Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQM6_LEIMU

TriTrypDb:

LmxM.16.0670

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQM6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	442	446	PF00656	0.604
CLV_C14_Caspase3-7	610	614	PF00656	0.566
CLV_NRD_NRD_1	267	269	PF00675	0.513
CLV_NRD_NRD_1	5	7	PF00675	0.790
CLV_NRD_NRD_1	651	653	PF00675	0.513
CLV_PCSK_KEX2_1	267	269	PF00082	0.513
CLV_PCSK_KEX2_1	5	7	PF00082	0.790
CLV_PCSK_KEX2_1	536	538	PF00082	0.670
CLV_PCSK_KEX2_1	658	660	PF00082	0.685
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.670
CLV_PCSK_PC1ET2_1	658	660	PF00082	0.691
CLV_PCSK_SKI1_1	118	122	PF00082	0.689
CLV_PCSK_SKI1_1	202	206	PF00082	0.746
CLV_PCSK_SKI1_1	277	281	PF00082	0.389
CLV_PCSK_SKI1_1	320	324	PF00082	0.561
CLV_Separin_Metazoa	303	307	PF03568	0.222
DEG_Nend_Nbox_1	1	3	PF02207	0.740
DEG_SCF_FBW7_1	556	563	PF00400	0.714
DEG_SPOP_SBC_1	297	301	PF00917	0.436
DEG_SPOP_SBC_1	560	564	PF00917	0.776
DOC_MAPK_gen_1	574	583	PF00069	0.490
DOC_MAPK_MEF2A_6	515	522	PF00069	0.386
DOC_MAPK_NFAT4_5	515	523	PF00069	0.294
DOC_PP1_RVXF_1	513	520	PF00149	0.403
DOC_PP4_FxxP_1	269	272	PF00568	0.411
DOC_USP7_MATH_1	144	148	PF00917	0.570
DOC_USP7_MATH_1	163	167	PF00917	0.556
DOC_USP7_MATH_1	259	263	PF00917	0.513
DOC_USP7_MATH_1	439	443	PF00917	0.725
DOC_USP7_MATH_1	552	556	PF00917	0.819
DOC_USP7_MATH_1	561	565	PF00917	0.611
DOC_WW_Pin1_4	230	235	PF00397	0.641
DOC_WW_Pin1_4	268	273	PF00397	0.411
DOC_WW_Pin1_4	369	374	PF00397	0.508
DOC_WW_Pin1_4	379	384	PF00397	0.405
DOC_WW_Pin1_4	41	46	PF00397	0.725
DOC_WW_Pin1_4	556	561	PF00397	0.755
DOC_WW_Pin1_4	658	663	PF00397	0.490
LIG_14-3-3_CanoR_1	125	131	PF00244	0.811
LIG_14-3-3_CanoR_1	320	325	PF00244	0.538
LIG_14-3-3_CanoR_1	411	416	PF00244	0.432
LIG_14-3-3_CanoR_1	491	500	PF00244	0.352
LIG_Actin_WH2_2	637	654	PF00022	0.437
LIG_BIR_III_4	162	166	PF00653	0.530
LIG_BRCT_BRCA1_1	371	375	PF00533	0.611
LIG_Clathr_ClatBox_1	307	311	PF01394	0.513
LIG_deltaCOP1_diTrp_1	656	660	PF00928	0.460
LIG_FHA_1	112	118	PF00498	0.547
LIG_FHA_1	195	201	PF00498	0.603
LIG_FHA_1	284	290	PF00498	0.387
LIG_FHA_1	299	305	PF00498	0.285
LIG_FHA_1	494	500	PF00498	0.448
LIG_FHA_1	512	518	PF00498	0.620
LIG_FHA_1	620	626	PF00498	0.501
LIG_FHA_1	96	102	PF00498	0.744
LIG_FHA_2	216	222	PF00498	0.700
LIG_FHA_2	286	292	PF00498	0.350
LIG_FHA_2	321	327	PF00498	0.622
LIG_FHA_2	608	614	PF00498	0.693
LIG_Integrin_RGD_1	547	549	PF01839	0.709
LIG_LIR_Apic_2	505	510	PF02991	0.319
LIG_LIR_Gen_1	402	409	PF02991	0.391
LIG_LIR_Gen_1	469	477	PF02991	0.649
LIG_LIR_Gen_1	569	576	PF02991	0.562
LIG_LIR_Nem_3	372	378	PF02991	0.608
LIG_LIR_Nem_3	402	408	PF02991	0.403
LIG_LIR_Nem_3	469	474	PF02991	0.582
LIG_LIR_Nem_3	569	573	PF02991	0.569
LIG_LRP6_Inhibitor_1	472	478	PF00058	0.373
LIG_MAD2	392	400	PF02301	0.325
LIG_NRBOX	116	122	PF00104	0.762
LIG_Pex14_2	269	273	PF04695	0.411
LIG_Pex14_2	343	347	PF04695	0.582
LIG_Rb_LxCxE_1	181	201	PF01857	0.698
LIG_SH2_CRK	405	409	PF00017	0.391
LIG_SH2_CRK	507	511	PF00017	0.502
LIG_SH2_GRB2like	459	462	PF00017	0.555
LIG_SH2_NCK_1	239	243	PF00017	0.421
