Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQP1_LEIMU

TriTrypDb:

LmxM.16.0820

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQP1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	315	319	PF00656	0.746
CLV_NRD_NRD_1	142	144	PF00675	0.648
CLV_NRD_NRD_1	223	225	PF00675	0.682
CLV_NRD_NRD_1	306	308	PF00675	0.623
CLV_NRD_NRD_1	346	348	PF00675	0.741
CLV_NRD_NRD_1	357	359	PF00675	0.615
CLV_NRD_NRD_1	422	424	PF00675	0.797
CLV_NRD_NRD_1	441	443	PF00675	0.744
CLV_NRD_NRD_1	621	623	PF00675	0.543
CLV_NRD_NRD_1	88	90	PF00675	0.699
CLV_PCSK_FUR_1	344	348	PF00082	0.744
CLV_PCSK_FUR_1	355	359	PF00082	0.614
CLV_PCSK_KEX2_1	110	112	PF00082	0.465
CLV_PCSK_KEX2_1	142	144	PF00082	0.648
CLV_PCSK_KEX2_1	223	225	PF00082	0.689
CLV_PCSK_KEX2_1	306	308	PF00082	0.623
CLV_PCSK_KEX2_1	344	346	PF00082	0.734
CLV_PCSK_KEX2_1	357	359	PF00082	0.601
CLV_PCSK_KEX2_1	441	443	PF00082	0.754
CLV_PCSK_KEX2_1	621	623	PF00082	0.543
CLV_PCSK_KEX2_1	693	695	PF00082	0.674
CLV_PCSK_KEX2_1	697	699	PF00082	0.724
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.521
CLV_PCSK_PC1ET2_1	693	695	PF00082	0.529
CLV_PCSK_PC1ET2_1	697	699	PF00082	0.537
CLV_PCSK_PC7_1	617	623	PF00082	0.509
CLV_PCSK_SKI1_1	485	489	PF00082	0.546
CLV_PCSK_SKI1_1	68	72	PF00082	0.593
CLV_PCSK_SKI1_1	694	698	PF00082	0.541
DEG_APCC_DBOX_1	119	127	PF00400	0.489
DEG_SPOP_SBC_1	254	258	PF00917	0.579
DEG_SPOP_SBC_1	415	419	PF00917	0.626
DOC_ANK_TNKS_1	306	313	PF00023	0.618
DOC_CKS1_1	403	408	PF01111	0.726
DOC_MAPK_gen_1	110	117	PF00069	0.507
DOC_MAPK_MEF2A_6	110	117	PF00069	0.507
DOC_MAPK_MEF2A_6	43	51	PF00069	0.459
DOC_MAPK_RevD_3	410	424	PF00069	0.525
DOC_PP1_RVXF_1	288	294	PF00149	0.699
DOC_PP1_RVXF_1	558	564	PF00149	0.531
DOC_PP1_RVXF_1	88	95	PF00149	0.434
DOC_PP2B_LxvP_1	631	634	PF13499	0.788
DOC_USP7_MATH_1	164	168	PF00917	0.689
DOC_USP7_MATH_1	238	242	PF00917	0.754
DOC_USP7_MATH_1	254	258	PF00917	0.518
DOC_USP7_MATH_1	329	333	PF00917	0.758
DOC_USP7_MATH_1	401	405	PF00917	0.524
DOC_USP7_MATH_1	437	441	PF00917	0.724
DOC_USP7_MATH_1	537	541	PF00917	0.731
DOC_USP7_UBL2_3	693	697	PF12436	0.444
DOC_WW_Pin1_4	166	171	PF00397	0.662
DOC_WW_Pin1_4	215	220	PF00397	0.457
DOC_WW_Pin1_4	236	241	PF00397	0.626
DOC_WW_Pin1_4	31	36	PF00397	0.451
DOC_WW_Pin1_4	318	323	PF00397	0.735
DOC_WW_Pin1_4	346	351	PF00397	0.777
DOC_WW_Pin1_4	360	365	PF00397	0.625
DOC_WW_Pin1_4	376	381	PF00397	0.744
DOC_WW_Pin1_4	391	396	PF00397	0.805
DOC_WW_Pin1_4	397	402	PF00397	0.726
