Polysacc_synt_4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQP0_LEIMU

TriTrypDb:

LmxM.16.0810

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQP0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.281
CLV_C14_Caspase3-7	596	600	PF00656	0.592
CLV_MEL_PAP_1	312	318	PF00089	0.680
CLV_NRD_NRD_1	127	129	PF00675	0.591
CLV_NRD_NRD_1	291	293	PF00675	0.494
CLV_NRD_NRD_1	314	316	PF00675	0.699
CLV_NRD_NRD_1	386	388	PF00675	0.561
CLV_NRD_NRD_1	433	435	PF00675	0.541
CLV_NRD_NRD_1	570	572	PF00675	0.380
CLV_NRD_NRD_1	583	585	PF00675	0.348
CLV_NRD_NRD_1	69	71	PF00675	0.641
CLV_PCSK_KEX2_1	127	129	PF00082	0.561
CLV_PCSK_KEX2_1	314	316	PF00082	0.699
CLV_PCSK_KEX2_1	363	365	PF00082	0.485
CLV_PCSK_KEX2_1	386	388	PF00082	0.583
CLV_PCSK_KEX2_1	433	435	PF00082	0.541
CLV_PCSK_KEX2_1	583	585	PF00082	0.417
CLV_PCSK_KEX2_1	69	71	PF00082	0.629
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.565
CLV_PCSK_SKI1_1	24	28	PF00082	0.353
CLV_PCSK_SKI1_1	271	275	PF00082	0.537
CLV_PCSK_SKI1_1	293	297	PF00082	0.474
CLV_PCSK_SKI1_1	305	309	PF00082	0.684
CLV_PCSK_SKI1_1	363	367	PF00082	0.507
CLV_PCSK_SKI1_1	462	466	PF00082	0.480
CLV_PCSK_SKI1_1	583	587	PF00082	0.402
CLV_Separin_Metazoa	335	339	PF03568	0.298
DEG_SPOP_SBC_1	186	190	PF00917	0.489
DEG_SPOP_SBC_1	203	207	PF00917	0.431
DEG_SPOP_SBC_1	246	250	PF00917	0.386
DOC_CYCLIN_RxL_1	289	297	PF00134	0.332
DOC_CYCLIN_RxL_1	360	372	PF00134	0.315
DOC_MAPK_DCC_7	293	303	PF00069	0.298
DOC_MAPK_gen_1	127	133	PF00069	0.442
DOC_MAPK_gen_1	292	298	PF00069	0.278
DOC_MAPK_gen_1	360	368	PF00069	0.272
DOC_MAPK_gen_1	69	77	PF00069	0.398
DOC_MAPK_JIP1_4	403	409	PF00069	0.337
DOC_MAPK_MEF2A_6	32	41	PF00069	0.455
DOC_PP1_RVXF_1	22	28	PF00149	0.434
DOC_PP1_RVXF_1	362	369	PF00149	0.306
DOC_PP1_RVXF_1	423	429	PF00149	0.295
DOC_PP1_RVXF_1	519	525	PF00149	0.584
DOC_PP2B_LxvP_1	112	115	PF13499	0.523
DOC_PP4_FxxP_1	34	37	PF00568	0.410
DOC_PP4_FxxP_1	87	90	PF00568	0.299
DOC_PP4_MxPP_1	1	4	PF00568	0.638
DOC_USP7_MATH_1	146	150	PF00917	0.415
DOC_USP7_MATH_1	185	189	PF00917	0.517
DOC_USP7_MATH_1	197	201	PF00917	0.540
DOC_USP7_MATH_1	203	207	PF00917	0.440
DOC_USP7_MATH_1	222	226	PF00917	0.500
DOC_USP7_MATH_1	233	237	PF00917	0.507
DOC_USP7_MATH_1	76	80	PF00917	0.391
DOC_USP7_MATH_1	93	97	PF00917	0.514
DOC_WW_Pin1_4	160	165	PF00397	0.473
DOC_WW_Pin1_4	213	218	PF00397	0.371
DOC_WW_Pin1_4	234	239	PF00397	0.511
DOC_WW_Pin1_4	33	38	PF00397	0.322
DOC_WW_Pin1_4	475	480	PF00397	0.297
LIG_14-3-3_CanoR_1	314	319	PF00244	0.413
LIG_14-3-3_CanoR_1	338	347	PF00244	0.312
LIG_14-3-3_CanoR_1	418	426	PF00244	0.340
LIG_14-3-3_CanoR_1	571	581	PF00244	0.616
LIG_14-3-3_CanoR_1	587	591	PF00244	0.546
LIG_Actin_WH2_2	291	307	PF00022	0.329
LIG_APCC_ABBA_1	374	379	PF00400	0.302
LIG_BRCT_BRCA1_1	109	113	PF00533	0.533
LIG_BRCT_BRCA1_1	22	26	PF00533	0.452
