Glutaredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQN6_LEIMU

TriTrypDb:

LmxM.16.0770

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQN6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.633
CLV_C14_Caspase3-7	232	236	PF00656	0.554
CLV_C14_Caspase3-7	360	364	PF00656	0.558
CLV_C14_Caspase3-7	455	459	PF00656	0.418
CLV_C14_Caspase3-7	576	580	PF00656	0.477
CLV_NRD_NRD_1	189	191	PF00675	0.585
CLV_NRD_NRD_1	282	284	PF00675	0.640
CLV_NRD_NRD_1	327	329	PF00675	0.693
CLV_NRD_NRD_1	355	357	PF00675	0.644
CLV_NRD_NRD_1	42	44	PF00675	0.430
CLV_NRD_NRD_1	464	466	PF00675	0.392
CLV_NRD_NRD_1	467	469	PF00675	0.419
CLV_NRD_NRD_1	521	523	PF00675	0.465
CLV_NRD_NRD_1	530	532	PF00675	0.407
CLV_PCSK_FUR_1	465	469	PF00082	0.470
CLV_PCSK_KEX2_1	188	190	PF00082	0.588
CLV_PCSK_KEX2_1	282	284	PF00082	0.522
CLV_PCSK_KEX2_1	327	329	PF00082	0.693
CLV_PCSK_KEX2_1	41	43	PF00082	0.450
CLV_PCSK_KEX2_1	464	466	PF00082	0.392
CLV_PCSK_KEX2_1	467	469	PF00082	0.419
CLV_PCSK_KEX2_1	520	522	PF00082	0.496
CLV_PCSK_KEX2_1	530	532	PF00082	0.403
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.469
CLV_PCSK_PC7_1	184	190	PF00082	0.592
CLV_PCSK_PC7_1	517	523	PF00082	0.445
CLV_PCSK_SKI1_1	42	46	PF00082	0.412
DEG_APCC_DBOX_1	530	538	PF00400	0.507
DEG_Nend_Nbox_1	1	3	PF02207	0.436
DEG_SCF_FBW7_2	198	205	PF00400	0.517
DEG_SPOP_SBC_1	183	187	PF00917	0.594
DEG_SPOP_SBC_1	542	546	PF00917	0.533
DEG_SPOP_SBC_1	67	71	PF00917	0.615
DOC_CDC14_PxL_1	534	542	PF14671	0.554
DOC_CYCLIN_RxL_1	14	26	PF00134	0.396
DOC_MAPK_gen_1	436	445	PF00069	0.339
DOC_PP2B_LxvP_1	107	110	PF13499	0.595
DOC_PP2B_LxvP_1	539	542	PF13499	0.549
DOC_USP7_MATH_1	102	106	PF00917	0.558
DOC_USP7_MATH_1	234	238	PF00917	0.631
DOC_USP7_MATH_1	281	285	PF00917	0.585
DOC_USP7_MATH_1	297	301	PF00917	0.734
DOC_USP7_MATH_1	332	336	PF00917	0.675
DOC_USP7_MATH_1	350	354	PF00917	0.532
DOC_USP7_MATH_1	5	9	PF00917	0.516
DOC_USP7_MATH_1	548	552	PF00917	0.648
DOC_USP7_MATH_1	83	87	PF00917	0.604
DOC_USP7_MATH_1	92	96	PF00917	0.571
DOC_WW_Pin1_4	198	203	PF00397	0.614
DOC_WW_Pin1_4	205	210	PF00397	0.670
DOC_WW_Pin1_4	314	319	PF00397	0.704
DOC_WW_Pin1_4	553	558	PF00397	0.543
DOC_WW_Pin1_4	69	74	PF00397	0.605
DOC_WW_Pin1_4	98	103	PF00397	0.612
LIG_14-3-3_CanoR_1	164	171	PF00244	0.564
LIG_14-3-3_CanoR_1	184	191	PF00244	0.637
LIG_14-3-3_CanoR_1	386	390	PF00244	0.378
LIG_14-3-3_CanoR_1	567	573	PF00244	0.576
LIG_14-3-3_CanoR_1	574	583	PF00244	0.521
LIG_Actin_WH2_2	46	61	PF00022	0.355
LIG_BRCT_BRCA1_1	458	462	PF00533	0.492
LIG_Clathr_ClatBox_1	484	488	PF01394	0.361
LIG_DCNL_PONY_1	1	4	PF03556	0.435
LIG_EVH1_1	107	111	PF00568	0.475
LIG_FHA_1	1	7	PF00498	0.494
LIG_FHA_1	14	20	PF00498	0.423
