Membrane transport protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane transport protein, putative

Species:

Leishmania mexicana

UniProt:

E9AQN9_LEIMU

TriTrypDb:

LmxM.16.0800

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AQN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQN9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0009914	hormone transport	4	9
GO:0009987	cellular process	1	9
GO:0010817	regulation of hormone levels	3	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0055085	transmembrane transport	2	9
GO:0060918	auxin transport	5	9
GO:0065007	biological regulation	1	9
GO:0065008	regulation of biological quality	2	9
GO:0080162	endoplasmic reticulum to cytosol auxin transport	3	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.424
CLV_C14_Caspase3-7	341	345	PF00656	0.505
CLV_C14_Caspase3-7	618	622	PF00656	0.670
CLV_C14_Caspase3-7	627	631	PF00656	0.575
CLV_NRD_NRD_1	106	108	PF00675	0.609
CLV_NRD_NRD_1	356	358	PF00675	0.245
CLV_NRD_NRD_1	490	492	PF00675	0.397
CLV_PCSK_FUR_1	354	358	PF00082	0.191
CLV_PCSK_KEX2_1	269	271	PF00082	0.422
CLV_PCSK_KEX2_1	356	358	PF00082	0.245
CLV_PCSK_KEX2_1	389	391	PF00082	0.339
CLV_PCSK_KEX2_1	490	492	PF00082	0.397
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.409
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.338
CLV_PCSK_PC7_1	385	391	PF00082	0.338
CLV_PCSK_SKI1_1	262	266	PF00082	0.341
CLV_PCSK_SKI1_1	443	447	PF00082	0.318
CLV_PCSK_SKI1_1	467	471	PF00082	0.397
CLV_PCSK_SKI1_1	490	494	PF00082	0.278
CLV_PCSK_SKI1_1	642	646	PF00082	0.424
CLV_PCSK_SKI1_1	718	722	PF00082	0.292
DEG_Nend_UBRbox_2	1	3	PF02207	0.656
DEG_SPOP_SBC_1	130	134	PF00917	0.477
DEG_SPOP_SBC_1	525	529	PF00917	0.597
DOC_ANK_TNKS_1	505	512	PF00023	0.538
DOC_CKS1_1	400	405	PF01111	0.597
DOC_CYCLIN_RxL_1	487	494	PF00134	0.475
DOC_MAPK_DCC_7	146	156	PF00069	0.439
DOC_MAPK_DCC_7	467	477	PF00069	0.546
DOC_MAPK_gen_1	107	114	PF00069	0.394
DOC_MAPK_gen_1	257	266	PF00069	0.567
DOC_MAPK_gen_1	389	397	PF00069	0.538
DOC_MAPK_MEF2A_6	107	114	PF00069	0.401
DOC_MAPK_MEF2A_6	13	22	PF00069	0.391
DOC_MAPK_MEF2A_6	147	156	PF00069	0.381
DOC_MAPK_MEF2A_6	57	65	PF00069	0.624
DOC_MAPK_MEF2A_6	66	73	PF00069	0.491
DOC_MAPK_MEF2A_6	684	692	PF00069	0.331
DOC_PP1_RVXF_1	716	723	PF00149	0.483
DOC_PP2B_LxvP_1	176	179	PF13499	0.353
DOC_PP2B_LxvP_1	282	285	PF13499	0.754
DOC_PP2B_LxvP_1	694	697	PF13499	0.438
DOC_PP4_FxxP_1	397	400	PF00568	0.391
DOC_USP7_MATH_1	131	135	PF00917	0.544
DOC_USP7_MATH_1	525	529	PF00917	0.581
DOC_USP7_MATH_1	699	703	PF00917	0.369
DOC_USP7_UBL2_3	142	146	PF12436	0.567
DOC_USP7_UBL2_3	253	257	PF12436	0.562
DOC_USP7_UBL2_3	443	447	PF12436	0.524
DOC_WW_Pin1_4	126	131	PF00397	0.565
DOC_WW_Pin1_4	310	315	PF00397	0.762