DOC_WW_Pin1_4	435	440	PF00397	0.830
DOC_WW_Pin1_4	520	525	PF00397	0.386
DOC_WW_Pin1_4	610	615	PF00397	0.581
DOC_WW_Pin1_4	621	626	PF00397	0.742
LIG_14-3-3_CanoR_1	194	202	PF00244	0.614
LIG_14-3-3_CanoR_1	231	240	PF00244	0.752
LIG_14-3-3_CanoR_1	262	266	PF00244	0.528
LIG_14-3-3_CanoR_1	357	363	PF00244	0.607
LIG_14-3-3_CanoR_1	414	421	PF00244	0.742
LIG_14-3-3_CanoR_1	441	447	PF00244	0.698
LIG_14-3-3_CanoR_1	533	537	PF00244	0.651
LIG_14-3-3_CanoR_1	560	566	PF00244	0.528
LIG_14-3-3_CanoR_1	652	661	PF00244	0.696
LIG_14-3-3_CanoR_1	714	723	PF00244	0.656
LIG_14-3-3_CanoR_1	89	93	PF00244	0.442
LIG_Actin_WH2_2	596	611	PF00022	0.495
LIG_APCC_ABBA_1	492	497	PF00400	0.625
LIG_BIR_II_1	1	5	PF00653	0.455
LIG_BIR_III_2	172	176	PF00653	0.708
LIG_BRCT_BRCA1_1	240	244	PF00533	0.801
LIG_BRCT_BRCA1_1	348	352	PF00533	0.700
LIG_BRCT_BRCA1_1	393	397	PF00533	0.731
LIG_BRCT_BRCA1_1	94	98	PF00533	0.519
LIG_Clathr_ClatBox_1	493	497	PF01394	0.527
LIG_deltaCOP1_diTrp_1	584	588	PF00928	0.567
LIG_EH1_1	183	191	PF00400	0.588
LIG_eIF4E_1	184	190	PF01652	0.582
LIG_FHA_1	398	404	PF00498	0.565
LIG_FHA_1	552	558	PF00498	0.496
LIG_FHA_1	627	633	PF00498	0.795
LIG_FHA_1	97	103	PF00498	0.265
LIG_FHA_2	126	132	PF00498	0.453
LIG_FHA_2	167	173	PF00498	0.507
LIG_FHA_2	272	278	PF00498	0.543
LIG_FHA_2	420	426	PF00498	0.800
LIG_FHA_2	547	553	PF00498	0.518
LIG_FHA_2	562	568	PF00498	0.430
LIG_FHA_2	676	682	PF00498	0.622
LIG_Integrin_RGD_1	275	277	PF01839	0.546
LIG_LIR_Gen_1	451	460	PF02991	0.556
LIG_LIR_Gen_1	462	469	PF02991	0.496
LIG_LIR_Gen_1	535	542	PF02991	0.751
LIG_LIR_Gen_1	564	572	PF02991	0.489
LIG_LIR_Gen_1	584	593	PF02991	0.239
LIG_LIR_Gen_1	659	665	PF02991	0.690
LIG_LIR_Gen_1	91	102	PF02991	0.337
LIG_LIR_Nem_3	196	202	PF02991	0.451
LIG_LIR_Nem_3	373	378	PF02991	0.812
LIG_LIR_Nem_3	451	457	PF02991	0.569
LIG_LIR_Nem_3	462	467	PF02991	0.640
LIG_LIR_Nem_3	513	517	PF02991	0.504
LIG_LIR_Nem_3	564	568	PF02991	0.493
LIG_LIR_Nem_3	584	588	PF02991	0.236
LIG_LIR_Nem_3	61	66	PF02991	0.446
LIG_LIR_Nem_3	659	664	PF02991	0.758
LIG_MYND_1	630	634	PF01753	0.712
LIG_Pex14_1	199	203	PF04695	0.511
LIG_Pex14_2	94	98	PF04695	0.519
LIG_Rb_pABgroove_1	484	492	PF01858	0.480
LIG_RPA_C_Fungi	295	307	PF08784	0.507
LIG_SH2_CRK	454	458	PF00017	0.590
LIG_SH2_GRB2like	191	194	PF00017	0.507
LIG_SH2_PTP2	508	511	PF00017	0.600
LIG_SH2_STAP1	52	56	PF00017	0.459
LIG_SH2_STAT5	184	187	PF00017	0.481
LIG_SH2_STAT5	191	194	PF00017	0.492
LIG_SH2_STAT5	215	218	PF00017	0.474
LIG_SH2_STAT5	454	457	PF00017	0.666