LIG_FHA_1	154	160	PF00498	0.633
LIG_FHA_1	190	196	PF00498	0.654
LIG_FHA_1	199	205	PF00498	0.625
LIG_FHA_1	319	325	PF00498	0.722
LIG_FHA_1	451	457	PF00498	0.376
LIG_FHA_1	487	493	PF00498	0.444
LIG_FHA_1	558	564	PF00498	0.599
LIG_FHA_1	62	68	PF00498	0.577
LIG_FHA_1	70	76	PF00498	0.605
LIG_FHA_2	379	385	PF00498	0.522
LIG_FHA_2	43	49	PF00498	0.478
LIG_FHA_2	495	501	PF00498	0.381
LIG_FHA_2	574	580	PF00498	0.490
LIG_Integrin_RGD_1	361	363	PF01839	0.621
LIG_LIR_Apic_2	105	109	PF02991	0.587
LIG_LIR_Gen_1	494	501	PF02991	0.358
LIG_LIR_Nem_3	494	498	PF02991	0.383
LIG_MLH1_MIPbox_1	458	462	PF16413	0.492
LIG_MYND_1	538	542	PF01753	0.567
LIG_PCNA_PIPBox_1	393	402	PF02747	0.367
LIG_PCNA_yPIPBox_3	386	400	PF02747	0.371
LIG_PTB_Apo_2	439	446	PF02174	0.377
LIG_REV1ctd_RIR_1	459	469	PF16727	0.419
LIG_RPA_C_Fungi	233	245	PF08784	0.539
LIG_SH2_SRC	106	109	PF00017	0.595
LIG_SH2_STAT5	106	109	PF00017	0.595
LIG_SH2_STAT5	191	194	PF00017	0.598
LIG_SH2_STAT5	342	345	PF00017	0.570
LIG_SH2_STAT5	368	371	PF00017	0.643
LIG_SH2_STAT5	470	473	PF00017	0.404
LIG_SH3_3	105	111	PF00018	0.455
LIG_SH3_3	197	203	PF00018	0.684
LIG_SH3_3	255	261	PF00018	0.525
LIG_SH3_3	326	332	PF00018	0.695
LIG_SH3_3	335	341	PF00018	0.626
LIG_SH3_3	477	483	PF00018	0.434
LIG_SH3_3	85	91	PF00018	0.657
LIG_SH3_CIN85_PxpxPR_1	111	116	PF14604	0.546
LIG_SUMO_SIM_par_1	452	460	PF11976	0.396
LIG_TRAF2_1	203	206	PF00917	0.517
LIG_TRAF2_1	382	385	PF00917	0.543
LIG_TRAF2_1	497	500	PF00917	0.384
LIG_UBA3_1	374	379	PF00899	0.504
LIG_UBA3_1	439	447	PF00899	0.376
MOD_CDC14_SPxK_1	101	104	PF00782	0.617
MOD_CDK_SPxK_1	98	104	PF00069	0.615
MOD_CK1_1	140	146	PF00069	0.670
MOD_CK1_1	162	168	PF00069	0.569
MOD_CK1_1	196	202	PF00069	0.646
MOD_CK1_1	284	290	PF00069	0.643
MOD_CK1_1	320	326	PF00069	0.687
MOD_CK1_1	544	550	PF00069	0.558
MOD_CK1_1	551	557	PF00069	0.612
MOD_CK1_1	566	572	PF00069	0.686
MOD_CK1_1	95	101	PF00069	0.786
MOD_CK2_1	378	384	PF00069	0.531
MOD_CK2_1	42	48	PF00069	0.489
MOD_CK2_1	494	500	PF00069	0.380
MOD_GlcNHglycan	139	142	PF01048	0.584
MOD_GlcNHglycan	145	148	PF01048	0.575
MOD_GlcNHglycan	161	164	PF01048	0.669
MOD_GlcNHglycan	195	198	PF01048	0.649
MOD_GlcNHglycan	231	234	PF01048	0.599
MOD_GlcNHglycan	257	261	PF01048	0.646
MOD_GlcNHglycan	269	273	PF01048	0.549
MOD_GlcNHglycan	286	289	PF01048	0.702
MOD_GlcNHglycan	307	310	PF01048	0.546
MOD_GlcNHglycan	334	337	PF01048	0.683
MOD_GlcNHglycan	351	355	PF01048	0.526
MOD_GlcNHglycan	546	549	PF01048	0.606
MOD_GlcNHglycan	553	556	PF01048	0.600
MOD_GlcNHglycan	81	84	PF01048	0.607
MOD_GlcNHglycan	85	88	PF01048	0.611
MOD_GlcNHglycan	94	97	PF01048	0.729
MOD_GSK3_1	149	156	PF00069	0.629