DOC_WW_Pin1_4	399	404	PF00397	0.548
DOC_WW_Pin1_4	468	473	PF00397	0.542
DOC_WW_Pin1_4	654	659	PF00397	0.490
LIG_14-3-3_CanoR_1	321	327	PF00244	0.585
LIG_14-3-3_CanoR_1	357	366	PF00244	0.558
LIG_14-3-3_CanoR_1	406	416	PF00244	0.391
LIG_14-3-3_CanoR_1	459	463	PF00244	0.493
LIG_14-3-3_CanoR_1	592	601	PF00244	0.674
LIG_14-3-3_CanoR_1	634	639	PF00244	0.638
LIG_Actin_WH2_2	625	641	PF00022	0.681
LIG_BIR_III_2	127	131	PF00653	0.410
LIG_BRCT_BRCA1_1	158	162	PF00533	0.401
LIG_BRCT_BRCA1_1	215	219	PF00533	0.412
LIG_BRCT_BRCA1_1	470	474	PF00533	0.597
LIG_BRCT_BRCA1_1	656	660	PF00533	0.391
LIG_CtBP_PxDLS_1	103	107	PF00389	0.469
LIG_CtBP_PxDLS_1	497	501	PF00389	0.542
LIG_deltaCOP1_diTrp_1	427	433	PF00928	0.524
LIG_FHA_1	202	208	PF00498	0.374
LIG_FHA_1	22	28	PF00498	0.505
LIG_FHA_1	277	283	PF00498	0.664
LIG_FHA_1	30	36	PF00498	0.299
LIG_FHA_1	335	341	PF00498	0.503
LIG_FHA_1	394	400	PF00498	0.512
LIG_FHA_1	42	48	PF00498	0.184
LIG_FHA_1	572	578	PF00498	0.645
LIG_FHA_1	633	639	PF00498	0.622
LIG_FHA_2	133	139	PF00498	0.494
LIG_FHA_2	166	172	PF00498	0.409
LIG_FHA_2	614	620	PF00498	0.795
LIG_FHA_2	625	631	PF00498	0.572
LIG_LIR_Apic_2	394	400	PF02991	0.391
LIG_LIR_Gen_1	150	158	PF02991	0.376
LIG_LIR_Gen_1	216	227	PF02991	0.352
LIG_LIR_Gen_1	233	243	PF02991	0.307
LIG_LIR_Gen_1	461	469	PF02991	0.546
LIG_LIR_Gen_1	471	482	PF02991	0.465
LIG_LIR_Gen_1	554	563	PF02991	0.675
LIG_LIR_Gen_1	657	668	PF02991	0.400
LIG_LIR_Nem_3	150	156	PF02991	0.413
LIG_LIR_Nem_3	159	165	PF02991	0.352
LIG_LIR_Nem_3	225	231	PF02991	0.334
LIG_LIR_Nem_3	233	239	PF02991	0.420
LIG_LIR_Nem_3	461	465	PF02991	0.560
LIG_LIR_Nem_3	471	477	PF02991	0.483
LIG_LIR_Nem_3	547	552	PF02991	0.712
LIG_LIR_Nem_3	554	559	PF02991	0.674
LIG_LIR_Nem_3	657	663	PF02991	0.405
LIG_LIR_Nem_3	703	709	PF02991	0.538
LIG_LIR_Nem_3	89	95	PF02991	0.394
LIG_LIR_Nem_3	96	102	PF02991	0.424
LIG_LYPXL_yS_3	549	552	PF13949	0.670
LIG_NRBOX	474	480	PF00104	0.391
LIG_PDZ_Class_1	740	745	PF00595	0.377
LIG_Pex14_2	372	376	PF04695	0.391
LIG_Pex14_2	424	428	PF04695	0.442
LIG_Pex14_2	663	667	PF04695	0.494
LIG_PTB_Apo_2	34	41	PF02174	0.409
LIG_Rb_pABgroove_1	110	118	PF01858	0.398
LIG_REV1ctd_RIR_1	90	96	PF16727	0.430
LIG_SH2_CRK	116	120	PF00017	0.297
LIG_SH2_CRK	99	103	PF00017	0.446
LIG_SH2_PTP2	153	156	PF00017	0.381
LIG_SH2_PTP2	228	231	PF00017	0.391
LIG_SH2_SRC	116	119	PF00017	0.356
LIG_SH2_STAP1	191	195	PF00017	0.388
LIG_SH2_STAP1	364	368	PF00017	0.538
LIG_SH2_STAP1	426	430	PF00017	0.588
LIG_SH2_STAP1	438	442	PF00017	0.512
LIG_SH2_STAP1	565	569	PF00017	0.626
LIG_SH2_STAT3	569	572	PF00017	0.698
LIG_SH2_STAT5	118	121	PF00017	0.390
LIG_SH2_STAT5	153	156	PF00017	0.381
LIG_SH2_STAT5	228	231	PF00017	0.317
LIG_SH2_STAT5	326	329	PF00017	0.538
