Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQN1_LEIMU

TriTrypDb:

LmxM.16.0720

Length:

530

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

E9AQN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQN1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.518
CLV_C14_Caspase3-7	80	84	PF00656	0.495
CLV_C14_Caspase3-7	88	92	PF00656	0.487
CLV_NRD_NRD_1	278	280	PF00675	0.530
CLV_NRD_NRD_1	505	507	PF00675	0.632
CLV_PCSK_KEX2_1	111	113	PF00082	0.686
CLV_PCSK_KEX2_1	278	280	PF00082	0.572
CLV_PCSK_KEX2_1	505	507	PF00082	0.632
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.596
CLV_PCSK_SKI1_1	451	455	PF00082	0.531
DEG_APCC_DBOX_1	458	466	PF00400	0.546
DEG_Nend_UBRbox_2	1	3	PF02207	0.572
DEG_SPOP_SBC_1	168	172	PF00917	0.411
DOC_CKS1_1	197	202	PF01111	0.454
DOC_CKS1_1	476	481	PF01111	0.494
DOC_CYCLIN_RxL_1	214	222	PF00134	0.422
DOC_CYCLIN_yClb3_PxF_3	204	210	PF00134	0.423
DOC_CYCLIN_yCln2_LP_2	197	203	PF00134	0.452
DOC_MAPK_RevD_3	264	279	PF00069	0.435
DOC_PP2B_LxvP_1	126	129	PF13499	0.402
DOC_PP2B_LxvP_1	202	205	PF13499	0.563
DOC_USP7_MATH_1	145	149	PF00917	0.308
DOC_USP7_MATH_1	169	173	PF00917	0.500
DOC_USP7_MATH_1	179	183	PF00917	0.581
DOC_USP7_MATH_1	231	235	PF00917	0.391
DOC_USP7_MATH_1	361	365	PF00917	0.549
DOC_USP7_MATH_1	385	389	PF00917	0.392
DOC_USP7_MATH_1	438	442	PF00917	0.538
DOC_USP7_MATH_1	470	474	PF00917	0.564
DOC_USP7_MATH_1	492	496	PF00917	0.643
DOC_USP7_MATH_1	5	9	PF00917	0.552
DOC_WW_Pin1_4	196	201	PF00397	0.566
DOC_WW_Pin1_4	434	439	PF00397	0.485
DOC_WW_Pin1_4	475	480	PF00397	0.756
DOC_WW_Pin1_4	97	102	PF00397	0.696
LIG_14-3-3_CanoR_1	166	175	PF00244	0.473
LIG_14-3-3_CanoR_1	30	36	PF00244	0.531
LIG_14-3-3_CanoR_1	315	322	PF00244	0.536
LIG_14-3-3_CanoR_1	363	370	PF00244	0.502
LIG_14-3-3_CanoR_1	457	463	PF00244	0.543
LIG_14-3-3_CanoR_1	505	515	PF00244	0.651
LIG_Actin_WH2_2	137	154	PF00022	0.384
LIG_BIR_III_2	485	489	PF00653	0.552
LIG_BRCT_BRCA1_1	119	123	PF00533	0.462
LIG_BRCT_BRCA1_1	524	528	PF00533	0.385
LIG_Clathr_ClatBox_1	335	339	PF01394	0.248
LIG_CSL_BTD_1	126	129	PF09270	0.402
LIG_eIF4E_1	396	402	PF01652	0.403
LIG_FHA_1	168	174	PF00498	0.436
LIG_FHA_1	197	203	PF00498	0.662
LIG_FHA_1	213	219	PF00498	0.331
LIG_FHA_1	345	351	PF00498	0.417
LIG_FHA_1	440	446	PF00498	0.552
LIG_FHA_1	507	513	PF00498	0.611
LIG_FHA_2	398	404	PF00498	0.540
LIG_FHA_2	506	512	PF00498	0.615
LIG_FHA_2	78	84	PF00498	0.516
LIG_LIR_Nem_3	120	126	PF02991	0.458
LIG_LIR_Nem_3	34	39	PF02991	0.532
LIG_LIR_Nem_3	388	392	PF02991	0.311
LIG_MYND_1	200	204	PF01753	0.459
LIG_PDZ_Class_2	525	530	PF00595	0.405
LIG_Pex14_1	32	36	PF04695	0.539
LIG_Pex14_2	123	127	PF04695	0.459
LIG_SH2_GRB2like	396	399	PF00017	0.366
LIG_SH2_NCK_1	370	374	PF00017	0.631
LIG_SH2_SRC	418	421	PF00017	0.415
LIG_SH2_STAT5	348	351	PF00017	0.500
LIG_SH2_STAT5	39	42	PF00017	0.455
LIG_SH2_STAT5	396	399	PF00017	0.366
LIG_SH2_STAT5	418	421	PF00017	0.415
LIG_SH3_3	10	16	PF00018	0.613
LIG_SH3_3	202	208	PF00018	0.505
LIG_SH3_3	300	306	PF00018	0.443
