Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQP3_LEIMU

TriTrypDb:

LmxM.16.0840

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQP3

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018026	peptidyl-lysine monomethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	783	787	PF00656	0.616
CLV_C14_Caspase3-7	87	91	PF00656	0.551
CLV_NRD_NRD_1	130	132	PF00675	0.444
CLV_NRD_NRD_1	174	176	PF00675	0.642
CLV_NRD_NRD_1	295	297	PF00675	0.540
CLV_NRD_NRD_1	366	368	PF00675	0.538
CLV_NRD_NRD_1	454	456	PF00675	0.709
CLV_NRD_NRD_1	459	461	PF00675	0.697
CLV_NRD_NRD_1	532	534	PF00675	0.603
CLV_NRD_NRD_1	577	579	PF00675	0.669
CLV_NRD_NRD_1	62	64	PF00675	0.449
CLV_NRD_NRD_1	670	672	PF00675	0.589
CLV_PCSK_FUR_1	128	132	PF00082	0.448
CLV_PCSK_KEX2_1	130	132	PF00082	0.444
CLV_PCSK_KEX2_1	174	176	PF00082	0.701
CLV_PCSK_KEX2_1	295	297	PF00082	0.603
CLV_PCSK_KEX2_1	366	368	PF00082	0.519
CLV_PCSK_KEX2_1	459	461	PF00082	0.686
CLV_PCSK_KEX2_1	577	579	PF00082	0.536
CLV_PCSK_KEX2_1	670	672	PF00082	0.589
CLV_PCSK_PC7_1	126	132	PF00082	0.446
CLV_PCSK_PC7_1	455	461	PF00082	0.538
CLV_PCSK_SKI1_1	311	315	PF00082	0.508
CLV_PCSK_SKI1_1	560	564	PF00082	0.501
DEG_APCC_DBOX_1	559	567	PF00400	0.551
DEG_SCF_FBW7_1	626	633	PF00400	0.578
DOC_CDC14_PxL_1	520	528	PF14671	0.574
DOC_CKS1_1	711	716	PF01111	0.630
DOC_CYCLIN_RxL_1	775	786	PF00134	0.479
DOC_MAPK_FxFP_2	390	393	PF00069	0.492
DOC_MAPK_gen_1	467	475	PF00069	0.670
DOC_MAPK_gen_1	533	540	PF00069	0.701
DOC_MAPK_MEF2A_6	554	563	PF00069	0.395
DOC_PP1_RVXF_1	729	736	PF00149	0.352
DOC_PP2B_LxvP_1	521	524	PF13499	0.599
DOC_PP4_FxxP_1	234	237	PF00568	0.396
DOC_PP4_FxxP_1	390	393	PF00568	0.510
DOC_PP4_FxxP_1	711	714	PF00568	0.580
DOC_USP7_MATH_1	112	116	PF00917	0.578
DOC_USP7_MATH_1	146	150	PF00917	0.417
DOC_USP7_MATH_1	282	286	PF00917	0.619
DOC_USP7_MATH_1	29	33	PF00917	0.469
DOC_USP7_MATH_1	409	413	PF00917	0.425
DOC_USP7_MATH_1	435	439	PF00917	0.516
DOC_USP7_MATH_1	548	552	PF00917	0.593
DOC_USP7_MATH_1	55	59	PF00917	0.382
DOC_USP7_MATH_1	589	593	PF00917	0.556
DOC_USP7_MATH_1	706	710	PF00917	0.447
DOC_USP7_MATH_1	781	785	PF00917	0.538
DOC_USP7_MATH_1	84	88	PF00917	0.694
DOC_WW_Pin1_4	266	271	PF00397	0.703
DOC_WW_Pin1_4	353	358	PF00397	0.702
DOC_WW_Pin1_4	613	618	PF00397	0.484
DOC_WW_Pin1_4	626	631	PF00397	0.520
DOC_WW_Pin1_4	642	647	PF00397	0.426
DOC_WW_Pin1_4	697	702	PF00397	0.435
DOC_WW_Pin1_4	710	715	PF00397	0.460
DOC_WW_Pin1_4	719	724	PF00397	0.421
LIG_14-3-3_CanoR_1	116	125	PF00244	0.622
LIG_14-3-3_CanoR_1	166	173	PF00244	0.457
LIG_14-3-3_CanoR_1	277	284	PF00244	0.529
LIG_14-3-3_CanoR_1	289	295	PF00244	0.676
LIG_14-3-3_CanoR_1	296	302	PF00244	0.410
LIG_14-3-3_CanoR_1	57	67	PF00244	0.357
