259	PF01048	0.599
MOD_GlcNHglycan	278	281	PF01048	0.649
MOD_GlcNHglycan	56	59	PF01048	0.668
MOD_GlcNHglycan	61	64	PF01048	0.713
MOD_GlcNHglycan	70	73	PF01048	0.531
MOD_GlcNHglycan	80	83	PF01048	0.647
MOD_GlcNHglycan	94	97	PF01048	0.569
MOD_GSK3_1	101	108	PF00069	0.522
MOD_GSK3_1	146	153	PF00069	0.528
MOD_GSK3_1	199	206	PF00069	0.601
MOD_GSK3_1	262	269	PF00069	0.672
MOD_GSK3_1	50	57	PF00069	0.664
MOD_GSK3_1	64	71	PF00069	0.537
MOD_GSK3_1	88	95	PF00069	0.633
MOD_N-GLC_1	266	271	PF02516	0.566
MOD_NEK2_1	101	106	PF00069	0.502
MOD_NEK2_1	266	271	PF00069	0.615
MOD_NEK2_1	6	11	PF00069	0.617
MOD_PIKK_1	102	108	PF00454	0.539
MOD_PIKK_1	251	257	PF00454	0.517
MOD_PIKK_1	282	288	PF00454	0.483
MOD_PKA_1	68	74	PF00069	0.545
MOD_PKA_1	88	94	PF00069	0.591
MOD_PKA_1	99	105	PF00069	0.477
MOD_PKA_2	229	235	PF00069	0.467
MOD_PKA_2	88	94	PF00069	0.636
MOD_PKA_2	99	105	PF00069	0.379
MOD_PKB_1	192	200	PF00069	0.559
MOD_Plk_1	262	268	PF00069	0.673
MOD_ProDKin_1	289	295	PF00069	0.667
MOD_ProDKin_1	50	56	PF00069	0.647
TRG_ENDOCYTIC_2	32	35	PF00928	0.496
TRG_ER_diArg_1	119	122	PF00400	0.480
TRG_ER_diArg_1	192	194	PF00400	0.632
TRG_ER_diArg_1	29	31	PF00400	0.483
TRG_ER_diArg_1	87	89	PF00400	0.586
TRG_ER_diArg_1	99	101	PF00400	0.501
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P756	Leptomonas seymouri	32%	96%
A0A3S7WU02	Leishmania donovani	81%	100%
A4H8L3	Leishmania braziliensis	63%	100%
E9AGN6	Leishmania infantum	82%	100%
Q4QES9	Leishmania major	79%	100%