TP6A_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

meiotic recombination protein SPO11, putative

Species:

Leishmania mexicana

UniProt:

E9AQM2_LEIMU

TriTrypDb:

LmxM.16.0630

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005694	chromosome	5	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0000228	nuclear chromosome	6	1

Expansion

Sequence features

E9AQM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQM2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000706	meiotic DNA double-strand break processing	3	1
GO:0000729	DNA double-strand break processing	5	1
GO:0006310	DNA recombination	5	1
GO:0007131	reciprocal meiotic recombination	3	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0035825	homologous recombination	6	1
GO:0042138	meiotic DNA double-strand break formation	4	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0140527	reciprocal homologous recombination	7	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0003916	DNA topoisomerase activity	3	7
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0008094	ATP-dependent activity, acting on DNA	2	7
GO:0016853	isomerase activity	2	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0140657	ATP-dependent activity	1	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	417	421	PF00656	0.583
CLV_C14_Caspase3-7	501	505	PF00656	0.413
CLV_C14_Caspase3-7	537	541	PF00656	0.517
CLV_NRD_NRD_1	27	29	PF00675	0.354
CLV_NRD_NRD_1	344	346	PF00675	0.416
CLV_NRD_NRD_1	418	420	PF00675	0.480
CLV_NRD_NRD_1	46	48	PF00675	0.533
CLV_NRD_NRD_1	543	545	PF00675	0.678
CLV_NRD_NRD_1	628	630	PF00675	0.618
CLV_NRD_NRD_1	648	650	PF00675	0.257
CLV_NRD_NRD_1	68	70	PF00675	0.632
CLV_PCSK_KEX2_1	27	29	PF00082	0.354
CLV_PCSK_KEX2_1	344	346	PF00082	0.416
CLV_PCSK_KEX2_1	418	420	PF00082	0.562
CLV_PCSK_KEX2_1	46	48	PF00082	0.533
CLV_PCSK_KEX2_1	513	515	PF00082	0.366
CLV_PCSK_KEX2_1	542	544	PF00082	0.641
CLV_PCSK_KEX2_1	627	629	PF00082	0.624
CLV_PCSK_KEX2_1	648	650	PF00082	0.377
CLV_PCSK_KEX2_1	67	69	PF00082	0.638
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.300
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.493
CLV_PCSK_PC7_1	414	420	PF00082	0.454
CLV_PCSK_PC7_1	509	515	PF00082	0.293
CLV_PCSK_SKI1_1	122	126	PF00082	0.505
CLV_PCSK_SKI1_1	283	287	PF00082	0.531
CLV_PCSK_SKI1_1	344	348	PF00082	0.408
CLV_Separin_Metazoa	24	28	PF03568	0.367
DEG_APCC_DBOX_1	133	141	PF00400	0.280
DEG_APCC_DBOX_1	320	328	PF00400	0.422
DEG_APCC_DBOX_1	343	351	PF00400	0.416
DEG_SPOP_SBC_1	258	262	PF00917	0.482
DOC_ANK_TNKS_1	242	249	PF00023	0.447
DOC_CDC14_PxL_1	396	404	PF14671	0.398
DOC_MAPK_DCC_7	86	96	PF00069	0.492
DOC_MAPK_gen_1	184	192	PF00069	0.338
DOC_MAPK_gen_1	27	33	PF00069	0.357
DOC_MAPK_MEF2A_6	134	142	PF00069	0.316
DOC_MAPK_MEF2A_6	326	333	PF00069	0.384
DOC_MAPK_RevD_3	31	47	PF00069	0.413
DOC_PP2B_LxvP_1	183	186	PF13499	0.338
DOC_PP2B_LxvP_1	41	44	PF13499	0.481
DOC_PP4_FxxP_1	298	301	PF00568	0.496
DOC_USP7_MATH_1	104	108	PF00917	0.580
