eIF2A domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor eIF2A, putative

Species:

Leishmania mexicana

UniProt:

E9AQM8_LEIMU

TriTrypDb:

LmxM.16.0690

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0015935	small ribosomal subunit	4	1
GO:0022627	cytosolic small ribosomal subunit	5	1
GO:0032991	protein-containing complex	1	1
GO:0044391	ribosomal subunit	3	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AQM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQM8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0000049	tRNA binding	5	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043022	ribosome binding	4	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.341
CLV_NRD_NRD_1	138	140	PF00675	0.389
CLV_NRD_NRD_1	523	525	PF00675	0.622
CLV_NRD_NRD_1	549	551	PF00675	0.757
CLV_PCSK_KEX2_1	119	121	PF00082	0.456
CLV_PCSK_KEX2_1	138	140	PF00082	0.389
CLV_PCSK_KEX2_1	523	525	PF00082	0.622
CLV_PCSK_KEX2_1	548	550	PF00082	0.713
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.452
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.713
CLV_PCSK_SKI1_1	231	235	PF00082	0.470
CLV_PCSK_SKI1_1	244	248	PF00082	0.181
CLV_PCSK_SKI1_1	312	316	PF00082	0.263
CLV_PCSK_SKI1_1	466	470	PF00082	0.284
DEG_SPOP_SBC_1	60	64	PF00917	0.478
DOC_ANK_TNKS_1	317	324	PF00023	0.353
DOC_MAPK_gen_1	11	18	PF00069	0.360
DOC_MAPK_gen_1	450	459	PF00069	0.472
DOC_MAPK_MEF2A_6	11	20	PF00069	0.432
DOC_PP4_FxxP_1	275	278	PF00568	0.562
DOC_PP4_FxxP_1	90	93	PF00568	0.470
DOC_USP7_MATH_1	176	180	PF00917	0.623
DOC_USP7_MATH_1	415	419	PF00917	0.501
DOC_USP7_MATH_2	185	191	PF00917	0.473
DOC_USP7_UBL2_3	238	242	PF12436	0.381
DOC_WW_Pin1_4	101	106	PF00397	0.459
DOC_WW_Pin1_4	118	123	PF00397	0.380
DOC_WW_Pin1_4	274	279	PF00397	0.538
DOC_WW_Pin1_4	329	334	PF00397	0.459
DOC_WW_Pin1_4	492	497	PF00397	0.541
LIG_14-3-3_CanoR_1	244	249	PF00244	0.444
LIG_14-3-3_CanoR_1	312	319	PF00244	0.534
LIG_14-3-3_CanoR_1	347	353	PF00244	0.472
LIG_14-3-3_CanoR_1	466	475	PF00244	0.497
LIG_14-3-3_CanoR_1	83	87	PF00244	0.472
LIG_APCC_ABBA_1	18	23	PF00400	0.436
LIG_BIR_II_1	1	5	PF00653	0.567
LIG_BRCT_BRCA1_1	438	442	PF00533	0.479
LIG_BRCT_BRCA1_1	444	448	PF00533	0.482
LIG_BRCT_BRCA1_1	99	103	PF00533	0.514
LIG_CSL_BTD_1	275	278	PF09270	0.562
LIG_FHA_1	106	112	PF00498	0.389
LIG_FHA_1	199	205	PF00498	0.529
LIG_FHA_1	245	251	PF00498	0.345
LIG_FHA_1	299	305	PF00498	0.510
LIG_FHA_1	411	417	PF00498	0.514
LIG_FHA_1	60	66	PF00498	0.395
LIG_FHA_2	149	155	PF00498	0.403
LIG_FHA_2	323	329	PF00498	0.522
LIG_FHA_2	332	338	PF00498	0.492
LIG_FHA_2	360	366	PF00498	0.497
LIG_FHA_2	64	70	PF00498	0.441
LIG_LIR_Apic_2	273	278	PF02991	0.506
LIG_LIR_Apic_2	88	93	PF02991	0.475
