Fe-S_biosyn domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Iron-sulfur assembly protein 1, putative

Species:

Leishmania mexicana

UniProt:

E9AQP2_LEIMU

TriTrypDb:

LmxM.16.0830

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQP2

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0016226	iron-sulfur cluster assembly	4	11
GO:0022607	cellular component assembly	4	11
GO:0031163	metallo-sulfur cluster assembly	5	11
GO:0044237	cellular metabolic process	2	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051540	metal cluster binding	2	11
GO:0051537	2 iron, 2 sulfur cluster binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	91	95	PF00656	0.584
CLV_NRD_NRD_1	152	154	PF00675	0.451
CLV_NRD_NRD_1	17	19	PF00675	0.534
CLV_NRD_NRD_1	192	194	PF00675	0.269
CLV_NRD_NRD_1	219	221	PF00675	0.295
CLV_PCSK_KEX2_1	133	135	PF00082	0.457
CLV_PCSK_KEX2_1	152	154	PF00082	0.351
CLV_PCSK_KEX2_1	17	19	PF00082	0.671
CLV_PCSK_KEX2_1	191	193	PF00082	0.246
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.569
CLV_PCSK_PC7_1	187	193	PF00082	0.257
CLV_PCSK_SKI1_1	141	145	PF00082	0.429
CLV_PCSK_SKI1_1	152	156	PF00082	0.420
CLV_PCSK_SKI1_1	17	21	PF00082	0.570
DEG_COP1_1	175	186	PF00400	0.418
DEG_Nend_UBRbox_3	1	3	PF02207	0.518
DEG_SCF_TRCP1_1	43	49	PF00400	0.539
DEG_SPOP_SBC_1	28	32	PF00917	0.700
DOC_CKS1_1	145	150	PF01111	0.498
DOC_CYCLIN_RxL_1	14	23	PF00134	0.566
DOC_MAPK_RevD_3	4	18	PF00069	0.414
DOC_PP1_RVXF_1	132	139	PF00149	0.508
DOC_PP4_FxxP_1	266	269	PF00568	0.444
DOC_USP7_MATH_1	112	116	PF00917	0.689
DOC_USP7_MATH_1	173	177	PF00917	0.537
DOC_USP7_MATH_1	209	213	PF00917	0.553
DOC_USP7_MATH_1	216	220	PF00917	0.538
DOC_USP7_MATH_1	28	32	PF00917	0.697
DOC_USP7_MATH_1	46	50	PF00917	0.696
DOC_USP7_MATH_1	95	99	PF00917	0.736
DOC_USP7_UBL2_3	263	267	PF12436	0.501
DOC_USP7_UBL2_3	63	67	PF12436	0.599
DOC_WW_Pin1_4	126	131	PF00397	0.485
DOC_WW_Pin1_4	144	149	PF00397	0.375
DOC_WW_Pin1_4	214	219	PF00397	0.538
DOC_WW_Pin1_4	69	74	PF00397	0.721
LIG_14-3-3_CanoR_1	113	123	PF00244	0.586
LIG_BIR_III_2	119	123	PF00653	0.638
LIG_CaM_IQ_9	55	71	PF13499	0.439
LIG_FHA_1	1	7	PF00498	0.551
LIG_FHA_1	36	42	PF00498	0.642
LIG_FHA_1	56	62	PF00498	0.593
LIG_FHA_1	69	75	PF00498	0.497
LIG_FHA_2	249	255	PF00498	0.444
LIG_FHA_2	256	262	PF00498	0.529
LIG_LIR_Apic_2	265	269	PF02991	0.444
LIG_LIR_Apic_2	77	81	PF02991	0.610
LIG_LIR_Nem_3	243	249	PF02991	0.518