DOC_USP7_MATH_1	115	119	PF00917	0.457
DOC_USP7_MATH_1	123	127	PF00917	0.542
DOC_USP7_MATH_1	258	262	PF00917	0.702
DOC_USP7_MATH_1	379	383	PF00917	0.508
DOC_USP7_MATH_1	386	390	PF00917	0.575
DOC_USP7_MATH_1	467	471	PF00917	0.711
DOC_USP7_MATH_1	490	494	PF00917	0.690
DOC_USP7_MATH_1	521	525	PF00917	0.708
DOC_USP7_MATH_1	565	569	PF00917	0.450
DOC_WW_Pin1_4	438	443	PF00397	0.813
DOC_WW_Pin1_4	46	51	PF00397	0.446
DOC_WW_Pin1_4	475	480	PF00397	0.658
DOC_WW_Pin1_4	486	491	PF00397	0.611
DOC_WW_Pin1_4	522	527	PF00397	0.662
DOC_WW_Pin1_4	59	64	PF00397	0.487
DOC_WW_Pin1_4	6	11	PF00397	0.464
DOC_WW_Pin1_4	87	92	PF00397	0.526
LIG_14-3-3_CanoR_1	122	128	PF00244	0.551
LIG_14-3-3_CanoR_1	164	172	PF00244	0.423
LIG_14-3-3_CanoR_1	276	285	PF00244	0.501
LIG_14-3-3_CanoR_1	377	387	PF00244	0.472
LIG_14-3-3_CanoR_1	51	56	PF00244	0.485
LIG_14-3-3_CanoR_1	571	575	PF00244	0.575
LIG_14-3-3_CanoR_1	583	587	PF00244	0.417
LIG_BIR_II_1	1	5	PF00653	0.397
LIG_BIR_III_2	383	387	PF00653	0.462
LIG_EVH1_2	634	638	PF00568	0.430
LIG_FHA_1	166	172	PF00498	0.335
LIG_FHA_1	618	624	PF00498	0.479
LIG_FHA_2	152	158	PF00498	0.280
LIG_FHA_2	18	24	PF00498	0.327
LIG_FHA_2	499	505	PF00498	0.449
LIG_Integrin_RGD_1	149	151	PF01839	0.299
LIG_LIR_Apic_2	394	400	PF02991	0.373
LIG_LIR_Apic_2	606	612	PF02991	0.430
LIG_LIR_Gen_1	157	166	PF02991	0.394
LIG_LIR_Gen_1	3	13	PF02991	0.505
LIG_LIR_Nem_3	141	147	PF02991	0.426
LIG_LIR_Nem_3	157	163	PF02991	0.289
LIG_LIR_Nem_3	205	209	PF02991	0.472
LIG_LIR_Nem_3	280	285	PF02991	0.591
LIG_LIR_Nem_3	3	8	PF02991	0.497
LIG_LIR_Nem_3	393	399	PF02991	0.426
LIG_LIR_Nem_3	401	407	PF02991	0.378
LIG_NRBOX	36	42	PF00104	0.551
LIG_NRBOX	514	520	PF00104	0.452
LIG_SH2_CRK	160	164	PF00017	0.322
LIG_SH2_CRK	206	210	PF00017	0.375
LIG_SH2_CRK	397	401	PF00017	0.302
LIG_SH2_CRK	609	613	PF00017	0.451
LIG_SH2_CRK	72	76	PF00017	0.584
LIG_SH2_NCK_1	397	401	PF00017	0.302
LIG_SH2_NCK_1	609	613	PF00017	0.451
LIG_SH2_NCK_1	72	76	PF00017	0.487
LIG_SH2_STAP1	613	617	PF00017	0.456
LIG_SH2_STAT3	613	616	PF00017	0.297
LIG_SH2_STAT3	76	79	PF00017	0.483
LIG_SH2_STAT5	199	202	PF00017	0.452
LIG_SH2_STAT5	32	35	PF00017	0.411
LIG_SH2_STAT5	499	502	PF00017	0.307
LIG_SH2_STAT5	609	612	PF00017	0.498
LIG_SH3_3	429	435	PF00018	0.676
LIG_SH3_3	91	97	PF00018	0.597
LIG_SUMO_SIM_anti_2	604	610	PF11976	0.277
LIG_SUMO_SIM_par_1	136	141	PF11976	0.335
LIG_SUMO_SIM_par_1	306	311	PF11976	0.296
LIG_TRAF2_1	219	222	PF00917	0.529
LIG_TYR_ITIM	158	163	PF00017	0.379
LIG_TYR_ITIM	204	209	PF00017	0.352
MOD_CDK_SPK_2	46	51	PF00069	0.446
MOD_CK1_1	259	265	PF00069	0.764
MOD_CK1_1	272	278	PF00069	0.560
MOD_CK1_1	391	397	PF00069	0.422
MOD_CK1_1	463	469	PF00069	0.625
MOD_CK1_1	470	476	PF00069	0.720
MOD_CK1_1	489	495	PF00069	0.584
MOD_CK1_1	570	576	PF00069	0.599
MOD_CK2_1	1	7	PF00069	0.463
MOD_CK2_1	547	553	PF00069	0.562
MOD_Cter_Amidation	540	543	PF01082	0.549
MOD_GlcNHglycan	213	216	PF01048	0.565
MOD_GlcNHglycan	229	232	PF01048	0.404
MOD_GlcNHglycan	254	257	PF01048	0.583
MOD_GlcNHglycan	271	274	PF01048	0.630