LIG_SH2_STAT5	508	511	PF00017	0.498
LIG_SH2_STAT5	515	518	PF00017	0.488
LIG_SH2_STAT5	69	72	PF00017	0.500
LIG_SH3_3	112	118	PF00018	0.469
LIG_SH3_3	400	406	PF00018	0.763
LIG_SH3_3	518	524	PF00018	0.408
LIG_SUMO_SIM_anti_2	484	491	PF11976	0.384
MOD_CDC14_SPxK_1	438	441	PF00782	0.830
MOD_CDK_SPxK_1	435	441	PF00069	0.831
MOD_CDK_SPxxK_3	435	442	PF00069	0.833
MOD_CDK_SPxxK_3	610	617	PF00069	0.425
MOD_CK1_1	166	172	PF00069	0.540
MOD_CK1_1	206	212	PF00069	0.489
MOD_CK1_1	239	245	PF00069	0.750
MOD_CK1_1	353	359	PF00069	0.782
MOD_CK1_1	360	366	PF00069	0.650
MOD_CK1_1	373	379	PF00069	0.633
MOD_CK1_1	39	45	PF00069	0.462
MOD_CK1_1	419	425	PF00069	0.797
MOD_CK1_1	444	450	PF00069	0.688
MOD_CK1_1	519	525	PF00069	0.554
MOD_CK1_1	545	551	PF00069	0.583
MOD_CK1_1	680	686	PF00069	0.503
MOD_CK1_1	80	86	PF00069	0.479
MOD_CK2_1	125	131	PF00069	0.451
MOD_CK2_1	249	255	PF00069	0.520
MOD_CK2_1	39	45	PF00069	0.462
MOD_CK2_1	425	431	PF00069	0.535
MOD_CK2_1	653	659	PF00069	0.724
MOD_DYRK1A_RPxSP_1	391	395	PF00069	0.728
MOD_GlcNHglycan	155	158	PF01048	0.601
MOD_GlcNHglycan	203	206	PF01048	0.528
MOD_GlcNHglycan	209	212	PF01048	0.487
MOD_GlcNHglycan	234	237	PF01048	0.648
MOD_GlcNHglycan	241	244	PF01048	0.687
MOD_GlcNHglycan	296	299	PF01048	0.780
MOD_GlcNHglycan	318	321	PF01048	0.729
MOD_GlcNHglycan	327	330	PF01048	0.686
MOD_GlcNHglycan	365	368	PF01048	0.762
MOD_GlcNHglycan	372	375	PF01048	0.817
MOD_GlcNHglycan	469	472	PF01048	0.585
MOD_GlcNHglycan	524	527	PF01048	0.719
MOD_GlcNHglycan	634	637	PF01048	0.640
MOD_GlcNHglycan	717	720	PF01048	0.693
MOD_GSK3_1	125	132	PF00069	0.449
MOD_GSK3_1	14	21	PF00069	0.429
MOD_GSK3_1	153	160	PF00069	0.640
MOD_GSK3_1	203	210	PF00069	0.461
MOD_GSK3_1	232	239	PF00069	0.712
MOD_GSK3_1	249	256	PF00069	0.778
MOD_GSK3_1	312	319	PF00069	0.772
MOD_GSK3_1	325	332	PF00069	0.621
MOD_GSK3_1	346	353	PF00069	0.703
MOD_GSK3_1	358	365	PF00069	0.627
MOD_GSK3_1	393	400	PF00069	0.525
MOD_GSK3_1	415	422	PF00069	0.614
MOD_GSK3_1	431	438	PF00069	0.676
MOD_GSK3_1	463	470	PF00069	0.371
MOD_GSK3_1	516	523	PF00069	0.418
MOD_GSK3_1	537	544	PF00069	0.743
MOD_GSK3_1	637	644	PF00069	0.598
MOD_GSK3_1	88	95	PF00069	0.434
MOD_N-GLC_1	330	335	PF02516	0.526
MOD_N-GLC_1	675	680	PF02516	0.500
MOD_NEK2_1	30	35	PF00069	0.447
MOD_NEK2_1	325	330	PF00069	0.809
MOD_NEK2_1	370	375	PF00069	0.770
MOD_NEK2_1	516	521	PF00069	0.446
MOD_NEK2_1	660	665	PF00069	0.687
MOD_NEK2_2	537	542	PF00069	0.577
MOD_PIKK_1	150	156	PF00454	0.789
