Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AQK8_LEIMU

TriTrypDb:

LmxM.16.0500

Length:

216

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin: surface protein with roles in host adhesion, especially at the amastigote stage.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 18
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

E9AQK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	28	30	PF00675	0.575
CLV_PCSK_SKI1_1	41	45	PF00082	0.531
CLV_PCSK_SKI1_1	5	9	PF00082	0.276
CLV_PCSK_SKI1_1	75	79	PF00082	0.550
DEG_APCC_DBOX_1	4	12	PF00400	0.431
DEG_Nend_UBRbox_1	1	4	PF02207	0.543
DEG_SCF_FBW7_1	52	59	PF00400	0.295
DOC_MAPK_gen_1	2	11	PF00069	0.546
DOC_MAPK_MEF2A_6	2	11	PF00069	0.514
DOC_MAPK_NFAT4_5	5	13	PF00069	0.380
DOC_PP1_RVXF_1	39	45	PF00149	0.292
DOC_PP1_RVXF_1	73	79	PF00149	0.339
DOC_PP2B_LxvP_1	150	153	PF13499	0.291
DOC_USP7_MATH_1	193	197	PF00917	0.743
DOC_WW_Pin1_4	52	57	PF00397	0.394
LIG_14-3-3_CanoR_1	63	68	PF00244	0.388
LIG_DLG_GKlike_1	63	70	PF00625	0.290
LIG_EH1_1	77	85	PF00400	0.180
LIG_FHA_1	112	118	PF00498	0.339
LIG_FHA_1	14	20	PF00498	0.458
LIG_FHA_1	204	210	PF00498	0.563
LIG_FHA_1	57	63	PF00498	0.431
LIG_FHA_2	200	206	PF00498	0.566
LIG_LIR_Gen_1	119	129	PF02991	0.349
LIG_LIR_Gen_1	64	74	PF02991	0.349
LIG_LIR_Nem_3	119	124	PF02991	0.327
LIG_LIR_Nem_3	162	167	PF02991	0.314
LIG_LIR_Nem_3	38	43	PF02991	0.324
LIG_LIR_Nem_3	64	70	PF02991	0.502
LIG_NRBOX	5	11	PF00104	0.428
LIG_Pex14_2	121	125	PF04695	0.342
LIG_Pex14_2	137	141	PF04695	0.279
LIG_SH2_STAP1	65	69	PF00017	0.426
LIG_SH2_STAT5	149	152	PF00017	0.390
LIG_SUMO_SIM_anti_2	126	131	PF11976	0.333
LIG_SUMO_SIM_par_1	58	64	PF11976	0.285
LIG_UBA3_1	23	30	PF00899	0.447
MOD_CK1_1	32	38	PF00069	0.509
MOD_GlcNHglycan	195	198	PF01048	0.345
MOD_GlcNHglycan	52	55	PF01048	0.633
MOD_GSK3_1	107	114	PF00069	0.551
MOD_GSK3_1	199	206	PF00069	0.651
MOD_GSK3_1	46	53	PF00069	0.372
MOD_N-GLC_1	107	112	PF02516	0.378
MOD_N-GLC_1	203	208	PF02516	0.362
MOD_N-GLC_1	32	37	PF02516	0.622
MOD_N-GLC_1	46	51	PF02516	0.560
MOD_NEK2_1	111	116	PF00069	0.347
MOD_NEK2_1	123	128	PF00069	0.345
MOD_NEK2_1	13	18	PF00069	0.362
MOD_NEK2_1	46	51	PF00069	0.295
MOD_PKA_1	29	35	PF00069	0.342
MOD_Plk_1	107	113	PF00069	0.578
MOD_Plk_1	32	38	PF00069	0.281
MOD_Plk_1	46	52	PF00069	0.367
MOD_Plk_4	112	118	PF00069	0.414
MOD_Plk_4	32	38	PF00069	0.452
MOD_Plk_4	56	62	PF00069	0.456
MOD_Plk_4	82	88	PF00069	0.368
MOD_ProDKin_1	52	58	PF00069	0.394
TRG_DiLeu_BaEn_1	162	167	PF01217	0.298
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.482
TRG_ENDOCYTIC_2	40	43	PF00928	0.326
TRG_ER_diArg_1	190	193	PF00400	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z4	Leptomonas seymouri	28%	100%
A0A0N0P3Z6	Leptomonas seymouri	33%	96%
A0A0N0P4D5	Leptomonas seymouri	34%	100%
A0A0N1HU04	Leptomonas seymouri	27%	69%
A0A0N1PD13	Leptomonas seymouri	24%	92%
A0A3Q8IIZ2	Leishmania donovani	61%	97%
A0A3R7KFR8	Trypanosoma rangeli	29%	100%
A0A3S5H6X1	Leishmania donovani	37%	100%
A0A3S7WTU4	Leishmania donovani	27%	100%
A4H8H3	Leishmania braziliensis	30%	100%
A4H8H5	Leishmania braziliensis	36%	100%
A4H8H6	Leishmania braziliensis	43%	100%
A4HWU5	Leishmania infantum	27%	100%
A4HWU7	Leishmania infantum	37%	100%
A4HWU8	Leishmania infantum	60%	97%
E9AQK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AQK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	95%
Q4QEX0	Leishmania major	60%	100%
Q4QEX1	Leishmania major	39%	100%
Q4QEX3	Leishmania major	28%	100%