Amastin surface glycofamily protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AQK5_LEIMU

TriTrypDb:

LmxM.16.0470

Length:

184

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin: surface protein with roles in host adhesion, especially at the amastigote stage.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 18
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	18
GO:0110165	cellular anatomical entity	1	18

Expansion

Sequence features

E9AQK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AQK5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.480
CLV_NRD_NRD_1	28	30	PF00675	0.610
CLV_PCSK_SKI1_1	107	111	PF00082	0.340
DEG_Nend_Nbox_1	1	3	PF02207	0.699
DOC_MAPK_gen_1	29	35	PF00069	0.489
LIG_APCC_ABBA_1	176	181	PF00400	0.334
LIG_FHA_1	146	152	PF00498	0.520
LIG_FHA_1	2	8	PF00498	0.655
LIG_FHA_2	157	163	PF00498	0.480
LIG_GBD_Chelix_1	6	14	PF00786	0.382
LIG_HCF-1_HBM_1	59	62	PF13415	0.325
LIG_LIR_Gen_1	122	131	PF02991	0.448
LIG_LIR_Gen_1	162	172	PF02991	0.332
LIG_LIR_Nem_3	122	126	PF02991	0.417
LIG_LIR_Nem_3	162	167	PF02991	0.380
LIG_LIR_Nem_3	59	65	PF02991	0.521
LIG_SH2_NCK_1	158	162	PF00017	0.323
LIG_SH2_SRC	48	51	PF00017	0.372
LIG_SH2_STAT5	158	161	PF00017	0.426
LIG_SH2_STAT5	45	48	PF00017	0.447
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.499
LIG_SUMO_SIM_par_1	116	122	PF11976	0.363
LIG_TYR_ITIM	46	51	PF00017	0.373
LIG_UBA3_1	24	31	PF00899	0.554
LIG_WRC_WIRS_1	120	125	PF05994	0.386
MOD_CK1_1	119	125	PF00069	0.497
MOD_CK1_1	129	135	PF00069	0.448
MOD_CK2_1	156	162	PF00069	0.487
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_1	116	121	PF00069	0.393
MOD_NEK2_1	126	131	PF00069	0.412
MOD_PKA_1	107	113	PF00069	0.509
MOD_PKA_2	66	72	PF00069	0.446
MOD_Plk_1	145	151	PF00069	0.463
MOD_Plk_2-3	36	42	PF00069	0.313
MOD_Plk_4	116	122	PF00069	0.459
MOD_Plk_4	129	135	PF00069	0.480
MOD_Plk_4	156	162	PF00069	0.305
MOD_Plk_4	20	26	PF00069	0.515
MOD_SUMO_rev_2	36	44	PF00179	0.397
TRG_DiLeu_BaEn_1	162	167	PF01217	0.366
TRG_ENDOCYTIC_2	158	161	PF00928	0.376
TRG_ENDOCYTIC_2	48	51	PF00928	0.335
TRG_NLS_MonoExtN_4	26	33	PF00514	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z4	Leptomonas seymouri	40%	100%
A0A0N0P3Z6	Leptomonas seymouri	29%	81%
A0A0N0P4D5	Leptomonas seymouri	34%	88%
A0A1X0P9D7	Trypanosomatidae	27%	86%
A0A3Q8IIZ2	Leishmania donovani	33%	83%
A0A3R7KFR8	Trypanosoma rangeli	30%	100%
A0A3S5H6X1	Leishmania donovani	30%	92%
A0A3S7WTU4	Leishmania donovani	85%	100%
A4H8H3	Leishmania braziliensis	64%	100%
A4H8H5	Leishmania braziliensis	29%	100%
A4H8H6	Leishmania braziliensis	33%	100%
A4HWU5	Leishmania infantum	85%	100%
A4HWU7	Leishmania infantum	30%	92%
A4HWU8	Leishmania infantum	33%	83%
E9AQK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	89%
E9AQK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4QEX0	Leishmania major	31%	100%
Q4QEX1	Leishmania major	30%	100%
Q4QEX3	Leishmania major	85%	100%