LIG_BRCT_BRCA1_1	224	228	PF00533	0.365
LIG_BRCT_BRCA1_1	4	8	PF00533	0.749
LIG_BRCT_BRCA1_1	42	46	PF00533	0.150
LIG_Clathr_ClatBox_1	407	411	PF01394	0.263
LIG_FHA_1	238	244	PF00498	0.487
LIG_FHA_1	324	330	PF00498	0.404
LIG_FHA_1	373	379	PF00498	0.346
LIG_FHA_1	525	531	PF00498	0.560
LIG_FHA_1	541	547	PF00498	0.611
LIG_FHA_2	237	243	PF00498	0.489
LIG_FHA_2	483	489	PF00498	0.347
LIG_HP1_1	37	41	PF01393	0.306
LIG_Integrin_RGD_1	259	261	PF01839	0.461
LIG_LIR_Apic_2	31	37	PF02991	0.536
LIG_LIR_Apic_2	55	61	PF02991	0.359
LIG_LIR_Gen_1	250	257	PF02991	0.436
LIG_LIR_Gen_1	36	46	PF02991	0.328
LIG_LIR_Gen_1	504	514	PF02991	0.593
LIG_LIR_Gen_1	533	540	PF02991	0.578
LIG_LIR_Nem_3	169	175	PF02991	0.296
LIG_LIR_Nem_3	249	255	PF02991	0.471
LIG_LIR_Nem_3	341	347	PF02991	0.297
LIG_LIR_Nem_3	36	41	PF02991	0.339
LIG_LIR_Nem_3	420	426	PF02991	0.307
LIG_LIR_Nem_3	43	49	PF02991	0.357
LIG_LIR_Nem_3	504	509	PF02991	0.513
LIG_LIR_Nem_3	533	538	PF02991	0.502
LIG_PCNA_yPIPBox_3	314	328	PF02747	0.430
LIG_Pex14_1	461	465	PF04695	0.283
LIG_SH2_CRK	172	176	PF00017	0.297
LIG_SH2_PTP2	38	41	PF00017	0.410
LIG_SH2_PTP2	58	61	PF00017	0.242
LIG_SH2_SRC	177	180	PF00017	0.368
LIG_SH2_SRC	549	552	PF00017	0.498
LIG_SH2_STAP1	290	294	PF00017	0.311
LIG_SH2_STAP1	405	409	PF00017	0.271
LIG_SH2_STAT5	177	180	PF00017	0.324
LIG_SH2_STAT5	18	21	PF00017	0.517
LIG_SH2_STAT5	252	255	PF00017	0.364
LIG_SH2_STAT5	38	41	PF00017	0.378
LIG_SH2_STAT5	384	387	PF00017	0.367
LIG_SH2_STAT5	49	52	PF00017	0.272
LIG_SH2_STAT5	549	552	PF00017	0.498
LIG_SH2_STAT5	58	61	PF00017	0.242
LIG_SH3_3	375	381	PF00018	0.373
LIG_SH3_3	441	447	PF00018	0.357
LIG_SH3_3	473	479	PF00018	0.322
LIG_SH3_3	534	540	PF00018	0.520
LIG_SH3_3	545	551	PF00018	0.523
LIG_SUMO_SIM_anti_2	151	156	PF11976	0.391
LIG_SUMO_SIM_anti_2	406	411	PF11976	0.324
LIG_SUMO_SIM_par_1	406	411	PF11976	0.268
LIG_TRAF2_1	61	64	PF00917	0.450
LIG_TYR_ITIM	170	175	PF00017	0.359
LIG_WRC_WIRS_1	483	488	PF05994	0.351
MOD_CDK_SPxxK_3	160	167	PF00069	0.475
MOD_CK1_1	134	140	PF00069	0.412
MOD_CK1_1	160	166	PF00069	0.471
MOD_CK1_1	20	26	PF00069	0.437
MOD_CK1_1	204	210	PF00069	0.623
MOD_CK1_1	213	219	PF00069	0.548
MOD_CK1_1	231	237	PF00069	0.626
MOD_CK1_1	372	378	PF00069	0.484
MOD_CK1_1	478	484	PF00069	0.297
MOD_CK1_1	533	539	PF00069	0.471
MOD_CK1_1	593	599	PF00069	0.671
MOD_CK2_1	114	120	PF00069	0.497
MOD_CK2_1	213	219	PF00069	0.689
MOD_CK2_1	236	242	PF00069	0.660
MOD_CMANNOS	578	581	PF00535	0.432
MOD_GlcNHglycan	116	119	PF01048	0.546
MOD_GlcNHglycan	143	146	PF01048	0.533
MOD_GlcNHglycan	148	151	PF01048	0.475
MOD_GlcNHglycan	183	186	PF01048	0.735
MOD_GlcNHglycan	206	209	PF01048	0.705
MOD_GlcNHglycan	224	227	PF01048	0.767
MOD_GlcNHglycan	231	234	PF01048	0.712
MOD_GlcNHglycan	332	335	PF01048	0.334
MOD_GlcNHglycan	42	45	PF01048	0.422
MOD_GlcNHglycan	529	533	PF01048	0.517