LIG_SH2_STAT5	539	542	PF00017	0.539
LIG_SH2_STAT5	662	665	PF00017	0.316
LIG_SH2_STAT5	724	727	PF00017	0.357
LIG_SH2_STAT5	741	744	PF00017	0.348
LIG_SH3_3	200	206	PF00018	0.351
LIG_SH3_3	397	403	PF00018	0.475
LIG_SH3_3	419	425	PF00018	0.598
LIG_SH3_3	547	553	PF00018	0.739
LIG_SUMO_SIM_anti_2	515	521	PF11976	0.536
LIG_SUMO_SIM_anti_2	60	65	PF11976	0.614
LIG_SUMO_SIM_anti_2	685	691	PF11976	0.438
LIG_SUMO_SIM_par_1	153	160	PF11976	0.374
LIG_SUMO_SIM_par_1	204	211	PF11976	0.408
LIG_SUMO_SIM_par_1	43	49	PF11976	0.309
LIG_SUMO_SIM_par_1	688	693	PF11976	0.392
LIG_SUMO_SIM_par_1	724	730	PF11976	0.287
LIG_SUMO_SIM_par_1	74	80	PF11976	0.430
LIG_TRAF2_1	616	619	PF00917	0.760
LIG_TRFH_1	549	553	PF08558	0.730
LIG_TYR_ITIM	114	119	PF00017	0.474
LIG_TYR_ITIM	151	156	PF00017	0.396
LIG_UBA3_1	260	269	PF00899	0.578
LIG_UBA3_1	664	671	PF00899	0.548
LIG_Vh1_VBS_1	41	59	PF01044	0.274
LIG_WRC_WIRS_1	625	630	PF05994	0.519
MOD_CDK_SPxxK_3	399	406	PF00069	0.538
MOD_CK1_1	129	135	PF00069	0.573
MOD_CK1_1	208	214	PF00069	0.375
MOD_CK1_1	215	221	PF00069	0.389
MOD_CK1_1	330	336	PF00069	0.563
MOD_CK1_1	350	356	PF00069	0.498
MOD_CK1_1	407	413	PF00069	0.442
MOD_CK1_1	512	518	PF00069	0.513
MOD_CK1_1	580	586	PF00069	0.684
MOD_CK1_1	727	733	PF00069	0.363
MOD_CK1_1	74	80	PF00069	0.491
MOD_CK2_1	132	138	PF00069	0.494
MOD_CK2_1	165	171	PF00069	0.448
MOD_CK2_1	310	316	PF00069	0.744
MOD_CK2_1	613	619	PF00069	0.747
MOD_Cter_Amidation	387	390	PF01082	0.338
MOD_GlcNHglycan	224	227	PF01048	0.581
MOD_GlcNHglycan	241	244	PF01048	0.244
MOD_GlcNHglycan	329	332	PF01048	0.285
MOD_GlcNHglycan	360	363	PF01048	0.385
MOD_GlcNHglycan	386	389	PF01048	0.339
MOD_GlcNHglycan	448	451	PF01048	0.338
MOD_GlcNHglycan	528	531	PF01048	0.352
MOD_GlcNHglycan	607	610	PF01048	0.542
MOD_GlcNHglycan	79	82	PF01048	0.455
MOD_GlcNHglycan	99	102	PF01048	0.606
MOD_GSK3_1	126	133	PF00069	0.577
MOD_GSK3_1	201	208	PF00069	0.358
MOD_GSK3_1	27	34	PF00069	0.421
MOD_GSK3_1	276	283	PF00069	0.680
MOD_GSK3_1	330	337	PF00069	0.563
MOD_GSK3_1	345	352	PF00069	0.505
MOD_GSK3_1	358	365	PF00069	0.574
MOD_GSK3_1	36	43	PF00069	0.342
MOD_GSK3_1	368	375	PF00069	0.555
MOD_GSK3_1	46	53	PF00069	0.302
MOD_GSK3_1	509	516	PF00069	0.501
MOD_GSK3_1	654	661	PF00069	0.491
MOD_GSK3_1	678	685	PF00069	0.438
MOD_GSK3_1	695	702	PF00069	0.438
MOD_GSK3_1	733	740	PF00069	0.412
MOD_LATS_1	268	274	PF00433	0.527
MOD_N-GLC_1	36	41	PF02516	0.413
MOD_N-GLC_1	700	705	PF02516	0.391
MOD_NEK2_1	222	227	PF00069	0.393
MOD_NEK2_1	230	235	PF00069	0.373
MOD_NEK2_1	239	244	PF00069	0.256
MOD_NEK2_1	327	332	PF00069	0.397
MOD_NEK2_1	334	339	PF00069	0.416
MOD_NEK2_1	366	371	PF00069	0.560
MOD_NEK2_1	372	377	PF00069	0.575
MOD_NEK2_1	40	45	PF00069	0.423
MOD_NEK2_1	46	51	PF00069	0.384
MOD_NEK2_1	52	57	PF00069	0.373
