Peptidyl-prolyl cis-trans isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9AQM3_LEIMU

TriTrypDb:

LmxM.16.0640

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AQM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQM3

Function

Biological processes
Term	Name	Level	Count
GO:0001932	regulation of protein phosphorylation	7	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031399	regulation of protein modification process	6	1
GO:0042325	regulation of phosphorylation	7	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901407	obsolete regulation of phosphorylation of RNA polymerase II C-terminal domain	8	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1
GO:0000413	protein peptidyl-prolyl isomerization	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018208	peptidyl-proline modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0016853	isomerase activity	2	8
GO:0016859	cis-trans isomerase activity	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.721
CLV_NRD_NRD_1	159	161	PF00675	0.688
CLV_NRD_NRD_1	172	174	PF00675	0.606
CLV_NRD_NRD_1	272	274	PF00675	0.742
CLV_NRD_NRD_1	275	277	PF00675	0.688
CLV_NRD_NRD_1	360	362	PF00675	0.531
CLV_NRD_NRD_1	488	490	PF00675	0.636
CLV_NRD_NRD_1	503	505	PF00675	0.607
CLV_NRD_NRD_1	631	633	PF00675	0.587
CLV_NRD_NRD_1	9	11	PF00675	0.705
CLV_PCSK_FUR_1	273	277	PF00082	0.773
CLV_PCSK_FUR_1	318	322	PF00082	0.701
CLV_PCSK_KEX2_1	159	161	PF00082	0.685
CLV_PCSK_KEX2_1	170	172	PF00082	0.607
CLV_PCSK_KEX2_1	272	274	PF00082	0.667
CLV_PCSK_KEX2_1	275	277	PF00082	0.640
CLV_PCSK_KEX2_1	320	322	PF00082	0.703
CLV_PCSK_KEX2_1	362	364	PF00082	0.485
CLV_PCSK_KEX2_1	488	490	PF00082	0.673
CLV_PCSK_KEX2_1	503	505	PF00082	0.593
CLV_PCSK_KEX2_1	633	635	PF00082	0.590
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.700
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.682
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.528
CLV_PCSK_PC1ET2_1	633	635	PF00082	0.641
CLV_PCSK_PC7_1	167	173	PF00082	0.689
CLV_PCSK_PC7_1	358	364	PF00082	0.473
CLV_PCSK_PC7_1	629	635	PF00082	0.577
CLV_PCSK_SKI1_1	305	309	PF00082	0.727
CLV_PCSK_SKI1_1	320	324	PF00082	0.581
CLV_PCSK_SKI1_1	636	640	PF00082	0.714
CLV_PCSK_SKI1_1	86	90	PF00082	0.644
DEG_Nend_UBRbox_3	1	3	PF02207	0.758
DEG_SPOP_SBC_1	287	291	PF00917	0.511
DOC_CYCLIN_RxL_1	83	90	PF00134	0.704
DOC_MAPK_gen_1	167	177	PF00069	0.680
DOC_MAPK_gen_1	629	639	PF00069	0.715
DOC_MAPK_MEF2A_6	256	263	PF00069	0.687
DOC_MAPK_MEF2A_6	428	437	PF00069	0.765
DOC_MAPK_MEF2A_6	514	523	PF00069	0.623
DOC_MAPK_RevD_3	306	321	PF00069	0.771
DOC_PP2B_PxIxI_1	432	438	PF00149	0.754
DOC_USP7_MATH_1	127	131	PF00917	0.732
DOC_USP7_MATH_1	132	136	PF00917	0.751
DOC_USP7_MATH_1	140	144	PF00917	0.737
DOC_USP7_MATH_1	211	215	PF00917	0.755
DOC_USP7_MATH_1	217	221	PF00917	0.779
DOC_USP7_MATH_1	413	417	PF00917	0.663
DOC_USP7_MATH_1	43	47	PF00917	0.715
DOC_USP7_MATH_1	487	491	PF00917	0.682
DOC_WW_Pin1_4	100	105	PF00397	0.641