MOD_GlcNHglycan	590	593	PF01048	0.508
MOD_GlcNHglycan	95	98	PF01048	0.645
MOD_GSK3_1	181	188	PF00069	0.573
MOD_GSK3_1	197	204	PF00069	0.448
MOD_GSK3_1	206	213	PF00069	0.531
MOD_GSK3_1	220	227	PF00069	0.460
MOD_GSK3_1	229	236	PF00069	0.717
MOD_GSK3_1	368	375	PF00069	0.480
MOD_GSK3_1	474	481	PF00069	0.286
MOD_GSK3_1	482	489	PF00069	0.331
MOD_GSK3_1	524	531	PF00069	0.410
MOD_GSK3_1	586	593	PF00069	0.411
MOD_N-GLC_1	372	377	PF02516	0.479
MOD_N-GLC_1	533	538	PF02516	0.503
MOD_N-GLC_2	277	279	PF02516	0.356
MOD_N-GLC_2	439	441	PF02516	0.466
MOD_NEK2_1	17	22	PF00069	0.434
MOD_NEK2_1	228	233	PF00069	0.599
MOD_NEK2_1	294	299	PF00069	0.459
MOD_NEK2_1	368	373	PF00069	0.373
MOD_NEK2_1	40	45	PF00069	0.357
MOD_NEK2_1	486	491	PF00069	0.459
MOD_NEK2_1	570	575	PF00069	0.573
MOD_NEK2_1	590	595	PF00069	0.457
MOD_NEK2_1	77	82	PF00069	0.491
MOD_NEK2_2	171	176	PF00069	0.421
MOD_NEK2_2	339	344	PF00069	0.461
MOD_PIKK_1	272	278	PF00454	0.467
MOD_PIKK_1	305	311	PF00454	0.526
MOD_PIKK_1	572	578	PF00454	0.614
MOD_PIKK_1	590	596	PF00454	0.358
MOD_PKA_1	314	320	PF00069	0.633
MOD_PKA_1	583	589	PF00069	0.604
MOD_PKA_2	12	18	PF00069	0.533
MOD_PKA_2	141	147	PF00069	0.594
MOD_PKA_2	20	26	PF00069	0.573
MOD_PKA_2	314	320	PF00069	0.486
MOD_PKA_2	417	423	PF00069	0.426
MOD_PKA_2	570	576	PF00069	0.559
MOD_PKA_2	583	589	PF00069	0.583
MOD_Plk_1	372	378	PF00069	0.438
MOD_Plk_1	533	539	PF00069	0.412
MOD_Plk_1	540	546	PF00069	0.418
MOD_Plk_4	210	216	PF00069	0.606
MOD_Plk_4	307	313	PF00069	0.591
MOD_Plk_4	323	329	PF00069	0.217
MOD_Plk_4	354	360	PF00069	0.460
MOD_Plk_4	478	484	PF00069	0.322
MOD_ProDKin_1	160	166	PF00069	0.604
MOD_ProDKin_1	213	219	PF00069	0.459
MOD_ProDKin_1	234	240	PF00069	0.653
MOD_ProDKin_1	33	39	PF00069	0.322
MOD_ProDKin_1	475	481	PF00069	0.297
MOD_SUMO_for_1	501	504	PF00179	0.464
MOD_SUMO_rev_2	195	203	PF00179	0.526
MOD_SUMO_rev_2	399	404	PF00179	0.456
TRG_ENDOCYTIC_2	172	175	PF00928	0.353
TRG_ENDOCYTIC_2	252	255	PF00928	0.588
TRG_ENDOCYTIC_2	344	347	PF00928	0.480
TRG_ENDOCYTIC_2	38	41	PF00928	0.332
TRG_ENDOCYTIC_2	405	408	PF00928	0.322
TRG_ENDOCYTIC_2	423	426	PF00928	0.340
TRG_ER_diArg_1	126	128	PF00400	0.490
TRG_ER_diArg_1	313	315	PF00400	0.627
TRG_ER_diArg_1	385	387	PF00400	0.428
TRG_ER_diArg_1	432	434	PF00400	0.417
TRG_ER_diArg_1	582	584	PF00400	0.499
TRG_ER_diArg_1	59	62	PF00400	0.454
TRG_ER_diArg_1	69	71	PF00400	0.530
TRG_Pf-PMV_PEXEL_1	364	369	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R7	Leptomonas seymouri	65%	100%
A0A0S4IJV1	Bodo saltans	37%	100%
A0A1X0NZ16	Trypanosomatidae	44%	100%
A0A3Q8IJ17	Leishmania donovani	92%	100%
A4H8K5	Leishmania braziliensis	81%	100%
A4HWX8	Leishmania infantum	93%	100%
C9ZW26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4QET8	Leishmania major	92%	100%
V5D930	Trypanosoma cruzi	49%	100%