MOD_NEK2_1	524	529	PF00069	0.506
MOD_NEK2_1	595	600	PF00069	0.736
MOD_NEK2_1	65	70	PF00069	0.462
MOD_NEK2_1	682	687	PF00069	0.414
MOD_NEK2_1	733	738	PF00069	0.407
MOD_NEK2_2	393	398	PF00069	0.538
MOD_PIKK_1	196	202	PF00454	0.385
MOD_PIKK_1	276	282	PF00454	0.647
MOD_PIKK_1	284	290	PF00454	0.658
MOD_PIKK_1	320	326	PF00454	0.538
MOD_PIKK_1	374	380	PF00454	0.597
MOD_PIKK_1	448	454	PF00454	0.490
MOD_PK_1	147	153	PF00069	0.435
MOD_PKA_1	146	152	PF00069	0.448
MOD_PKA_1	446	452	PF00069	0.540
MOD_PKA_2	320	326	PF00069	0.565
MOD_PKA_2	384	390	PF00069	0.560
MOD_PKA_2	458	464	PF00069	0.596
MOD_PKA_2	65	71	PF00069	0.525
MOD_PKA_2	678	684	PF00069	0.446
MOD_Plk_1	36	42	PF00069	0.289
MOD_Plk_1	393	399	PF00069	0.538
MOD_Plk_1	561	567	PF00069	0.617
MOD_Plk_1	682	688	PF00069	0.355
MOD_Plk_1	700	706	PF00069	0.251
MOD_Plk_2-3	117	123	PF00069	0.468
MOD_Plk_4	205	211	PF00069	0.347
MOD_Plk_4	41	47	PF00069	0.366
MOD_Plk_4	473	479	PF00069	0.460
MOD_Plk_4	496	502	PF00069	0.512
MOD_Plk_4	513	519	PF00069	0.493
MOD_Plk_4	585	591	PF00069	0.682
MOD_Plk_4	595	601	PF00069	0.643
MOD_Plk_4	624	630	PF00069	0.684
MOD_Plk_4	65	71	PF00069	0.506
MOD_Plk_4	682	688	PF00069	0.328
MOD_Plk_4	700	706	PF00069	0.251
MOD_Plk_4	724	730	PF00069	0.373
MOD_Plk_4	737	743	PF00069	0.389
MOD_ProDKin_1	126	132	PF00069	0.568
MOD_ProDKin_1	310	316	PF00069	0.762
MOD_ProDKin_1	399	405	PF00069	0.548
MOD_ProDKin_1	468	474	PF00069	0.542
MOD_ProDKin_1	654	660	PF00069	0.490
MOD_SUMO_for_1	436	439	PF00179	0.534
MOD_SUMO_rev_2	439	445	PF00179	0.560
TRG_DiLeu_BaEn_1	554	559	PF01217	0.685
TRG_DiLeu_BaEn_4	554	560	PF01217	0.666
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.617
TRG_DiLeu_BaLyEn_6	503	508	PF01217	0.538
TRG_DiLeu_BaLyEn_6	547	552	PF01217	0.680
TRG_ENDOCYTIC_2	116	119	PF00928	0.288
TRG_ENDOCYTIC_2	153	156	PF00928	0.381
TRG_ENDOCYTIC_2	228	231	PF00928	0.351
TRG_ENDOCYTIC_2	236	239	PF00928	0.331
TRG_ENDOCYTIC_2	549	552	PF00928	0.670
TRG_ENDOCYTIC_2	662	665	PF00928	0.274
TRG_ENDOCYTIC_2	709	712	PF00928	0.641
TRG_ENDOCYTIC_2	99	102	PF00928	0.444
TRG_ER_diArg_1	354	357	PF00400	0.448
TRG_ER_diArg_1	489	491	PF00400	0.597
TRG_NLS_MonoCore_2	141	146	PF00514	0.580
TRG_NLS_MonoExtC_3	141	146	PF00514	0.556
TRG_NLS_MonoExtN_4	142	149	PF00514	0.542
TRG_NLS_MonoExtN_4	443	450	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	490	494	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.256

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILL2	Leptomonas seymouri	52%	100%
A0A3S5H6X7	Leishmania donovani	87%	99%
A0A422ND25	Trypanosoma rangeli	33%	100%
A4H8K4	Leishmania braziliensis	66%	99%
A4HWX7	Leishmania infantum	87%	99%
C9ZW27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4QET9	Leishmania major	83%	100%