LIG_LIR_Gen_1	279	287	PF02991	0.538
LIG_LIR_Gen_1	438	448	PF02991	0.506
LIG_LIR_Gen_1	64	75	PF02991	0.511
LIG_LIR_Gen_1	85	94	PF02991	0.476
LIG_LIR_Nem_3	247	251	PF02991	0.489
LIG_LIR_Nem_3	279	285	PF02991	0.538
LIG_LIR_Nem_3	297	302	PF02991	0.458
LIG_LIR_Nem_3	391	395	PF02991	0.458
LIG_LIR_Nem_3	438	443	PF02991	0.500
LIG_LIR_Nem_3	445	451	PF02991	0.473
LIG_LIR_Nem_3	469	475	PF02991	0.472
LIG_LIR_Nem_3	64	70	PF02991	0.467
LIG_LIR_Nem_3	85	89	PF02991	0.502
LIG_LYPXL_yS_3	472	475	PF13949	0.472
LIG_NRBOX	334	340	PF00104	0.506
LIG_Pex14_2	86	90	PF04695	0.524
LIG_SH2_CRK	299	303	PF00017	0.458
LIG_SH2_CRK	395	399	PF00017	0.491
LIG_SH2_CRK	440	444	PF00017	0.510
LIG_SH2_CRK	509	513	PF00017	0.614
LIG_SH2_NCK_1	223	227	PF00017	0.501
LIG_SH2_NCK_1	395	399	PF00017	0.501
LIG_SH2_PTP2	282	285	PF00017	0.538
LIG_SH2_STAP1	67	71	PF00017	0.378
LIG_SH2_STAT5	109	112	PF00017	0.459
LIG_SH2_STAT5	156	159	PF00017	0.353
LIG_SH2_STAT5	282	285	PF00017	0.538
LIG_SH2_STAT5	38	41	PF00017	0.538
LIG_SH2_STAT5	67	70	PF00017	0.477
LIG_SH3_1	531	537	PF00018	0.689
LIG_SH3_3	1	7	PF00018	0.301
LIG_SH3_3	154	160	PF00018	0.441
LIG_SH3_3	48	54	PF00018	0.510
LIG_SH3_3	531	537	PF00018	0.648
LIG_SH3_3	89	95	PF00018	0.495
LIG_SH3_4	238	245	PF00018	0.394
LIG_SH3_4	503	510	PF00018	0.645
LIG_SUMO_SIM_anti_2	2	7	PF11976	0.468
LIG_SUMO_SIM_anti_2	209	215	PF11976	0.538
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.467
LIG_TRAF2_1	185	188	PF00917	0.674
LIG_TRAF2_1	499	502	PF00917	0.730
LIG_TYR_ITIM	65	70	PF00017	0.364
LIG_UBA3_1	233	238	PF00899	0.354
LIG_UBA3_1	338	344	PF00899	0.423
LIG_UBA3_1	5	12	PF00899	0.410
LIG_WRPW_2	237	240	PF00400	0.363
MOD_CDK_SPK_2	101	106	PF00069	0.510
MOD_CDK_SPK_2	492	497	PF00069	0.566
MOD_CK1_1	174	180	PF00069	0.628
MOD_CK1_1	294	300	PF00069	0.305
MOD_CK1_1	36	42	PF00069	0.296
MOD_CK1_1	410	416	PF00069	0.433
MOD_CK1_1	85	91	PF00069	0.487
MOD_CK2_1	124	130	PF00069	0.455
MOD_CK2_1	148	154	PF00069	0.402
MOD_CK2_1	24	30	PF00069	0.468
MOD_CK2_1	310	316	PF00069	0.213
MOD_CK2_1	331	337	PF00069	0.423
MOD_CK2_1	359	365	PF00069	0.274
MOD_CK2_1	63	69	PF00069	0.450
MOD_DYRK1A_RPxSP_1	492	496	PF00069	0.534
MOD_GlcNHglycan	278	281	PF01048	0.344
MOD_GlcNHglycan	292	296	PF01048	0.311
MOD_GlcNHglycan	30	34	PF01048	0.590
MOD_GlcNHglycan	384	387	PF01048	0.416
MOD_GlcNHglycan	418	421	PF01048	0.387
MOD_GSK3_1	124	131	PF00069	0.478
MOD_GSK3_1	171	178	PF00069	0.572
MOD_GSK3_1	187	194	PF00069	0.716
MOD_GSK3_1	270	277	PF00069	0.290
MOD_GSK3_1	29	36	PF00069	0.312
MOD_GSK3_1	294	301	PF00069	0.311
MOD_GSK3_1	416	423	PF00069	0.356
MOD_GSK3_1	442	449	PF00069	0.400
MOD_GSK3_1	59	66	PF00069	0.469
MOD_GSK3_1	97	104	PF00069	0.380