LIG_14-3-3_CanoR_1	679	688	PF00244	0.385
LIG_14-3-3_CanoR_1	718	722	PF00244	0.568
LIG_14-3-3_CanoR_1	767	772	PF00244	0.553
LIG_Actin_WH2_2	120	135	PF00022	0.468
LIG_Actin_WH2_2	160	176	PF00022	0.459
LIG_Actin_WH2_2	502	519	PF00022	0.548
LIG_Actin_WH2_2	690	706	PF00022	0.457
LIG_AP2alpha_1	402	406	PF02296	0.474
LIG_APCC_ABBA_1	399	404	PF00400	0.465
LIG_BIR_II_1	1	5	PF00653	0.645
LIG_BIR_III_4	547	551	PF00653	0.596
LIG_BRCT_BRCA1_1	355	359	PF00533	0.457
LIG_BRCT_BRCA1_1	386	390	PF00533	0.384
LIG_CaM_NSCaTE_8	634	641	PF13499	0.522
LIG_CSL_BTD_1	711	714	PF09270	0.580
LIG_deltaCOP1_diTrp_1	212	219	PF00928	0.400
LIG_deltaCOP1_diTrp_1	394	402	PF00928	0.349
LIG_deltaCOP1_diTrp_1	666	672	PF00928	0.514
LIG_deltaCOP1_diTrp_1	675	680	PF00928	0.544
LIG_deltaCOP1_diTrp_1	772	779	PF00928	0.538
LIG_eIF4E_1	503	509	PF01652	0.401
LIG_FHA_1	103	109	PF00498	0.586
LIG_FHA_1	148	154	PF00498	0.425
LIG_FHA_1	345	351	PF00498	0.526
LIG_FHA_1	428	434	PF00498	0.609
LIG_FHA_1	463	469	PF00498	0.566
LIG_FHA_1	491	497	PF00498	0.388
LIG_FHA_1	535	541	PF00498	0.751
LIG_FHA_1	568	574	PF00498	0.487
LIG_FHA_1	643	649	PF00498	0.546
LIG_FHA_1	741	747	PF00498	0.364
LIG_FHA_1	751	757	PF00498	0.652
LIG_FHA_1	766	772	PF00498	0.570
LIG_FHA_2	247	253	PF00498	0.731
LIG_FHA_2	631	637	PF00498	0.625
LIG_LIR_Apic_2	232	237	PF02991	0.465
LIG_LIR_Apic_2	279	284	PF02991	0.456
LIG_LIR_Apic_2	387	393	PF02991	0.499
LIG_LIR_Apic_2	709	714	PF02991	0.584
LIG_LIR_Gen_1	290	299	PF02991	0.583
LIG_LIR_Gen_1	394	405	PF02991	0.349
LIG_LIR_Gen_1	480	491	PF02991	0.494
LIG_LIR_Gen_1	674	685	PF02991	0.319
LIG_LIR_Gen_1	737	746	PF02991	0.440
LIG_LIR_Gen_1	772	782	PF02991	0.530
LIG_LIR_LC3C_4	725	730	PF02991	0.453
LIG_LIR_Nem_3	290	294	PF02991	0.591
LIG_LIR_Nem_3	404	408	PF02991	0.398
LIG_LIR_Nem_3	480	486	PF02991	0.484
LIG_LIR_Nem_3	674	680	PF02991	0.576
LIG_LIR_Nem_3	683	688	PF02991	0.545
LIG_LIR_Nem_3	772	777	PF02991	0.486
LIG_LIR_Nem_3	790	795	PF02991	0.539
LIG_MYND_1	518	522	PF01753	0.502
LIG_MYND_1	539	543	PF01753	0.585
LIG_NRBOX	634	640	PF00104	0.488
LIG_NRBOX	9	15	PF00104	0.397
LIG_PCNA_PIPBox_1	773	782	PF02747	0.525
LIG_PCNA_yPIPBox_3	767	780	PF02747	0.553
LIG_Pex14_1	287	291	PF04695	0.604
LIG_Pex14_1	735	739	PF04695	0.406
LIG_Pex14_2	378	382	PF04695	0.449
LIG_Pex14_2	402	406	PF04695	0.429
LIG_RPA_C_Fungi	291	303	PF08784	0.415
LIG_SH2_CRK	164	168	PF00017	0.391
LIG_SH2_CRK	227	231	PF00017	0.416
LIG_SH2_CRK	281	285	PF00017	0.413
LIG_SH2_CRK	611	615	PF00017	0.591
LIG_SH2_GRB2like	227	230	PF00017	0.435
LIG_SH2_GRB2like	405	408	PF00017	0.348
LIG_SH2_GRB2like	739	742	PF00017	0.530
LIG_SH2_NCK_1	281	285	PF00017	0.413
LIG_SH2_NCK_1	503	507	PF00017	0.541
LIG_SH2_PTP2	156	159	PF00017	0.378
LIG_SH2_PTP2	291	294	PF00017	0.587
