Nucleolar protein, Nop52 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein,Nop52, putative

Species:

Leishmania mexicana

UniProt:

E9AQP7_LEIMU

TriTrypDb:

LmxM.16.0890

Length:

658

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	11
GO:0030688	preribosome, small subunit precursor	4	11
GO:0032991	protein-containing complex	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQP7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.558
CLV_NRD_NRD_1	129	131	PF00675	0.544
CLV_NRD_NRD_1	144	146	PF00675	0.498
CLV_NRD_NRD_1	277	279	PF00675	0.339
CLV_NRD_NRD_1	455	457	PF00675	0.434
CLV_NRD_NRD_1	514	516	PF00675	0.423
CLV_NRD_NRD_1	557	559	PF00675	0.558
CLV_NRD_NRD_1	580	582	PF00675	0.407
CLV_NRD_NRD_1	619	621	PF00675	0.562
CLV_NRD_NRD_1	631	633	PF00675	0.534
CLV_NRD_NRD_1	639	641	PF00675	0.591
CLV_NRD_NRD_1	8	10	PF00675	0.568
CLV_PCSK_FUR_1	629	633	PF00082	0.683
CLV_PCSK_KEX2_1	10	12	PF00082	0.626
CLV_PCSK_KEX2_1	128	130	PF00082	0.553
CLV_PCSK_KEX2_1	144	146	PF00082	0.479
CLV_PCSK_KEX2_1	277	279	PF00082	0.426
CLV_PCSK_KEX2_1	306	308	PF00082	0.777
CLV_PCSK_KEX2_1	327	329	PF00082	0.746
CLV_PCSK_KEX2_1	437	439	PF00082	0.409
CLV_PCSK_KEX2_1	455	457	PF00082	0.343
CLV_PCSK_KEX2_1	473	475	PF00082	0.676
CLV_PCSK_KEX2_1	477	479	PF00082	0.549
CLV_PCSK_KEX2_1	48	50	PF00082	0.414
CLV_PCSK_KEX2_1	556	558	PF00082	0.540
CLV_PCSK_KEX2_1	580	582	PF00082	0.392
CLV_PCSK_KEX2_1	631	633	PF00082	0.626
CLV_PCSK_KEX2_1	639	641	PF00082	0.631
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.692
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.812
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.746
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.409
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.670
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.549
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.433
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.637
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.619
CLV_PCSK_PC7_1	125	131	PF00082	0.546
CLV_PCSK_SKI1_1	246	250	PF00082	0.355
CLV_PCSK_SKI1_1	278	282	PF00082	0.378
CLV_PCSK_SKI1_1	285	289	PF00082	0.378
CLV_PCSK_SKI1_1	321	325	PF00082	0.809
CLV_PCSK_SKI1_1	384	388	PF00082	0.482
CLV_PCSK_SKI1_1	437	441	PF00082	0.476
CLV_PCSK_SKI1_1	528	532	PF00082	0.439
CLV_PCSK_SKI1_1	561	565	PF00082	0.540
CLV_PCSK_SKI1_1	581	585	PF00082	0.555
CLV_PCSK_SKI1_1	616	620	PF00082	0.624
CLV_Separin_Metazoa	406	410	PF03568	0.486
DEG_Nend_UBRbox_1	1	4	PF02207	0.613
DEG_SPOP_SBC_1	388	392	PF00917	0.288
