ATPase family associated with various cellular activities (AAA) domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQK9_LEIMU

TriTrypDb:

LmxM.16.0510

Length:

1203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AQK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQK9

Function

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Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	3
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	3
GO:0019222	regulation of metabolic process	3	3
GO:0031323	regulation of cellular metabolic process	4	3
GO:0043484	regulation of RNA splicing	6	3
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0051171	regulation of nitrogen compound metabolic process	4	3
GO:0051252	regulation of RNA metabolic process	5	3
GO:0051726	regulation of cell cycle	4	3

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1199	1203	PF00656	0.578
CLV_C14_Caspase3-7	128	132	PF00656	0.594
CLV_C14_Caspase3-7	236	240	PF00656	0.568
CLV_C14_Caspase3-7	302	306	PF00656	0.544
CLV_C14_Caspase3-7	355	359	PF00656	0.736
CLV_C14_Caspase3-7	65	69	PF00656	0.735
CLV_C14_Caspase3-7	650	654	PF00656	0.666
CLV_C14_Caspase3-7	942	946	PF00656	0.570
CLV_C14_Caspase3-7	983	987	PF00656	0.528
CLV_NRD_NRD_1	1035	1037	PF00675	0.506

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WTU9	Leishmania donovani	86%	100%
A4H8H7	Leishmania braziliensis	71%	100%
A4HWU9	Leishmania infantum	85%	100%
Q4QEW9	Leishmania major	85%	99%

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