Putative metallopeptidase (Metallo-peptidase, clan mp, family m67)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COP9 signalosome complex subunit 5, putative

Species:

Leishmania mexicana

UniProt:

E9AQP4_LEIMU

TriTrypDb:

LmxM.16.0850

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0008180	COP9 signalosome	3	7
GO:0032991	protein-containing complex	1	7
GO:0140513	nuclear protein-containing complex	2	7
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQP4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0019538	protein metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0000338	protein deneddylation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004175	endopeptidase activity	4	7
GO:0004222	metalloendopeptidase activity	5	7
GO:0005488	binding	1	7
GO:0008233	peptidase activity	3	7
GO:0008237	metallopeptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:0019783	ubiquitin-like protein peptidase activity	4	1
GO:0019784	deNEDDylase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.475
CLV_C14_Caspase3-7	372	376	PF00656	0.783
CLV_C14_Caspase3-7	461	465	PF00656	0.496
CLV_NRD_NRD_1	148	150	PF00675	0.379
CLV_NRD_NRD_1	348	350	PF00675	0.635
CLV_NRD_NRD_1	449	451	PF00675	0.625
CLV_NRD_NRD_1	54	56	PF00675	0.462
CLV_PCSK_KEX2_1	148	150	PF00082	0.379
CLV_PCSK_KEX2_1	348	350	PF00082	0.635
CLV_PCSK_KEX2_1	54	56	PF00082	0.462
CLV_PCSK_SKI1_1	78	82	PF00082	0.480
DOC_ANK_TNKS_1	210	217	PF00023	0.463
DOC_CKS1_1	20	25	PF01111	0.759
DOC_CKS1_1	42	47	PF01111	0.494
DOC_CYCLIN_yCln2_LP_2	301	307	PF00134	0.548
DOC_MAPK_gen_1	57	66	PF00069	0.470
DOC_MAPK_HePTP_8	289	301	PF00069	0.611
DOC_MAPK_MEF2A_6	269	277	PF00069	0.453
DOC_MAPK_MEF2A_6	292	301	PF00069	0.612
DOC_PP4_FxxP_1	119	122	PF00568	0.379
DOC_USP7_MATH_1	13	17	PF00917	0.673
DOC_USP7_MATH_1	226	230	PF00917	0.664
DOC_USP7_MATH_1	236	240	PF00917	0.649
DOC_USP7_MATH_1	243	247	PF00917	0.626
DOC_USP7_MATH_1	36	40	PF00917	0.479
DOC_USP7_MATH_1	88	92	PF00917	0.364
DOC_WW_Pin1_4	19	24	PF00397	0.700
DOC_WW_Pin1_4	352	357	PF00397	0.462
DOC_WW_Pin1_4	4	9	PF00397	0.732
DOC_WW_Pin1_4	41	46	PF00397	0.495
DOC_WW_Pin1_4	439	444	PF00397	0.604
LIG_14-3-3_CanoR_1	222	231	PF00244	0.659
LIG_14-3-3_CanoR_1	276	286	PF00244	0.471
LIG_AP2alpha_2	187	189	PF02296	0.448
LIG_BIR_II_1	1	5	PF00653	0.744
LIG_BRCT_BRCA1_1	299	303	PF00533	0.535
LIG_BRCT_BRCA1_1	455	459	PF00533	0.701
LIG_BRCT_BRCA1_1	62	66	PF00533	0.537
LIG_CtBP_PxDLS_1	296	300	PF00389	0.495
LIG_deltaCOP1_diTrp_1	40	47	PF00928	0.580
LIG_EH1_1	97	105	PF00400	0.379
LIG_FHA_1	353	359	PF00498	0.497
LIG_FHA_2	175	181	PF00498	0.289
LIG_FHA_2	210	216	PF00498	0.454
LIG_FHA_2	245	251	PF00498	0.671
LIG_FHA_2	382	388	PF00498	0.419
LIG_FHA_2	447	453	PF00498	0.555
LIG_HP1_1	188	192	PF01393	0.430
LIG_LIR_Apic_2	116	122	PF02991	0.379
LIG_LIR_Apic_2	249	255	PF02991	0.669
LIG_LIR_Apic_2	39	45	PF02991	0.416
LIG_LIR_Gen_1	187	197	PF02991	0.433
LIG_LIR_Gen_1	403	413	PF02991	0.701
LIG_LIR_Gen_1	44	53	PF02991	0.557
LIG_LIR_Gen_1	452	459	PF02991	0.696
LIG_LIR_Gen_1	63	74	PF02991	0.519
LIG_LIR_Nem_3	187	192	PF02991	0.436
LIG_LIR_Nem_3	403	408	PF02991	0.699
LIG_LIR_Nem_3	452	458	PF02991	0.695
LIG_LIR_Nem_3	63	69	PF02991	0.498
LIG_MAD2	423	431	PF02301	0.412
LIG_MLH1_MIPbox_1	62	66	PF16413	0.537
LIG_PCNA_PIPBox_1	101	110	PF02747	0.379
LIG_PDZ_Class_3	467	472	PF00595	0.674
LIG_Pex14_1	43	47	PF04695	0.581
LIG_Pex14_2	455	459	PF04695	0.701
LIG_Pex14_2	61	65	PF04695	0.478
