Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AQP6_LEIMU

TriTrypDb:

LmxM.16.0870

Length:

684

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQP6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	517	521	PF00656	0.415
CLV_NRD_NRD_1	197	199	PF00675	0.562
CLV_NRD_NRD_1	349	351	PF00675	0.649
CLV_NRD_NRD_1	442	444	PF00675	0.415
CLV_NRD_NRD_1	640	642	PF00675	0.401
CLV_NRD_NRD_1	671	673	PF00675	0.401
CLV_PCSK_KEX2_1	197	199	PF00082	0.514
CLV_PCSK_KEX2_1	349	351	PF00082	0.649
CLV_PCSK_KEX2_1	442	444	PF00082	0.415
CLV_PCSK_KEX2_1	662	664	PF00082	0.358
CLV_PCSK_KEX2_1	671	673	PF00082	0.443
CLV_PCSK_PC1ET2_1	662	664	PF00082	0.391
CLV_PCSK_SKI1_1	198	202	PF00082	0.618
CLV_PCSK_SKI1_1	209	213	PF00082	0.582
CLV_PCSK_SKI1_1	225	229	PF00082	0.571
CLV_PCSK_SKI1_1	397	401	PF00082	0.444
CLV_PCSK_SKI1_1	420	424	PF00082	0.395
CLV_PCSK_SKI1_1	523	527	PF00082	0.461
CLV_PCSK_SKI1_1	671	675	PF00082	0.405
DEG_Kelch_Keap1_1	24	29	PF01344	0.522
DEG_SPOP_SBC_1	101	105	PF00917	0.717
DEG_SPOP_SBC_1	243	247	PF00917	0.446
DOC_ANK_TNKS_1	348	355	PF00023	0.589
DOC_CKS1_1	153	158	PF01111	0.635
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.611
DOC_MAPK_gen_1	215	224	PF00069	0.458
DOC_MAPK_gen_1	272	282	PF00069	0.555
DOC_MAPK_gen_1	439	447	PF00069	0.425
DOC_MAPK_gen_1	641	648	PF00069	0.201
DOC_MAPK_HePTP_8	212	224	PF00069	0.505
DOC_MAPK_MEF2A_6	215	224	PF00069	0.430
DOC_MAPK_MEF2A_6	442	449	PF00069	0.436
DOC_PP1_RVXF_1	176	183	PF00149	0.662
DOC_PP1_RVXF_1	195	202	PF00149	0.467
DOC_PP1_RVXF_1	415	422	PF00149	0.438
DOC_PP2B_LxvP_1	166	169	PF13499	0.710
DOC_USP7_MATH_1	162	166	PF00917	0.758
DOC_USP7_MATH_1	234	238	PF00917	0.693
DOC_USP7_MATH_1	243	247	PF00917	0.626
DOC_USP7_MATH_1	375	379	PF00917	0.758
DOC_USP7_MATH_1	532	536	PF00917	0.438
DOC_USP7_MATH_1	602	606	PF00917	0.422
DOC_USP7_MATH_1	72	76	PF00917	0.750
DOC_USP7_MATH_1	86	90	PF00917	0.710
DOC_USP7_UBL2_3	397	401	PF12436	0.438
DOC_WW_Pin1_4	111	116	PF00397	0.773
DOC_WW_Pin1_4	122	127	PF00397	0.723
DOC_WW_Pin1_4	152	157	PF00397	0.614
DOC_WW_Pin1_4	164	169	PF00397	0.682
DOC_WW_Pin1_4	173	178	PF00397	0.660
DOC_WW_Pin1_4	344	349	PF00397	0.584
DOC_WW_Pin1_4	48	53	PF00397	0.724
DOC_WW_Pin1_4	56	61	PF00397	0.787
DOC_WW_Pin1_4	82	87	PF00397	0.743
LIG_14-3-3_CanoR_1	100	110	PF00244	0.714
LIG_14-3-3_CanoR_1	130	138	PF00244	0.721
LIG_14-3-3_CanoR_1	161	167	PF00244	0.715