LIG_SH2_NCK_1	460	464	PF00017	0.551
LIG_SH2_STAP1	36	40	PF00017	0.684
LIG_SH2_STAT5	405	408	PF00017	0.397
LIG_SH2_STAT5	503	506	PF00017	0.569
LIG_SH3_2	29	34	PF14604	0.581
LIG_SH3_3	238	244	PF00018	0.566
LIG_SH3_3	26	32	PF00018	0.736
LIG_SH3_3	292	298	PF00018	0.347
LIG_SH3_3	370	376	PF00018	0.439
LIG_SUMO_SIM_anti_2	580	585	PF11976	0.599
LIG_SUMO_SIM_par_1	285	293	PF11976	0.513
LIG_TYR_ITIM	403	408	PF00017	0.333
LIG_UBA3_1	517	524	PF00899	0.339
MOD_CK1_1	255	261	PF00069	0.436
MOD_CK1_1	342	348	PF00069	0.600
MOD_CK1_1	414	420	PF00069	0.600
MOD_CK1_1	449	455	PF00069	0.726
MOD_CK1_1	494	500	PF00069	0.336
MOD_CK1_1	555	561	PF00069	0.713
MOD_CK2_1	175	181	PF00069	0.677
MOD_CK2_1	215	221	PF00069	0.604
MOD_CK2_1	237	243	PF00069	0.652
MOD_CK2_1	259	265	PF00069	0.478
MOD_CK2_1	285	291	PF00069	0.332
MOD_CK2_1	297	303	PF00069	0.250
MOD_CK2_1	320	326	PF00069	0.566
MOD_CK2_1	409	415	PF00069	0.500
MOD_CMANNOS	498	501	PF00535	0.448
MOD_CMANNOS	657	660	PF00535	0.590
MOD_DYRK1A_RPxSP_1	379	383	PF00069	0.453
MOD_GlcNHglycan	128	131	PF01048	0.796
MOD_GlcNHglycan	145	149	PF01048	0.545
MOD_GlcNHglycan	165	168	PF01048	0.708
MOD_GlcNHglycan	223	227	PF01048	0.765
MOD_GlcNHglycan	257	260	PF01048	0.300
MOD_GlcNHglycan	261	264	PF01048	0.373
MOD_GlcNHglycan	344	347	PF01048	0.458
MOD_GlcNHglycan	563	566	PF01048	0.638
MOD_GlcNHglycan	598	601	PF01048	0.709
MOD_GSK3_1	230	237	PF00069	0.691
MOD_GSK3_1	255	262	PF00069	0.476
MOD_GSK3_1	268	275	PF00069	0.333
MOD_GSK3_1	338	345	PF00069	0.617
MOD_GSK3_1	410	417	PF00069	0.576
MOD_GSK3_1	548	555	PF00069	0.705
MOD_GSK3_1	556	563	PF00069	0.793
MOD_GSK3_1	601	608	PF00069	0.695
MOD_GSK3_1	95	102	PF00069	0.784
MOD_LATS_1	123	129	PF00433	0.800
MOD_N-GLC_2	493	495	PF02516	0.284
MOD_NEK2_1	1	6	PF00069	0.730
MOD_NEK2_1	126	131	PF00069	0.705
MOD_NEK2_1	215	220	PF00069	0.720
MOD_NEK2_1	273	278	PF00069	0.513
MOD_NEK2_1	310	315	PF00069	0.329
MOD_NEK2_1	394	399	PF00069	0.309
MOD_NEK2_1	511	516	PF00069	0.514
MOD_NEK2_2	234	239	PF00069	0.488
MOD_NEK2_2	339	344	PF00069	0.598
MOD_PKA_2	124	130	PF00069	0.719
MOD_PKA_2	410	416	PF00069	0.574
MOD_PKA_2	651	657	PF00069	0.503
MOD_Plk_1	105	111	PF00069	0.520
MOD_Plk_1	310	316	PF00069	0.375
MOD_Plk_1	428	434	PF00069	0.712
MOD_Plk_4	234	240	PF00069	0.486
MOD_Plk_4	494	500	PF00069	0.448
MOD_Plk_4	99	105	PF00069	0.674
MOD_ProDKin_1	230	236	PF00069	0.636
MOD_ProDKin_1	268	274	PF00069	0.411
MOD_ProDKin_1	369	375	PF00069	0.503
MOD_ProDKin_1	379	385	PF00069	0.397
MOD_ProDKin_1	41	47	PF00069	0.729
MOD_ProDKin_1	556	562	PF00069	0.754
MOD_SUMO_rev_2	342	351	PF00179	0.440
TRG_DiLeu_BaEn_1	292	297	PF01217	0.513
TRG_DiLeu_BaEn_2	264	270	PF01217	0.513
TRG_ENDOCYTIC_2	405	408	PF00928	0.397
TRG_ENDOCYTIC_2	459	462	PF00928	0.458
TRG_ER_diArg_1	267	269	PF00400	0.513
TRG_ER_diArg_1	376	379	PF00400	0.442
TRG_ER_diArg_1	477	480	PF00400	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUK6	Leptomonas seymouri	33%	100%
A0A3S7WTX7	Leishmania donovani	78%	98%
A4H8I9	Leishmania braziliensis	57%	100%
E9AGN3	Leishmania infantum	78%	98%
Q4QEV2	Leishmania major	77%	100%