DOC_CKS1_1	98	103	PF01111	0.685
DOC_CYCLIN_yClb5_NLxxxL_5	105	113	PF00134	0.613
DOC_MAPK_gen_1	266	275	PF00069	0.355
DOC_MAPK_gen_1	9	17	PF00069	0.585
DOC_MAPK_MEF2A_6	105	113	PF00069	0.589
DOC_PP1_RVXF_1	244	250	PF00149	0.355
DOC_PP2B_LxvP_1	237	240	PF13499	0.408
DOC_PP4_FxxP_1	443	446	PF00568	0.382
DOC_USP7_MATH_1	157	161	PF00917	0.536
DOC_USP7_MATH_1	296	300	PF00917	0.648
DOC_USP7_MATH_1	370	374	PF00917	0.249
DOC_USP7_MATH_1	612	616	PF00917	0.638
DOC_USP7_UBL2_3	2	6	PF12436	0.616
DOC_USP7_UBL2_3	473	477	PF12436	0.682
DOC_USP7_UBL2_3	593	597	PF12436	0.503
DOC_USP7_UBL2_3	95	99	PF12436	0.636
DOC_WW_Pin1_4	300	305	PF00397	0.770
DOC_WW_Pin1_4	314	319	PF00397	0.736
DOC_WW_Pin1_4	484	489	PF00397	0.577
DOC_WW_Pin1_4	97	102	PF00397	0.684
LIG_14-3-3_CanoR_1	191	196	PF00244	0.521
LIG_14-3-3_CanoR_1	528	538	PF00244	0.463
LIG_14-3-3_CanoR_1	539	547	PF00244	0.537
LIG_14-3-3_CanoR_1	71	79	PF00244	0.501
LIG_APCC_ABBAyCdc20_2	648	654	PF00400	0.610
LIG_FHA_1	369	375	PF00498	0.486
LIG_FHA_1	394	400	PF00498	0.425
LIG_FHA_2	192	198	PF00498	0.563
LIG_FHA_2	645	651	PF00498	0.571
LIG_GBD_Chelix_1	374	382	PF00786	0.511
LIG_IBAR_NPY_1	102	104	PF08397	0.627
LIG_LIR_Apic_2	441	446	PF02991	0.387
LIG_LIR_Gen_1	197	207	PF02991	0.400
LIG_LIR_Gen_1	270	280	PF02991	0.336
LIG_LIR_Gen_1	401	412	PF02991	0.367
LIG_LIR_Gen_1	414	425	PF02991	0.337
LIG_LIR_Nem_3	148	153	PF02991	0.671
LIG_LIR_Nem_3	197	202	PF02991	0.408
LIG_LIR_Nem_3	260	264	PF02991	0.372
LIG_LIR_Nem_3	270	275	PF02991	0.298
LIG_LIR_Nem_3	377	382	PF02991	0.480
LIG_LIR_Nem_3	401	407	PF02991	0.360
LIG_LIR_Nem_3	441	447	PF02991	0.445
LIG_LIR_Nem_3	545	550	PF02991	0.573
LIG_MAD2	438	446	PF02301	0.413
LIG_PCNA_TLS_4	266	273	PF02747	0.447
LIG_PCNA_TLS_4	437	444	PF02747	0.398
LIG_REV1ctd_RIR_1	510	520	PF16727	0.454
LIG_SH2_CRK	153	157	PF00017	0.747
LIG_SH2_CRK	250	254	PF00017	0.408
LIG_SH2_GRB2like	106	109	PF00017	0.596
LIG_SH2_NCK_1	153	157	PF00017	0.669
LIG_SH2_STAP1	83	87	PF00017	0.585
LIG_SH2_STAT3	380	383	PF00017	0.411
LIG_SH2_STAT5	215	218	PF00017	0.361
LIG_SH2_STAT5	272	275	PF00017	0.402
LIG_SH2_STAT5	283	286	PF00017	0.408
LIG_SH2_STAT5	380	383	PF00017	0.388
LIG_SH2_STAT5	434	437	PF00017	0.435
LIG_SH2_STAT5	68	71	PF00017	0.447
LIG_SH2_STAT5	93	96	PF00017	0.622
LIG_SH3_1	95	101	PF00018	0.637
LIG_SH3_3	333	339	PF00018	0.689
LIG_SH3_3	95	101	PF00018	0.651
LIG_SH3_4	222	229	PF00018	0.335
LIG_SUMO_SIM_anti_2	201	206	PF11976	0.334
LIG_SUMO_SIM_par_1	32	37	PF11976	0.564
LIG_TRAF2_1	121	124	PF00917	0.568
LIG_TYR_ITIM	248	253	PF00017	0.447
