ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AQN4_LEIMU

TriTrypDb:

LmxM.16.0750

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.496
CLV_C14_Caspase3-7	160	164	PF00656	0.505
CLV_C14_Caspase3-7	20	24	PF00656	0.360
CLV_C14_Caspase3-7	319	323	PF00656	0.444
CLV_C14_Caspase3-7	365	369	PF00656	0.602
CLV_C14_Caspase3-7	448	452	PF00656	0.511
CLV_C14_Caspase3-7	487	491	PF00656	0.611
CLV_C14_Caspase3-7	552	556	PF00656	0.627
CLV_NRD_NRD_1	546	548	PF00675	0.606
CLV_NRD_NRD_1	580	582	PF00675	0.611
CLV_NRD_NRD_1	68	70	PF00675	0.295
CLV_PCSK_FUR_1	577	581	PF00082	0.504
CLV_PCSK_KEX2_1	545	547	PF00082	0.599
CLV_PCSK_KEX2_1	579	581	PF00082	0.625
CLV_PCSK_KEX2_1	68	70	PF00082	0.400
CLV_PCSK_SKI1_1	211	215	PF00082	0.481
CLV_PCSK_SKI1_1	228	232	PF00082	0.363
CLV_PCSK_SKI1_1	25	29	PF00082	0.493
CLV_PCSK_SKI1_1	250	254	PF00082	0.470
CLV_PCSK_SKI1_1	422	426	PF00082	0.451
CLV_PCSK_SKI1_1	51	55	PF00082	0.346
DEG_COP1_1	188	199	PF00400	0.407
DEG_Nend_Nbox_1	1	3	PF02207	0.416
DEG_SCF_FBW7_1	15	20	PF00400	0.424
DEG_SPOP_SBC_1	363	367	PF00917	0.582
DEG_SPOP_SBC_1	484	488	PF00917	0.756
DOC_CYCLIN_RxL_1	417	429	PF00134	0.445
DOC_MAPK_gen_1	165	174	PF00069	0.526
DOC_MAPK_MEF2A_6	167	176	PF00069	0.456
DOC_PP1_RVXF_1	559	566	PF00149	0.430
DOC_PP4_MxPP_1	176	179	PF00568	0.454
DOC_USP7_MATH_1	108	112	PF00917	0.634
DOC_USP7_MATH_1	154	158	PF00917	0.604
DOC_USP7_MATH_1	204	208	PF00917	0.713
DOC_USP7_MATH_1	363	367	PF00917	0.532
DOC_USP7_MATH_1	371	375	PF00917	0.553
DOC_USP7_MATH_1	549	553	PF00917	0.662
DOC_WW_Pin1_4	103	108	PF00397	0.686
DOC_WW_Pin1_4	13	18	PF00397	0.390
DOC_WW_Pin1_4	291	296	PF00397	0.675
DOC_WW_Pin1_4	303	308	PF00397	0.408
DOC_WW_Pin1_4	463	468	PF00397	0.452
LIG_14-3-3_CanoR_1	211	216	PF00244	0.436
LIG_14-3-3_CanoR_1	362	371	PF00244	0.455
LIG_14-3-3_CanoR_1	42	50	PF00244	0.493
LIG_14-3-3_CanoR_1	506	515	PF00244	0.495
LIG_14-3-3_CanoR_1	68	78	PF00244	0.444
LIG_BIR_III_4	113	117	PF00653	0.494
LIG_EVH1_2	458	462	PF00568	0.398
LIG_FHA_1	115	121	PF00498	0.355
LIG_FHA_1	292	298	PF00498	0.613
LIG_FHA_1	57	63	PF00498	0.357
LIG_FHA_2	18	24	PF00498	0.353
LIG_FHA_2	334	340	PF00498	0.440
LIG_FHA_2	485	491	PF00498	0.652
LIG_GBD_Chelix_1	433	441	PF00786	0.274
LIG_LIR_Gen_1	131	141	PF02991	0.468
LIG_LIR_Gen_1	23	33	PF02991	0.312
LIG_LIR_Gen_1	258	269	PF02991	0.432
LIG_LIR_Nem_3	131	137	PF02991	0.465
LIG_LIR_Nem_3	185	190	PF02991	0.443
LIG_LIR_Nem_3	23	29	PF02991	0.328
LIG_LIR_Nem_3	258	264	PF02991	0.444
LIG_LIR_Nem_3	72	78	PF02991	0.444
LIG_LYPXL_S_1	74	78	PF13949	0.433
LIG_LYPXL_yS_3	75	78	PF13949	0.437
LIG_MYND_1	76	80	PF01753	0.451
LIG_NRBOX	268	274	PF00104	0.383