MOD_GlcNHglycan	288	291	PF01048	0.476
MOD_GlcNHglycan	388	391	PF01048	0.566
MOD_GlcNHglycan	420	423	PF01048	0.606
MOD_GlcNHglycan	447	450	PF01048	0.601
MOD_GlcNHglycan	458	461	PF01048	0.673
MOD_GlcNHglycan	465	468	PF01048	0.658
MOD_GlcNHglycan	469	472	PF01048	0.610
MOD_GlcNHglycan	483	486	PF01048	0.531
MOD_GlcNHglycan	561	565	PF01048	0.549
MOD_GSK3_1	252	259	PF00069	0.771
MOD_GSK3_1	261	268	PF00069	0.511
MOD_GSK3_1	271	278	PF00069	0.602
MOD_GSK3_1	452	459	PF00069	0.782
MOD_GSK3_1	463	470	PF00069	0.653
MOD_GSK3_1	474	481	PF00069	0.638
MOD_GSK3_1	486	493	PF00069	0.497
MOD_GSK3_1	556	563	PF00069	0.605
MOD_N-GLC_1	172	177	PF02516	0.338
MOD_N-GLC_1	463	468	PF02516	0.484
MOD_N-GLC_2	303	305	PF02516	0.355
MOD_NEK2_1	1	6	PF00069	0.570
MOD_NEK2_1	138	143	PF00069	0.368
MOD_NEK2_1	211	216	PF00069	0.518
MOD_NEK2_1	233	238	PF00069	0.485
MOD_NEK2_1	257	262	PF00069	0.682
MOD_NEK2_1	269	274	PF00069	0.555
MOD_NEK2_1	277	282	PF00069	0.430
MOD_NEK2_1	36	41	PF00069	0.437
MOD_NEK2_1	445	450	PF00069	0.665
MOD_NEK2_1	546	551	PF00069	0.483
MOD_NEK2_1	617	622	PF00069	0.529
MOD_NEK2_1	78	83	PF00069	0.532
MOD_NEK2_2	123	128	PF00069	0.479
MOD_NEK2_2	129	134	PF00069	0.352
MOD_PIKK_1	113	119	PF00454	0.505
MOD_PIKK_1	151	157	PF00454	0.315
MOD_PIKK_1	165	171	PF00454	0.230
MOD_PIKK_1	277	283	PF00454	0.448
MOD_PIKK_1	314	320	PF00454	0.225
MOD_PIKK_1	633	639	PF00454	0.479
MOD_PKA_1	418	424	PF00069	0.525
MOD_PKA_2	275	281	PF00069	0.636
MOD_PKA_2	418	424	PF00069	0.676
MOD_PKA_2	570	576	PF00069	0.419
MOD_PKA_2	582	588	PF00069	0.536
MOD_Plk_1	172	178	PF00069	0.338
MOD_Plk_1	547	553	PF00069	0.477
MOD_Plk_2-3	556	562	PF00069	0.471
MOD_Plk_4	138	144	PF00069	0.238
MOD_Plk_4	233	239	PF00069	0.371
MOD_Plk_4	36	42	PF00069	0.496
MOD_ProDKin_1	438	444	PF00069	0.813
MOD_ProDKin_1	46	52	PF00069	0.446
MOD_ProDKin_1	475	481	PF00069	0.659
MOD_ProDKin_1	486	492	PF00069	0.607
MOD_ProDKin_1	522	528	PF00069	0.665
MOD_ProDKin_1	59	65	PF00069	0.486
MOD_ProDKin_1	6	12	PF00069	0.465
MOD_ProDKin_1	87	93	PF00069	0.526
MOD_SUMO_for_1	601	604	PF00179	0.341
TRG_DiLeu_BaEn_4	221	227	PF01217	0.419
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.411
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.387
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.375
TRG_ENDOCYTIC_2	159	162	PF00928	0.373
TRG_ENDOCYTIC_2	206	209	PF00928	0.511
TRG_ENDOCYTIC_2	282	285	PF00928	0.477
TRG_ENDOCYTIC_2	396	399	PF00928	0.404
TRG_ER_diArg_1	26	28	PF00400	0.363
TRG_ER_diArg_1	344	346	PF00400	0.440
TRG_ER_diArg_1	435	438	PF00400	0.582
TRG_ER_diArg_1	45	47	PF00400	0.433
TRG_ER_diArg_1	542	544	PF00400	0.549
TRG_ER_diArg_1	626	629	PF00400	0.568
TRG_ER_diArg_1	647	649	PF00400	0.430
TRG_NES_CRM1_1	19	35	PF08389	0.423
TRG_NLS_MonoExtC_3	66	71	PF00514	0.480
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C1	Leptomonas seymouri	39%	98%
A0A3S7WTW1	Leishmania donovani	82%	100%
A4H8I5	Leishmania braziliensis	68%	100%
Q4QEV6	Leishmania major	84%	100%
V5BH86	Trypanosoma cruzi	29%	100%