DOC_WW_Pin1_4	123	128	PF00397	0.748
DOC_WW_Pin1_4	218	223	PF00397	0.702
LIG_14-3-3_CanoR_1	241	247	PF00244	0.655
LIG_14-3-3_CanoR_1	305	311	PF00244	0.684
LIG_14-3-3_CanoR_1	321	325	PF00244	0.563
LIG_14-3-3_CanoR_1	361	368	PF00244	0.736
LIG_14-3-3_CanoR_1	395	399	PF00244	0.654
LIG_14-3-3_CanoR_1	408	413	PF00244	0.547
LIG_14-3-3_CanoR_1	488	495	PF00244	0.642
LIG_14-3-3_CanoR_1	503	508	PF00244	0.720
LIG_14-3-3_CanoR_1	566	574	PF00244	0.536
LIG_14-3-3_CanoR_1	579	583	PF00244	0.555
LIG_Actin_WH2_2	256	274	PF00022	0.721
LIG_BIR_III_2	124	128	PF00653	0.700
LIG_BIR_III_4	476	480	PF00653	0.627
LIG_FHA_1	126	132	PF00498	0.691
LIG_FHA_1	22	28	PF00498	0.618
LIG_FHA_1	258	264	PF00498	0.619
LIG_FHA_1	291	297	PF00498	0.493
LIG_FHA_1	516	522	PF00498	0.572
LIG_FHA_1	65	71	PF00498	0.634
LIG_FHA_2	243	249	PF00498	0.731
LIG_FHA_2	287	293	PF00498	0.625
LIG_FHA_2	409	415	PF00498	0.612
LIG_FHA_2	442	448	PF00498	0.798
LIG_FHA_2	550	556	PF00498	0.500
LIG_FHA_2	566	572	PF00498	0.547
LIG_Integrin_RGD_1	533	535	PF01839	0.678
LIG_LIR_Apic_2	309	313	PF02991	0.677
LIG_LIR_Gen_1	255	264	PF02991	0.590
LIG_LIR_Gen_1	330	340	PF02991	0.678
LIG_LIR_Gen_1	49	60	PF02991	0.588
LIG_LIR_Gen_1	588	596	PF02991	0.555
LIG_LIR_Nem_3	255	261	PF02991	0.600
LIG_LIR_Nem_3	330	336	PF02991	0.707
LIG_LIR_Nem_3	339	344	PF02991	0.761
LIG_LIR_Nem_3	49	55	PF02991	0.574
LIG_LIR_Nem_3	562	567	PF02991	0.566
LIG_LIR_Nem_3	581	587	PF02991	0.517
LIG_LIR_Nem_3	588	592	PF02991	0.517
LIG_LIR_Nem_3	593	599	PF02991	0.517
LIG_LIR_Nem_3	82	88	PF02991	0.554
LIG_NRBOX	88	94	PF00104	0.617
LIG_PTB_Apo_2	459	466	PF02174	0.641
LIG_PTB_Phospho_1	459	465	PF10480	0.764
LIG_SH2_CRK	191	195	PF00017	0.744
LIG_SH2_PTP2	258	261	PF00017	0.639
LIG_SH2_PTP2	333	336	PF00017	0.775
LIG_SH2_PTP2	403	406	PF00017	0.621
LIG_SH2_SRC	191	194	PF00017	0.735
LIG_SH2_SRC	195	198	PF00017	0.738
LIG_SH2_STAT5	195	198	PF00017	0.800
LIG_SH2_STAT5	258	261	PF00017	0.597
LIG_SH2_STAT5	333	336	PF00017	0.775
LIG_SH2_STAT5	403	406	PF00017	0.618
LIG_SH2_STAT5	418	421	PF00017	0.716
LIG_SH2_STAT5	469	472	PF00017	0.661
LIG_SH3_3	191	197	PF00018	0.685
LIG_SH3_3	331	337	PF00018	0.775
LIG_SH3_3	457	463	PF00018	0.684
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.478
LIG_SUMO_SIM_anti_2	456	461	PF11976	0.653
LIG_SUMO_SIM_anti_2	517	523	PF11976	0.623
LIG_SUMO_SIM_par_1	34	39	PF11976	0.615
LIG_TYR_ITIM	582	587	PF00017	0.376
MOD_CK1_1	130	136	PF00069	0.775
MOD_CK1_1	143	149	PF00069	0.601
MOD_CK1_1	15	21	PF00069	0.622
MOD_CK1_1	199	205	PF00069	0.690
MOD_CK1_1	218	224	PF00069	0.468
MOD_CK1_1	236	242	PF00069	0.450
MOD_CK1_1	247	253	PF00069	0.585
MOD_CK1_1	46	52	PF00069	0.661
MOD_CK2_1	549	555	PF00069	0.376
MOD_GlcNHglycan	14	17	PF01048	0.517
MOD_GlcNHglycan	142	145	PF01048	0.663
MOD_GlcNHglycan	198	201	PF01048	0.698
MOD_GlcNHglycan	2	5	PF01048	0.758
MOD_GlcNHglycan	213	216	PF01048	0.688
MOD_GlcNHglycan	217	220	PF01048	0.492
MOD_GlcNHglycan	234	238	PF01048	0.683
MOD_GlcNHglycan	338	341	PF01048	0.696