LIG_LIR_Nem_3	279	284	PF02991	0.397
LIG_SH2_SRC	247	250	PF00017	0.444
LIG_SH2_STAP1	198	202	PF00017	0.444
LIG_SH2_STAT5	156	159	PF00017	0.354
LIG_SH2_STAT5	200	203	PF00017	0.444
LIG_SH2_STAT5	247	250	PF00017	0.462
LIG_SH2_STAT5	255	258	PF00017	0.444
LIG_SH3_3	142	148	PF00018	0.501
LIG_SxIP_EBH_1	67	79	PF03271	0.596
LIG_TRFH_1	144	148	PF08558	0.355
LIG_WRC_WIRS_1	1	6	PF05994	0.411
LIG_WRC_WIRS_1	62	67	PF05994	0.510
MOD_CDK_SPxK_1	214	220	PF00069	0.520
MOD_CDK_SPxxK_3	126	133	PF00069	0.468
MOD_CDK_SPxxK_3	214	221	PF00069	0.501
MOD_CDK_SPxxK_3	69	76	PF00069	0.640
MOD_CK1_1	114	120	PF00069	0.585
MOD_CK1_1	176	182	PF00069	0.522
MOD_CK1_1	196	202	PF00069	0.417
MOD_CK1_1	39	45	PF00069	0.774
MOD_CK1_1	49	55	PF00069	0.654
MOD_CK2_1	112	118	PF00069	0.545
MOD_CK2_1	255	261	PF00069	0.540
MOD_CK2_1	74	80	PF00069	0.657
MOD_GlcNHglycan	165	168	PF01048	0.550
MOD_GlcNHglycan	183	186	PF01048	0.204
MOD_GlcNHglycan	195	198	PF01048	0.230
MOD_GlcNHglycan	207	210	PF01048	0.259
MOD_GlcNHglycan	211	214	PF01048	0.269
MOD_GlcNHglycan	43	46	PF01048	0.696
MOD_GlcNHglycan	97	100	PF01048	0.605
MOD_GSK3_1	172	179	PF00069	0.423
MOD_GSK3_1	205	212	PF00069	0.550
MOD_GSK3_1	35	42	PF00069	0.707
MOD_GSK3_1	51	58	PF00069	0.549
MOD_N-GLC_1	36	41	PF02516	0.749
MOD_NEK2_1	19	24	PF00069	0.578
MOD_NEK2_1	41	46	PF00069	0.461
MOD_NEK2_1	51	56	PF00069	0.668
MOD_NEK2_1	61	66	PF00069	0.675
MOD_PIKK_1	55	61	PF00454	0.614
MOD_PKA_2	112	118	PF00069	0.593
MOD_PKA_2	39	45	PF00069	0.694
MOD_PKA_2	68	74	PF00069	0.673
MOD_PKB_1	191	199	PF00069	0.457
MOD_Plk_1	36	42	PF00069	0.476
MOD_Plk_4	277	283	PF00069	0.529
MOD_Plk_4	51	57	PF00069	0.518
MOD_ProDKin_1	126	132	PF00069	0.481
MOD_ProDKin_1	144	150	PF00069	0.368
MOD_ProDKin_1	214	220	PF00069	0.538
MOD_ProDKin_1	69	75	PF00069	0.724
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.482
TRG_ENDOCYTIC_2	62	65	PF00928	0.685
TRG_ER_diArg_1	151	153	PF00400	0.352
TRG_ER_diArg_1	17	19	PF00400	0.534
TRG_ER_diArg_1	190	193	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6U6	Leptomonas seymouri	68%	100%
A0A1X0NZ22	Trypanosomatidae	58%	100%
A0A3Q8IAJ0	Leishmania donovani	88%	100%
A0A422NDJ9	Trypanosoma rangeli	51%	100%
A4H8K7	Leishmania braziliensis	78%	100%
A4HWY0	Leishmania infantum	89%	100%
C9ZW24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
Q4QET6	Leishmania major	85%	100%
V5BHL1	Trypanosoma cruzi	49%	91%