Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQM5_LEIMU

TriTrypDb:

LmxM.16.0660

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AQM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQM5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.527
CLV_NRD_NRD_1	371	373	PF00675	0.500
CLV_NRD_NRD_1	396	398	PF00675	0.450
CLV_NRD_NRD_1	461	463	PF00675	0.493
CLV_NRD_NRD_1	517	519	PF00675	0.580
CLV_NRD_NRD_1	53	55	PF00675	0.541
CLV_NRD_NRD_1	66	68	PF00675	0.526
CLV_PCSK_FUR_1	51	55	PF00082	0.447
CLV_PCSK_KEX2_1	301	303	PF00082	0.428
CLV_PCSK_KEX2_1	411	413	PF00082	0.482
CLV_PCSK_KEX2_1	461	463	PF00082	0.534
CLV_PCSK_KEX2_1	509	511	PF00082	0.592
CLV_PCSK_KEX2_1	517	519	PF00082	0.553
CLV_PCSK_KEX2_1	53	55	PF00082	0.457
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.428
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.570
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.592
CLV_PCSK_SKI1_1	148	152	PF00082	0.609
CLV_PCSK_SKI1_1	491	495	PF00082	0.616
CLV_Separin_Metazoa	108	112	PF03568	0.553
DEG_APCC_DBOX_1	553	561	PF00400	0.606
DEG_Nend_UBRbox_1	1	4	PF02207	0.476
DEG_SPOP_SBC_1	274	278	PF00917	0.579
DOC_MAPK_gen_1	461	468	PF00069	0.435
DOC_MAPK_gen_1	51	59	PF00069	0.469
DOC_MAPK_gen_1	67	73	PF00069	0.471
DOC_PP2B_LxvP_1	11	14	PF13499	0.576
DOC_USP7_MATH_1	275	279	PF00917	0.740
DOC_USP7_MATH_1	346	350	PF00917	0.616
DOC_USP7_MATH_1	392	396	PF00917	0.598
LIG_14-3-3_CanoR_1	136	141	PF00244	0.549
LIG_14-3-3_CanoR_1	280	288	PF00244	0.538
LIG_14-3-3_CanoR_1	341	350	PF00244	0.503
LIG_14-3-3_CanoR_1	397	406	PF00244	0.589
LIG_14-3-3_CanoR_1	412	417	PF00244	0.536
LIG_14-3-3_CanoR_1	430	438	PF00244	0.509
LIG_Actin_WH2_2	196	214	PF00022	0.454
LIG_BRCT_BRCA1_1	277	281	PF00533	0.523
LIG_DLG_GKlike_1	136	144	PF00625	0.472
LIG_FHA_1	115	121	PF00498	0.526
LIG_FHA_1	206	212	PF00498	0.612
LIG_FHA_1	240	246	PF00498	0.428
LIG_FHA_1	274	280	PF00498	0.593
LIG_FHA_1	282	288	PF00498	0.478
LIG_FHA_1	323	329	PF00498	0.482
LIG_FHA_1	54	60	PF00498	0.460
LIG_FHA_2	140	146	PF00498	0.540
LIG_FHA_2	413	419	PF00498	0.483
LIG_LIR_Gen_1	450	459	PF02991	0.513
LIG_LIR_Gen_1	535	545	PF02991	0.487
LIG_LIR_Nem_3	450	456	PF02991	0.518
LIG_LIR_Nem_3	535	540	PF02991	0.486
LIG_NRBOX	6	12	PF00104	0.499
LIG_PCNA_yPIPBox_3	2	11	PF02747	0.469
LIG_RPA_C_Fungi	153	165	PF08784	0.619
LIG_SH2_CRK	38	42	PF00017	0.510
LIG_SH2_NCK_1	453	457	PF00017	0.531
LIG_SH2_SRC	453	456	PF00017	0.549
LIG_SH2_SRC	98	101	PF00017	0.462
LIG_SH2_STAP1	38	42	PF00017	0.379
LIG_SH2_STAT5	98	101	PF00017	0.542
LIG_SUMO_SIM_anti_2	244	249	PF11976	0.443
LIG_TRAF2_1	365	368	PF00917	0.516
LIG_TRAF2_1	415	418	PF00917	0.452
LIG_TRAF2_1	441	444	PF00917	0.445
MOD_CK1_1	139	145	PF00069	0.557
MOD_CK1_1	269	275	PF00069	0.692
MOD_CK1_1	391	397	PF00069	0.537
