Chitinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Chitinase

Gene product:

chitinase

Species:

Leishmania mexicana

UniProt:

E9AQN8_LEIMU

TriTrypDb:

LmxM.16.0790

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 4
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQN8

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	8
GO:0008152	metabolic process	1	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	7
GO:0005488	binding	1	8
GO:0008061	chitin binding	3	8
GO:0016787	hydrolase activity	2	8
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	7
GO:0097367	carbohydrate derivative binding	2	8
GO:0004568	chitinase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.416
CLV_NRD_NRD_1	151	153	PF00675	0.312
CLV_NRD_NRD_1	164	166	PF00675	0.399
CLV_NRD_NRD_1	215	217	PF00675	0.399
CLV_NRD_NRD_1	222	224	PF00675	0.311
CLV_NRD_NRD_1	291	293	PF00675	0.333
CLV_NRD_NRD_1	307	309	PF00675	0.365
CLV_NRD_NRD_1	324	326	PF00675	0.273
CLV_NRD_NRD_1	374	376	PF00675	0.405
CLV_PCSK_FUR_1	116	120	PF00082	0.477
CLV_PCSK_FUR_1	220	224	PF00082	0.185
CLV_PCSK_KEX2_1	118	120	PF00082	0.419
CLV_PCSK_KEX2_1	150	152	PF00082	0.267
CLV_PCSK_KEX2_1	215	217	PF00082	0.399
CLV_PCSK_KEX2_1	222	224	PF00082	0.311
CLV_PCSK_KEX2_1	291	293	PF00082	0.356
CLV_PCSK_KEX2_1	307	309	PF00082	0.405
CLV_PCSK_KEX2_1	324	326	PF00082	0.227
CLV_PCSK_KEX2_1	374	376	PF00082	0.405
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.405
CLV_PCSK_PC7_1	218	224	PF00082	0.185
CLV_PCSK_SKI1_1	151	155	PF00082	0.386
CLV_PCSK_SKI1_1	223	227	PF00082	0.237
CLV_PCSK_SKI1_1	308	312	PF00082	0.386
DEG_APCC_DBOX_1	3	11	PF00400	0.618
DEG_SCF_FBW7_1	22	28	PF00400	0.427
DOC_CKS1_1	22	27	PF01111	0.426
DOC_MAPK_gen_1	165	172	PF00069	0.399
DOC_MAPK_gen_1	215	221	PF00069	0.185
DOC_MAPK_gen_1	222	230	PF00069	0.172
DOC_MAPK_gen_1	307	316	PF00069	0.405
DOC_MAPK_MEF2A_6	307	316	PF00069	0.356
DOC_MAPK_NFAT4_5	307	315	PF00069	0.405
DOC_PP2B_LxvP_1	312	315	PF13499	0.351
DOC_USP7_MATH_1	232	236	PF00917	0.405
DOC_USP7_MATH_1	25	29	PF00917	0.647
DOC_USP7_MATH_1	265	269	PF00917	0.458
DOC_USP7_MATH_1	42	46	PF00917	0.601
DOC_USP7_MATH_1	444	448	PF00917	0.711
DOC_WW_Pin1_4	21	26	PF00397	0.424
DOC_WW_Pin1_4	399	404	PF00397	0.521
DOC_WW_Pin1_4	445	450	PF00397	0.613
DOC_WW_Pin1_4	52	57	PF00397	0.567
LIG_14-3-3_CanoR_1	194	198	PF00244	0.399
LIG_14-3-3_CanoR_1	223	229	PF00244	0.185
LIG_14-3-3_CanoR_1	244	250	PF00244	0.453
LIG_14-3-3_CanoR_1	307	313	PF00244	0.419
LIG_14-3-3_CanoR_1	357	365	PF00244	0.386
LIG_14-3-3_CanoR_1	4	8	PF00244	0.464
LIG_Actin_WH2_2	87	102	PF00022	0.477
LIG_APCC_ABBA_1	281	286	PF00400	0.438
LIG_BRCT_BRCA1_1	137	141	PF00533	0.351
LIG_Clathr_ClatBox_1	101	105	PF01394	0.399
LIG_deltaCOP1_diTrp_1	182	189	PF00928	0.354
LIG_deltaCOP1_diTrp_1	332	341	PF00928	0.405
LIG_eIF4E_1	331	337	PF01652	0.302
LIG_EVH1_2	56	60	PF00568	0.341
LIG_FHA_1	179	185	PF00498	0.405
LIG_FHA_1	278	284	PF00498	0.360
LIG_FHA_1	309	315	PF00498	0.405
LIG_FHA_1	83	89	PF00498	0.351
LIG_FHA_1	96	102	PF00498	0.477
LIG_FHA_2	177	183	PF00498	0.473
LIG_FHA_2	346	352	PF00498	0.399
LIG_FHA_2	366	372	PF00498	0.431
LIG_LIR_Apic_2	171	177	PF02991	0.351
LIG_LIR_Gen_1	112	121	PF02991	0.473
LIG_LIR_Gen_1	138	149	PF02991	0.405
LIG_LIR_Gen_1	181	191	PF02991	0.405
LIG_LIR_Gen_1	248	257	PF02991	0.399
LIG_LIR_Gen_1	329	338	PF02991	0.398
LIG_LIR_Gen_1	368	377	PF02991	0.468
LIG_LIR_Gen_1	73	84	PF02991	0.418
LIG_LIR_Nem_3	112	117	PF02991	0.404
LIG_LIR_Nem_3	138	144	PF02991	0.405
LIG_LIR_Nem_3	181	186	PF02991	0.405
LIG_LIR_Nem_3	248	254	PF02991	0.454
LIG_LIR_Nem_3	329	334	PF02991	0.349
LIG_LIR_Nem_3	360	365	PF02991	0.361
LIG_LIR_Nem_3	366	370	PF02991	0.383
LIG_LIR_Nem_3	416	420	PF02991	0.593
LIG_LIR_Nem_3	61	66	PF02991	0.335
LIG_LIR_Nem_3	73	79	PF02991	0.375
LIG_Pex14_2	337	341	PF04695	0.386
LIG_SH2_CRK	437	441	PF00017	0.622
LIG_SH2_NCK_1	199	203	PF00017	0.399
LIG_SH2_NCK_1	437	441	PF00017	0.622
LIG_SH2_PTP2	251	254	PF00017	0.386
LIG_SH2_SRC	257	260	PF00017	0.405
LIG_SH2_SRC	370	373	PF00017	0.337
LIG_SH2_STAP1	18	22	PF00017	0.524
LIG_SH2_STAP1	199	203	PF00017	0.399
LIG_SH2_STAP1	257	261	PF00017	0.405
LIG_SH2_STAP1	271	275	PF00017	0.332
LIG_SH2_STAP1	331	335	PF00017	0.370
LIG_SH2_STAP1	76	80	PF00017	0.351
LIG_SH2_STAT5	251	254	PF00017	0.349
LIG_SH2_STAT5	65	68	PF00017	0.351
LIG_SH3_3	19	25	PF00018	0.423
LIG_TYR_ITIM	249	254	PF00017	0.399
LIG_TYR_ITSM	366	373	PF00017	0.477
MOD_CK1_1	20	26	PF00069	0.607
MOD_CK1_1	274	280	PF00069	0.439
MOD_CK1_1	402	408	PF00069	0.491
MOD_CK2_1	107	113	PF00069	0.405
MOD_CK2_1	176	182	PF00069	0.405
MOD_CK2_1	264	270	PF00069	0.405
MOD_CK2_1	345	351	PF00069	0.481
MOD_GlcNHglycan	109	112	PF01048	0.399
MOD_GlcNHglycan	137	140	PF01048	0.369
MOD_GlcNHglycan	241	244	PF01048	0.477
MOD_GlcNHglycan	27	30	PF01048	0.622
MOD_GlcNHglycan	385	388	PF01048	0.367
MOD_GlcNHglycan	426	429	PF01048	0.733
MOD_GlcNHglycan	432	435	PF01048	0.658
MOD_GlcNHglycan	44	47	PF01048	0.501
MOD_GlcNHglycan	90	93	PF01048	0.399
MOD_GSK3_1	16	23	PF00069	0.582
MOD_GSK3_1	260	267	PF00069	0.444
MOD_GSK3_1	38	45	PF00069	0.673
MOD_GSK3_1	398	405	PF00069	0.461
MOD_GSK3_1	420	427	PF00069	0.516
MOD_LATS_1	306	312	PF00433	0.477
MOD_N-GLC_1	383	388	PF02516	0.473
MOD_N-GLC_1	47	52	PF02516	0.764
MOD_NEK2_1	17	22	PF00069	0.602
MOD_NEK2_1	193	198	PF00069	0.399
MOD_NEK2_1	420	425	PF00069	0.610
MOD_NEK2_2	58	63	PF00069	0.466
MOD_PKA_1	308	314	PF00069	0.423
MOD_PKA_2	193	199	PF00069	0.399
MOD_PKA_2	3	9	PF00069	0.459
MOD_Plk_1	47	53	PF00069	0.635
MOD_Plk_4	271	277	PF00069	0.405
MOD_Plk_4	3	9	PF00069	0.562
MOD_Plk_4	345	351	PF00069	0.399
MOD_Plk_4	402	408	PF00069	0.437
MOD_ProDKin_1	21	27	PF00069	0.426
MOD_ProDKin_1	399	405	PF00069	0.515
MOD_ProDKin_1	445	451	PF00069	0.614
MOD_ProDKin_1	52	58	PF00069	0.558
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.399
TRG_ENDOCYTIC_2	251	254	PF00928	0.359
TRG_ENDOCYTIC_2	331	334	PF00928	0.339
TRG_ENDOCYTIC_2	370	373	PF00928	0.402
TRG_ENDOCYTIC_2	76	79	PF00928	0.431
TRG_ER_diArg_1	116	119	PF00400	0.412
TRG_ER_diArg_1	149	152	PF00400	0.271
TRG_ER_diArg_1	215	218	PF00400	0.413
TRG_ER_diArg_1	219	222	PF00400	0.396
TRG_ER_diArg_1	291	293	PF00400	0.333
TRG_ER_diArg_1	299	302	PF00400	0.185
TRG_ER_diArg_1	324	326	PF00400	0.477
TRG_NLS_MonoExtC_3	373	378	PF00514	0.373
TRG_NLS_MonoExtN_4	374	379	PF00514	0.373
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.302
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.185
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P753	Leptomonas seymouri	56%	93%
A0A0S4J833	Bodo saltans	33%	100%
A4H8K3	Leishmania braziliensis	76%	100%
A4HWX6	Leishmania infantum	89%	100%
E9QRF2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
O60994	Leishmania donovani	89%	100%
O81862	Arabidopsis thaliana	26%	100%
Q4QEU0	Leishmania major	90%	100%
Q873X9	Neosartorya fumigata	25%	100%