MOD_N-GLC_1	124	129	PF02516	0.459
MOD_N-GLC_1	204	209	PF02516	0.579
MOD_N-GLC_1	310	315	PF02516	0.380
MOD_N-GLC_1	410	415	PF02516	0.387
MOD_N-GLC_2	348	350	PF02516	0.423
MOD_NEK2_1	172	177	PF00069	0.569
MOD_NEK2_1	310	315	PF00069	0.365
MOD_NEK2_1	382	387	PF00069	0.308
MOD_NEK2_1	442	447	PF00069	0.356
MOD_NEK2_2	124	129	PF00069	0.459
MOD_PIKK_1	541	547	PF00454	0.469
MOD_PKA_2	36	42	PF00069	0.463
MOD_PKA_2	52	58	PF00069	0.392
MOD_PKA_2	82	88	PF00069	0.479
MOD_Plk_1	12	18	PF00069	0.427
MOD_Plk_1	124	130	PF00069	0.461
MOD_Plk_1	310	316	PF00069	0.325
MOD_Plk_1	33	39	PF00069	0.307
MOD_Plk_1	410	416	PF00069	0.423
MOD_Plk_1	45	51	PF00069	0.246
MOD_Plk_2-3	191	197	PF00069	0.707
MOD_Plk_2-3	322	328	PF00069	0.423
MOD_Plk_4	105	111	PF00069	0.365
MOD_Plk_4	12	18	PF00069	0.415
MOD_Plk_4	124	130	PF00069	0.449
MOD_Plk_4	176	182	PF00069	0.670
MOD_Plk_4	270	276	PF00069	0.308
MOD_Plk_4	294	300	PF00069	0.331
MOD_Plk_4	348	354	PF00069	0.311
MOD_Plk_4	443	449	PF00069	0.349
MOD_Plk_4	538	544	PF00069	0.582
MOD_Plk_4	85	91	PF00069	0.507
MOD_ProDKin_1	101	107	PF00069	0.455
MOD_ProDKin_1	118	124	PF00069	0.370
MOD_ProDKin_1	274	280	PF00069	0.423
MOD_ProDKin_1	329	335	PF00069	0.312
MOD_ProDKin_1	492	498	PF00069	0.550
MOD_SUMO_for_1	287	290	PF00179	0.311
MOD_SUMO_for_1	319	322	PF00179	0.423
MOD_SUMO_rev_2	495	504	PF00179	0.624
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.518
TRG_ENDOCYTIC_2	113	116	PF00928	0.417
TRG_ENDOCYTIC_2	282	285	PF00928	0.423
TRG_ENDOCYTIC_2	299	302	PF00928	0.311
TRG_ENDOCYTIC_2	440	443	PF00928	0.412
TRG_ENDOCYTIC_2	472	475	PF00928	0.331
TRG_ENDOCYTIC_2	67	70	PF00928	0.368
TRG_ER_diArg_1	137	139	PF00400	0.388
TRG_ER_diArg_1	450	453	PF00400	0.322
TRG_ER_diArg_1	522	524	PF00400	0.611
TRG_ER_diLys_1	546	551	PF00400	0.662
TRG_ER_FFAT_1	36	48	PF00635	0.264
TRG_NES_CRM1_1	308	322	PF08389	0.423
TRG_NLS_MonoCore_2	545	550	PF00514	0.657
TRG_NLS_MonoExtC_3	545	550	PF00514	0.657
TRG_NLS_MonoExtN_4	546	551	PF00514	0.754
TRG_Pf-PMV_PEXEL_1	312	316	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCC7	Leptomonas seymouri	76%	100%
A0A1X0NNW1	Trypanosomatidae	50%	99%
A0A3S5H6X4	Leishmania donovani	94%	100%
A0A422N2R4	Trypanosoma rangeli	51%	100%
A4H8J1	Leishmania braziliensis	87%	100%
A4HWW6	Leishmania infantum	94%	100%
C9ZPL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
O74965	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	96%
Q4QEV0	Leishmania major	96%	100%
Q4QRJ7	Danio rerio	24%	95%
Q54PV7	Dictyostelium discoideum	27%	91%
Q5ZKC1	Gallus gallus	24%	94%
Q7ZY11	Xenopus laevis	25%	95%
Q8BJW6	Mus musculus	25%	95%
Q9BY44	Homo sapiens	24%	94%
Q9VNX8	Drosophila melanogaster	27%	86%
V5BCM0	Trypanosoma cruzi	52%	100%