MOD_CK1_1	536	542	PF00069	0.544
MOD_CK2_1	139	145	PF00069	0.537
MOD_CK2_1	149	155	PF00069	0.441
MOD_CK2_1	280	286	PF00069	0.538
MOD_CK2_1	346	352	PF00069	0.605
MOD_CK2_1	412	418	PF00069	0.462
MOD_CK2_1	429	435	PF00069	0.497
MOD_CK2_1	444	450	PF00069	0.501
MOD_GlcNHglycan	262	265	PF01048	0.682
MOD_GlcNHglycan	268	271	PF01048	0.654
MOD_GlcNHglycan	272	275	PF01048	0.617
MOD_GlcNHglycan	306	310	PF01048	0.455
MOD_GlcNHglycan	344	347	PF01048	0.555
MOD_GlcNHglycan	390	393	PF01048	0.573
MOD_GlcNHglycan	394	397	PF01048	0.525
MOD_GlcNHglycan	400	403	PF01048	0.486
MOD_GlcNHglycan	421	424	PF01048	0.564
MOD_GlcNHglycan	446	449	PF01048	0.468
MOD_GSK3_1	235	242	PF00069	0.566
MOD_GSK3_1	256	263	PF00069	0.576
MOD_GSK3_1	266	273	PF00069	0.616
MOD_GSK3_1	342	349	PF00069	0.602
MOD_GSK3_1	388	395	PF00069	0.533
MOD_N-GLC_1	239	244	PF02516	0.560
MOD_NEK2_1	360	365	PF00069	0.565
MOD_NEK2_1	468	473	PF00069	0.460
MOD_NEK2_1	71	76	PF00069	0.476
MOD_NEK2_1	83	88	PF00069	0.435
MOD_NEK2_2	275	280	PF00069	0.655
MOD_PIKK_1	187	193	PF00454	0.523
MOD_PIKK_1	239	245	PF00454	0.419
MOD_PIKK_1	382	388	PF00454	0.623
MOD_PK_1	489	495	PF00069	0.526
MOD_PKA_1	411	417	PF00069	0.382
MOD_PKA_1	53	59	PF00069	0.387
MOD_PKA_2	388	394	PF00069	0.574
MOD_PKA_2	411	417	PF00069	0.579
MOD_PKA_2	429	435	PF00069	0.465
MOD_PKA_2	53	59	PF00069	0.542
MOD_PKA_2	533	539	PF00069	0.514
MOD_PKB_1	51	59	PF00069	0.385
MOD_Plk_1	305	311	PF00069	0.443
MOD_Plk_1	367	373	PF00069	0.531
MOD_Plk_1	489	495	PF00069	0.420
MOD_Plk_2-3	169	175	PF00069	0.674
MOD_Plk_2-3	429	435	PF00069	0.507
MOD_Plk_4	533	539	PF00069	0.494
MOD_SUMO_for_1	485	488	PF00179	0.480
MOD_SUMO_rev_2	159	165	PF00179	0.538
MOD_SUMO_rev_2	297	303	PF00179	0.453
MOD_SUMO_rev_2	358	366	PF00179	0.483
MOD_SUMO_rev_2	414	422	PF00179	0.463
TRG_DiLeu_BaEn_3	226	232	PF01217	0.549
TRG_DiLeu_BaEn_4	107	113	PF01217	0.567
TRG_DiLeu_BaEn_4	47	53	PF01217	0.434
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.400
TRG_ENDOCYTIC_2	38	41	PF00928	0.519
TRG_ENDOCYTIC_2	453	456	PF00928	0.536
TRG_ENDOCYTIC_2	463	466	PF00928	0.549
TRG_ER_diArg_1	110	113	PF00400	0.548
TRG_ER_diArg_1	228	231	PF00400	0.494
TRG_ER_diArg_1	353	356	PF00400	0.397
TRG_ER_diArg_1	461	463	PF00400	0.534
TRG_ER_diArg_1	51	54	PF00400	0.554
TRG_ER_diArg_1	517	519	PF00400	0.577
TRG_NES_CRM1_1	104	115	PF08389	0.550
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBD3	Leptomonas seymouri	67%	91%
A0A0S4JEJ6	Bodo saltans	35%	95%
A0A1X0NNU4	Trypanosomatidae	38%	98%
A0A3S7WTX4	Leishmania donovani	93%	100%
A0A422MW68	Trypanosoma rangeli	38%	98%
A4H8I8	Leishmania braziliensis	83%	100%
A4HWW5	Leishmania infantum	93%	100%
C9ZPQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4QEV3	Leishmania major	92%	100%
V5AX96	Trypanosoma cruzi	39%	98%