LIG_SH2_STAP1	227	231	PF00017	0.431
LIG_SH2_STAP1	481	485	PF00017	0.407
LIG_SH2_STAT3	481	484	PF00017	0.464
LIG_SH2_STAT5	156	159	PF00017	0.343
LIG_SH2_STAT5	209	212	PF00017	0.539
LIG_SH2_STAT5	291	294	PF00017	0.556
LIG_SH2_STAT5	391	394	PF00017	0.499
LIG_SH2_STAT5	405	408	PF00017	0.284
LIG_SH2_STAT5	544	547	PF00017	0.474
LIG_SH2_STAT5	611	614	PF00017	0.378
LIG_SH2_STAT5	739	742	PF00017	0.524
LIG_SH2_STAT5	792	795	PF00017	0.473
LIG_SH3_1	611	617	PF00018	0.602
LIG_SH3_3	267	273	PF00018	0.694
LIG_SH3_3	420	426	PF00018	0.590
LIG_SH3_3	536	542	PF00018	0.703
LIG_SH3_3	611	617	PF00018	0.581
LIG_SH3_3	645	651	PF00018	0.470
LIG_SH3_5	401	405	PF00018	0.344
LIG_SUMO_SIM_anti_2	504	510	PF11976	0.470
LIG_SUMO_SIM_anti_2	724	731	PF11976	0.514
LIG_TRAF2_1	183	186	PF00917	0.651
LIG_TRAF2_1	307	310	PF00917	0.284
LIG_TRAF2_1	594	597	PF00917	0.616
LIG_TRAF2_1	722	725	PF00917	0.560
LIG_TRAF2_1	788	791	PF00917	0.497
LIG_TRAF2_2	582	587	PF00917	0.406
LIG_TRFH_1	514	518	PF08558	0.458
LIG_TYR_ITIM	154	159	PF00017	0.341
LIG_Vh1_VBS_1	552	570	PF01044	0.525
MOD_CDK_SPxxK_3	697	704	PF00069	0.450
MOD_CDK_SPxxK_3	719	726	PF00069	0.348
MOD_CK1_1	149	155	PF00069	0.425
MOD_CK1_1	2	8	PF00069	0.592
MOD_CK1_1	259	265	PF00069	0.721
MOD_CK1_1	290	296	PF00069	0.677
MOD_CK1_1	352	358	PF00069	0.735
MOD_CK1_1	412	418	PF00069	0.414
MOD_CK1_1	568	574	PF00069	0.535
MOD_CK1_1	58	64	PF00069	0.329
MOD_CK1_1	710	716	PF00069	0.526
MOD_CK2_1	116	122	PF00069	0.626
MOD_CK2_1	246	252	PF00069	0.660
MOD_CK2_1	501	507	PF00069	0.403
MOD_CK2_1	654	660	PF00069	0.601
MOD_CK2_1	719	725	PF00069	0.540
MOD_CK2_1	794	800	PF00069	0.585
MOD_Cter_Amidation	531	534	PF01082	0.603
MOD_GlcNHglycan	1	4	PF01048	0.684
MOD_GlcNHglycan	175	178	PF01048	0.670
MOD_GlcNHglycan	184	190	PF01048	0.681
MOD_GlcNHglycan	22	25	PF01048	0.477
MOD_GlcNHglycan	261	264	PF01048	0.762
MOD_GlcNHglycan	284	287	PF01048	0.473
MOD_GlcNHglycan	567	570	PF01048	0.552
MOD_GlcNHglycan	639	642	PF01048	0.459
MOD_GlcNHglycan	682	685	PF01048	0.515
MOD_GSK3_1	112	119	PF00069	0.543
MOD_GSK3_1	185	192	PF00069	0.719
MOD_GSK3_1	203	210	PF00069	0.494
MOD_GSK3_1	252	259	PF00069	0.656
MOD_GSK3_1	349	356	PF00069	0.721
MOD_GSK3_1	458	465	PF00069	0.699
MOD_GSK3_1	486	493	PF00069	0.552
MOD_GSK3_1	512	519	PF00069	0.516
MOD_GSK3_1	561	568	PF00069	0.516
MOD_GSK3_1	626	633	PF00069	0.560
MOD_GSK3_1	671	678	PF00069	0.375
MOD_GSK3_1	706	713	PF00069	0.475
MOD_GSK3_1	752	759	PF00069	0.627
MOD_N-GLC_1	263	268	PF02516	0.623
MOD_N-GLC_1	412	417	PF02516	0.397
MOD_N-GLC_1	686	691	PF02516	0.512
MOD_N-GLC_1	740	745	PF02516	0.497
MOD_N-GLC_1	95	100	PF02516	0.604
MOD_NEK2_1	132	137	PF00069	0.404
MOD_NEK2_1	173	178	PF00069	0.711
MOD_NEK2_1	297	302	PF00069	0.547