LIG_14-3-3_CanoR_1	275	280	PF00244	0.525
LIG_14-3-3_CanoR_1	404	412	PF00244	0.419
LIG_14-3-3_CanoR_1	420	425	PF00244	0.383
LIG_14-3-3_CanoR_1	442	446	PF00244	0.415
LIG_14-3-3_CanoR_1	671	680	PF00244	0.584
LIG_BIR_II_1	1	5	PF00653	0.762
LIG_BRCT_BRCA1_1	123	127	PF00533	0.761
LIG_BRCT_BRCA1_1	272	276	PF00533	0.550
LIG_BRCT_BRCA1_1	401	405	PF00533	0.438
LIG_BRCT_BRCA1_1	417	421	PF00533	0.438
LIG_CaM_IQ_9	282	297	PF13499	0.546
LIG_deltaCOP1_diTrp_1	558	565	PF00928	0.422
LIG_DLG_GKlike_1	275	282	PF00625	0.594
LIG_FHA_1	103	109	PF00498	0.653
LIG_FHA_1	112	118	PF00498	0.549
LIG_FHA_1	367	373	PF00498	0.686
LIG_FHA_1	442	448	PF00498	0.427
LIG_FHA_1	545	551	PF00498	0.438
LIG_FHA_1	581	587	PF00498	0.438
LIG_FHA_1	663	669	PF00498	0.356
LIG_FHA_1	676	682	PF00498	0.520
LIG_FHA_2	325	331	PF00498	0.642
LIG_FHA_2	366	372	PF00498	0.705
LIG_FHA_2	515	521	PF00498	0.422
LIG_FHA_2	594	600	PF00498	0.438
LIG_FHA_2	628	634	PF00498	0.427
LIG_FXI_DFP_1	572	576	PF00024	0.391
LIG_GBD_Chelix_1	430	438	PF00786	0.391
LIG_GBD_Chelix_1	477	485	PF00786	0.422
LIG_Integrin_RGD_1	465	467	PF01839	0.454
LIG_LIR_Apic_2	10	15	PF02991	0.538
LIG_LIR_Apic_2	132	138	PF02991	0.721
LIG_LIR_Apic_2	179	185	PF02991	0.647
LIG_LIR_Apic_2	539	545	PF02991	0.357
LIG_LIR_Gen_1	278	285	PF02991	0.581
LIG_LIR_Gen_1	418	428	PF02991	0.430
LIG_LIR_Gen_1	432	440	PF02991	0.277
LIG_LIR_Nem_3	249	254	PF02991	0.540
LIG_LIR_Nem_3	273	279	PF02991	0.626
LIG_LIR_Nem_3	322	326	PF02991	0.628
LIG_LIR_Nem_3	379	385	PF02991	0.777
LIG_LIR_Nem_3	418	424	PF02991	0.430
LIG_LIR_Nem_3	432	436	PF02991	0.277
LIG_LIR_Nem_3	574	578	PF02991	0.357
LIG_LIR_Nem_3	657	661	PF02991	0.417
LIG_LYPXL_SIV_4	381	389	PF13949	0.694
LIG_PDZ_Class_2	679	684	PF00595	0.667
LIG_Pex14_2	106	110	PF04695	0.480
LIG_Pex14_2	469	473	PF04695	0.438
LIG_PTB_Apo_2	501	508	PF02174	0.438
LIG_REV1ctd_RIR_1	199	207	PF16727	0.655
LIG_SH2_CRK	12	16	PF00017	0.535
LIG_SH2_CRK	254	258	PF00017	0.525
LIG_SH2_CRK	382	386	PF00017	0.777
LIG_SH2_CRK	658	662	PF00017	0.438
LIG_SH2_PTP2	279	282	PF00017	0.572
LIG_SH2_SRC	452	455	PF00017	0.438
LIG_SH2_SRC	529	532	PF00017	0.415
LIG_SH2_STAP1	606	610	PF00017	0.422
LIG_SH2_STAP1	644	648	PF00017	0.422
LIG_SH2_STAT5	152	155	PF00017	0.586
LIG_SH2_STAT5	251	254	PF00017	0.517
LIG_SH2_STAT5	279	282	PF00017	0.572
LIG_SH2_STAT5	433	436	PF00017	0.357
LIG_SH2_STAT5	567	570	PF00017	0.357
LIG_SH2_STAT5	680	683	PF00017	0.567
LIG_SH3_1	135	141	PF00018	0.662
LIG_SH3_2	156	161	PF14604	0.704
LIG_SH3_3	135	141	PF00018	0.662
LIG_SH3_3	153	159	PF00018	0.566
LIG_SH3_3	169	175	PF00018	0.697
LIG_SH3_3	187	193	PF00018	0.437
LIG_SH3_3	220	226	PF00018	0.389
LIG_SH3_3	361	367	PF00018	0.605
LIG_SH3_3	46	52	PF00018	0.724
LIG_SH3_3	570	576	PF00018	0.357
LIG_SH3_3	59	65	PF00018	0.824
LIG_SH3_CIN85_PxpxPR_1	173	178	PF14604	0.680
LIG_Sin3_3	232	239	PF02671	0.628
LIG_SUMO_SIM_par_1	357	363	PF11976	0.513
LIG_SUMO_SIM_par_1	651	657	PF11976	0.438
LIG_TRAF2_1	368	371	PF00917	0.698
LIG_TRAF2_1	595	598	PF00917	0.422
LIG_TYR_ITIM	431	436	PF00017	0.381
LIG_TYR_ITIM	656	661	PF00017	0.438
LIG_TYR_ITSM	250	257	PF00017	0.391
MOD_CDC14_SPxK_1	158	161	PF00782	0.677
MOD_CDC14_SPxK_1	347	350	PF00782	0.669
MOD_CDK_SPK_2	173	178	PF00069	0.680
MOD_CDK_SPK_2	344	349	PF00069	0.669
MOD_CDK_SPxK_1	155	161	PF00069	0.647
MOD_CDK_SPxK_1	344	350	PF00069	0.665
MOD_CK1_1	111	117	PF00069	0.682
MOD_CK1_1	125	131	PF00069	0.596
MOD_CK1_1	164	170	PF00069	0.653
MOD_CK1_1	2	8	PF00069	0.670
MOD_CK1_1	246	252	PF00069	0.592
MOD_CK1_1	253	259	PF00069	0.457
MOD_CK1_1	278	284	PF00069	0.469
MOD_CK1_1	390	396	PF00069	0.371
MOD_CK1_1	536	542	PF00069	0.438
MOD_CK1_1	605	611	PF00069	0.490
MOD_CK1_1	75	81	PF00069	0.777
MOD_CK2_1	173	179	PF00069	0.759
MOD_CK2_1	20	26	PF00069	0.754
MOD_CK2_1	316	322	PF00069	0.680
MOD_CK2_1	324	330	PF00069	0.630
MOD_CK2_1	365	371	PF00069	0.696
MOD_CK2_1	627	633	PF00069	0.427
MOD_Cter_Amidation	195	198	PF01082	0.489
MOD_Cter_Amidation	669	672	PF01082	0.399
MOD_GlcNHglycan	118	121	PF01048	0.721
MOD_GlcNHglycan	194	197	PF01048	0.592
MOD_GlcNHglycan	236	239	PF01048	0.685
MOD_GlcNHglycan	291	294	PF01048	0.580
MOD_GlcNHglycan	318	321	PF01048	0.677
MOD_GlcNHglycan	338	341	PF01048	0.617
MOD_GlcNHglycan	378	381	PF01048	0.744
MOD_GlcNHglycan	45	49	PF01048	0.751
MOD_GlcNHglycan	607	610	PF01048	0.503
MOD_GlcNHglycan	623	626	PF01048	0.455
MOD_GlcNHglycan	74	77	PF01048	0.786
MOD_GSK3_1	109	116	PF00069	0.651
MOD_GSK3_1	121	128	PF00069	0.631
MOD_GSK3_1	242	249	PF00069	0.626
MOD_GSK3_1	280	287	PF00069	0.529
MOD_GSK3_1	324	331	PF00069	0.691
MOD_GSK3_1	383	390	PF00069	0.663
MOD_GSK3_1	399	406	PF00069	0.337
MOD_GSK3_1	44	51	PF00069	0.707
MOD_GSK3_1	469	476	PF00069	0.438
MOD_GSK3_1	532	539	PF00069	0.415
MOD_GSK3_1	554	561	PF00069	0.391
MOD_GSK3_1	612	619	PF00069	0.430
MOD_GSK3_1	66	73	PF00069	0.785
MOD_GSK3_1	671	678	PF00069	0.474
MOD_GSK3_1	82	89	PF00069	0.614
MOD_N-GLC_1	637	642	PF02516	0.492
MOD_N-GLC_2	41	43	PF02516	0.705
MOD_NEK2_1	1	6	PF00069	0.738
MOD_NEK2_1	108	113	PF00069	0.595
MOD_NEK2_1	242	247	PF00069	0.675
MOD_NEK2_1	469	474	PF00069	0.400
MOD_NEK2_1	479	484	PF00069	0.324
MOD_NEK2_2	415	420	PF00069	0.364
MOD_NEK2_2	95	100	PF00069	0.582
MOD_PIKK_1	580	586	PF00454	0.438
MOD_PIKK_1	66	72	PF00454	0.701
MOD_PIKK_1	75	81	PF00454	0.684
MOD_PK_1	642	648	PF00069	0.201
MOD_PKA_1	316	322	PF00069	0.680
MOD_PKA_1	662	668	PF00069	0.438
MOD_PKA_1	671	677	PF00069	0.526
MOD_PKA_2	129	135	PF00069	0.737
MOD_PKA_2	13	19	PF00069	0.660
MOD_PKA_2	289	295	PF00069	0.574
MOD_PKA_2	403	409	PF00069	0.321
MOD_PKA_2	441	447	PF00069	0.415
MOD_PKA_2	662	668	PF00069	0.438
MOD_PKA_2	671	677	PF00069	0.526
MOD_Plk_1	328	334	PF00069	0.663
MOD_Plk_1	44	50	PF00069	0.549
MOD_Plk_1	469	475	PF00069	0.438
MOD_Plk_4	167	173	PF00069	0.675
MOD_Plk_4	253	259	PF00069	0.442
MOD_Plk_4	275	281	PF00069	0.592
MOD_Plk_4	420	426	PF00069	0.387
MOD_Plk_4	469	475	PF00069	0.393
MOD_Plk_4	567	573	PF00069	0.438
MOD_ProDKin_1	111	117	PF00069	0.775
MOD_ProDKin_1	122	128	PF00069	0.725
MOD_ProDKin_1	152	158	PF00069	0.628
MOD_ProDKin_1	164	170	PF00069	0.687
MOD_ProDKin_1	173	179	PF00069	0.661
MOD_ProDKin_1	344	350	PF00069	0.581
MOD_ProDKin_1	48	54	PF00069	0.725
MOD_ProDKin_1	56	62	PF00069	0.789
MOD_ProDKin_1	82	88	PF00069	0.742
MOD_SUMO_for_1	304	307	PF00179	0.577
MOD_SUMO_for_1	500	503	PF00179	0.357
MOD_SUMO_for_1	548	551	PF00179	0.438
MOD_SUMO_rev_2	402	412	PF00179	0.492
TRG_DiLeu_BaLyEn_6	182	187	PF01217	0.644
TRG_ENDOCYTIC_2	254	257	PF00928	0.525
TRG_ENDOCYTIC_2	279	282	PF00928	0.572
TRG_ENDOCYTIC_2	323	326	PF00928	0.613
TRG_ENDOCYTIC_2	382	385	PF00928	0.781
TRG_ENDOCYTIC_2	433	436	PF00928	0.375
TRG_ENDOCYTIC_2	658	661	PF00928	0.438
TRG_ER_diArg_1	197	199	PF00400	0.514
TRG_ER_diArg_1	348	350	PF00400	0.658
TRG_ER_diArg_1	671	673	PF00400	0.346
TRG_Pf-PMV_PEXEL_1	137	142	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	671	675	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE38	Leptomonas seymouri	68%	100%
A0A0S4JLW5	Bodo saltans	36%	90%
A0A3S5H6X9	Leishmania donovani	91%	100%
A4H8L1	Leishmania braziliensis	76%	100%
A4HWY3	Leishmania infantum	91%	100%
C9ZW20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4QET2	Leishmania major	91%	100%