Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQK7_LEIMU

TriTrypDb:

LmxM.16.0490

Length:

206

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin: surface protein with roles in host adhesion, especially at the amastigote stage.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 18
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

E9AQK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQK7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.522
CLV_C14_Caspase3-7	53	57	PF00656	0.392
CLV_NRD_NRD_1	28	30	PF00675	0.611
DEG_Nend_UBRbox_1	1	4	PF02207	0.582
DEG_SPOP_SBC_1	111	115	PF00917	0.285
DOC_MAPK_gen_1	2	12	PF00069	0.581
DOC_MAPK_MEF2A_6	2	10	PF00069	0.554
DOC_USP7_MATH_1	111	115	PF00917	0.293
DOC_USP7_MATH_1	123	127	PF00917	0.258
DOC_WW_Pin1_4	47	52	PF00397	0.340
LIG_14-3-3_CanoR_1	46	51	PF00244	0.361
LIG_14-3-3_CanoR_1	62	67	PF00244	0.482
LIG_BRCT_BRCA1_1	21	25	PF00533	0.385
LIG_FHA_1	126	132	PF00498	0.376
LIG_FHA_1	14	20	PF00498	0.524
LIG_FHA_1	144	150	PF00498	0.566
LIG_FHA_1	36	42	PF00498	0.468
LIG_FHA_1	86	92	PF00498	0.484
LIG_FHA_2	48	54	PF00498	0.318
LIG_LIR_Gen_1	113	123	PF02991	0.441
LIG_LIR_Nem_3	113	119	PF02991	0.419
LIG_LIR_Nem_3	160	165	PF02991	0.349
LIG_LIR_Nem_3	22	28	PF02991	0.385
LIG_LIR_Nem_3	40	45	PF02991	0.360
LIG_Pex14_2	176	180	PF04695	0.433
LIG_SH2_STAP1	64	68	PF00017	0.475
LIG_SH2_STAP1	77	81	PF00017	0.406
LIG_SH2_STAT3	66	69	PF00017	0.366
LIG_SH2_STAT5	163	166	PF00017	0.353
LIG_SH2_STAT5	42	45	PF00017	0.423
LIG_SH2_STAT5	77	80	PF00017	0.367
LIG_SUMO_SIM_par_1	10	16	PF11976	0.379
LIG_WRC_WIRS_1	116	121	PF05994	0.367
MOD_CK1_1	118	124	PF00069	0.473
MOD_CK2_1	47	53	PF00069	0.361
MOD_GlcNHglycan	125	128	PF01048	0.316
MOD_GlcNHglycan	93	96	PF01048	0.476
MOD_GSK3_1	111	118	PF00069	0.405
MOD_GSK3_1	125	132	PF00069	0.400
MOD_GSK3_1	13	20	PF00069	0.403
MOD_GSK3_1	183	190	PF00069	0.578
MOD_GSK3_1	81	88	PF00069	0.371
MOD_GSK3_1	91	98	PF00069	0.401
MOD_N-GLC_1	102	107	PF02516	0.318
MOD_N-GLC_1	34	39	PF02516	0.624
MOD_NEK2_1	110	115	PF00069	0.403
MOD_NEK2_1	129	134	PF00069	0.364
MOD_NEK2_1	13	18	PF00069	0.398
MOD_NEK2_1	182	187	PF00069	0.456
MOD_NEK2_1	60	65	PF00069	0.435
MOD_NEK2_1	90	95	PF00069	0.400
MOD_PIKK_1	143	149	PF00454	0.501
MOD_PKA_2	45	51	PF00069	0.419
MOD_Plk_1	102	108	PF00069	0.516
MOD_Plk_1	143	149	PF00069	0.488
MOD_Plk_4	112	118	PF00069	0.403
MOD_Plk_4	132	138	PF00069	0.447
MOD_Plk_4	19	25	PF00069	0.452
MOD_Plk_4	37	43	PF00069	0.352
MOD_Plk_4	75	81	PF00069	0.315
MOD_ProDKin_1	47	53	PF00069	0.350
TRG_DiLeu_BaEn_1	160	165	PF01217	0.331
TRG_ENDOCYTIC_2	76	79	PF00928	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z4	Leptomonas seymouri	30%	100%
A0A0N0P3Z6	Leptomonas seymouri	37%	91%
A0A0N0P4D5	Leptomonas seymouri	33%	99%
A0A0N1HU04	Leptomonas seymouri	29%	66%
A0A1X0P9D7	Trypanosomatidae	28%	97%
A0A3Q8IIZ2	Leishmania donovani	33%	93%
A0A3R7KFR8	Trypanosoma rangeli	28%	100%
A0A3S5H6X1	Leishmania donovani	85%	100%
A0A3S7WTU4	Leishmania donovani	28%	100%
A4H8H3	Leishmania braziliensis	27%	100%
A4H8H5	Leishmania braziliensis	65%	100%
A4H8H6	Leishmania braziliensis	39%	100%
A4HWU5	Leishmania infantum	28%	100%
A4HWU7	Leishmania infantum	85%	100%
A4HWU8	Leishmania infantum	33%	93%
E9AQK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	98%
E9AQK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	95%
Q4QEX0	Leishmania major	34%	100%
Q4QEX1	Leishmania major	86%	100%
Q4QEX3	Leishmania major	30%	99%