MOD_GlcNHglycan	349	352	PF01048	0.655
MOD_GlcNHglycan	44	48	PF01048	0.645
MOD_GlcNHglycan	489	492	PF01048	0.723
MOD_GlcNHglycan	495	498	PF01048	0.646
MOD_GlcNHglycan	568	571	PF01048	0.353
MOD_GlcNHglycan	96	99	PF01048	0.681
MOD_GSK3_1	11	18	PF00069	0.576
MOD_GSK3_1	123	130	PF00069	0.731
MOD_GSK3_1	140	147	PF00069	0.734
MOD_GSK3_1	211	218	PF00069	0.761
MOD_GSK3_1	286	293	PF00069	0.608
MOD_GSK3_1	320	327	PF00069	0.709
MOD_GSK3_1	343	350	PF00069	0.734
MOD_GSK3_1	614	621	PF00069	0.467
MOD_N-GLC_1	515	520	PF02516	0.568
MOD_N-GLC_2	54	56	PF02516	0.559
MOD_NEK2_1	242	247	PF00069	0.621
MOD_NEK2_1	28	33	PF00069	0.581
MOD_NEK2_1	393	398	PF00069	0.601
MOD_NEK2_1	559	564	PF00069	0.376
MOD_NEK2_1	616	621	PF00069	0.517
MOD_NEK2_1	92	97	PF00069	0.645
MOD_NEK2_2	132	137	PF00069	0.713
MOD_NEK2_2	413	418	PF00069	0.675
MOD_PIKK_1	559	565	PF00454	0.429
MOD_PIKK_1	614	620	PF00454	0.488
MOD_PKA_1	320	326	PF00069	0.779
MOD_PKA_1	361	367	PF00069	0.463
MOD_PKA_1	503	509	PF00069	0.731
MOD_PKA_2	320	326	PF00069	0.742
MOD_PKA_2	394	400	PF00069	0.662
MOD_PKA_2	487	493	PF00069	0.690
MOD_PKA_2	503	509	PF00069	0.681
MOD_PKA_2	565	571	PF00069	0.467
MOD_PKA_2	578	584	PF00069	0.373
MOD_Plk_1	247	253	PF00069	0.618
MOD_Plk_1	29	35	PF00069	0.584
MOD_Plk_1	413	419	PF00069	0.658
MOD_Plk_1	43	49	PF00069	0.572
MOD_Plk_1	515	521	PF00069	0.624
MOD_Plk_2-3	588	594	PF00069	0.418
MOD_Plk_4	227	233	PF00069	0.692
MOD_Plk_4	320	326	PF00069	0.708
MOD_Plk_4	413	419	PF00069	0.725
MOD_Plk_4	503	509	PF00069	0.717
MOD_Plk_4	517	523	PF00069	0.525
MOD_ProDKin_1	100	106	PF00069	0.640
MOD_ProDKin_1	123	129	PF00069	0.747
MOD_ProDKin_1	218	224	PF00069	0.701
MOD_SUMO_rev_2	531	539	PF00179	0.597
MOD_SUMO_rev_2	569	578	PF00179	0.376
TRG_DiLeu_BaEn_1	517	522	PF01217	0.625
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.684
TRG_ENDOCYTIC_2	191	194	PF00928	0.744
TRG_ENDOCYTIC_2	258	261	PF00928	0.639
TRG_ENDOCYTIC_2	333	336	PF00928	0.775
TRG_ENDOCYTIC_2	403	406	PF00928	0.704
TRG_ENDOCYTIC_2	584	587	PF00928	0.376
TRG_ENDOCYTIC_2	85	88	PF00928	0.577
TRG_ER_diArg_1	158	160	PF00400	0.732
TRG_ER_diArg_1	171	173	PF00400	0.647
TRG_ER_diArg_1	271	273	PF00400	0.738
TRG_ER_diArg_1	274	276	PF00400	0.689
TRG_ER_diArg_1	487	489	PF00400	0.497
TRG_ER_diArg_1	631	634	PF00400	0.552
TRG_NLS_Bipartite_1	159	174	PF00514	0.574
TRG_NLS_MonoCore_2	169	174	PF00514	0.700
TRG_NLS_MonoExtC_3	631	636	PF00514	0.566
TRG_NLS_MonoExtN_4	167	174	PF00514	0.693
TRG_NLS_MonoExtN_4	358	365	PF00514	0.471
TRG_NLS_MonoExtN_4	629	636	PF00514	0.556
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.703
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	604	608	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.701

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB00	Leptomonas seymouri	55%	100%
A0A3Q8ICH7	Leishmania donovani	90%	91%
A4H8I6	Leishmania braziliensis	81%	100%
A4HWW3	Leishmania infantum	90%	91%
C9ZPQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QEV5	Leishmania major	88%	100%