MOD_NEK2_1	561	566	PF00069	0.647
MOD_NEK2_1	680	685	PF00069	0.541
MOD_NEK2_1	751	756	PF00069	0.747
MOD_NEK2_1	765	770	PF00069	0.530
MOD_NEK2_2	315	320	PF00069	0.242
MOD_NEK2_2	349	354	PF00069	0.468
MOD_NEK2_2	512	517	PF00069	0.547
MOD_PIKK_1	165	171	PF00454	0.406
MOD_PIKK_1	357	363	PF00454	0.645
MOD_PIKK_1	561	567	PF00454	0.520
MOD_PK_1	256	262	PF00069	0.622
MOD_PK_1	441	447	PF00069	0.446
MOD_PK_1	767	773	PF00069	0.549
MOD_PKA_2	132	138	PF00069	0.279
MOD_PKA_2	165	171	PF00069	0.462
MOD_PKA_2	173	179	PF00069	0.571
MOD_PKA_2	276	282	PF00069	0.754
MOD_PKA_2	458	464	PF00069	0.588
MOD_PKA_2	516	522	PF00069	0.579
MOD_PKA_2	675	681	PF00069	0.359
MOD_PKA_2	717	723	PF00069	0.580
MOD_PKB_1	439	447	PF00069	0.443
MOD_Plk_1	393	399	PF00069	0.457
MOD_Plk_2-3	654	660	PF00069	0.504
MOD_Plk_2-3	794	800	PF00069	0.538
MOD_Plk_4	149	155	PF00069	0.307
MOD_Plk_4	256	262	PF00069	0.646
MOD_Plk_4	381	387	PF00069	0.317
MOD_Plk_4	412	418	PF00069	0.555
MOD_Plk_4	516	522	PF00069	0.530
MOD_Plk_4	548	554	PF00069	0.728
MOD_Plk_4	599	605	PF00069	0.586
MOD_Plk_4	630	636	PF00069	0.473
MOD_Plk_4	707	713	PF00069	0.451
MOD_ProDKin_1	266	272	PF00069	0.702
MOD_ProDKin_1	353	359	PF00069	0.703
MOD_ProDKin_1	613	619	PF00069	0.479
MOD_ProDKin_1	626	632	PF00069	0.510
MOD_ProDKin_1	642	648	PF00069	0.425
MOD_ProDKin_1	697	703	PF00069	0.430
MOD_ProDKin_1	710	716	PF00069	0.468
MOD_ProDKin_1	719	725	PF00069	0.415
MOD_SUMO_for_1	138	141	PF00179	0.511
MOD_SUMO_rev_2	616	626	PF00179	0.542
TRG_DiLeu_BaEn_1	724	729	PF01217	0.472
TRG_DiLeu_BaEn_3	394	400	PF01217	0.291
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.750
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.436
TRG_DiLeu_BaLyEn_6	723	728	PF01217	0.485
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.433
TRG_ENDOCYTIC_2	156	159	PF00928	0.343
TRG_ENDOCYTIC_2	164	167	PF00928	0.387
TRG_ENDOCYTIC_2	227	230	PF00928	0.426
TRG_ENDOCYTIC_2	291	294	PF00928	0.499
TRG_ENDOCYTIC_2	503	506	PF00928	0.416
TRG_ENDOCYTIC_2	739	742	PF00928	0.605
TRG_ER_diArg_1	125	128	PF00400	0.450
TRG_ER_diArg_1	130	133	PF00400	0.408
TRG_ER_diArg_1	173	175	PF00400	0.630
TRG_ER_diArg_1	294	296	PF00400	0.592
TRG_ER_diArg_1	439	442	PF00400	0.626
TRG_ER_diArg_1	576	578	PF00400	0.529
TRG_ER_diArg_1	669	671	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	778	783	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I059	Leptomonas seymouri	50%	99%
A0A1X0NQD9	Trypanosomatidae	27%	100%
A0A3R7NAY7	Trypanosoma rangeli	29%	100%
A0A3S7WTX8	Leishmania donovani	88%	100%
A4H8K8	Leishmania braziliensis	74%	98%
C9ZPM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AGN5	Leishmania infantum	88%	100%
Q4QET5	Leishmania major	88%	100%
V5BLP9	Trypanosoma cruzi	28%	100%