LIG_NRBOX	528	534	PF00104	0.380
LIG_Pex14_1	49	53	PF04695	0.337
LIG_Pex14_1	71	75	PF04695	0.370
LIG_Pex14_2	2	6	PF04695	0.355
LIG_Pex14_2	356	360	PF04695	0.382
LIG_PTAP_UEV_1	150	155	PF05743	0.649
LIG_SH2_CRK	261	265	PF00017	0.378
LIG_SH2_STAT3	190	193	PF00017	0.461
LIG_SH2_STAT5	119	122	PF00017	0.338
LIG_SH2_STAT5	26	29	PF00017	0.401
LIG_SH3_3	148	154	PF00018	0.607
LIG_SH3_3	275	281	PF00018	0.546
LIG_SH3_3	301	307	PF00018	0.427
LIG_SH3_3	447	453	PF00018	0.466
LIG_SH3_3	99	105	PF00018	0.714
LIG_TRAF2_1	183	186	PF00917	0.466
LIG_TYR_ITSM	257	264	PF00017	0.395
MOD_CDK_SPK_2	463	468	PF00069	0.484
MOD_CDK_SPxK_1	15	21	PF00069	0.427
MOD_CK1_1	207	213	PF00069	0.532
MOD_CK1_1	488	494	PF00069	0.742
MOD_CK1_1	535	541	PF00069	0.465
MOD_CK2_1	333	339	PF00069	0.322
MOD_Cter_Amidation	66	69	PF01082	0.394
MOD_GlcNHglycan	151	154	PF01048	0.649
MOD_GlcNHglycan	206	209	PF01048	0.645
MOD_GlcNHglycan	406	409	PF01048	0.279
MOD_GlcNHglycan	487	490	PF01048	0.732
MOD_GlcNHglycan	510	513	PF01048	0.478
MOD_GlcNHglycan	573	576	PF01048	0.311
MOD_GSK3_1	11	18	PF00069	0.388
MOD_GSK3_1	207	214	PF00069	0.581
MOD_GSK3_1	256	263	PF00069	0.457
MOD_GSK3_1	299	306	PF00069	0.358
MOD_GSK3_1	400	407	PF00069	0.416
MOD_GSK3_1	484	491	PF00069	0.766
MOD_LATS_1	147	153	PF00433	0.601
MOD_NEK2_1	11	16	PF00069	0.378
MOD_NEK2_1	128	133	PF00069	0.362
MOD_NEK2_1	27	32	PF00069	0.453
MOD_NEK2_1	299	304	PF00069	0.429
MOD_NEK2_1	435	440	PF00069	0.385
MOD_NEK2_1	508	513	PF00069	0.572
MOD_NEK2_1	532	537	PF00069	0.367
MOD_PIKK_1	198	204	PF00454	0.669
MOD_PIKK_1	400	406	PF00454	0.421
MOD_PIKK_1	435	441	PF00454	0.448
MOD_PIKK_1	69	75	PF00454	0.448
MOD_PK_1	260	266	PF00069	0.380
MOD_PKB_1	165	173	PF00069	0.484
MOD_Plk_1	284	290	PF00069	0.480
MOD_Plk_4	114	120	PF00069	0.403
MOD_Plk_4	260	266	PF00069	0.380
MOD_ProDKin_1	103	109	PF00069	0.685
MOD_ProDKin_1	13	19	PF00069	0.399
MOD_ProDKin_1	291	297	PF00069	0.660
MOD_ProDKin_1	303	309	PF00069	0.404
MOD_ProDKin_1	463	469	PF00069	0.458
MOD_SUMO_rev_2	395	403	PF00179	0.420
TRG_DiLeu_BaEn_1	429	434	PF01217	0.506
TRG_ENDOCYTIC_2	26	29	PF00928	0.401
TRG_ENDOCYTIC_2	261	264	PF00928	0.384
TRG_ENDOCYTIC_2	75	78	PF00928	0.361
TRG_ER_diArg_1	129	132	PF00400	0.393
TRG_ER_diArg_1	391	394	PF00400	0.484
TRG_ER_diArg_1	545	547	PF00400	0.565
TRG_ER_diArg_1	577	580	PF00400	0.478
TRG_ER_diArg_1	68	70	PF00400	0.307
TRG_ER_diArg_1	83	86	PF00400	0.345
TRG_Pf-PMV_PEXEL_1	422	427	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Z9	Leptomonas seymouri	52%	100%
A0A3S7WTW8	Leishmania donovani	89%	99%
A4H8J7	Leishmania braziliensis	80%	100%
A4HWX2	Leishmania infantum	89%	99%
Q4QEU4	Leishmania major	87%	100%