LIG_Vh1_VBS_1	360	378	PF01044	0.262
LIG_WRC_WIRS_1	440	445	PF05994	0.250
MOD_CDC14_SPxK_1	303	306	PF00782	0.713
MOD_CDK_SPxK_1	300	306	PF00069	0.714
MOD_CDK_SPxxK_3	300	307	PF00069	0.771
MOD_CDK_SPxxK_3	314	321	PF00069	0.735
MOD_CK1_1	322	328	PF00069	0.753
MOD_CK1_1	389	395	PF00069	0.549
MOD_CK2_1	191	197	PF00069	0.571
MOD_CK2_1	314	320	PF00069	0.799
MOD_CK2_1	332	338	PF00069	0.614
MOD_CK2_1	529	535	PF00069	0.482
MOD_GlcNHglycan	298	301	PF01048	0.710
MOD_GlcNHglycan	346	349	PF01048	0.580
MOD_GlcNHglycan	420	423	PF01048	0.508
MOD_GlcNHglycan	540	543	PF01048	0.570
MOD_GSK3_1	296	303	PF00069	0.714
MOD_GSK3_1	319	326	PF00069	0.738
MOD_GSK3_1	364	371	PF00069	0.529
MOD_GSK3_1	389	396	PF00069	0.473
MOD_GSK3_1	462	469	PF00069	0.436
MOD_NEK2_1	323	328	PF00069	0.512
MOD_NEK2_1	349	354	PF00069	0.558
MOD_NEK2_1	418	423	PF00069	0.508
MOD_NEK2_1	550	555	PF00069	0.635
MOD_PIKK_1	427	433	PF00454	0.461
MOD_PIKK_1	468	474	PF00454	0.636
MOD_PKA_1	473	479	PF00069	0.728
MOD_PKA_2	473	479	PF00069	0.748
MOD_PKA_2	538	544	PF00069	0.570
MOD_PKA_2	70	76	PF00069	0.517
MOD_PKB_1	189	197	PF00069	0.581
MOD_Plk_1	319	325	PF00069	0.734
MOD_Plk_1	332	338	PF00069	0.480
MOD_Plk_1	79	85	PF00069	0.573
MOD_Plk_2-3	260	266	PF00069	0.355
MOD_Plk_4	191	197	PF00069	0.571
MOD_Plk_4	370	376	PF00069	0.402
MOD_Plk_4	439	445	PF00069	0.245
MOD_ProDKin_1	300	306	PF00069	0.770
MOD_ProDKin_1	314	320	PF00069	0.734
MOD_ProDKin_1	484	490	PF00069	0.568
MOD_ProDKin_1	97	103	PF00069	0.681
MOD_SUMO_for_1	305	308	PF00179	0.755
MOD_SUMO_rev_2	560	566	PF00179	0.649
TRG_ENDOCYTIC_2	106	109	PF00928	0.564
TRG_ENDOCYTIC_2	250	253	PF00928	0.386
TRG_ENDOCYTIC_2	272	275	PF00928	0.378
TRG_ENDOCYTIC_2	283	286	PF00928	0.378
TRG_ER_diArg_1	128	130	PF00400	0.586
TRG_ER_diArg_1	136	139	PF00400	0.550
TRG_ER_diArg_1	276	278	PF00400	0.434
TRG_ER_diArg_1	556	558	PF00400	0.527
TRG_ER_diArg_1	8	11	PF00400	0.616
TRG_NLS_Bipartite_1	620	635	PF00514	0.584
TRG_NLS_MonoCore_2	638	643	PF00514	0.617
TRG_NLS_MonoExtN_4	629	635	PF00514	0.593
TRG_NLS_MonoExtN_4	639	644	PF00514	0.605
TRG_Pf-PMV_PEXEL_1	255	260	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	561	565	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R2	Leptomonas seymouri	68%	97%
A0A0S4JIU4	Bodo saltans	36%	100%
A0A3S7WTZ9	Leishmania donovani	91%	99%
A0A422NDR1	Trypanosoma rangeli	39%	100%
A4H8L2	Leishmania braziliensis	84%	100%
A4HWY4	Leishmania infantum	91%	99%
C9ZW19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QET0	Leishmania major	91%	100%
V5BD23	Trypanosoma cruzi	37%	100%