LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AQK7_LEIMU
TriTrypDb:
LmxM.16.0490
Length:
206

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin: surface protein with roles in host adhesion, especially at the amastigote stage.. Localization: Cell surface (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 3, no: 18
NetGPI no yes: 0, no: 21
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 19
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Expansion

Sequence features

E9AQK7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQK7

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 105 109 PF00656 0.522
CLV_C14_Caspase3-7 53 57 PF00656 0.392
CLV_NRD_NRD_1 28 30 PF00675 0.611
DEG_Nend_UBRbox_1 1 4 PF02207 0.582
DEG_SPOP_SBC_1 111 115 PF00917 0.285
DOC_MAPK_gen_1 2 12 PF00069 0.581
DOC_MAPK_MEF2A_6 2 10 PF00069 0.554
DOC_USP7_MATH_1 111 115 PF00917 0.293
DOC_USP7_MATH_1 123 127 PF00917 0.258
DOC_WW_Pin1_4 47 52 PF00397 0.340
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P3Z4 Leptomonas seymouri 30% 100%
A0A0N0P3Z6 Leptomonas seymouri 37% 91%
A0A0N0P4D5 Leptomonas seymouri 33% 99%
A0A0N1HU04 Leptomonas seymouri 29% 66%
A0A1X0P9D7 Trypanosomatidae 28% 97%
A0A3Q8IIZ2 Leishmania donovani 33% 93%
A0A3R7KFR8 Trypanosoma rangeli 28% 100%
A0A3S5H6X1 Leishmania donovani 85% 100%
A0A3S7WTU4 Leishmania donovani 28% 100%
A4H8H3 Leishmania braziliensis 27% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS