Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQP5_LEIMU

TriTrypDb:

LmxM.16.0860

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQP5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.489
CLV_NRD_NRD_1	294	296	PF00675	0.530
CLV_PCSK_KEX2_1	288	290	PF00082	0.578
CLV_PCSK_KEX2_1	294	296	PF00082	0.530
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.578
CLV_PCSK_SKI1_1	201	205	PF00082	0.586
DEG_SPOP_SBC_1	121	125	PF00917	0.734
DEG_SPOP_SBC_1	166	170	PF00917	0.527
DOC_CKS1_1	98	103	PF01111	0.552
DOC_MAPK_gen_1	294	300	PF00069	0.521
DOC_MAPK_MEF2A_6	175	183	PF00069	0.632
DOC_PP4_FxxP_1	252	255	PF00568	0.589
DOC_PP4_FxxP_1	32	35	PF00568	0.455
DOC_SPAK_OSR1_1	295	299	PF12202	0.527
DOC_USP7_MATH_1	144	148	PF00917	0.593
DOC_USP7_MATH_1	167	171	PF00917	0.646
DOC_USP7_MATH_1	191	195	PF00917	0.700
DOC_USP7_MATH_1	2	6	PF00917	0.511
DOC_USP7_MATH_1	278	282	PF00917	0.588
DOC_WW_Pin1_4	212	217	PF00397	0.779
DOC_WW_Pin1_4	251	256	PF00397	0.585
DOC_WW_Pin1_4	72	77	PF00397	0.529
DOC_WW_Pin1_4	97	102	PF00397	0.547
LIG_14-3-3_CanoR_1	180	184	PF00244	0.616
LIG_14-3-3_CanoR_1	55	61	PF00244	0.432
LIG_14-3-3_CanoR_1	82	86	PF00244	0.501
LIG_Actin_WH2_2	99	115	PF00022	0.572
LIG_BRCT_BRCA1_1	206	210	PF00533	0.615
LIG_BRCT_BRCA1_1	253	257	PF00533	0.590
LIG_BRCT_BRCA1_1	35	39	PF00533	0.511
LIG_BRCT_BRCA1_1	61	65	PF00533	0.427
LIG_EVH1_1	17	21	PF00568	0.453
LIG_FHA_1	200	206	PF00498	0.591
LIG_FHA_1	92	98	PF00498	0.576
LIG_FHA_2	242	248	PF00498	0.729
LIG_FHA_2	82	88	PF00498	0.495
LIG_LIR_Apic_2	249	255	PF02991	0.588
LIG_LIR_Apic_2	9	13	PF02991	0.500
LIG_LIR_Gen_1	100	108	PF02991	0.665
LIG_LIR_Gen_1	141	150	PF02991	0.620
LIG_LIR_Nem_3	100	106	PF02991	0.658
LIG_LIR_Nem_3	62	67	PF02991	0.436
LIG_MAD2	23	31	PF02301	0.461
LIG_MLH1_MIPbox_1	35	39	PF16413	0.511
LIG_MLH1_MIPbox_1	61	65	PF16413	0.427
LIG_PTB_Apo_2	96	103	PF02174	0.605
LIG_SH2_CRK	290	294	PF00017	0.620
LIG_SH2_PTP2	10	13	PF00017	0.451
LIG_SH2_SRC	85	88	PF00017	0.487
LIG_SH2_STAT5	10	13	PF00017	0.451
LIG_SH2_STAT5	51	54	PF00017	0.445
LIG_SH2_STAT5	60	63	PF00017	0.473
LIG_SH2_STAT5	64	67	PF00017	0.501
LIG_SH2_STAT5	85	88	PF00017	0.487
LIG_SH3_2	18	23	PF14604	0.456
LIG_SH3_3	15	21	PF00018	0.458
LIG_SH3_3	184	190	PF00018	0.659
LIG_SUMO_SIM_anti_2	266	273	PF11976	0.528
LIG_SUMO_SIM_par_1	201	207	PF11976	0.594
LIG_TRAF2_1	108	111	PF00917	0.685
MOD_CDC14_SPxK_1	79	82	PF00782	0.567
MOD_CDK_SPK_2	72	77	PF00069	0.497
MOD_CDK_SPxK_1	76	82	PF00069	0.562
MOD_CK1_1	123	129	PF00069	0.628
MOD_CK1_1	130	136	PF00069	0.584
MOD_CK1_1	212	218	PF00069	0.617
MOD_CK1_1	280	286	PF00069	0.500
MOD_CK1_1	75	81	PF00069	0.499
MOD_CK2_1	191	197	PF00069	0.680
MOD_CK2_1	241	247	PF00069	0.737
MOD_GlcNHglycan	118	121	PF01048	0.675
MOD_GlcNHglycan	126	129	PF01048	0.641
MOD_GlcNHglycan	211	214	PF01048	0.558
MOD_GlcNHglycan	260	263	PF01048	0.720
MOD_GlcNHglycan	280	283	PF01048	0.476
MOD_GlcNHglycan	40	43	PF01048	0.443
MOD_GlcNHglycan	61	64	PF01048	0.423
MOD_GSK3_1	116	123	PF00069	0.660
MOD_GSK3_1	127	134	PF00069	0.590
MOD_GSK3_1	161	168	PF00069	0.599
MOD_GSK3_1	204	211	PF00069	0.608
MOD_GSK3_1	218	225	PF00069	0.657
MOD_GSK3_1	235	242	PF00069	0.554
MOD_GSK3_1	273	280	PF00069	0.729
MOD_GSK3_1	33	40	PF00069	0.496
MOD_GSK3_1	72	79	PF00069	0.516
MOD_GSK3_1	81	88	PF00069	0.534
MOD_N-GLC_1	208	213	PF02516	0.627
MOD_NEK2_1	122	127	PF00069	0.649
MOD_NEK2_1	199	204	PF00069	0.611
MOD_NEK2_1	257	262	PF00069	0.662
MOD_NEK2_1	274	279	PF00069	0.648
MOD_NEK2_1	37	42	PF00069	0.505
MOD_PKA_2	179	185	PF00069	0.596
MOD_PKA_2	81	87	PF00069	0.500
MOD_Plk_1	246	252	PF00069	0.663
MOD_Plk_4	174	180	PF00069	0.622
MOD_Plk_4	265	271	PF00069	0.646
MOD_Plk_4	33	39	PF00069	0.514
MOD_Plk_4	81	87	PF00069	0.500
MOD_ProDKin_1	212	218	PF00069	0.779
MOD_ProDKin_1	251	257	PF00069	0.586
MOD_ProDKin_1	72	78	PF00069	0.530
MOD_ProDKin_1	97	103	PF00069	0.551
MOD_SUMO_rev_2	105	115	PF00179	0.542
MOD_SUMO_rev_2	153	162	PF00179	0.682
MOD_SUMO_rev_2	62	70	PF00179	0.446
TRG_ENDOCYTIC_2	64	67	PF00928	0.444
TRG_ER_diArg_1	293	295	PF00400	0.566
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5G6	Leptomonas seymouri	50%	100%
A0A3Q8IAC4	Leishmania donovani	88%	100%
A4H8L0	Leishmania braziliensis	72%	100%
A4HWY2	Leishmania infantum	88%	100%
Q4QET3	Leishmania major	85%	100%