LIG_SH3_3	384	390	PF00018	0.410
LIG_SH3_3	473	479	PF00018	0.476
LIG_SUMO_SIM_anti_2	271	276	PF11976	0.440
LIG_SUMO_SIM_par_1	217	222	PF11976	0.358
LIG_TRAF2_1	41	44	PF00917	0.587
MOD_CK1_1	351	357	PF00069	0.497
MOD_CK1_1	495	501	PF00069	0.686
MOD_CK1_1	510	516	PF00069	0.488
MOD_CK1_1	69	75	PF00069	0.697
MOD_CK1_1	8	14	PF00069	0.760
MOD_CK2_1	179	185	PF00069	0.636
MOD_CK2_1	397	403	PF00069	0.450
MOD_CK2_1	505	511	PF00069	0.527
MOD_GlcNHglycan	220	224	PF01048	0.537
MOD_GlcNHglycan	282	285	PF01048	0.569
MOD_GlcNHglycan	316	319	PF01048	0.655
MOD_GlcNHglycan	364	367	PF01048	0.553
MOD_GlcNHglycan	374	377	PF01048	0.626
MOD_GlcNHglycan	472	475	PF01048	0.586
MOD_GlcNHglycan	69	72	PF01048	0.674
MOD_GlcNHglycan	7	10	PF01048	0.712
MOD_GSK3_1	147	154	PF00069	0.368
MOD_GSK3_1	231	238	PF00069	0.404
MOD_GSK3_1	241	248	PF00069	0.298
MOD_GSK3_1	280	287	PF00069	0.377
MOD_GSK3_1	31	38	PF00069	0.540
MOD_GSK3_1	344	351	PF00069	0.394
MOD_GSK3_1	434	441	PF00069	0.548
MOD_GSK3_1	466	473	PF00069	0.503
MOD_GSK3_1	506	513	PF00069	0.619
MOD_GSK3_1	93	100	PF00069	0.626
MOD_N-GLC_1	245	250	PF02516	0.440
MOD_N-GLC_1	397	402	PF02516	0.408
MOD_N-GLC_1	470	475	PF02516	0.620
MOD_NEK2_1	151	156	PF00069	0.298
MOD_NEK2_1	219	224	PF00069	0.343
MOD_NEK2_1	235	240	PF00069	0.335
MOD_NEK2_1	322	327	PF00069	0.528
MOD_NEK2_1	338	343	PF00069	0.307
MOD_NEK2_1	344	349	PF00069	0.398
MOD_NEK2_1	35	40	PF00069	0.566
MOD_NEK2_1	372	377	PF00069	0.578
MOD_NEK2_1	397	402	PF00069	0.370
MOD_NEK2_1	466	471	PF00069	0.559
MOD_NEK2_1	61	66	PF00069	0.518
MOD_NEK2_2	133	138	PF00069	0.384
MOD_NEK2_2	169	174	PF00069	0.387
MOD_NEK2_2	212	217	PF00069	0.410
MOD_NEK2_2	31	36	PF00069	0.492
MOD_NEK2_2	446	451	PF00069	0.579
MOD_PIKK_1	492	498	PF00454	0.634
MOD_PKA_1	505	511	PF00069	0.610
MOD_PKA_2	151	157	PF00069	0.345
MOD_PKA_2	314	320	PF00069	0.597
MOD_PKA_2	362	368	PF00069	0.534
MOD_PKA_2	458	464	PF00069	0.546
MOD_PKA_2	505	511	PF00069	0.658
MOD_PKA_2	66	72	PF00069	0.565
MOD_PKB_1	65	73	PF00069	0.562
MOD_Plk_1	351	357	PF00069	0.505
MOD_Plk_1	397	403	PF00069	0.374
MOD_Plk_4	231	237	PF00069	0.397
MOD_Plk_4	31	37	PF00069	0.546
MOD_Plk_4	344	350	PF00069	0.409
MOD_Plk_4	397	403	PF00069	0.450
MOD_ProDKin_1	196	202	PF00069	0.563
MOD_ProDKin_1	434	440	PF00069	0.483
MOD_ProDKin_1	475	481	PF00069	0.756
MOD_ProDKin_1	97	103	PF00069	0.695
MOD_SUMO_rev_2	417	423	PF00179	0.409
TRG_DiLeu_BaEn_1	511	516	PF01217	0.499
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.472
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.459
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.280
TRG_ER_diArg_1	277	279	PF00400	0.578
TRG_ER_diArg_1	505	507	PF00400	0.632
TRG_NES_CRM1_1	413	427	PF08389	0.304
TRG_NES_CRM1_1	46	57	PF08389	0.387
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	162	167	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJG7	Leptomonas seymouri	36%	100%
A0A3S5H6X5	Leishmania donovani	84%	100%
A4H8J4	Leishmania braziliensis	68%	100%
A4HWW9	Leishmania infantum	85%	100%
Q4QEU7	Leishmania major	83%	100%