LIG_SH2_CRK	252	256	PF00017	0.659
LIG_SH2_STAP1	167	171	PF00017	0.379
LIG_SH2_STAT5	143	146	PF00017	0.379
LIG_SH3_3	190	196	PF00018	0.424
LIG_SH3_3	2	8	PF00018	0.577
LIG_SH3_3	21	27	PF00018	0.463
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.274
LIG_SUMO_SIM_par_1	295	300	PF11976	0.499
LIG_SUMO_SIM_par_1	389	394	PF11976	0.678
LIG_TRAF2_1	177	180	PF00917	0.191
LIG_TRFH_1	252	256	PF08558	0.474
MOD_CDK_SPxxK_3	4	11	PF00069	0.682
MOD_CK1_1	246	252	PF00069	0.593
MOD_CK1_1	351	357	PF00069	0.566
MOD_CK1_1	4	10	PF00069	0.681
MOD_CK1_1	439	445	PF00069	0.773
MOD_CK1_1	454	460	PF00069	0.551
MOD_CK2_1	106	112	PF00069	0.348
MOD_CK2_1	123	129	PF00069	0.281
MOD_CK2_1	174	180	PF00069	0.191
MOD_CK2_1	209	215	PF00069	0.433
MOD_CK2_1	381	387	PF00069	0.423
MOD_CK2_1	446	452	PF00069	0.570
MOD_GlcNHglycan	1	4	PF01048	0.630
MOD_GlcNHglycan	171	174	PF01048	0.379
MOD_GlcNHglycan	224	227	PF01048	0.657
MOD_GlcNHglycan	228	231	PF01048	0.644
MOD_GlcNHglycan	239	242	PF01048	0.566
MOD_GlcNHglycan	24	27	PF01048	0.560
MOD_GlcNHglycan	279	282	PF01048	0.569
MOD_GlcNHglycan	315	318	PF01048	0.679
MOD_GlcNHglycan	323	326	PF01048	0.530
MOD_GlcNHglycan	360	363	PF01048	0.740
MOD_GlcNHglycan	371	374	PF01048	0.684
MOD_GlcNHglycan	375	379	PF01048	0.567
MOD_GlcNHglycan	460	463	PF01048	0.514
MOD_GSK3_1	113	120	PF00069	0.357
MOD_GSK3_1	165	172	PF00069	0.379
MOD_GSK3_1	175	182	PF00069	0.379
MOD_GSK3_1	18	25	PF00069	0.723
MOD_GSK3_1	199	206	PF00069	0.495
MOD_GSK3_1	220	227	PF00069	0.686
MOD_GSK3_1	237	244	PF00069	0.486
MOD_GSK3_1	295	302	PF00069	0.514
MOD_GSK3_1	344	351	PF00069	0.568
MOD_GSK3_1	453	460	PF00069	0.643
MOD_GSK3_1	65	72	PF00069	0.422
MOD_N-GLC_1	18	23	PF02516	0.512
MOD_N-GLC_1	241	246	PF02516	0.585
MOD_NEK2_1	1	6	PF00069	0.773
MOD_NEK2_1	115	120	PF00069	0.357
MOD_NEK2_1	297	302	PF00069	0.490
MOD_NEK2_1	305	310	PF00069	0.549
MOD_NEK2_1	31	36	PF00069	0.668
MOD_NEK2_1	358	363	PF00069	0.766
MOD_NEK2_1	458	463	PF00069	0.704
MOD_NEK2_1	65	70	PF00069	0.446
MOD_NEK2_1	73	78	PF00069	0.336
MOD_NEK2_1	81	86	PF00069	0.285
MOD_NEK2_2	165	170	PF00069	0.379
MOD_NEK2_2	203	208	PF00069	0.468
MOD_PIKK_1	13	19	PF00454	0.687
MOD_PIKK_1	133	139	PF00454	0.332
MOD_PIKK_1	175	181	PF00454	0.379
MOD_PIKK_1	88	94	PF00454	0.379
MOD_PK_1	348	354	PF00069	0.567
MOD_PKA_1	348	354	PF00069	0.567
MOD_PKA_2	348	354	PF00069	0.567
MOD_PKA_2	446	452	PF00069	0.588
MOD_PKB_1	222	230	PF00069	0.657
MOD_PKB_1	399	407	PF00069	0.591
MOD_Plk_1	128	134	PF00069	0.372
MOD_Plk_1	451	457	PF00069	0.756
MOD_Plk_2-3	381	387	PF00069	0.423
MOD_Plk_4	454	460	PF00069	0.700
MOD_Plk_4	60	66	PF00069	0.455
MOD_Plk_4	69	75	PF00069	0.379
MOD_ProDKin_1	19	25	PF00069	0.697
MOD_ProDKin_1	352	358	PF00069	0.464
MOD_ProDKin_1	4	10	PF00069	0.733
MOD_ProDKin_1	41	47	PF00069	0.498
MOD_ProDKin_1	439	445	PF00069	0.604
TRG_DiLeu_BaEn_1	403	408	PF01217	0.598
TRG_DiLeu_BaEn_1	99	104	PF01217	0.379
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.629
TRG_DiLeu_BaLyEn_6	386	391	PF01217	0.696
TRG_ENDOCYTIC_2	167	170	PF00928	0.379
TRG_ENDOCYTIC_2	270	273	PF00928	0.377
TRG_ER_diArg_1	148	150	PF00400	0.379
TRG_ER_diArg_1	398	401	PF00400	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD30	Leptomonas seymouri	56%	100%
A0A3Q8IAE8	Leishmania donovani	90%	96%
A4H8K9	Leishmania braziliensis	77%	100%
A4HWY1	Leishmania infantum	90%	100%
Q4P804	Ustilago maydis (strain 521 / FGSC 9021)	32%	100%
Q4QET4	Leishmania major	90%	100%