MOD_GSK3_1	159	166	PF00069	0.614
MOD_GSK3_1	178	185	PF00069	0.671
MOD_GSK3_1	189	196	PF00069	0.699
MOD_GSK3_1	234	241	PF00069	0.625
MOD_GSK3_1	291	298	PF00069	0.664
MOD_GSK3_1	310	317	PF00069	0.767
MOD_GSK3_1	332	339	PF00069	0.686
MOD_GSK3_1	468	475	PF00069	0.337
MOD_GSK3_1	5	12	PF00069	0.502
MOD_GSK3_1	544	551	PF00069	0.630
MOD_GSK3_1	553	560	PF00069	0.630
MOD_GSK3_1	59	66	PF00069	0.586
MOD_GSK3_1	67	74	PF00069	0.570
MOD_GSK3_1	79	86	PF00069	0.673
MOD_GSK3_1	92	99	PF00069	0.725
MOD_N-GLC_1	178	183	PF02516	0.653
MOD_N-GLC_1	267	272	PF02516	0.628
MOD_NEK2_1	267	272	PF00069	0.663
MOD_NEK2_1	31	36	PF00069	0.324
MOD_NEK2_1	378	383	PF00069	0.431
MOD_NEK2_1	4	9	PF00069	0.633
MOD_NEK2_1	422	427	PF00069	0.396
MOD_NEK2_1	486	491	PF00069	0.469
MOD_NEK2_1	81	86	PF00069	0.613
MOD_NEK2_2	5	10	PF00069	0.506
MOD_PIKK_1	178	184	PF00454	0.635
MOD_PIKK_1	189	195	PF00454	0.597
MOD_PIKK_1	388	394	PF00454	0.605
MOD_PKA_1	189	195	PF00069	0.518
MOD_PKA_1	42	48	PF00069	0.489
MOD_PKA_2	143	149	PF00069	0.627
MOD_PKA_2	163	169	PF00069	0.531
MOD_PKA_2	183	189	PF00069	0.540
MOD_PKA_2	281	287	PF00069	0.594
MOD_PKA_2	31	37	PF00069	0.383
MOD_PKA_2	385	391	PF00069	0.390
MOD_PKA_2	42	48	PF00069	0.476
MOD_PKA_2	566	572	PF00069	0.509
MOD_PKA_2	573	579	PF00069	0.480
MOD_PKA_2	76	82	PF00069	0.650
MOD_Plk_1	402	408	PF00069	0.457
MOD_Plk_1	487	493	PF00069	0.328
MOD_Plk_2-3	385	391	PF00069	0.377
MOD_Plk_2-3	403	409	PF00069	0.446
MOD_Plk_2-3	494	500	PF00069	0.380
MOD_Plk_4	130	136	PF00069	0.629
MOD_Plk_4	320	326	PF00069	0.728
MOD_Plk_4	403	409	PF00069	0.460
MOD_Plk_4	487	493	PF00069	0.320
MOD_Plk_4	5	11	PF00069	0.492
MOD_Plk_4	63	69	PF00069	0.531
MOD_ProDKin_1	198	204	PF00069	0.635
MOD_ProDKin_1	205	211	PF00069	0.670
MOD_ProDKin_1	314	320	PF00069	0.705
MOD_ProDKin_1	553	559	PF00069	0.543
MOD_ProDKin_1	69	75	PF00069	0.607
MOD_ProDKin_1	98	104	PF00069	0.612
MOD_SUMO_for_1	53	56	PF00179	0.504
MOD_SUMO_rev_2	372	381	PF00179	0.730
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.511
TRG_DiLeu_BaLyEn_6	480	485	PF01217	0.383
TRG_DiLeu_BaLyEn_6	535	540	PF01217	0.554
TRG_ER_diArg_1	142	145	PF00400	0.639
TRG_ER_diArg_1	188	190	PF00400	0.521
TRG_ER_diArg_1	242	245	PF00400	0.626
TRG_ER_diArg_1	282	285	PF00400	0.541
TRG_ER_diArg_1	327	329	PF00400	0.815
TRG_ER_diArg_1	42	44	PF00400	0.430
TRG_ER_diArg_1	436	439	PF00400	0.387
TRG_ER_diArg_1	464	467	PF00400	0.404
TRG_ER_diArg_1	519	522	PF00400	0.452
TRG_Pf-PMV_PEXEL_1	521	525	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS0	Leptomonas seymouri	36%	76%
A0A3Q8IDN2	Leishmania donovani	82%	100%
A4H8J9	Leishmania braziliensis	65%	95%
A4HWX4	Leishmania infantum	81%	100%
Q4QEU2	Leishmania major	81%	100%