MOD_PIKK_1	203	209	PF00454	0.556
MOD_PIKK_1	431	437	PF00454	0.536
MOD_PKA_1	357	363	PF00069	0.626
MOD_PKA_1	441	447	PF00069	0.815
MOD_PKA_2	119	125	PF00069	0.498
MOD_PKA_2	193	199	PF00069	0.625
MOD_PKA_2	230	236	PF00069	0.791
MOD_PKA_2	261	267	PF00069	0.530
MOD_PKA_2	329	335	PF00069	0.741
MOD_PKA_2	357	363	PF00069	0.626
MOD_PKA_2	415	421	PF00069	0.732
MOD_PKA_2	441	447	PF00069	0.713
MOD_PKA_2	532	538	PF00069	0.616
MOD_PKA_2	653	659	PF00069	0.710
MOD_PKA_2	686	692	PF00069	0.509
MOD_PKA_2	715	721	PF00069	0.653
MOD_PKA_2	77	83	PF00069	0.473
MOD_PKA_2	88	94	PF00069	0.413
MOD_PKB_1	355	363	PF00069	0.628
MOD_PKB_1	391	399	PF00069	0.618
MOD_PKB_1	414	422	PF00069	0.521
MOD_Plk_1	113	119	PF00069	0.507
MOD_Plk_1	254	260	PF00069	0.525
MOD_Plk_1	424	430	PF00069	0.525
MOD_Plk_1	680	686	PF00069	0.503
MOD_Plk_2-3	249	255	PF00069	0.520
MOD_Plk_2-3	425	431	PF00069	0.605
MOD_Plk_4	129	135	PF00069	0.459
MOD_Plk_4	185	191	PF00069	0.580
MOD_Plk_4	25	31	PF00069	0.434
MOD_Plk_4	452	458	PF00069	0.608
MOD_Plk_4	463	469	PF00069	0.402
MOD_Plk_4	537	543	PF00069	0.708
MOD_Plk_4	546	552	PF00069	0.615
MOD_Plk_4	660	666	PF00069	0.688
MOD_Plk_4	88	94	PF00069	0.443
MOD_ProDKin_1	166	172	PF00069	0.662
MOD_ProDKin_1	215	221	PF00069	0.461
MOD_ProDKin_1	236	242	PF00069	0.627
MOD_ProDKin_1	31	37	PF00069	0.447
MOD_ProDKin_1	318	324	PF00069	0.731
MOD_ProDKin_1	346	352	PF00069	0.779
MOD_ProDKin_1	360	366	PF00069	0.624
MOD_ProDKin_1	376	382	PF00069	0.744
MOD_ProDKin_1	391	397	PF00069	0.808
MOD_ProDKin_1	402	408	PF00069	0.803
MOD_ProDKin_1	435	441	PF00069	0.831
MOD_ProDKin_1	520	526	PF00069	0.399
MOD_ProDKin_1	610	616	PF00069	0.589
MOD_ProDKin_1	621	627	PF00069	0.740
TRG_DiLeu_BaEn_1	594	599	PF01217	0.454
TRG_DiLeu_BaLyEn_6	627	632	PF01217	0.717
TRG_ENDOCYTIC_2	454	457	PF00928	0.597
TRG_ENDOCYTIC_2	479	482	PF00928	0.502
TRG_ENDOCYTIC_2	508	511	PF00928	0.439
TRG_ENDOCYTIC_2	52	55	PF00928	0.458
TRG_ENDOCYTIC_2	536	539	PF00928	0.758
TRG_ER_diArg_1	223	225	PF00400	0.674
TRG_ER_diArg_1	343	346	PF00400	0.747
TRG_ER_diArg_1	355	358	PF00400	0.601
TRG_ER_diArg_1	682	685	PF00400	0.532
TRG_ER_diArg_1	714	717	PF00400	0.629
TRG_NES_CRM1_1	484	500	PF08389	0.516
TRG_NES_CRM1_1	597	610	PF08389	0.489
TRG_Pf-PMV_PEXEL_1	703	708	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8H2	Leptomonas seymouri	38%	100%
A0A3S5H6X8	Leishmania donovani	79%	100%
A4H8K6	Leishmania braziliensis	62%	100%
A4HWX9	Leishmania infantum	79%	100%
Q4QET7	Leishmania major	78%	100%